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The map label for this gene is adk

Identifier: 18311366

GI number: 18311366

Start: 2741335

End: 2741991

Strand: Reverse

Name: adk

Synonym: CPE2384

Alternate gene names: 18311366

Gene position: 2741991-2741335 (Counterclockwise)

Preceding gene: 18311367

Following gene: 18311365

Centisome position: 90.45

GC content: 33.33

Gene sequence:

>657_bases
ATGCCCGTGAAGATAGTTTTATTAGGTCCTCCTGGAGCAGGAAAAGGAACACAGGCAAAATCAATTAGTAATAGATATTC
AATTCCTCACATATCTACAGGAGATATCTTTAGAAAAAATATTTCAGAGAATACTCCTTTAGGTATTGAGGCTAAATCAT
ACATGGATAATGGACAGTTAGTTCCAGATGAAGTAACTATCAACATGGTAAAAGATAGACTTCAACAAGATGATTGTAAG
AACGGATATTTATTAGATGGTTTCCCAAGAACAGTTCATCAAGCAGAAGCTTTAGATAACTTCTTAACTGAAAGAGAAGA
GTCAATAGACACAGCTCTTTTAATAGAAGTACCTAAAGAATTTATACTTGAAAGAATGACAGGAAGAAGAGTTTGTCCTT
CATGTGGAGCAAGTTATCACATAAAGTTTAATCCACCAACTAATGATGGAAAATGTGATCTTTGCGGATCAGATGTTATT
CAAAGAAAAGATGACACTGAAGAAACAGTTAAGGAAAGACTTGATGTGTATGAAAATCAAACACAACCATTAATTGATTT
TTATAAAAACAAAAAGCAACTTTCAGTAGTAGATGGAACACAAGCAATAAACGAGGTCTTTGAGAGTATCTGTAAAATAT
TAGGGAGCGACAAGTAA

Upstream 100 bases:

>100_bases
TAGTTTCTGTTTCATTAGAAATAATGAGACAATTAGAATCTCAATTAACAATGAGACATTACCAAGGATTCTTAAAATAG
AAATACAAGTTATGGAGATG

Downstream 100 bases:

>100_bases
TGATAATTCTTAAGAATGAGAATGAAATCGACCTAATGAGGAAAGCAGGAAAGATTCTTGGAGAGACACTTAACCTGCTT
AAGGAGAAAGTAAGACCTGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MPVKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGIEAKSYMDNGQLVPDEVTINMVKDRLQQDDCK
NGYLLDGFPRTVHQAEALDNFLTEREESIDTALLIEVPKEFILERMTGRRVCPSCGASYHIKFNPPTNDGKCDLCGSDVI
QRKDDTEETVKERLDVYENQTQPLIDFYKNKKQLSVVDGTQAINEVFESICKILGSDK

Sequences:

>Translated_218_residues
MPVKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGIEAKSYMDNGQLVPDEVTINMVKDRLQQDDCK
NGYLLDGFPRTVHQAEALDNFLTEREESIDTALLIEVPKEFILERMTGRRVCPSCGASYHIKFNPPTNDGKCDLCGSDVI
QRKDDTEETVKERLDVYENQTQPLIDFYKNKKQLSVVDGTQAINEVFESICKILGSDK
>Mature_217_residues
PVKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGIEAKSYMDNGQLVPDEVTINMVKDRLQQDDCKN
GYLLDGFPRTVHQAEALDNFLTEREESIDTALLIEVPKEFILERMTGRRVCPSCGASYHIKFNPPTNDGKCDLCGSDVIQ
RKDDTEETVKERLDVYENQTQPLIDFYKNKKQLSVVDGTQAINEVFESICKILGSDK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=43.2692307692308, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=43.2692307692308, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=40.0943396226415, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI310110345, Length=214, Percent_Identity=34.1121495327103, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI53832003, Length=214, Percent_Identity=34.1121495327103, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI8051579, Length=214, Percent_Identity=34.1121495327103, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI53832001, Length=214, Percent_Identity=34.1121495327103, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=30.6603773584906, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=28.3653846153846, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=26.605504587156, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144899, Length=220, Percent_Identity=25.9090909090909, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI28144897, Length=220, Percent_Identity=25.9090909090909, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI237858799, Length=131, Percent_Identity=32.0610687022901, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=47.7064220183486, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=38.4976525821596, Blast_Score=179, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=26.2672811059908, Blast_Score=116, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=207, Percent_Identity=27.536231884058, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=24.6445497630332, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=214, Percent_Identity=24.7663551401869, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=45.3703703703704, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=37.4358974358974, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=26.3157894736842, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=41.0377358490566, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=37.8787878787879, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=37.8787878787879, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI221459597, Length=214, Percent_Identity=29.9065420560748, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356893, Length=214, Percent_Identity=29.9065420560748, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=25, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=25, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CLOPE (Q8XHU4)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563300.1
- ProteinModelPortal:   Q8XHU4
- SMR:   Q8XHU4
- GeneID:   990745
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2384
- NMPDR:   fig|195102.1.peg.2447
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- PhylomeDB:   Q8XHU4
- ProtClustDB:   PRK00279
- BioCyc:   CPER195102:CPE2384-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24383; Mature: 24252

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGIEAKSYMDNGQL
CCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCCCC
VPDEVTINMVKDRLQQDDCKNGYLLDGFPRTVHQAEALDNFLTEREESIDTALLIEVPKE
CCHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
FILERMTGRRVCPSCGASYHIKFNPPTNDGKCDLCGSDVIQRKDDTEETVKERLDVYENQ
HHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCC
TQPLIDFYKNKKQLSVVDGTQAINEVFESICKILGSDK
CCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PVKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGIEAKSYMDNGQL
CEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCCCC
VPDEVTINMVKDRLQQDDCKNGYLLDGFPRTVHQAEALDNFLTEREESIDTALLIEVPKE
CCHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
FILERMTGRRVCPSCGASYHIKFNPPTNDGKCDLCGSDVIQRKDDTEETVKERLDVYENQ
HHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCC
TQPLIDFYKNKKQLSVVDGTQAINEVFESICKILGSDK
CCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842