BacMap

Definition	Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence.
Accession	NC_010602
Length	3,599,677

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The map label for this gene is fabG1 [C]

Identifier: 183219634

GI number: 183219634

Start: 202350

End: 203117

Strand: Direct

Name: fabG1 [C]

Synonym: LEPBI_I0209

Alternate gene names: 183219634

Gene position: 202350-203117 (Clockwise)

Preceding gene: 183219632

Following gene: 183219638

Centisome position: 5.62

GC content: 45.18

Gene sequence:

>768_bases
ATGGATTCAAAGAATATGCGCATTGTCCTTGTTACCGGGGCAAACCAGGGGATAGGGTTCCAGGTAGCCAAAGAATTAGC
AATGAAAGGAAAGAAAGTGCTCTTAGGGTCTCGCGATAAAAAACGAGGGGAAAAAGCGGCAAAAGAGATTGGGAATGGAT
GTGTCGCCATCCATTTGGATGTAACGGATCGAAAGTCGATTCAAGATGCGAGTGAGTTCATCCGACGAGAATATGGTCGA
CTCGATGTGTTGGTCAATAATGCAGGTATTTCCAATACCAGGATGCAAAAACTGGGTTTATCCATGCATGAATACATGGC
GTCAACTCGGGCAAGCATCGCATCGATTGATGAAATGCGCGTTGTTTGGGATACCAATGTGTTTGGCGTACTTACCGTGT
ACCAGGCGATGTTACCTTTGCTTAGGGAATCTAAAGATGCTCGGATTGTAAATGTCTCAAGCACATTAGGATCGCTCAAT
CTGAATGCAGACCCTAATTCCGATTACAGTTCCTTTTATAGTCCAGTGTATGCGGCATCAAAAACGGCACTGAATGGAAT
CACACTTTCCATGATGTTGGAATTGAAAGACACATCGATCAAGGTGAATTTAGTATCGCCAGGTTTTACCAAATCGGCCC
TGACTAATTTCGAAGGGTTTGAGAGCCTTGAAGATGGGGCACGCGAAGTGGTGAGGGTTGCCGAACTTGGACCAGAAGGA
CCAACTGGTACCTTTACGACTTGGGATAACGTGTTAGTTCCTTGGTAA

Upstream 100 bases:

>100_bases
ATACGATACTAACCAGTTCCGATACTATTTGGTTCCGTAAGTAGGCTCGGGCCAAATGGAAATCGGGAACATGTTTAGAT
TTGAGTAGGAGTGTGAAACG

Downstream 100 bases:

>100_bases
TGGACGAGAGAAAATCTAAAATTGAAACTAACGTCAATAATCTAAGACGTTAGTTTCAAAATGGATGACACATGATTCAT
CACAAACTGTTTCATTCTAT

Product: 3-oxoacyl-[acyl-carrier-protein] reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MDSKNMRIVLVTGANQGIGFQVAKELAMKGKKVLLGSRDKKRGEKAAKEIGNGCVAIHLDVTDRKSIQDASEFIRREYGR
LDVLVNNAGISNTRMQKLGLSMHEYMASTRASIASIDEMRVVWDTNVFGVLTVYQAMLPLLRESKDARIVNVSSTLGSLN
LNADPNSDYSSFYSPVYAASKTALNGITLSMMLELKDTSIKVNLVSPGFTKSALTNFEGFESLEDGAREVVRVAELGPEG
PTGTFTTWDNVLVPW

Sequences:

>Translated_255_residues
MDSKNMRIVLVTGANQGIGFQVAKELAMKGKKVLLGSRDKKRGEKAAKEIGNGCVAIHLDVTDRKSIQDASEFIRREYGR
LDVLVNNAGISNTRMQKLGLSMHEYMASTRASIASIDEMRVVWDTNVFGVLTVYQAMLPLLRESKDARIVNVSSTLGSLN
LNADPNSDYSSFYSPVYAASKTALNGITLSMMLELKDTSIKVNLVSPGFTKSALTNFEGFESLEDGAREVVRVAELGPEG
PTGTFTTWDNVLVPW
>Mature_255_residues
MDSKNMRIVLVTGANQGIGFQVAKELAMKGKKVLLGSRDKKRGEKAAKEIGNGCVAIHLDVTDRKSIQDASEFIRREYGR
LDVLVNNAGISNTRMQKLGLSMHEYMASTRASIASIDEMRVVWDTNVFGVLTVYQAMLPLLRESKDARIVNVSSTLGSLN
LNADPNSDYSSFYSPVYAASKTALNGITLSMMLELKDTSIKVNLVSPGFTKSALTNFEGFESLEDGAREVVRVAELGPEG
PTGTFTTWDNVLVPW

