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The map label for this gene is nadB [H]

Identifier: 183219891

GI number: 183219891

Start: 467471

End: 469072

Strand: Reverse

Name: nadB [H]

Synonym: LEPBI_I0473

Alternate gene names: 183219891

Gene position: 469072-467471 (Counterclockwise)

Preceding gene: 183219892

Following gene: 183219889

Centisome position: 13.03

GC content: 42.13

Gene sequence:

>1602_bases
GTGACACGAATTAAATCAGATTTCCTGATCATTGGAAGCGGAGTGAGTGGACTCTTTACCGCATTAAAATTGGCTCCGCT
TGGTTCGGTCGTTGTTGTCACCAAAAAAGCTGACTATGAATCCAATACCAACTATGCACAAGGTGGTATTGCTTCTGTTT
TTGACGATCAGGACAAATTTGAAGAACACATCAAGGACACCTTGGAATCAGGTGCTGGATTATGTGATCTCGAAGCAGTT
CGTGTTTTGGTAGAAGAAGGACCCACTCGAGTCAAAGAACTTTTAGAATTAGGGGTACCATTTACCAGAAACCAAACTGG
TGAATTGGATTTGGCTCGTGAAGGTGGTCATAGTAAAAATAGGATCATCCATTCACTTGACCGAACAGGAAGTGCTGTTG
AACAATCATTACTCGACAACGTCCATTCAAATCCAAATATCCGAATTTTAGAAAACCATGCCTGTGTAGATTTAATCACC
AAACATCATTTAAAAGACAAAGACAACCTACCATTACGATGTTATGGTGCCTATATTGTTGATACTGAAACTGGGGAAGT
TTTTCCAGTCCTTGCTAAAAAAACTATTTTAGCAACCGGTGGAGCAGGCCAAGTCTATCTTCATACAACCAATCCGAATA
TCGCAACTGGTGACGGAGTTGCAAGTGCCTATCGAGCTGGAGCCATTGTCAAAAACATGGAATTTTACCAGTTCCATCCC
ACATCCTTATTCCACGAACAAGGGAATAGTTTTTTAATCTCAGAAGCCGTTCGTGGCCATGGTGGCATCTTACGCGAAAT
AGGTGGTCGGCCATTTATGAAAGATTATCATACTTTGGGAGAATTGGCACCAAGAGATATCGTGGCACGAGCCATCGACG
ACACGATGAAAAAAAGAGGAGAACCTCATGTTCTGCTTGATATCACACACAGACCCGCAAACGACATCATCAGCCATTTC
CCTTCGATTTACGAACGATGTAAAAAGTTAGGTATTGATATCACAACGGATCCTATTCCTGTGGTTCCTGCAGCGCATTA
TATGTGCGGTGGTGTTGCCACCGACCTTCTTGGACGAACTAACATAGCCGATTTGTATGCTTGTGGTGAAACTACATGTA
CGGGAGTGCATGGTGGGAACCGATTGGCTTCGAATAGTTTATTGGAGTGTTTGGTTTTTTCCCATCGAATTGCAGAAGAC
ATTCGGTCCCAAGGGAAACTAAACTATTCTTCGGAAACTGATTTGATTCCAGATTGGAATAAAGAAGGAACTACCAATAC
GGAAGAATGGGTTCTCATCTCACATGACCTAATCGAAATCAAAACCATCATGAGTAATTATGTTGGAATCGTTCGTTCAG
ACATGCGATTGGAACGGGCACTTCGCCGCTTGAAACTGATCTCAGAAGAAGTGAAAGACTACTACAATCGAACCACTGTT
TCACTAGGTTTATTAGAACTTCGTAATTTAGTAAAGGTTGCTGAGTTGATTGTGAGATCGGCACTTTTACGGAAGGAAAG
CCGAGGGCTTCATTTTAGCACGGATTACCCAGAAGATCGCACCCCATCCAGACAAGATACAATCCTATCTCATAAATTAT
AA

Upstream 100 bases:

