Click here to switch to the map view.

The map label for this gene is frlA [H]

Identifier: 183219873

GI number: 183219873

Start: 449859

End: 451235

Strand: Reverse

Name: frlA [H]

Synonym: LEPBI_I0454

Alternate gene names: 183219873

Gene position: 451235-449859 (Counterclockwise)

Preceding gene: 183219874

Following gene: 183219870

Centisome position: 12.54

GC content: 40.67

Gene sequence:

>1377_bases
TTGGAATTAAAACGTAGCCTTAATACTTTTGATTCCATTTCCGTTCTCTTTTCCTCCATGGTGGGGTCGGGGATTTTTTT
CACTTCTGGATACTTAATCAAAGAAACTGGCAACCTCTGGATTGTCCTCTTTTGTTGGATCATCGGCGGTCTACTTGCCC
TCTCTGGATCCATCACATATGCATATGCGGCTCGTCTCCTTCCCTTTGCGGGAGGCGATTATGTGTATCTCAAAGTTGCC
TACTCGCCAGCCATCGCGTTCATGAGTGGGTGGTCCTCTCTACTCACCAATTTTTCAGCCTGTGTATCGGTCTTAGCACT
CGCCTTTGGAAAGTATGTACAAATTTTATTCCCAGGCCTTCCCTACTTTGAATCACCCACGTATACATTCCTTGGTCTCG
ACTTACAAGTGAGTTCCCTTACCTTCATCGGAATGATCCCCATTCTATTTTTTAGTGGATTGAATTATTTTGGGATCAAA
TCAGCAGTACGAGTGCAAAACGTTTTTGCTGTTTTAAAAATCACGGGACTACTTCTCTTTTTAGCACTTGGATTTTCGAT
TGGTTCCACCCACTGGGGTTATTTATTCGAATCTCCATTTCCCAATCTTTTCGAATTATCTTTTTATTCTAAAGTTCTCA
TTGGCATCGTCCCAGTTTCCTTCTCCTATCTTGGTTGGAATATGATCACCTACATTGCAGAAGAAGTGAAACAACCAGAA
AAAACCATTGTTCGATCAGCCATCACTGCTTGTTTTCTTGTCGCAGGGCTTTATTTTGCCATCAATTTACTTTTTGTGAT
CTCAGCTCCCATTGGAGAATTGGCAGGGCAAGATGGGATTGGTGCCATCGCCTTTCAAAAGTTATTCGGTTCGGATTATT
CCATTTTAACTACAAGTTTCATTGCATGGGTGATTTTGGGATCCATGTCCGCCATCCTCATTGGTGGGAGTCGGGTTTAC
TTTGCGATGGCAAGAGATGGTGTGTTTTTACCAAGTTTTTCCAAAGTCCATCCCAAATGGCATAGCCCTTATGTTTCGAT
TTTTTTTCAGGCATTTGTTGCGATTCTCTTTTTGTTTGTGAAAGAAATCGAATCTTTGCTTTATATGATCACTTGTTCCA
TACTCATTTTGTCTTGTCTCACCGCAGCAACTCCGTTTCGATTTGAAAAGATGGGAATGAAATCGGATTACAAAATTCCA
TTTTATCCTCTGCCAATCTTTTTATATATCTTTGCCAACATTGCTGTGATGGTGATTTTATTTGTAGAAAAACCAATCAC
GGCTTCTTGGGGCCTTATGATCACACTCATCGCCTTACCAGTGTATTATCTATTCCGATTGGACAAAAAGATGGTTTCAA
CAAAAAAGAAATCATAA

Upstream 100 bases:

>100_bases
GCTAAGCCCAGAAGAATTCAAAGGTAAAATTGGATCGGTCTCTACGGCTTCCATGAAACCAATTTCGGAAACCATGGTCA
AACGTCTCCTCGGCAGTTAA

Downstream 100 bases:

>100_bases
AAACCAATGAAACTTGTGGATTAATTTTTAAGCAATTGCCATAAAGGTTCTGCCAATGATGGGCATCACATCATCTTTTG
CGAGCACCCATACCACATCC

Product: putative amino-acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MELKRSLNTFDSISVLFSSMVGSGIFFTSGYLIKETGNLWIVLFCWIIGGLLALSGSITYAYAARLLPFAGGDYVYLKVA
YSPAIAFMSGWSSLLTNFSACVSVLALAFGKYVQILFPGLPYFESPTYTFLGLDLQVSSLTFIGMIPILFFSGLNYFGIK
SAVRVQNVFAVLKITGLLLFLALGFSIGSTHWGYLFESPFPNLFELSFYSKVLIGIVPVSFSYLGWNMITYIAEEVKQPE
KTIVRSAITACFLVAGLYFAINLLFVISAPIGELAGQDGIGAIAFQKLFGSDYSILTTSFIAWVILGSMSAILIGGSRVY
FAMARDGVFLPSFSKVHPKWHSPYVSIFFQAFVAILFLFVKEIESLLYMITCSILILSCLTAATPFRFEKMGMKSDYKIP
FYPLPIFLYIFANIAVMVILFVEKPITASWGLMITLIALPVYYLFRLDKKMVSTKKKS

Sequences:

>Translated_458_residues
MELKRSLNTFDSISVLFSSMVGSGIFFTSGYLIKETGNLWIVLFCWIIGGLLALSGSITYAYAARLLPFAGGDYVYLKVA
YSPAIAFMSGWSSLLTNFSACVSVLALAFGKYVQILFPGLPYFESPTYTFLGLDLQVSSLTFIGMIPILFFSGLNYFGIK
SAVRVQNVFAVLKITGLLLFLALGFSIGSTHWGYLFESPFPNLFELSFYSKVLIGIVPVSFSYLGWNMITYIAEEVKQPE
KTIVRSAITACFLVAGLYFAINLLFVISAPIGELAGQDGIGAIAFQKLFGSDYSILTTSFIAWVILGSMSAILIGGSRVY
FAMARDGVFLPSFSKVHPKWHSPYVSIFFQAFVAILFLFVKEIESLLYMITCSILILSCLTAATPFRFEKMGMKSDYKIP
FYPLPIFLYIFANIAVMVILFVEKPITASWGLMITLIALPVYYLFRLDKKMVSTKKKS
>Mature_458_residues
MELKRSLNTFDSISVLFSSMVGSGIFFTSGYLIKETGNLWIVLFCWIIGGLLALSGSITYAYAARLLPFAGGDYVYLKVA
YSPAIAFMSGWSSLLTNFSACVSVLALAFGKYVQILFPGLPYFESPTYTFLGLDLQVSSLTFIGMIPILFFSGLNYFGIK
SAVRVQNVFAVLKITGLLLFLALGFSIGSTHWGYLFESPFPNLFELSFYSKVLIGIVPVSFSYLGWNMITYIAEEVKQPE
KTIVRSAITACFLVAGLYFAINLLFVISAPIGELAGQDGIGAIAFQKLFGSDYSILTTSFIAWVILGSMSAILIGGSRVY
FAMARDGVFLPSFSKVHPKWHSPYVSIFFQAFVAILFLFVKEIESLLYMITCSILILSCLTAATPFRFEKMGMKSDYKIP
FYPLPIFLYIFANIAVMVILFVEKPITASWGLMITLIALPVYYLFRLDKKMVSTKKKS

Specific function: May be involved in fructoselysine transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=450, Percent_Identity=26.2222222222222, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI7657683, Length=458, Percent_Identity=25.1091703056769, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI115648063, Length=458, Percent_Identity=24.6724890829694, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI115648022, Length=458, Percent_Identity=24.6724890829694, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI186910308, Length=456, Percent_Identity=24.5614035087719, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI186910306, Length=456, Percent_Identity=24.5614035087719, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI186910304, Length=456, Percent_Identity=24.5614035087719, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI71979932, Length=457, Percent_Identity=26.0393873085339, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI187423910, Length=413, Percent_Identity=23.4866828087167, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI7657591, Length=413, Percent_Identity=23.4866828087167, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI9790235, Length=443, Percent_Identity=23.2505643340858, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507047, Length=412, Percent_Identity=23.0582524271845, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI258614005, Length=415, Percent_Identity=23.855421686747, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258614003, Length=415, Percent_Identity=23.855421686747, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258645169, Length=406, Percent_Identity=24.8768472906404, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI71999149, Length=437, Percent_Identity=22.4256292906178, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI33286430, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082250, Length=467, Percent_Identity=29.7644539614561, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87081869, Length=371, Percent_Identity=26.4150943396226, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082023, Length=305, Percent_Identity=25.9016393442623, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=452, Percent_Identity=24.7787610619469, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982612, Length=463, Percent_Identity=25.2699784017279, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982608, Length=463, Percent_Identity=25.2699784017279, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17568033, Length=456, Percent_Identity=25, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193208714, Length=369, Percent_Identity=26.5582655826558, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32566695, Length=369, Percent_Identity=26.5582655826558, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32566699, Length=468, Percent_Identity=23.2905982905983, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71993915, Length=463, Percent_Identity=23.7580993520518, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71995388, Length=465, Percent_Identity=25.1612903225806, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71995382, Length=465, Percent_Identity=25.1612903225806, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71990446, Length=459, Percent_Identity=20.9150326797386, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987339, Length=448, Percent_Identity=25.4464285714286, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982623, Length=293, Percent_Identity=25.2559726962457, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=382, Percent_Identity=23.8219895287958, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321492, Length=363, Percent_Identity=22.8650137741047, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357367, Length=453, Percent_Identity=25.8278145695364, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24651635, Length=450, Percent_Identity=25.7777777777778, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24651633, Length=450, Percent_Identity=25.7777777777778, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221331183, Length=456, Percent_Identity=24.780701754386, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17647653, Length=456, Percent_Identity=24.780701754386, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24664379, Length=456, Percent_Identity=24.780701754386, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI45550968, Length=463, Percent_Identity=24.8380129589633, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19921172, Length=463, Percent_Identity=24.8380129589633, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24641995, Length=373, Percent_Identity=25.201072386059, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641993, Length=406, Percent_Identity=24.8768472906404, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24667468, Length=381, Percent_Identity=25.7217847769029, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221512776, Length=398, Percent_Identity=22.6130653266332, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666159, Length=398, Percent_Identity=22.6130653266332, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50825; Mature: 50825

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKRSLNTFDSISVLFSSMVGSGIFFTSGYLIKETGNLWIVLFCWIIGGLLALSGSITY
CCCHHHHCHHHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
AYAARLLPFAGGDYVYLKVAYSPAIAFMSGWSSLLTNFSACVSVLALAFGKYVQILFPGL
HHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PYFESPTYTFLGLDLQVSSLTFIGMIPILFFSGLNYFGIKSAVRVQNVFAVLKITGLLLF
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LALGFSIGSTHWGYLFESPFPNLFELSFYSKVLIGIVPVSFSYLGWNMITYIAEEVKQPE
HHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
KTIVRSAITACFLVAGLYFAINLLFVISAPIGELAGQDGIGAIAFQKLFGSDYSILTTSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
IAWVILGSMSAILIGGSRVYFAMARDGVFLPSFSKVHPKWHSPYVSIFFQAFVAILFLFV
HHHHHHHCCHHEEECCCEEEEEEECCCEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
KEIESLLYMITCSILILSCLTAATPFRFEKMGMKSDYKIPFYPLPIFLYIFANIAVMVIL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVEKPITASWGLMITLIALPVYYLFRLDKKMVSTKKKS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELKRSLNTFDSISVLFSSMVGSGIFFTSGYLIKETGNLWIVLFCWIIGGLLALSGSITY
CCCHHHHCHHHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHCCCHHH
AYAARLLPFAGGDYVYLKVAYSPAIAFMSGWSSLLTNFSACVSVLALAFGKYVQILFPGL
HHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PYFESPTYTFLGLDLQVSSLTFIGMIPILFFSGLNYFGIKSAVRVQNVFAVLKITGLLLF
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LALGFSIGSTHWGYLFESPFPNLFELSFYSKVLIGIVPVSFSYLGWNMITYIAEEVKQPE
HHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
KTIVRSAITACFLVAGLYFAINLLFVISAPIGELAGQDGIGAIAFQKLFGSDYSILTTSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
IAWVILGSMSAILIGGSRVYFAMARDGVFLPSFSKVHPKWHSPYVSIFFQAFVAILFLFV
HHHHHHHCCHHEEECCCEEEEEEECCCEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
KEIESLLYMITCSILILSCLTAATPFRFEKMGMKSDYKIPFYPLPIFLYIFANIAVMVIL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVEKPITASWGLMITLIALPVYYLFRLDKKMVSTKKKS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]