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The map label for this gene is glmS

Identifier: 18311309

GI number: 18311309

Start: 2677051

End: 2678883

Strand: Reverse

Name: glmS

Synonym: CPE2327

Alternate gene names: 18311309

Gene position: 2678883-2677051 (Counterclockwise)

Preceding gene: 18311311

Following gene: 18311308

Centisome position: 88.37

GC content: 31.7

Gene sequence:

>1833_bases
ATGTGCGGAATAGTTGGATACGTAGGACAGAAAAAGGCAACAGATATATTAGTTGAAGGATTATCAAAATTAGAGTATAG
AGGATATGACTCAGCTGGAGTTGCAGTTTTAGAAGACAATAAGATAAAGGCTGAAAAGCATAAAGGAAGATTAGCAAACC
TAGAAGGAATGTTAAATGAAAATCCAATAGAGGGTGGAATCGGAATAGGACATACTAGATGGGCTACACATGGAGAACCA
TCAGATGTTAACTCACATCCTCATTTAAATAATAAAGAAACAATAGCTGTAGTTCACAATGGAATCATTGAAAACTACAA
TGAATTAAGAAACTGGTTAATGGAAAAAGGATATGAATTTAAATCAGAAACTGATACGGAAGTTATTCCAAACTTAGTAG
ATTTCTACTATAAAGGTGATTTATTAGATGCAGTTATGGAAGCTACTAAACACATGGAAGGTTCATATGCTATTGGAGTT
ATATGTAATGATGAGCCAGAAAAATTAGTAGCTGTAAGAAAAGATAGTCCATTAATAGTTGGATTAGGAGAAAAAGAATA
TTTCATAGCTTCTGATATCCCAGCAGTTTTAAATCATACAAGAGAAGTTTATCTTTTAGAAGATAAAGAGTTTGTAGTAT
TAACAAATGATGGAGTTACTCTTTTTGATGAAGAAAAAAATCCAGTGGAAAAAGAAGTTTATCATATAACATGGAATGTT
GATGCTGCTGAAAAAGGTGGATATGAAGATTTTATGTTAAAAGAAATTAACGAGCAACCAAAAGCTATAAAAGATACAAT
GACTTCAAGAATAATGGAAGAAAAAGAAGTAACTTTAGATGATATATCAATAACTAAAGAATATTTAGATAATGTTGATA
GAGTATATATAGTTGCTTGTGGAACAGCTTACCATGCTGGAGTTATTGGAAAATACGCTATAGAAAAATTAGTTAGAATA
CCAGTAGAAGTTGATATAGCTTCAGAATTTAGATATAGAGATGCTGTTATTACAGATAAAACTTTAATAATAGTATTAAG
CCAATCAGGAGAAACTGCAGATACTTTAGCAGTTTTAAGAGATGGACAAGCAAAGGGTGCAAGAGTGTTAGCTGTAACTA
ACGTAGTAGGAAGCTCAGTTTCAAGAGAAGCTAACGATGTATTATATACATGGGCTGGTCCAGAGATAGCTGTTGCATCA
ACAAAAGCATATGTAACTCAATTAATTGCTATGTACACATTAGCATTACACTTTGCTGAATTAAAAGGAAGCAAATCAGT
AGAAGAAATTGAGGAAATCAAAAAAGCAATGCTTGAATTACCAGAAAAAGTTGAAGAAATCCTTAAAAATACAGATTTAA
TAAAAGAGTTTGCAGTTAAAGCATCTACAGAAAAAGATTTATACTTCTTAGGAAGAGGTATGGATTATGGAGTTGCAATG
GAAGGATCATTAAAACTTAAAGAGATCTCTTACATTCACTCAGAGGCTTATGCAGGTGGAGAACTTAAACATGGACCAAT
AGCTCTTATAGAAAAAGATATTCCAGTAATATCATTATTAACTCAAAGAGAGCTTATGGATAAAATGATAAGTAATGTTC
AAGAAGTTGTTACAAGAGGAGCTAACGTTTTAGGTGTTTGCTTCAAAGGTGACATGGAAGAAAGTAAGAGAAAAATGTTT
GAGGGATTAATAGAAATACCAGAAACATTAAGCTTATTATCACCAGTTTTAAGTGTTGTACCATTACAATTATTCTCATA
CTATGTAGCTAAAGCTAAAGGATTTGATGTTGATAAACCACGTAACTTAGCTAAATCAGTAACTGTTGAATAA

Upstream 100 bases:

>100_bases
GCCAATTGGGTGTTTAAAACCTTCTATGCAGTAAGAAGTTATATAAAGCTTATTTTGAAAGTTAGAATATAATTTTACAA
AAGGGAAGGAAGAAAATAAT

Downstream 100 bases:

>100_bases
AAAAAGGGGGATTTTGAATATGAATAATGAGAGTTTATTAAAATTATTAGCAGAGTATAAGGAAACTAAAAAGTGCCTTG
AAACAGGGTTAAACTGGTTA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNENPIEGGIGIGHTRWATHGEP
SDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEFKSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGV
ICNDEPEKLVAVRKDSPLIVGLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNV
DAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVACGTAYHAGVIGKYAIEKLVRI
PVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLRDGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVAS
TKAYVTQLIAMYTLALHFAELKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAM
EGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRGANVLGVCFKGDMEESKRKMF
EGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNENPIEGGIGIGHTRWATHGEP
SDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEFKSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGV
ICNDEPEKLVAVRKDSPLIVGLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNV
DAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVACGTAYHAGVIGKYAIEKLVRI
PVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLRDGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVAS
TKAYVTQLIAMYTLALHFAELKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAM
EGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRGANVLGVCFKGDMEESKRKMF
EGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKPRNLAKSVTVE
>Mature_610_residues
MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNENPIEGGIGIGHTRWATHGEP
SDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEFKSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGV
ICNDEPEKLVAVRKDSPLIVGLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNV
DAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVACGTAYHAGVIGKYAIEKLVRI
PVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLRDGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVAS
TKAYVTQLIAMYTLALHFAELKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAM
EGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRGANVLGVCFKGDMEESKRKMF
EGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=36.2043795620438, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=35.5263157894737, Blast_Score=412, Evalue=1e-115,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=46.4285714285714, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1788651, Length=216, Percent_Identity=27.3148148148148, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=37.2413793103448, Blast_Score=296, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17532899, Length=438, Percent_Identity=37.2146118721461, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=438, Percent_Identity=37.2146118721461, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=37.1824480369515, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=31.9540229885057, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=37.9807692307692, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357745, Length=695, Percent_Identity=36.9784172661871, Blast_Score=434, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CLOPE (Q8XHZ7)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563243.1
- ProteinModelPortal:   Q8XHZ7
- SMR:   Q8XHZ7
- GeneID:   990689
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2327
- NMPDR:   fig|195102.1.peg.2390
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- PhylomeDB:   Q8XHZ7
- ProtClustDB:   PRK00331
- BioCyc:   CPER195102:CPE2327-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67804; Mature: 67804

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEECHHHCCCCCCHHHCCCC
NPIEGGIGIGHTRWATHGEPSDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCC
KSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGVICNDEPEKLVAVRKDSPLIV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCEEE
GLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNV
ECCCCCEEEECCCHHHHCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCCEEEEEEEEC
DAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVAC
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEE
GTAYHAGVIGKYAIEKLVRIPVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLR
CCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCEEEECCEEEEEEECCCCCHHHHHHHC
DGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVASTKAYVTQLIAMYTLALHFAE
CCCCCCCEEEEEEHHHCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHH
LKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAM
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEE
EGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRG
CCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ANVLGVCFKGDMEESKRKMFEGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKP
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGYVGQKKATDILVEGLSKLEYRGYDSAGVAVLEDNKIKAEKHKGRLANLEGMLNE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEECHHHCCCCCCHHHCCCC
NPIEGGIGIGHTRWATHGEPSDVNSHPHLNNKETIAVVHNGIIENYNELRNWLMEKGYEF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCC
KSETDTEVIPNLVDFYYKGDLLDAVMEATKHMEGSYAIGVICNDEPEKLVAVRKDSPLIV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCEEE
GLGEKEYFIASDIPAVLNHTREVYLLEDKEFVVLTNDGVTLFDEEKNPVEKEVYHITWNV
ECCCCCEEEECCCHHHHCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCCEEEEEEEEC
DAAEKGGYEDFMLKEINEQPKAIKDTMTSRIMEEKEVTLDDISITKEYLDNVDRVYIVAC
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEE
GTAYHAGVIGKYAIEKLVRIPVEVDIASEFRYRDAVITDKTLIIVLSQSGETADTLAVLR
CCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCEEEECCEEEEEEECCCCCHHHHHHHC
DGQAKGARVLAVTNVVGSSVSREANDVLYTWAGPEIAVASTKAYVTQLIAMYTLALHFAE
CCCCCCCEEEEEEHHHCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHH
LKGSKSVEEIEEIKKAMLELPEKVEEILKNTDLIKEFAVKASTEKDLYFLGRGMDYGVAM
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEE
EGSLKLKEISYIHSEAYAGGELKHGPIALIEKDIPVISLLTQRELMDKMISNVQEVVTRG
CCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ANVLGVCFKGDMEESKRKMFEGLIEIPETLSLLSPVLSVVPLQLFSYYVAKAKGFDVDKP
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842