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=221, Percent_Identity=34.3891402714932, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502599, Length=290, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7657478, Length=220, Percent_Identity=33.1818181818182, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI19743808, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI150247226, Length=217, Percent_Identity=28.110599078341, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4502601, Length=291, Percent_Identity=26.4604810996564, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI20149619, Length=219, Percent_Identity=27.8538812785388, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI10190746, Length=229, Percent_Identity=31.0043668122271, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI225579078, Length=224, Percent_Identity=29.0178571428571, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI40254992, Length=209, Percent_Identity=27.7511961722488, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7706318, Length=213, Percent_Identity=30.5164319248826, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI186928839, Length=217, Percent_Identity=30.8755760368664, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI310128830, Length=223, Percent_Identity=28.2511210762332, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI310115468, Length=223, Percent_Identity=28.2511210762332, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=26.6393442622951, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4758504, Length=217, Percent_Identity=25.3456221198157, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI22507405, Length=218, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI59889578, Length=205, Percent_Identity=28.2926829268293, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI44680136, Length=217, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI44680133, Length=217, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI17738292, Length=217, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI40548397, Length=212, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI214010158, Length=212, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI214010156, Length=212, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI22758144, Length=212, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=250, Percent_Identity=25.6, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI223718074, Length=216, Percent_Identity=32.4074074074074, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40807363, Length=237, Percent_Identity=26.5822784810127, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=210, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082100, Length=213, Percent_Identity=32.8638497652582, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787820, Length=202, Percent_Identity=28.7128712871287, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790717, Length=210, Percent_Identity=30.4761904761905, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788459, Length=219, Percent_Identity=27.8538812785388, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=223, Percent_Identity=28.2511210762332, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786701, Length=210, Percent_Identity=29.5238095238095, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17505416, Length=226, Percent_Identity=34.5132743362832, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=215, Percent_Identity=28.3720930232558, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=215, Percent_Identity=29.7674418604651, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=213, Percent_Identity=28.6384976525822, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=219, Percent_Identity=28.7671232876712, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=221, Percent_Identity=28.9592760180996, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=231, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=213, Percent_Identity=30.5164319248826, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=222, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=257, Percent_Identity=29.9610894941634, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=213, Percent_Identity=31.4553990610329, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=215, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=217, Percent_Identity=26.7281105990783, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=219, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=211, Percent_Identity=27.0142180094787, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=220, Percent_Identity=25.4545454545455, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=213, Percent_Identity=31.4553990610329, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=225, Percent_Identity=31.1111111111111, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322067, Length=205, Percent_Identity=27.8048780487805, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=240, Percent_Identity=25.8333333333333, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554248, Length=293, Percent_Identity=30.3754266211604, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640117, Length=293, Percent_Identity=30.3754266211604, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI23397609, Length=207, Percent_Identity=33.8164251207729, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24656154, Length=269, Percent_Identity=30.1115241635688, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922628, Length=269, Percent_Identity=30.1115241635688, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640492, Length=223, Percent_Identity=25.5605381165919, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24586328, Length=222, Percent_Identity=30.6306306306306, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553409, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24647948, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24647946, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573296, Length=216, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641232, Length=235, Percent_Identity=27.2340425531915, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358495, Length=221, Percent_Identity=27.6018099547511, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921754, Length=216, Percent_Identity=28.7037037037037, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI22024069, Length=225, Percent_Identity=30.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571526, Length=212, Percent_Identity=31.1320754716981, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584752, Length=213, Percent_Identity=30.0469483568075, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647931, Length=235, Percent_Identity=28.5106382978723, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737361, Length=211, Percent_Identity=26.0663507109005, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641388, Length=239, Percent_Identity=29.2887029288703, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580925, Length=235, Percent_Identity=27.2340425531915, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281364892, Length=242, Percent_Identity=26.8595041322314, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648693, Length=221, Percent_Identity=28.9592760180996, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355889, Length=221, Percent_Identity=28.9592760180996, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357673, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640442, Length=212, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076371, Length=220, Percent_Identity=28.6363636363636, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27890; Mature: 27890

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSKNMRIVLVTGANQGIGFQVAKELAMKGKKVLLGSRDKKRGEKAAKEIGNGCVAIHLD
CCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEE
VTDRKSIQDASEFIRREYGRLDVLVNNAGISNTRMQKLGLSMHEYMASTRASIASIDEMR
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHEE
VVWDTNVFGVLTVYQAMLPLLRESKDARIVNVSSTLGSLNLNADPNSDYSSFYSPVYAAS
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHH
KTALNGITLSMMLELKDTSIKVNLVSPGFTKSALTNFEGFESLEDGAREVVRVAELGPEG
HHHHCCEEEEEEEEEECCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
PTGTFTTWDNVLVPW
CCCCEECCCCEEECC
>Mature Secondary Structure
MDSKNMRIVLVTGANQGIGFQVAKELAMKGKKVLLGSRDKKRGEKAAKEIGNGCVAIHLD
CCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEE
VTDRKSIQDASEFIRREYGRLDVLVNNAGISNTRMQKLGLSMHEYMASTRASIASIDEMR
CCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHEE
VVWDTNVFGVLTVYQAMLPLLRESKDARIVNVSSTLGSLNLNADPNSDYSSFYSPVYAAS
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHH
KTALNGITLSMMLELKDTSIKVNLVSPGFTKSALTNFEGFESLEDGAREVVRVAELGPEG
HHHHCCEEEEEEEEEECCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
PTGTFTTWDNVLVPW
CCCCEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]