>100_bases
GATTCGAAGTTTGGATTATATCGAAGGGATGATCAATACAAAATCATAGATTCCTAATTGGGATTTTATTGAAAGTATTT
TGAATACAATTGGATAGAAT

Downstream 100 bases:

>100_bases
AAAGTCCTGCGCCAGGGACCGAAGCGGAAATCCTTTCTCGTTATGAGAAAGATTGTAGCGAAGGGCCCGGTCCCTATTGT
AAAAATTATTTTTTCAAGTA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MTRIKSDFLIIGSGVSGLFTALKLAPLGSVVVVTKKADYESNTNYAQGGIASVFDDQDKFEEHIKDTLESGAGLCDLEAV
RVLVEEGPTRVKELLELGVPFTRNQTGELDLAREGGHSKNRIIHSLDRTGSAVEQSLLDNVHSNPNIRILENHACVDLIT
KHHLKDKDNLPLRCYGAYIVDTETGEVFPVLAKKTILATGGAGQVYLHTTNPNIATGDGVASAYRAGAIVKNMEFYQFHP
TSLFHEQGNSFLISEAVRGHGGILREIGGRPFMKDYHTLGELAPRDIVARAIDDTMKKRGEPHVLLDITHRPANDIISHF
PSIYERCKKLGIDITTDPIPVVPAAHYMCGGVATDLLGRTNIADLYACGETTCTGVHGGNRLASNSLLECLVFSHRIAED
IRSQGKLNYSSETDLIPDWNKEGTTNTEEWVLISHDLIEIKTIMSNYVGIVRSDMRLERALRRLKLISEEVKDYYNRTTV
SLGLLELRNLVKVAELIVRSALLRKESRGLHFSTDYPEDRTPSRQDTILSHKL

Sequences:

>Translated_533_residues
MTRIKSDFLIIGSGVSGLFTALKLAPLGSVVVVTKKADYESNTNYAQGGIASVFDDQDKFEEHIKDTLESGAGLCDLEAV
RVLVEEGPTRVKELLELGVPFTRNQTGELDLAREGGHSKNRIIHSLDRTGSAVEQSLLDNVHSNPNIRILENHACVDLIT
KHHLKDKDNLPLRCYGAYIVDTETGEVFPVLAKKTILATGGAGQVYLHTTNPNIATGDGVASAYRAGAIVKNMEFYQFHP
TSLFHEQGNSFLISEAVRGHGGILREIGGRPFMKDYHTLGELAPRDIVARAIDDTMKKRGEPHVLLDITHRPANDIISHF
PSIYERCKKLGIDITTDPIPVVPAAHYMCGGVATDLLGRTNIADLYACGETTCTGVHGGNRLASNSLLECLVFSHRIAED
IRSQGKLNYSSETDLIPDWNKEGTTNTEEWVLISHDLIEIKTIMSNYVGIVRSDMRLERALRRLKLISEEVKDYYNRTTV
SLGLLELRNLVKVAELIVRSALLRKESRGLHFSTDYPEDRTPSRQDTILSHKL
>Mature_532_residues
TRIKSDFLIIGSGVSGLFTALKLAPLGSVVVVTKKADYESNTNYAQGGIASVFDDQDKFEEHIKDTLESGAGLCDLEAVR
VLVEEGPTRVKELLELGVPFTRNQTGELDLAREGGHSKNRIIHSLDRTGSAVEQSLLDNVHSNPNIRILENHACVDLITK
HHLKDKDNLPLRCYGAYIVDTETGEVFPVLAKKTILATGGAGQVYLHTTNPNIATGDGVASAYRAGAIVKNMEFYQFHPT
SLFHEQGNSFLISEAVRGHGGILREIGGRPFMKDYHTLGELAPRDIVARAIDDTMKKRGEPHVLLDITHRPANDIISHFP
SIYERCKKLGIDITTDPIPVVPAAHYMCGGVATDLLGRTNIADLYACGETTCTGVHGGNRLASNSLLECLVFSHRIAEDI
RSQGKLNYSSETDLIPDWNKEGTTNTEEWVLISHDLIEIKTIMSNYVGIVRSDMRLERALRRLKLISEEVKDYYNRTTVS
LGLLELRNLVKVAELIVRSALLRKESRGLHFSTDYPEDRTPSRQDTILSHKL

