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The map label for this gene is pntB [H]

Identifier: 183219606

GI number: 183219606

Start: 175429

End: 176826

Strand: Direct

Name: pntB [H]

Synonym: LEPBI_I0181

Alternate gene names: 183219606

Gene position: 175429-176826 (Clockwise)

Preceding gene: 183219605

Following gene: 183219607

Centisome position: 4.87

GC content: 42.27

Gene sequence:

>1398_bases
ATGGAACTCATTAGTATTTTAAATCTCGCTTACCTCATAGCATCCATCCTATTCATCGTAGGAATCAAACAACTCGCGCA
TCCTAAAACAGCAACTCGAGGAAACTTCCTTGGTGCCCTTGGGATGCTCATTGCGGTTGTTGCCACACTTTTTGACCGAG
AAATTTTATCGTATGAGTGGATTGCGGTTGGGGTTCTCATCGGTTCCGTAATTGGGATCGTCCTTGCGATCAAAATCCAA
ATGACTGCGATGCCACAGCTTGTTGCCGTATTAAACGGATTTGGTGGTATCGCTTCCGTTTTTGTCGCTGGTGCAGCATT
ACAACTCTCTATTCCTAAATATCAGTACGCAGTCAATTACCAAGAAATTGTATCGATCGTGTTTTCCGCCATCGTAGGTG
GGATCACCTTCTCTGGAAGTTTTATCGCTTTTGGTAAGTTACAAGGTTTTATCACAGAAAAAGCAGTTCGTTACCCAGGT
GACCAACTGGTCAAAATTCTCGTAGGACTGACAGCAGTAGGACTCGGTGTTTACGGATGTTTGGAACCAACTGACGAATC
GATCTATTGGATTCTCAGTGGAGTCAGTTTATTTCTTGGGATCTTCCTTGTGATTCCGATTGGTGGAGCTGATATGCCAG
TTGTGATTTCACTCCTCAACTCCTATTCCGGTATCGCTGCATCTGCTACAGGATTTGTTCTCAACAATAATGTTCTCATC
ATTGCAGGATCACTCGTTGGTGCATCTGGAATCATTCTTACACAAATTATGTGTAAAGCGATGAATCGTAGTTTGACGAA
TGTTCTTTTTGGTGGATTCGGGGCTGTCGCTACAGAAATGAAAGATGATGGCGATTTTTACTCAGGTAAAGTGAAGTCAA
CGAGTGCCGAAGAAGTGGCAATGTTACTCGATGTAGCAAGAAGTGTAGTGATTGTTCCAGGATACGGAATGGCAGTTGCA
CAAGCACAACATACCGTGAGAGATTTATACCAATTACTCACTGCTCGTGGAATTGATGTTACCTTTGCAATCCATCCAGT
TGCAGGTCGTATGCCTGGTCACATGAACGTTTTACTTGCAGAAGCAGATATTCCTTATGATCGATTGAAAGAGATGGACG
AGATCAATAGTACTTTCGAAAATGTTGATGTTGTGATTGTGAATGGTGCCAATGATGTAACTAACCCTCTTGCAAAAACA
GATCCAAAATCTCCAATTGCTGGAATGCCGATATTGGATGTTGGAAACGCAAAAACGGTAGTTGTGATCAAAAGAAGTTT
GAGTCCAGGCTTTGCTGGAGTTCCTAATCCATTATTCATTGCTGACAACTGTTTGATGTTGTTTGGTGATGGTAAAAAGG
CAACGCAAGAAATGATCGCAGCTTTAAAAGAATCTTAG

Upstream 100 bases:

>100_bases
GATTACTCTCGGTAATTTTTGCCACTATCAACGTTGTGGGTGGATTTCTTGTCACTCATAGAATGCTTGGCATGTTTAAG
AAAAAGGATGCACCAAAATA

Downstream 100 bases:

>100_bases
AGTCGGAAGTTATGAAAAAACAAGTCTATATCGTTGATGACCATCCTCTTGTAGTAGATGCACTACAAAACCTAATTGCT
AAATCGGAAGATTTAGAGTG

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MELISILNLAYLIASILFIVGIKQLAHPKTATRGNFLGALGMLIAVVATLFDREILSYEWIAVGVLIGSVIGIVLAIKIQ
MTAMPQLVAVLNGFGGIASVFVAGAALQLSIPKYQYAVNYQEIVSIVFSAIVGGITFSGSFIAFGKLQGFITEKAVRYPG
DQLVKILVGLTAVGLGVYGCLEPTDESIYWILSGVSLFLGIFLVIPIGGADMPVVISLLNSYSGIAASATGFVLNNNVLI
IAGSLVGASGIILTQIMCKAMNRSLTNVLFGGFGAVATEMKDDGDFYSGKVKSTSAEEVAMLLDVARSVVIVPGYGMAVA
QAQHTVRDLYQLLTARGIDVTFAIHPVAGRMPGHMNVLLAEADIPYDRLKEMDEINSTFENVDVVIVNGANDVTNPLAKT
DPKSPIAGMPILDVGNAKTVVVIKRSLSPGFAGVPNPLFIADNCLMLFGDGKKATQEMIAALKES

Sequences:

>Translated_465_residues
MELISILNLAYLIASILFIVGIKQLAHPKTATRGNFLGALGMLIAVVATLFDREILSYEWIAVGVLIGSVIGIVLAIKIQ
MTAMPQLVAVLNGFGGIASVFVAGAALQLSIPKYQYAVNYQEIVSIVFSAIVGGITFSGSFIAFGKLQGFITEKAVRYPG
DQLVKILVGLTAVGLGVYGCLEPTDESIYWILSGVSLFLGIFLVIPIGGADMPVVISLLNSYSGIAASATGFVLNNNVLI
IAGSLVGASGIILTQIMCKAMNRSLTNVLFGGFGAVATEMKDDGDFYSGKVKSTSAEEVAMLLDVARSVVIVPGYGMAVA
QAQHTVRDLYQLLTARGIDVTFAIHPVAGRMPGHMNVLLAEADIPYDRLKEMDEINSTFENVDVVIVNGANDVTNPLAKT
DPKSPIAGMPILDVGNAKTVVVIKRSLSPGFAGVPNPLFIADNCLMLFGDGKKATQEMIAALKES
>Mature_465_residues
MELISILNLAYLIASILFIVGIKQLAHPKTATRGNFLGALGMLIAVVATLFDREILSYEWIAVGVLIGSVIGIVLAIKIQ
MTAMPQLVAVLNGFGGIASVFVAGAALQLSIPKYQYAVNYQEIVSIVFSAIVGGITFSGSFIAFGKLQGFITEKAVRYPG
DQLVKILVGLTAVGLGVYGCLEPTDESIYWILSGVSLFLGIFLVIPIGGADMPVVISLLNSYSGIAASATGFVLNNNVLI
IAGSLVGASGIILTQIMCKAMNRSLTNVLFGGFGAVATEMKDDGDFYSGKVKSTSAEEVAMLLDVARSVVIVPGYGMAVA
QAQHTVRDLYQLLTARGIDVTFAIHPVAGRMPGHMNVLLAEADIPYDRLKEMDEINSTFENVDVVIVNGANDVTNPLAKT
DPKSPIAGMPILDVGNAKTVVVIKRSLSPGFAGVPNPLFIADNCLMLFGDGKKATQEMIAALKES

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=472, Percent_Identity=42.3728813559322, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI122939153, Length=472, Percent_Identity=42.3728813559322, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1787886, Length=466, Percent_Identity=47.6394849785408, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17550456, Length=467, Percent_Identity=41.541755888651, Blast_Score=330, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49024; Mature: 49024

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELISILNLAYLIASILFIVGIKQLAHPKTATRGNFLGALGMLIAVVATLFDREILSYEW
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVGVLIGSVIGIVLAIKIQMTAMPQLVAVLNGFGGIASVFVAGAALQLSIPKYQYAVNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCHHEECCH
QEIVSIVFSAIVGGITFSGSFIAFGKLQGFITEKAVRYPGDQLVKILVGLTAVGLGVYGC
HHHHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
LEPTDESIYWILSGVSLFLGIFLVIPIGGADMPVVISLLNSYSGIAASATGFVLNNNVLI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCEEEECCEEE
IAGSLVGASGIILTQIMCKAMNRSLTNVLFGGFGAVATEMKDDGDFYSGKVKSTSAEEVA
EEECHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCHHHHH
MLLDVARSVVIVPGYGMAVAQAQHTVRDLYQLLTARGIDVTFAIHPVAGRMPGHMNVLLA
HHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEE
EADIPYDRLKEMDEINSTFENVDVVIVNGANDVTNPLAKTDPKSPIAGMPILDVGNAKTV
ECCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHCCCCCCCCCCCCCCCCCEEECCCCCEE
VVIKRSLSPGFAGVPNPLFIADNCLMLFGDGKKATQEMIAALKES
EEEEECCCCCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MELISILNLAYLIASILFIVGIKQLAHPKTATRGNFLGALGMLIAVVATLFDREILSYEW
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVGVLIGSVIGIVLAIKIQMTAMPQLVAVLNGFGGIASVFVAGAALQLSIPKYQYAVNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCHHEECCH
QEIVSIVFSAIVGGITFSGSFIAFGKLQGFITEKAVRYPGDQLVKILVGLTAVGLGVYGC
HHHHHHHHHHHHCCEEECCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
LEPTDESIYWILSGVSLFLGIFLVIPIGGADMPVVISLLNSYSGIAASATGFVLNNNVLI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCEEEECCEEE
IAGSLVGASGIILTQIMCKAMNRSLTNVLFGGFGAVATEMKDDGDFYSGKVKSTSAEEVA
EEECHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCHHHHH
MLLDVARSVVIVPGYGMAVAQAQHTVRDLYQLLTARGIDVTFAIHPVAGRMPGHMNVLLA
HHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEE
EADIPYDRLKEMDEINSTFENVDVVIVNGANDVTNPLAKTDPKSPIAGMPILDVGNAKTV
ECCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHCCCCCCCCCCCCCCCCCEEECCCCCEE
VVIKRSLSPGFAGVPNPLFIADNCLMLFGDGKKATQEMIAALKES
EEEEECCCCCCCCCCCCEEEECCEEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]