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The map label for this gene is pepA [H]

Identifier: 183219869

GI number: 183219869

Start: 445890

End: 447374

Strand: Reverse

Name: pepA [H]

Synonym: LEPBI_I0450

Alternate gene names: 183219869

Gene position: 447374-445890 (Counterclockwise)

Preceding gene: 183219870

Following gene: 183219865

Centisome position: 12.43

GC content: 43.16

Gene sequence:

>1485_bases
ATGAAAATCGAAATCTCTCCACTCCAAATCCAAATCGGTCAGGCAAAATCTGGTTCCTTTTATAAACTCATTCCAATTTT
CCAAGAAGAAGTGAAAGAAGAACTGGGAAAAAAATTCCCCATCCAAATTGAAACCAAAGTGTTCTCAGGTGAACTGGGAA
AAGAATTTCGGGATGAAGCAGAACACACCATCTATCTTGGTTTAGGTGAAAAAGAAAAATTAAACTTTCGGAAATTGATT
TCTCATTTTTTTAAGTATGGGGAAAAAATTCTCAACTATGATGGAATGGGTTTAGAAATCCATATCCCAAAAGCACTTTC
CAAAAAGTTTTCTGCAGACCGAATCGCCTACCAAATCGCCAATACATTGTTCATTGGAAGTTATCCGGTTTCCGTTTTAC
AAACCAAAAAAAAAGACAAAGAAAAAAAGAAAGTGGGATCTGTTTATCTCAAGTTCGAAGACAAATCTGTCACTACACTT
GCAGAAGCAGGACTTTCTAAAAGTAAAGTGGTCGCAAAACACGTCAATGGTGCTCGTCACATTGCCCACTTACCTGCTAA
TTATTTCACACCAAACGACTTTGTATCCAGGGCCAAAGAAATTGCCAAAGAATACAAACTCTCTGTAAAGGTATGGGAGG
AAGCCCAACTGAAAAAAGAGGGCCTTGGTGGAATCCTTGCCGTCTCTCGCGGTTCCGAACTGGAAGGCAAGATGGTGATT
TTGGAATACAAACCGACAAAGGCAAAAAAGAAATTTGCGATTGTGGGAAAAGGTCTTACCTTTGATACAGGTGGGATTTC
CTTAAAACCACCAGGTGAGATGCACGAAATGAAGTATGATATGTGTGGGGCAGCTGCCACCATACACGCGATTGGTGCCA
TTGCAGCCCTTGAAATCCCCATCCATATCATTGCAGCCATTGGGGTGGCAGAAAACATGCCAGATGGAAAAGCAATCAAA
CCAGGTGACGTTTACACAGCTTATAACGGAACCACCGTAGAAGTCCAAAACACGGATGCCGAAGGAAGGCTTGTGTTAGG
TGATGTATTGTCCTATGTTTCCAAAAATTACAAACCAGACTATATGGTGGACCTAGCGACACTCACTGGCGCTGTGATCA
TTGCCCTTGGGCATGAGGCCGCCGCCATCCTCACCAACTCAGATCCTCTTCGAGAAGCCCTATTCAAAGCATCCGAAGCA
TCCGATGACCGAGTTTGGGAACTCCCCCTTTGGGACGAATATGGTGAAGACCTGAAGTCAGACATTGCGGATTTAAAAAA
TATCACTGGTGGTGGAAAAGGTGCAGGAACCATTTCTGCAGGAATTTTTCTTTCTAAGTTTGTGGATGACTCCATCAACT
GGGCCCATATCGATATCGCAGGGGCCGCATGGAGAAAGAAAAAATCCGGAACCCAATTCCATGGCCCAACAGGATACGGT
GTACGGCTGTTAGTGGATCTTGCAAAGGAACTAGCAGGGAAATAA

Upstream 100 bases:

>100_bases
TACTCGATAGTTCTCTCAAAATTAAAAAAATCTATGACAGCGTGAAGGTAAAAGGACACGTTGAAGAAATCATCAAAGAC
ATTCAGGAAATCCAAGGGAA

Downstream 100 bases:

>100_bases
AGATTCCGAAGATTCCCTGTTAGTTGTTGGATAGAGGTATTTTTTATACAAAAACTCTCTATCCAACAATTTGGAATCCT
TTAGAAAAAAATGTTTCACC

Product: aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MKIEISPLQIQIGQAKSGSFYKLIPIFQEEVKEELGKKFPIQIETKVFSGELGKEFRDEAEHTIYLGLGEKEKLNFRKLI
SHFFKYGEKILNYDGMGLEIHIPKALSKKFSADRIAYQIANTLFIGSYPVSVLQTKKKDKEKKKVGSVYLKFEDKSVTTL
AEAGLSKSKVVAKHVNGARHIAHLPANYFTPNDFVSRAKEIAKEYKLSVKVWEEAQLKKEGLGGILAVSRGSELEGKMVI
LEYKPTKAKKKFAIVGKGLTFDTGGISLKPPGEMHEMKYDMCGAAATIHAIGAIAALEIPIHIIAAIGVAENMPDGKAIK
PGDVYTAYNGTTVEVQNTDAEGRLVLGDVLSYVSKNYKPDYMVDLATLTGAVIIALGHEAAAILTNSDPLREALFKASEA
SDDRVWELPLWDEYGEDLKSDIADLKNITGGGKGAGTISAGIFLSKFVDDSINWAHIDIAGAAWRKKKSGTQFHGPTGYG
VRLLVDLAKELAGK

Sequences:

>Translated_494_residues
MKIEISPLQIQIGQAKSGSFYKLIPIFQEEVKEELGKKFPIQIETKVFSGELGKEFRDEAEHTIYLGLGEKEKLNFRKLI
SHFFKYGEKILNYDGMGLEIHIPKALSKKFSADRIAYQIANTLFIGSYPVSVLQTKKKDKEKKKVGSVYLKFEDKSVTTL
AEAGLSKSKVVAKHVNGARHIAHLPANYFTPNDFVSRAKEIAKEYKLSVKVWEEAQLKKEGLGGILAVSRGSELEGKMVI
LEYKPTKAKKKFAIVGKGLTFDTGGISLKPPGEMHEMKYDMCGAAATIHAIGAIAALEIPIHIIAAIGVAENMPDGKAIK
PGDVYTAYNGTTVEVQNTDAEGRLVLGDVLSYVSKNYKPDYMVDLATLTGAVIIALGHEAAAILTNSDPLREALFKASEA
SDDRVWELPLWDEYGEDLKSDIADLKNITGGGKGAGTISAGIFLSKFVDDSINWAHIDIAGAAWRKKKSGTQFHGPTGYG
VRLLVDLAKELAGK
>Mature_494_residues
MKIEISPLQIQIGQAKSGSFYKLIPIFQEEVKEELGKKFPIQIETKVFSGELGKEFRDEAEHTIYLGLGEKEKLNFRKLI
SHFFKYGEKILNYDGMGLEIHIPKALSKKFSADRIAYQIANTLFIGSYPVSVLQTKKKDKEKKKVGSVYLKFEDKSVTTL
AEAGLSKSKVVAKHVNGARHIAHLPANYFTPNDFVSRAKEIAKEYKLSVKVWEEAQLKKEGLGGILAVSRGSELEGKMVI
LEYKPTKAKKKFAIVGKGLTFDTGGISLKPPGEMHEMKYDMCGAAATIHAIGAIAALEIPIHIIAAIGVAENMPDGKAIK
PGDVYTAYNGTTVEVQNTDAEGRLVLGDVLSYVSKNYKPDYMVDLATLTGAVIIALGHEAAAILTNSDPLREALFKASEA
SDDRVWELPLWDEYGEDLKSDIADLKNITGGGKGAGTISAGIFLSKFVDDSINWAHIDIAGAAWRKKKSGTQFHGPTGYG
VRLLVDLAKELAGK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=39.5705521472393, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=34.0425531914894, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1790710, Length=317, Percent_Identity=47.6340694006309, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=35, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=307, Percent_Identity=33.8762214983713, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=170, Percent_Identity=33.5294117647059, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=34.1935483870968, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=34.1935483870968, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=34.1935483870968, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24661038, Length=331, Percent_Identity=31.4199395770393, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21355725, Length=285, Percent_Identity=33.6842105263158, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI20129969, Length=334, Percent_Identity=33.2335329341317, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24662227, Length=301, Percent_Identity=32.2259136212625, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI161077148, Length=292, Percent_Identity=32.8767123287671, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20130057, Length=292, Percent_Identity=32.8767123287671, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129963, Length=290, Percent_Identity=34.8275862068965, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21355645, Length=292, Percent_Identity=32.8767123287671, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24662223, Length=292, Percent_Identity=32.8767123287671, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=32.3024054982818, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646701, Length=287, Percent_Identity=30.6620209059233, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646703, Length=287, Percent_Identity=30.6620209059233, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358201, Length=287, Percent_Identity=30.6620209059233, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54025; Mature: 54025