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=526, Percent_Identity=30.6083650190114, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1788928, Length=518, Percent_Identity=50.3861003861004, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1790597, Length=528, Percent_Identity=32.1969696969697, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786942, Length=554, Percent_Identity=33.9350180505415, Blast_Score=229, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=534, Percent_Identity=31.0861423220974, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=31.0280373831776, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71986328, Length=463, Percent_Identity=27.8617710583153, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322416, Length=542, Percent_Identity=31.3653136531365, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322701, Length=559, Percent_Identity=31.1270125223614, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6320788, Length=494, Percent_Identity=26.5182186234818, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322511, Length=496, Percent_Identity=25.4032258064516, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137288, Length=527, Percent_Identity=31.6888045540797, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24655642, Length=527, Percent_Identity=31.6888045540797, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24655647, Length=527, Percent_Identity=31.6888045540797, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24663005, Length=555, Percent_Identity=30.6306306306306, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 58988; Mature: 58857

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIKSDFLIIGSGVSGLFTALKLAPLGSVVVVTKKADYESNTNYAQGGIASVFDDQDKF
CCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCHHHH
EEHIKDTLESGAGLCDLEAVRVLVEEGPTRVKELLELGVPFTRNQTGELDLAREGGHSKN
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEHHCCCCCHH
RIIHSLDRTGSAVEQSLLDNVHSNPNIRILENHACVDLITKHHLKDKDNLPLRCYGAYIV
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEEEEEE
DTETGEVFPVLAKKTILATGGAGQVYLHTTNPNIATGDGVASAYRAGAIVKNMEFYQFHP
ECCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
TSLFHEQGNSFLISEAVRGHGGILREIGGRPFMKDYHTLGELAPRDIVARAIDDTMKKRG
HHHHHHCCCCEEEHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
EPHVLLDITHRPANDIISHFPSIYERCKKLGIDITTDPIPVVPAAHYMCGGVATDLLGRT
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NIADLYACGETTCTGVHGGNRLASNSLLECLVFSHRIAEDIRSQGKLNYSSETDLIPDWN
CHHHHEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KEGTTNTEEWVLISHDLIEIKTIMSNYVGIVRSDMRLERALRRLKLISEEVKDYYNRTTV
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLELRNLVKVAELIVRSALLRKESRGLHFSTDYPEDRTPSRQDTILSHKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TRIKSDFLIIGSGVSGLFTALKLAPLGSVVVVTKKADYESNTNYAQGGIASVFDDQDKF
CCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCHHHH
EEHIKDTLESGAGLCDLEAVRVLVEEGPTRVKELLELGVPFTRNQTGELDLAREGGHSKN
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEHHCCCCCHH
RIIHSLDRTGSAVEQSLLDNVHSNPNIRILENHACVDLITKHHLKDKDNLPLRCYGAYIV
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEEEEEE
DTETGEVFPVLAKKTILATGGAGQVYLHTTNPNIATGDGVASAYRAGAIVKNMEFYQFHP
ECCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
TSLFHEQGNSFLISEAVRGHGGILREIGGRPFMKDYHTLGELAPRDIVARAIDDTMKKRG
HHHHHHCCCCEEEHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
EPHVLLDITHRPANDIISHFPSIYERCKKLGIDITTDPIPVVPAAHYMCGGVATDLLGRT
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NIADLYACGETTCTGVHGGNRLASNSLLECLVFSHRIAEDIRSQGKLNYSSETDLIPDWN
CHHHHEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KEGTTNTEEWVLISHDLIEIKTIMSNYVGIVRSDMRLERALRRLKLISEEVKDYYNRTTV
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLELRNLVKVAELIVRSALLRKESRGLHFSTDYPEDRTPSRQDTILSHKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]