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The map label for this gene is proC [H]

Identifier: 182682677

GI number: 182682677

Start: 2456899

End: 2457753

Strand: Direct

Name: proC [H]

Synonym: XfasM23_2167

Alternate gene names: 182682677

Gene position: 2456899-2457753 (Clockwise)

Preceding gene: 182682674

Following gene: 182682678

Centisome position: 96.89

GC content: 58.48

Gene sequence:

>855_bases
ATGCCACACGTCACCCTACTTCCCAGCCCATCACAGATCGCATTCATCGGCGGCGGCAATATGGCGCGCAGCTTGATCGC
AGGCATGATCCGCCAAGGCGCCCCCAGCACGTCAATATGCGTCATCGAACCAATCGCCGCACTGCGCGATGCACTTATCG
CTGACTTCAAAATCAAGGCCGTCACCACAGCCACAGAAGCGGCCACCGACACCAGCACCTGGGTGCTGGCCGTGAAACCC
CAAGTGATGCCTGACGTGTGTGCCACCCTGCCACTTCCAGTGCAACCCAACACACCACTGGTTATCTCAATCGCTGCAGG
CATCACCACCTGCAAACTCAAACACTGGCTTGGCGACACCTGTGCGATTGTGCGCGCCATGCCGAATACCCCAGCCCTGC
TAGGTGCCGGCGTAACCGGACTATTCGCCACCTCACAAACCACGGGCACACAACGCACCATCGCTGAAGAACTCTTTAAC
AGCGTAGGCAAGACCCTATGGATCACCGAAGAAGCGTTAATGGACGCCGTGACTGCCGTATCAGGGAGCGGTCCAGCCTA
TGCGTTTTTGCTTGCCGAAGCGATGGAAACAGCAGCCATCATGCAAGGCCTCTCCACCGCAAACGCACGCACACTCGTCC
AGCAAACCCTATTGGGTGCCGCACGCATGATGACCGAGTCAGGGGAAACACCTGCCGCACTGCGCCACCGCGTCACCTCA
CCGCATGGGACCACCGAAGCGGCAATCACAACATTTCAAGAAAACGACTTCCAAACACTTGTCGCAAAAGCGATAGACGC
CGCCACCCGGCGCGCACGCGCCCTCGGAAAGATAAACGATACCGATCCCACCTGA

Upstream 100 bases:

>100_bases
CATTGCATCTCCGATCAACACGCATGGTTGACGCCCCGTGCAACATCGACGGTGGACAAGAGCTACCGCTACCATAATTG
CCTCCTTCTCCAGCATTGCT

Downstream 100 bases:

>100_bases
GAACACATAGATCCCCTGATAGCGAACACAATCGCAACACCGCCGATTTAGACACAGCAACGCACCAACACCCCAACCTC
GTAGCAATCATTTCCGGCAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPHVTLLPSPSQIAFIGGGNMARSLIAGMIRQGAPSTSICVIEPIAALRDALIADFKIKAVTTATEAATDTSTWVLAVKP
QVMPDVCATLPLPVQPNTPLVISIAAGITTCKLKHWLGDTCAIVRAMPNTPALLGAGVTGLFATSQTTGTQRTIAEELFN
SVGKTLWITEEALMDAVTAVSGSGPAYAFLLAEAMETAAIMQGLSTANARTLVQQTLLGAARMMTESGETPAALRHRVTS
PHGTTEAAITTFQENDFQTLVAKAIDAATRRARALGKINDTDPT

Sequences:

>Translated_284_residues
MPHVTLLPSPSQIAFIGGGNMARSLIAGMIRQGAPSTSICVIEPIAALRDALIADFKIKAVTTATEAATDTSTWVLAVKP
QVMPDVCATLPLPVQPNTPLVISIAAGITTCKLKHWLGDTCAIVRAMPNTPALLGAGVTGLFATSQTTGTQRTIAEELFN
SVGKTLWITEEALMDAVTAVSGSGPAYAFLLAEAMETAAIMQGLSTANARTLVQQTLLGAARMMTESGETPAALRHRVTS
PHGTTEAAITTFQENDFQTLVAKAIDAATRRARALGKINDTDPT
>Mature_283_residues
PHVTLLPSPSQIAFIGGGNMARSLIAGMIRQGAPSTSICVIEPIAALRDALIADFKIKAVTTATEAATDTSTWVLAVKPQ
VMPDVCATLPLPVQPNTPLVISIAAGITTCKLKHWLGDTCAIVRAMPNTPALLGAGVTGLFATSQTTGTQRTIAEELFNS
VGKTLWITEEALMDAVTAVSGSGPAYAFLLAEAMETAAIMQGLSTANARTLVQQTLLGAARMMTESGETPAALRHRVTSP
HGTTEAAITTFQENDFQTLVAKAIDAATRRARALGKINDTDPT

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=285, Percent_Identity=31.2280701754386, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI198041662, Length=274, Percent_Identity=28.1021897810219, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=285, Percent_Identity=31.2280701754386, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI24797097, Length=285, Percent_Identity=31.2280701754386, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI1786585, Length=273, Percent_Identity=36.2637362637363, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=33.210332103321, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=31.8021201413428, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=211, Percent_Identity=29.8578199052133, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=34.3283582089552, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=37.2781065088757, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=28.4697508896797, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29624; Mature: 29492

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVTLLPSPSQIAFIGGGNMARSLIAGMIRQGAPSTSICVIEPIAALRDALIADFKIKA
CCCEEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCEEEEE
VTTATEAATDTSTWVLAVKPQVMPDVCATLPLPVQPNTPLVISIAAGITTCKLKHWLGDT
EEEHHHCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHCCH
CAIVRAMPNTPALLGAGVTGLFATSQTTGTQRTIAEELFNSVGKTLWITEEALMDAVTAV
HHEEEECCCCCHHHHCCCHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
SGSGPAYAFLLAEAMETAAIMQGLSTANARTLVQQTLLGAARMMTESGETPAALRHRVTS
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
PHGTTEAAITTFQENDFQTLVAKAIDAATRRARALGKINDTDPT
CCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PHVTLLPSPSQIAFIGGGNMARSLIAGMIRQGAPSTSICVIEPIAALRDALIADFKIKA
CCEEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCEEEEE
VTTATEAATDTSTWVLAVKPQVMPDVCATLPLPVQPNTPLVISIAAGITTCKLKHWLGDT
EEEHHHCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHCCH
CAIVRAMPNTPALLGAGVTGLFATSQTTGTQRTIAEELFNSVGKTLWITEEALMDAVTAV
HHEEEECCCCCHHHHCCCHHEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
SGSGPAYAFLLAEAMETAAIMQGLSTANARTLVQQTLLGAARMMTESGETPAALRHRVTS
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
PHGTTEAAITTFQENDFQTLVAKAIDAATRRARALGKINDTDPT
CCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]