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The map label for this gene is purK [H]

Identifier: 182682646

GI number: 182682646

Start: 2406784

End: 2407968

Strand: Reverse

Name: purK [H]

Synonym: XfasM23_2136

Alternate gene names: 182682646

Gene position: 2407968-2406784 (Counterclockwise)

Preceding gene: 182682647

Following gene: 182682645

Centisome position: 94.96

GC content: 55.44

Gene sequence:

>1185_bases
ATGAAGACCCTCGGTATTCTTGGCGGTGGGCAACTGGCCCGTATGCTGGCGTTGGCTGCACCCCCATTGGGCGTGCGGGT
GTGTACCTTTGATCAAACTGTTGACGCTTGTGCTGGGCAGATGACGCCGCTCTGGGTTGGTTGTTTTGATGATGTGGCTG
CGTTGCGTGACTTTGTCACCCGGGTGGATGTCATCACTTTCGACTCTGAGAACCTGCCGGTTGCTAGTGTGCAAGTACTG
AAAGAACACGTCCCGGTGTATCCGAATCCAGAGGCGCTTGCAGTGGCCCAGGACAGGCTGAGTGAAAAAACCTTGTTTCG
TGACTTGGGGATTCCGGTGCCCGACTTCGTTGCTGTCGACAATCGGGCTGCTTTGGATGTGGCAATCGTCAAGGTGGGGA
CACCTTGTATCCTCAAGACGCGTCGGTTTGGTTACGATGGCAAAGGCCAATTCCGCATCAAGACGTTGACTGATGCGGAT
GCGGCTTGGGCCATGCTCGGTGAGCAAGCCGGAATAACCGGGTTGATTTTGGAAGCCTTTGTGCCATTCCAGCGTGAGAT
GAGCATCCTTGCTGTGCGCGGTTGTAACGGTCAGTTTCGTTCTTGGCCGTTGACAGAGAATTGGCATGTTGCTGGCGTTC
TTTCTGTCAGTTTGGCTCCAATGGCCGTTGATCCCACGCTGCAGGCTGCGGCTGAAGCCTATGCGCGTTTATTGGCTGAG
CGATTGGACTATGTGGGCGTGTTCGCACTAGAGCTGTTCGTCCACGATGGTCGATTACTTGCCAACGAGATGGCACCACG
CGTACATAACTCCGGACATTGGACGATTGAAGGGGCCGAAACGTCCCAGTTTGAAAATCACCTGCGTGCTGTATTTGGCT
TACCGCTCGGTAGCACTGCGATGCGTGGTTATGCCTGCATGGTCAATTGCTTAGGTGTCATGCCTGATCAACAGGCATTA
CTTGCCCTGTCAGGCCTACATTGGCACGACTATGGCAAGCAGCCACGCCAAGGGCGCAAGGTCGGTCATGCCACACTACG
TGCGGATCAACCTGCGGATTTAATGGCTTCTCTAGAGCAGGTCGGCGCAGTACTTGGGGATCAAGAGCGCGTGGCTGTGG
TGCTGGAGCGTTTGTCCGAGGAGGTGTCACGGAGGGATGCCGTTGCGGCGTCTTCTTCTGTCTGA

Upstream 100 bases:

>100_bases
CCGCGCTGTTGGTACCCGAAAATCCAGCAATGCGTCGGATGCTGACTGAGTTCCGCCAACGTCAGACGGATCAGGTGAAT
GCTGCGGACGATCCACGCCA

Downstream 100 bases:

>100_bases
GCTGATGTCAGCGATGGGCGAAAGCCTGGGCGTCCTCTCGAATGGCTGCGTGAATGCCTGAAGTCTGTGTCAATGGAGGA
TAGCGTCTGTGCTCGGTGCA

Product: phosphoribosylaminoimidazole carboxylase ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKTLGILGGGQLARMLALAAPPLGVRVCTFDQTVDACAGQMTPLWVGCFDDVAALRDFVTRVDVITFDSENLPVASVQVL
KEHVPVYPNPEALAVAQDRLSEKTLFRDLGIPVPDFVAVDNRAALDVAIVKVGTPCILKTRRFGYDGKGQFRIKTLTDAD
AAWAMLGEQAGITGLILEAFVPFQREMSILAVRGCNGQFRSWPLTENWHVAGVLSVSLAPMAVDPTLQAAAEAYARLLAE
RLDYVGVFALELFVHDGRLLANEMAPRVHNSGHWTIEGAETSQFENHLRAVFGLPLGSTAMRGYACMVNCLGVMPDQQAL
LALSGLHWHDYGKQPRQGRKVGHATLRADQPADLMASLEQVGAVLGDQERVAVVLERLSEEVSRRDAVAASSSV

Sequences:

>Translated_394_residues
MKTLGILGGGQLARMLALAAPPLGVRVCTFDQTVDACAGQMTPLWVGCFDDVAALRDFVTRVDVITFDSENLPVASVQVL
KEHVPVYPNPEALAVAQDRLSEKTLFRDLGIPVPDFVAVDNRAALDVAIVKVGTPCILKTRRFGYDGKGQFRIKTLTDAD
AAWAMLGEQAGITGLILEAFVPFQREMSILAVRGCNGQFRSWPLTENWHVAGVLSVSLAPMAVDPTLQAAAEAYARLLAE
RLDYVGVFALELFVHDGRLLANEMAPRVHNSGHWTIEGAETSQFENHLRAVFGLPLGSTAMRGYACMVNCLGVMPDQQAL
LALSGLHWHDYGKQPRQGRKVGHATLRADQPADLMASLEQVGAVLGDQERVAVVLERLSEEVSRRDAVAASSSV
>Mature_394_residues
MKTLGILGGGQLARMLALAAPPLGVRVCTFDQTVDACAGQMTPLWVGCFDDVAALRDFVTRVDVITFDSENLPVASVQVL
KEHVPVYPNPEALAVAQDRLSEKTLFRDLGIPVPDFVAVDNRAALDVAIVKVGTPCILKTRRFGYDGKGQFRIKTLTDAD
AAWAMLGEQAGITGLILEAFVPFQREMSILAVRGCNGQFRSWPLTENWHVAGVLSVSLAPMAVDPTLQAAAEAYARLLAE
RLDYVGVFALELFVHDGRLLANEMAPRVHNSGHWTIEGAETSQFENHLRAVFGLPLGSTAMRGYACMVNCLGVMPDQQAL
LALSGLHWHDYGKQPRQGRKVGHATLRADQPADLMASLEQVGAVLGDQERVAVVLERLSEEVSRRDAVAASSSV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=361, Percent_Identity=36.5650969529086, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1788155, Length=320, Percent_Identity=28.125, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=380, Percent_Identity=32.1052631578947, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42640; Mature: 42640

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGILGGGQLARMLALAAPPLGVRVCTFDQTVDACAGQMTPLWVGCFDDVAALRDFVT
CCCEEECCCHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
RVDVITFDSENLPVASVQVLKEHVPVYPNPEALAVAQDRLSEKTLFRDLGIPVPDFVAVD
HHEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
NRAALDVAIVKVGTPCILKTRRFGYDGKGQFRIKTLTDADAAWAMLGEQAGITGLILEAF
CCCEEEEEEEEECCCEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHH
VPFQREMSILAVRGCNGQFRSWPLTENWHVAGVLSVSLAPMAVDPTLQAAAEAYARLLAE
CCHHHCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEECHHHHHHHHHHHHHHHH
RLDYVGVFALELFVHDGRLLANEMAPRVHNSGHWTIEGAETSQFENHLRAVFGLPLGSTA
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHH
MRGYACMVNCLGVMPDQQALLALSGLHWHDYGKQPRQGRKVGHATLRADQPADLMASLEQ
HHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCCCCCHHCCCEECCCCCHHHHHHHHH
VGAVLGDQERVAVVLERLSEEVSRRDAVAASSSV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTLGILGGGQLARMLALAAPPLGVRVCTFDQTVDACAGQMTPLWVGCFDDVAALRDFVT
CCCEEECCCHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
RVDVITFDSENLPVASVQVLKEHVPVYPNPEALAVAQDRLSEKTLFRDLGIPVPDFVAVD
HHEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
NRAALDVAIVKVGTPCILKTRRFGYDGKGQFRIKTLTDADAAWAMLGEQAGITGLILEAF
CCCEEEEEEEEECCCEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHH
VPFQREMSILAVRGCNGQFRSWPLTENWHVAGVLSVSLAPMAVDPTLQAAAEAYARLLAE
CCHHHCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEECHHHHHHHHHHHHHHHH
RLDYVGVFALELFVHDGRLLANEMAPRVHNSGHWTIEGAETSQFENHLRAVFGLPLGSTA
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHH
MRGYACMVNCLGVMPDQQALLALSGLHWHDYGKQPRQGRKVGHATLRADQPADLMASLEQ
HHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCCCCCHHCCCEECCCCCHHHHHHHHH
VGAVLGDQERVAVVLERLSEEVSRRDAVAASSSV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]