Click here to switch to the map view.

The map label for this gene is fad [H]

Identifier: 183219648

GI number: 183219648

Start: 213879

End: 215594

Strand: Direct

Name: fad [H]

Synonym: LEPBI_I0223

Alternate gene names: 183219648

Gene position: 213879-215594 (Clockwise)

Preceding gene: 183219646

Following gene: 183219649

Centisome position: 5.94

GC content: 40.97

Gene sequence:

>1716_bases
ATGAGTCACCATATTTCTGAACATCCTTCCTTACAACCGTTTGATATTTCTGAGTACAAAGGCCTACGAGGTAAAAATTT
TTACGATATGGACCCTGCCTTGCAGAGAATGGTGGATCGTTATTCTGAATCTTTTGACCCAAAACACAAACTGGCCATGG
TGGAACACATCCGAGAGTATGGGGAGCTAGTCGGTGGGATTTTAGATGAACTTACCGAAGAATGCCACAAGGAAGGAAAA
TACGGTGAAGTGGTCAAATATGATCGCACTGGAAAACGAATCGATTTTATCAAATACTCAGATGAACAAAAACGTGCACG
GAAAATATCTTATGACCATGGAGTTGTGAATTTAGACTTCCATCGAGAATGGAACTATGAATTCACACATATTCACCGTT
ATGCGCTCACCTATTTGATGAATTTAAATGGTGAAGGTGGAGTTGCTTGTCCATTGGCCATGACCGATGGGATGATCCTT
GCTCTAAAAAAAATTGGAACCGAAGAACAAAAGAAAAAATATCTCCCTCTCGTTGCTGGCAAAGGAAGTGATTCACATTT
TATGGCAGGCCAATATGTGACAGAACGTGTGGGTGGTAGTAATGTTTCGGCCAACAGGACGATAGCGAAAAAACTACCGA
ACGGCAAATGGGAGTTAACCGGCGAAAAATGGTTTTGTTCCAACCCAGGTGACCTTTGGGTGACTACGGCCAAAATGGAA
GGAACAAACACGGTTGGAATGTTTCTTGTTCCTAGGATCAAGGAAAATGGCGAATTGAATGGCCAGCACATCCTTCGCAA
AAAAGACATCATCGGTTCGCGAGGTAAGATCACTGTTGAGATCATTTATGATAAAGTAGAAGCAGAAGAGTTTGGTCGTC
CTGGCCATGGGCTTGTGAATCTGATTCGTTACATCATCAAAACATCACGGCTCCATGTGGGACTTGGTTCATGTGGAAAC
GCAAGAAGGTCGGTCATGGAAGCATCGGAATATGCAAAATTTCGGACTGCTTATGGTAAAAAAATCTTAGAATTCCCTTC
CTTTGTGAAAACACTTGCAGAGATGCAAATTTTACAAACAGCAAATTGTTTTGTTAACTTTCGTTCGGTAGGACTTGCGG
AGAAGGGAGATGATGCGGCAGAAATCACTGTCCCACTTTTAAAATACAAATCTTCATCGCAAGCAAGTTACATCACACAA
AAAGCAATCCTGACGTTAGGTGGGAATGGTATCATTGGTGATTTTTCCCCTCTGCCAAGATTACATAATGATTCCATTAT
CAATGAAACTTGGGAAGGCACCCACTTGATCATTACTGATCATTGTTTGCATGCCTTACAAAAACCAAAGGTGTATGTCG
CTTTCCAATCACTCCTAGAGGAACTCACCAAAAATACGCAGAGCATTTCTGAATTGTCGAATGTATATACCCTTTTCCAA
TCCAAACGCAAAGAATTGGATCATTGTCTGAAAGAAGAGTCCAAAGAATGGAAAGATATGAATCGAGTTTATATTGCAGA
TCTCACATACCATGTGTTAGCACTAGCAGAATGGATTGAACAATCGGTTTTTGATGCAAAGAAAAAACTTCCAAACAAGT
ATCTATACTTTGCGAAAGGATATGCGGAAATGGTTCGCGATGGACTAGAGGCACCAAGACAAAAAGAAGGTGTGTTCTTT
GATCCCAAAGCTCTTGAGACCTTCTTATCCTTTTAA

Upstream 100 bases:

>100_bases
TTGTTTCCGCTTTTTGGACCATAAACTATCTCTGAAACCAATTTCAAATCGGGGTGACTTTTTTGCTAGTGAATCCTATT
CCTTTTTTTGAACTGGAGAT

Downstream 100 bases:

>100_bases
AGATGGAAAATTTTTTATTACTTGGAATCTGTTTTGGGCTGGGGTTACTCTTTCGAAGGTTTCCTCAGTTCCCCGAAACC
ACTCCCAAAGTTCTCAATGG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MSHHISEHPSLQPFDISEYKGLRGKNFYDMDPALQRMVDRYSESFDPKHKLAMVEHIREYGELVGGILDELTEECHKEGK
YGEVVKYDRTGKRIDFIKYSDEQKRARKISYDHGVVNLDFHREWNYEFTHIHRYALTYLMNLNGEGGVACPLAMTDGMIL
ALKKIGTEEQKKKYLPLVAGKGSDSHFMAGQYVTERVGGSNVSANRTIAKKLPNGKWELTGEKWFCSNPGDLWVTTAKME
GTNTVGMFLVPRIKENGELNGQHILRKKDIIGSRGKITVEIIYDKVEAEEFGRPGHGLVNLIRYIIKTSRLHVGLGSCGN
ARRSVMEASEYAKFRTAYGKKILEFPSFVKTLAEMQILQTANCFVNFRSVGLAEKGDDAAEITVPLLKYKSSSQASYITQ
KAILTLGGNGIIGDFSPLPRLHNDSIINETWEGTHLIITDHCLHALQKPKVYVAFQSLLEELTKNTQSISELSNVYTLFQ
SKRKELDHCLKEESKEWKDMNRVYIADLTYHVLALAEWIEQSVFDAKKKLPNKYLYFAKGYAEMVRDGLEAPRQKEGVFF
DPKALETFLSF

Sequences:

>Translated_571_residues
MSHHISEHPSLQPFDISEYKGLRGKNFYDMDPALQRMVDRYSESFDPKHKLAMVEHIREYGELVGGILDELTEECHKEGK
YGEVVKYDRTGKRIDFIKYSDEQKRARKISYDHGVVNLDFHREWNYEFTHIHRYALTYLMNLNGEGGVACPLAMTDGMIL
ALKKIGTEEQKKKYLPLVAGKGSDSHFMAGQYVTERVGGSNVSANRTIAKKLPNGKWELTGEKWFCSNPGDLWVTTAKME
GTNTVGMFLVPRIKENGELNGQHILRKKDIIGSRGKITVEIIYDKVEAEEFGRPGHGLVNLIRYIIKTSRLHVGLGSCGN
ARRSVMEASEYAKFRTAYGKKILEFPSFVKTLAEMQILQTANCFVNFRSVGLAEKGDDAAEITVPLLKYKSSSQASYITQ
KAILTLGGNGIIGDFSPLPRLHNDSIINETWEGTHLIITDHCLHALQKPKVYVAFQSLLEELTKNTQSISELSNVYTLFQ
SKRKELDHCLKEESKEWKDMNRVYIADLTYHVLALAEWIEQSVFDAKKKLPNKYLYFAKGYAEMVRDGLEAPRQKEGVFF
DPKALETFLSF
>Mature_570_residues
SHHISEHPSLQPFDISEYKGLRGKNFYDMDPALQRMVDRYSESFDPKHKLAMVEHIREYGELVGGILDELTEECHKEGKY
GEVVKYDRTGKRIDFIKYSDEQKRARKISYDHGVVNLDFHREWNYEFTHIHRYALTYLMNLNGEGGVACPLAMTDGMILA
LKKIGTEEQKKKYLPLVAGKGSDSHFMAGQYVTERVGGSNVSANRTIAKKLPNGKWELTGEKWFCSNPGDLWVTTAKMEG
TNTVGMFLVPRIKENGELNGQHILRKKDIIGSRGKITVEIIYDKVEAEEFGRPGHGLVNLIRYIIKTSRLHVGLGSCGNA
RRSVMEASEYAKFRTAYGKKILEFPSFVKTLAEMQILQTANCFVNFRSVGLAEKGDDAAEITVPLLKYKSSSQASYITQK
AILTLGGNGIIGDFSPLPRLHNDSIINETWEGTHLIITDHCLHALQKPKVYVAFQSLLEELTKNTQSISELSNVYTLFQS
KRKELDHCLKEESKEWKDMNRVYIADLTYHVLALAEWIEQSVFDAKKKLPNKYLYFAKGYAEMVRDGLEAPRQKEGVFFD
PKALETFLSF

