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The map label for this gene is norM [H]

Identifier: 183219580

GI number: 183219580

Start: 149922

End: 151346

Strand: Direct

Name: norM [H]

Synonym: LEPBI_I0155

Alternate gene names: 183219580

Gene position: 149922-151346 (Clockwise)

Preceding gene: 183219570

Following gene: 183219581

Centisome position: 4.16

GC content: 41.33

Gene sequence:

>1425_bases
ATGTTTCAGGGGGTAAACATCCATAAAGGTGGTTGTGTAGATCGATATACATATAAAAATGACAAAACTATGCTTCACAA
AATTAGACGCATCTTGAAGCCAACTCGACTCAATCAGAAAATTCTAAGTTTAGCAATCCCAGTTTTTTTTGGAATGATCA
GTTATACTGCCATTATGGTAGCGGATACTGCTATGGTCGGAAAGTTAGGGGAAGTGCCACTTGCCTCCGTTGGATTCGGT
GGAATGGTATATTTTTCCATCTTTGCATTCCTCATGGGTGGATCCATGGCCGTACAAATCATCGTAGCACGAAGATTTGG
CGAAAAAAATGAAAGAGGGGTCGGAATTACCCTTGTGAATTCGATTTATGTTTCGTTCGTACTCGGTTCCCTCTTATCTT
ATTTTGGATATCTCTATGCTCCAAGTCTTATGGCTTGGATTGGTGACGATCCAGAAGTAATCGAAGTGGCAGGCATTTAT
TTATCCTATCGTTTTGTAGGAACTGTTTTGTTTTTTGTTGGTTTCGCCTTACGTGGATTCTTCGATGGAATTGGAATTGT
ACAAGTTGGTATGATTTCGTCTATTGTCGCTGCGGTGACAAACATCTTCTTTAACTGGTTACTGATTTTTGGAAACTGGG
GTTTCCCTGCGATGGGAGTCAAAGGTGCGGCCATTGCATCAAGTCTCAGTTCTATCCCATCTCTCCTTGTTGTTTTATTT
TATTTTTTACGCAAAGATGTGATCCAATTCTTTCGATATGAAATTTTTTCCCCTAGCTTAGAAATCATCAAAGAATTGTG
CGTGGTAGGATTTGCCCCTGCACTCGAAGGAACGTTAGTTAATTTTGCTTTTTCTGGATTTTATAAAATTGCTGGAATGA
TCAGCACAACTACTCTCGCTTCTGCAAGTGTGGTGCTAACATGTCTTAGTTTGTCGTTTATGCCTGGTTTTTCGTTTGGA
ATTGCAGCCACAACCATCCTTGGACAAGCCATGGGCCAAGGGAAAATTCGTCTTGCCTATGAAGGGACAATGCGATCGGC
CACATTCTCTGCAATTGTCATGGGAAGTATGGGTTTATTTTTCATCATAGGTGGACCTTGGCTTATCAGTTTGTTTACCG
ATGTTCCATCAGTCATGAAGGAAGCCTATCCCGCCCTTTGTATCGTGGCTCTCATCCAAGTAGGAGATGCATACCATATG
GTGGTCGGTTCTGCACTTCGTAGTGCGGGAATGATGTACTATGTGATGTATGTGTATCTGATCGTTTCCTTTCTCATCAT
GTTACCACTCGCCTATCTCTTCGGGATAGTACTAAAATGGGGAACAATGGGGATTTGGTCTGCGTTTTTTATTTGGATTT
TACTCTTGGCAGTGCTTTTTGTCGGAAAATTTCGTAGGAAGGAGTGGGTGAACATACGAATTTAA

Upstream 100 bases:

>100_bases
AAAAAAGTGGAAGGTCGAATTTTGGTCCCATATGCTTTTTCGTAAGAATCTAAGTATAAGTGCCATCTAGGATTTGGATT
TTTTTTGCCAATGCGAAACA

Downstream 100 bases:

>100_bases
TAAGGTGAGGGAAGAATGAAACGCACAGAATTAGAACGACAAGCGATACAGAAATTTTTAAAGTCTGTGGAGCTTTTCAA
AAAACTTCCCCCATCGGTTC

Product: multidrug ABC transporter membrane protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MFQGVNIHKGGCVDRYTYKNDKTMLHKIRRILKPTRLNQKILSLAIPVFFGMISYTAIMVADTAMVGKLGEVPLASVGFG
GMVYFSIFAFLMGGSMAVQIIVARRFGEKNERGVGITLVNSIYVSFVLGSLLSYFGYLYAPSLMAWIGDDPEVIEVAGIY
LSYRFVGTVLFFVGFALRGFFDGIGIVQVGMISSIVAAVTNIFFNWLLIFGNWGFPAMGVKGAAIASSLSSIPSLLVVLF
YFLRKDVIQFFRYEIFSPSLEIIKELCVVGFAPALEGTLVNFAFSGFYKIAGMISTTTLASASVVLTCLSLSFMPGFSFG
IAATTILGQAMGQGKIRLAYEGTMRSATFSAIVMGSMGLFFIIGGPWLISLFTDVPSVMKEAYPALCIVALIQVGDAYHM
VVGSALRSAGMMYYVMYVYLIVSFLIMLPLAYLFGIVLKWGTMGIWSAFFIWILLLAVLFVGKFRRKEWVNIRI

Sequences:

>Translated_474_residues
MFQGVNIHKGGCVDRYTYKNDKTMLHKIRRILKPTRLNQKILSLAIPVFFGMISYTAIMVADTAMVGKLGEVPLASVGFG
GMVYFSIFAFLMGGSMAVQIIVARRFGEKNERGVGITLVNSIYVSFVLGSLLSYFGYLYAPSLMAWIGDDPEVIEVAGIY
LSYRFVGTVLFFVGFALRGFFDGIGIVQVGMISSIVAAVTNIFFNWLLIFGNWGFPAMGVKGAAIASSLSSIPSLLVVLF
YFLRKDVIQFFRYEIFSPSLEIIKELCVVGFAPALEGTLVNFAFSGFYKIAGMISTTTLASASVVLTCLSLSFMPGFSFG
IAATTILGQAMGQGKIRLAYEGTMRSATFSAIVMGSMGLFFIIGGPWLISLFTDVPSVMKEAYPALCIVALIQVGDAYHM
VVGSALRSAGMMYYVMYVYLIVSFLIMLPLAYLFGIVLKWGTMGIWSAFFIWILLLAVLFVGKFRRKEWVNIRI
>Mature_474_residues
MFQGVNIHKGGCVDRYTYKNDKTMLHKIRRILKPTRLNQKILSLAIPVFFGMISYTAIMVADTAMVGKLGEVPLASVGFG
GMVYFSIFAFLMGGSMAVQIIVARRFGEKNERGVGITLVNSIYVSFVLGSLLSYFGYLYAPSLMAWIGDDPEVIEVAGIY
LSYRFVGTVLFFVGFALRGFFDGIGIVQVGMISSIVAAVTNIFFNWLLIFGNWGFPAMGVKGAAIASSLSSIPSLLVVLF
YFLRKDVIQFFRYEIFSPSLEIIKELCVVGFAPALEGTLVNFAFSGFYKIAGMISTTTLASASVVLTCLSLSFMPGFSFG
IAATTILGQAMGQGKIRLAYEGTMRSATFSAIVMGSMGLFFIIGGPWLISLFTDVPSVMKEAYPALCIVALIQVGDAYHM
VVGSALRSAGMMYYVMYVYLIVSFLIMLPLAYLFGIVLKWGTMGIWSAFFIWILLLAVLFVGKFRRKEWVNIRI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=479, Percent_Identity=23.7995824634656, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=22.7790432801822, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=22.0183486238532, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 52081; Mature: 52081

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQGVNIHKGGCVDRYTYKNDKTMLHKIRRILKPTRLNQKILSLAIPVFFGMISYTAIMV
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTAMVGKLGEVPLASVGFGGMVYFSIFAFLMGGSMAVQIIVARRFGEKNERGVGITLVN
HHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEHHHH
SIYVSFVLGSLLSYFGYLYAPSLMAWIGDDPEVIEVAGIYLSYRFVGTVLFFVGFALRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDGIGIVQVGMISSIVAAVTNIFFNWLLIFGNWGFPAMGVKGAAIASSLSSIPSLLVVLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YFLRKDVIQFFRYEIFSPSLEIIKELCVVGFAPALEGTLVNFAFSGFYKIAGMISTTTLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASVVLTCLSLSFMPGFSFGIAATTILGQAMGQGKIRLAYEGTMRSATFSAIVMGSMGLF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEE
FIIGGPWLISLFTDVPSVMKEAYPALCIVALIQVGDAYHMVVGSALRSAGMMYYVMYVYL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IVSFLIMLPLAYLFGIVLKWGTMGIWSAFFIWILLLAVLFVGKFRRKEWVNIRI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MFQGVNIHKGGCVDRYTYKNDKTMLHKIRRILKPTRLNQKILSLAIPVFFGMISYTAIMV
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTAMVGKLGEVPLASVGFGGMVYFSIFAFLMGGSMAVQIIVARRFGEKNERGVGITLVN
HHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEHHHH
SIYVSFVLGSLLSYFGYLYAPSLMAWIGDDPEVIEVAGIYLSYRFVGTVLFFVGFALRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDGIGIVQVGMISSIVAAVTNIFFNWLLIFGNWGFPAMGVKGAAIASSLSSIPSLLVVLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YFLRKDVIQFFRYEIFSPSLEIIKELCVVGFAPALEGTLVNFAFSGFYKIAGMISTTTLA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASVVLTCLSLSFMPGFSFGIAATTILGQAMGQGKIRLAYEGTMRSATFSAIVMGSMGLF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEE
FIIGGPWLISLFTDVPSVMKEAYPALCIVALIQVGDAYHMVVGSALRSAGMMYYVMYVYL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IVSFLIMLPLAYLFGIVLKWGTMGIWSAFFIWILLLAVLFVGKFRRKEWVNIRI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]