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The map label for this gene is ygfA [C]

Identifier: 18311306

GI number: 18311306

Start: 2675031

End: 2675609

Strand: Reverse

Name: ygfA [C]

Synonym: CPE2324

Alternate gene names: 18311306

Gene position: 2675609-2675031 (Counterclockwise)

Preceding gene: 18311307

Following gene: 18311305

Centisome position: 88.26

GC content: 26.94

Gene sequence:

>579_bases
ATGGATAAGGGAGAGTTAAGAAAAGAAATTAAGCTAAAAAGAGAAAATATAGATAGAGATACTAAGTTAATGGCTGATGA
AAAAATAAGAAAAACTCTTTTGGAAAGTGATATATATAAGAATAGTAAGGTTGTATTTATATATGTAAATATGGACTCTG
AAGTAAATACAGTTGAGATAATAAAAGAATTATTAGCTTCAGATAAAAAGGTTGCAGTTCCTAAAGTTATTCCTGTTAGT
TTAAAAGAAAGACAAATGAAGGCTTTGAAAATAGAATCTTTACTTCAATTAAATGAAAGTGGTGCCTTTGGAATATTAGA
ACCAAGCATTGAATGTGAAGATATAAGTGAGGAAGTTGATTTAATTATAATACCTGGTTTAGCCTTTGATTTAAAGGGAA
ATAGATTAGGATATGGGGGAGGATTTTACGATAGATTTTTAAGTAAATACCCTAATAGTAAGAGAGTTGCTTTATGTTAT
GATTTTCAAGTTTTTGATGAAATTCCACATGAATTCTTTGATGAGAAGGTTGATTTAATAATAAGTGAAGAGAAAATTAT
TAGTTTAAAAAAATCATAA

Upstream 100 bases:

>100_bases
TTATGATGTATTTATACGAAAAGAATATTAAGTGTATTTATATAGTATTGCAATACAGAATATGGTAAAATTATTAAAAG
TCTATGAGGAGGAATTTCAT

Downstream 100 bases:

>100_bases
TAGTAAAATAATATTTTTGATAATTTTACTTTATTGATAATAAATTTTACTTATGTCAGAATTATATAAAATATAATTGT
GAGGTGGGGTAAACAATGAA

Product: 5-formyltetrahydrofolate cyclo-ligase family protein

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MDKGELRKEIKLKRENIDRDTKLMADEKIRKTLLESDIYKNSKVVFIYVNMDSEVNTVEIIKELLASDKKVAVPKVIPVS
LKERQMKALKIESLLQLNESGAFGILEPSIECEDISEEVDLIIIPGLAFDLKGNRLGYGGGFYDRFLSKYPNSKRVALCY
DFQVFDEIPHEFFDEKVDLIISEEKIISLKKS

Sequences:

>Translated_192_residues
MDKGELRKEIKLKRENIDRDTKLMADEKIRKTLLESDIYKNSKVVFIYVNMDSEVNTVEIIKELLASDKKVAVPKVIPVS
LKERQMKALKIESLLQLNESGAFGILEPSIECEDISEEVDLIIIPGLAFDLKGNRLGYGGGFYDRFLSKYPNSKRVALCY
DFQVFDEIPHEFFDEKVDLIISEEKIISLKKS
>Mature_192_residues
MDKGELRKEIKLKRENIDRDTKLMADEKIRKTLLESDIYKNSKVVFIYVNMDSEVNTVEIIKELLASDKKVAVPKVIPVS
LKERQMKALKIESLLQLNESGAFGILEPSIECEDISEEVDLIIIPGLAFDLKGNRLGYGGGFYDRFLSKYPNSKRVALCY
DFQVFDEIPHEFFDEKVDLIISEEKIISLKKS

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=195, Percent_Identity=29.2307692307692, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1789278, Length=149, Percent_Identity=28.8590604026846, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510857, Length=197, Percent_Identity=28.9340101522843, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321031, Length=206, Percent_Identity=30.5825242718447, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077430, Length=191, Percent_Identity=29.3193717277487, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 22053; Mature: 22053

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKGELRKEIKLKRENIDRDTKLMADEKIRKTLLESDIYKNSKVVFIYVNMDSEVNTVEI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
IKELLASDKKVAVPKVIPVSLKERQMKALKIESLLQLNESGAFGILEPSIECEDISEEVD
HHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
LIIIPGLAFDLKGNRLGYGGGFYDRFLSKYPNSKRVALCYDFQVFDEIPHEFFDEKVDLI
EEEECCEEEEECCCEECCCCCHHHHHHHHCCCCCEEEEEECHHHHHHCCHHHHCCHHEEE
ISEEKIISLKKS
ECCCCEEEECCC
>Mature Secondary Structure
MDKGELRKEIKLKRENIDRDTKLMADEKIRKTLLESDIYKNSKVVFIYVNMDSEVNTVEI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
IKELLASDKKVAVPKVIPVSLKERQMKALKIESLLQLNESGAFGILEPSIECEDISEEVD
HHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
LIIIPGLAFDLKGNRLGYGGGFYDRFLSKYPNSKRVALCYDFQVFDEIPHEFFDEKVDLI
EEEECCEEEEECCCEECCCCCHHHHHHHHCCCCCEEEEEECHHHHHHCCHHHHCCHHEEE
ISEEKIISLKKS
ECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]