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557235, Length=321, Percent_Identity=25.8566978193146, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI76496475, Length=321, Percent_Identity=25.8566978193146, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI21361497, Length=296, Percent_Identity=29.0540540540541, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI4503943, Length=297, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI4557233, Length=295, Percent_Identity=24.0677966101695, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87082384, Length=445, Percent_Identity=25.6179775280899, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI86563383, Length=498, Percent_Identity=26.9076305220884, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI86563381, Length=498, Percent_Identity=26.9076305220884, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17538396, Length=303, Percent_Identity=29.7029702970297, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=282, Percent_Identity=24.468085106383, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=280, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363737, Length=362, Percent_Identity=27.0718232044199, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646207, Length=350, Percent_Identity=22.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356377, Length=285, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 65000; Mature: 64869

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHHISEHPSLQPFDISEYKGLRGKNFYDMDPALQRMVDRYSESFDPKHKLAMVEHIREY
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GELVGGILDELTEECHKEGKYGEVVKYDRTGKRIDFIKYSDEQKRARKISYDHGVVNLDF
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEE
HREWNYEFTHIHRYALTYLMNLNGEGGVACPLAMTDGMILALKKIGTEEQKKKYLPLVAG
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHCCHHHHHHCCCEEEC
KGSDSHFMAGQYVTERVGGSNVSANRTIAKKLPNGKWELTGEKWFCSNPGDLWVTTAKME
CCCCCCEECHHHHHHHCCCCCCCCCCHHHHHCCCCCEEECCCEEEECCCCCEEEEEEEEC
GTNTVGMFLVPRIKENGELNGQHILRKKDIIGSRGKITVEIIYDKVEAEEFGRPGHGLVN
CCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEHHHHHHCCCCCHHHHH
LIRYIIKTSRLHVGLGSCGNARRSVMEASEYAKFRTAYGKKILEFPSFVKTLAEMQILQT
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANCFVNFRSVGLAEKGDDAAEITVPLLKYKSSSQASYITQKAILTLGGNGIIGDFSPLPR
HHHHEEHHHCCCCCCCCCCHHEEEHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCC
LHNDSIINETWEGTHLIITDHCLHALQKPKVYVAFQSLLEELTKNTQSISELSNVYTLFQ
CCCCCHHCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKRKELDHCLKEESKEWKDMNRVYIADLTYHVLALAEWIEQSVFDAKKKLPNKYLYFAKG
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
YAEMVRDGLEAPRQKEGVFFDPKALETFLSF
HHHHHHHHHCCCCCCCCCEECHHHHHHHHCC
>Mature Secondary Structure 
SHHISEHPSLQPFDISEYKGLRGKNFYDMDPALQRMVDRYSESFDPKHKLAMVEHIREY
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GELVGGILDELTEECHKEGKYGEVVKYDRTGKRIDFIKYSDEQKRARKISYDHGVVNLDF
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEE
HREWNYEFTHIHRYALTYLMNLNGEGGVACPLAMTDGMILALKKIGTEEQKKKYLPLVAG
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHCCHHHHHHCCCEEEC
KGSDSHFMAGQYVTERVGGSNVSANRTIAKKLPNGKWELTGEKWFCSNPGDLWVTTAKME
CCCCCCEECHHHHHHHCCCCCCCCCCHHHHHCCCCCEEECCCEEEECCCCCEEEEEEEEC
GTNTVGMFLVPRIKENGELNGQHILRKKDIIGSRGKITVEIIYDKVEAEEFGRPGHGLVN
CCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEHHHHHHCCCCCHHHHH
LIRYIIKTSRLHVGLGSCGNARRSVMEASEYAKFRTAYGKKILEFPSFVKTLAEMQILQT
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANCFVNFRSVGLAEKGDDAAEITVPLLKYKSSSQASYITQKAILTLGGNGIIGDFSPLPR
HHHHEEHHHCCCCCCCCCCHHEEEHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCC
LHNDSIINETWEGTHLIITDHCLHALQKPKVYVAFQSLLEELTKNTQSISELSNVYTLFQ
CCCCCHHCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKRKELDHCLKEESKEWKDMNRVYIADLTYHVLALAEWIEQSVFDAKKKLPNKYLYFAKG
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
YAEMVRDGLEAPRQKEGVFFDPKALETFLSF
HHHHHHHHHCCCCCCCCCEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]