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEISPLQIQIGQAKSGSFYKLIPIFQEEVKEELGKKFPIQIETKVFSGELGKEFRDEA
CEEEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCHHCHHHHCCC
EHTIYLGLGEKEKLNFRKLISHFFKYGEKILNYDGMGLEIHIPKALSKKFSADRIAYQIA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCHHHHHHHHH
NTLFIGSYPVSVLQTKKKDKEKKKVGSVYLKFEDKSVTTLAEAGLSKSKVVAKHVNGARH
HEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHCCCCHHHHHHHHCCCCHH
IAHLPANYFTPNDFVSRAKEIAKEYKLSVKVWEEAQLKKEGLGGILAVSRGSELEGKMVI
EEECCCCCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCEEE
LEYKPTKAKKKFAIVGKGLTFDTGGISLKPPGEMHEMKYDMCGAAATIHAIGAIAALEIP
EEECCCCCCCEEEEEECCEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHIIAAIGVAENMPDGKAIKPGDVYTAYNGTTVEVQNTDAEGRLVLGDVLSYVSKNYKPD
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHHCCCCCC
YMVDLATLTGAVIIALGHEAAAILTNSDPLREALFKASEASDDRVWELPLWDEYGEDLKS
CEEEHHHHCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHH
DIADLKNITGGGKGAGTISAGIFLSKFVDDSINWAHIDIAGAAWRKKKSGTQFHGPTGYG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCH
VRLLVDLAKELAGK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKIEISPLQIQIGQAKSGSFYKLIPIFQEEVKEELGKKFPIQIETKVFSGELGKEFRDEA
CEEEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEECCHHCHHHHCCC
EHTIYLGLGEKEKLNFRKLISHFFKYGEKILNYDGMGLEIHIPKALSKKFSADRIAYQIA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCHHHHHHHHH
NTLFIGSYPVSVLQTKKKDKEKKKVGSVYLKFEDKSVTTLAEAGLSKSKVVAKHVNGARH
HEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHCCCCHHHHHHHHCCCCHH
IAHLPANYFTPNDFVSRAKEIAKEYKLSVKVWEEAQLKKEGLGGILAVSRGSELEGKMVI
EEECCCCCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCEEE
LEYKPTKAKKKFAIVGKGLTFDTGGISLKPPGEMHEMKYDMCGAAATIHAIGAIAALEIP
EEECCCCCCCEEEEEECCEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHIIAAIGVAENMPDGKAIKPGDVYTAYNGTTVEVQNTDAEGRLVLGDVLSYVSKNYKPD
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHHCCCCCC
YMVDLATLTGAVIIALGHEAAAILTNSDPLREALFKASEASDDRVWELPLWDEYGEDLKS
CEEEHHHHCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHH
DIADLKNITGGGKGAGTISAGIFLSKFVDDSINWAHIDIAGAAWRKKKSGTQFHGPTGYG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCH
VRLLVDLAKELAGK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA