Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 182682634

GI number: 182682634

Start: 2393039

End: 2394337

Strand: Direct

Name: hemA

Synonym: XfasM23_2122

Alternate gene names: 182682634

Gene position: 2393039-2394337 (Clockwise)

Preceding gene: 182682611

Following gene: 182682635

Centisome position: 94.37

GC content: 56.51

Gene sequence:

>1299_bases
ATGACGTTGTGGGTACTCGGACTGAACCATCAAACTGCGCCAATGGAGCTACGCGAACGGGCCTCTTTCGTCGGTGATGC
ATTGCCACGCGCACTTGATTCACTGCGCAACCTCCCCAATGTGAACGAAGCCGCACTGCTATCCACCTGCAACCGTACCG
AGTTATACGCCGAGACCACAAATGCGCAAATGCTGCTGAACTGGCTCGAACAACACAGACCAGGATTACAAAACCACTTA
TATCAATATCGCGACGCAGCGGCAGTCAGGCACCTATTCAGAGTCGCCACAGGCCTAGACTCAATGGTCCTCGGGGAGTC
ACAAATCCTCGGCCAAGTCAAGGATTCCTGGTCCATGGCACGCACCCACGGCACCCTTGGCAACACACTTGACCGGCTAT
TCCAACATAGCTTCTCCGTCGCCAAGCACGCACGCACAAATACACGGATTGGCACCAACCCAGTCTCAATAGCCTCAACC
GCAGTGCGACTAGCACAAGACGCCTTCTCCCCGCTGAACGAATCGACCGTATTGCTCATCGGCGCCGGCGAGACCATCCA
ACTGGCAGCCAAACACCTGAGCGAAGGACGAGTACAACGCCTGTTAATTGCCAACCGCACCCACGCCAAAGCGCAGATGC
TGGCCAGCCAGCATGGTGGCTACGCACTCCCCCTGACCGAACTAAACCTCCACCTTGCCGAAGCCGACATCATCTTCTCG
GCCACTGCCGCACCTACCCCTATAGTCACCCAATCCAACGTCGAAAGCGCACTACACATCCGAAAACGAAAACCCATACT
GCTATTTGACCTAGCAATACCACGCGATATCGAGACCGAAGTAGGAACACTCACCGACGCCTACCTATACACCATTGACG
ACCTGGAGCGCGCCGTGGAAGAAAACCGGCACAGCCGGCGCGAAGCAGCCGAAACCGCTGAGGCCATCATTGAATTACAA
GTCAAACGCTACATGGATACACTTCAAGCGCAGGCACACCAAGCCCCACTACGGCGCCTACGCACCTTCGGCACAACGAC
CCGGGATGAACTGCTGACACGCGCACGGCGACAACTAGCAAACGGCCGTCCCGCCGAAGAAGTCCTGGAACAACTTGCCC
ATGGCCTGACAAACCGCCTGTTACACCCTCCAACTGCCGCACTGCGCGAAGCCGCACTCGCCAACAACACCGAGCTAGTT
CGTGCAGCAGAACAACTCTTTCCAGAGAAACCCGGCTACCACCACCCCACCCTTCAGACAACGATTGTGAAAACCGATGA
AACCGACCCTGCGTCGTAA

Upstream 100 bases:

>100_bases
ATGGAACTGTAAGGATGCGAATCGGCACGAGCATCGGGAGCAACCGGACCGTAAAATGGAGGACATGAATAACAAGCAGC
TTATAGCAAGTAACTGAACG

Downstream 100 bases:

>100_bases
ACTGGAAGCACTCGCCGAGCGCCATGAAGAACTCGAACGCTTGCTCTCTGATCCCAAAATCGCCTCTGACACCGACAGAT
TCCGTACATACTCCCGCGAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTLWVLGLNHQTAPMELRERASFVGDALPRALDSLRNLPNVNEAALLSTCNRTELYAETTNAQMLLNWLEQHRPGLQNHL
YQYRDAAAVRHLFRVATGLDSMVLGESQILGQVKDSWSMARTHGTLGNTLDRLFQHSFSVAKHARTNTRIGTNPVSIAST
AVRLAQDAFSPLNESTVLLIGAGETIQLAAKHLSEGRVQRLLIANRTHAKAQMLASQHGGYALPLTELNLHLAEADIIFS
ATAAPTPIVTQSNVESALHIRKRKPILLFDLAIPRDIETEVGTLTDAYLYTIDDLERAVEENRHSRREAAETAEAIIELQ
VKRYMDTLQAQAHQAPLRRLRTFGTTTRDELLTRARRQLANGRPAEEVLEQLAHGLTNRLLHPPTAALREAALANNTELV
RAAEQLFPEKPGYHHPTLQTTIVKTDETDPAS

Sequences:

>Translated_432_residues
MTLWVLGLNHQTAPMELRERASFVGDALPRALDSLRNLPNVNEAALLSTCNRTELYAETTNAQMLLNWLEQHRPGLQNHL
YQYRDAAAVRHLFRVATGLDSMVLGESQILGQVKDSWSMARTHGTLGNTLDRLFQHSFSVAKHARTNTRIGTNPVSIAST
AVRLAQDAFSPLNESTVLLIGAGETIQLAAKHLSEGRVQRLLIANRTHAKAQMLASQHGGYALPLTELNLHLAEADIIFS
ATAAPTPIVTQSNVESALHIRKRKPILLFDLAIPRDIETEVGTLTDAYLYTIDDLERAVEENRHSRREAAETAEAIIELQ
VKRYMDTLQAQAHQAPLRRLRTFGTTTRDELLTRARRQLANGRPAEEVLEQLAHGLTNRLLHPPTAALREAALANNTELV
RAAEQLFPEKPGYHHPTLQTTIVKTDETDPAS
>Mature_431_residues
TLWVLGLNHQTAPMELRERASFVGDALPRALDSLRNLPNVNEAALLSTCNRTELYAETTNAQMLLNWLEQHRPGLQNHLY
QYRDAAAVRHLFRVATGLDSMVLGESQILGQVKDSWSMARTHGTLGNTLDRLFQHSFSVAKHARTNTRIGTNPVSIASTA
VRLAQDAFSPLNESTVLLIGAGETIQLAAKHLSEGRVQRLLIANRTHAKAQMLASQHGGYALPLTELNLHLAEADIIFSA
TAAPTPIVTQSNVESALHIRKRKPILLFDLAIPRDIETEVGTLTDAYLYTIDDLERAVEENRHSRREAAETAEAIIELQV
KRYMDTLQAQAHQAPLRRLRTFGTTTRDELLTRARRQLANGRPAEEVLEQLAHGLTNRLLHPPTAALREAALANNTELVR
AAEQLFPEKPGYHHPTLQTTIVKTDETDPAS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=406, Percent_Identity=46.7980295566502, Blast_Score=342, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_XYLF2 (B2IA84)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830794.1
- ProteinModelPortal:   B2IA84
- SMR:   B2IA84
- GeneID:   6203196
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2122
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47967; Mature: 47836

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 101-101 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLWVLGLNHQTAPMELRERASFVGDALPRALDSLRNLPNVNEAALLSTCNRTELYAETT
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEECC
NAQMLLNWLEQHRPGLQNHLYQYRDAAAVRHLFRVATGLDSMVLGESQILGQVKDSWSMA
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHH
RTHGTLGNTLDRLFQHSFSVAKHARTNTRIGTNPVSIASTAVRLAQDAFSPLNESTVLLI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
GAGETIQLAAKHLSEGRVQRLLIANRTHAKAQMLASQHGGYALPLTELNLHLAEADIIFS
ECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHEEEHHHEEEE
ATAAPTPIVTQSNVESALHIRKRKPILLFDLAIPRDIETEVGTLTDAYLYTIDDLERAVE
CCCCCCCCEECCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHCHHHHHHHHHHHHHHHHH
ENRHSRREAAETAEAIIELQVKRYMDTLQAQAHQAPLRRLRTFGTTTRDELLTRARRQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NGRPAEEVLEQLAHGLTNRLLHPPTAALREAALANNTELVRAAEQLFPEKPGYHHPTLQT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEE
TIVKTDETDPAS
EEEECCCCCCCC
>Mature Secondary Structure 
TLWVLGLNHQTAPMELRERASFVGDALPRALDSLRNLPNVNEAALLSTCNRTELYAETT
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEECC
NAQMLLNWLEQHRPGLQNHLYQYRDAAAVRHLFRVATGLDSMVLGESQILGQVKDSWSMA
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHH
RTHGTLGNTLDRLFQHSFSVAKHARTNTRIGTNPVSIASTAVRLAQDAFSPLNESTVLLI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
GAGETIQLAAKHLSEGRVQRLLIANRTHAKAQMLASQHGGYALPLTELNLHLAEADIIFS
ECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHEEEHHHEEEE
ATAAPTPIVTQSNVESALHIRKRKPILLFDLAIPRDIETEVGTLTDAYLYTIDDLERAVE
CCCCCCCCEECCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHCHHHHHHHHHHHHHHHHH
ENRHSRREAAETAEAIIELQVKRYMDTLQAQAHQAPLRRLRTFGTTTRDELLTRARRQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NGRPAEEVLEQLAHGLTNRLLHPPTAALREAALANNTELVRAAEQLFPEKPGYHHPTLQT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEE
TIVKTDETDPAS
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA