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The map label for this gene is pth

Identifier: 182682628

GI number: 182682628

Start: 2387229

End: 2387807

Strand: Reverse

Name: pth

Synonym: XfasM23_2116

Alternate gene names: 182682628

Gene position: 2387807-2387229 (Counterclockwise)

Preceding gene: 182682629

Following gene: 182682627

Centisome position: 94.17

GC content: 48.36

Gene sequence:

>579_bases
ATGTTAGGGCTGCGTTTGATAGTTGGGCTCGGCAATCCGGGTAGTGAGTACATCAAAACCAGGCACAATGCTGGGTTTCG
CTTTGTCGATGGTTTAGTTCAGCGTGAGGGGCAGTGCTGGGCGTTGGAGTCTAAGTTGTTTGCTTACGTTGCTCGTGTGT
TTATCGCTGGGCAATGGGTATGGTTACTACGCCCAGTCACTTTTATGAATTTGAGCGGCAAGTCGATTTGTGCCGGTTTG
AATTTTTGGAAAATTAAACCGGAGCAAATGTTGGTTGCTCACGATGAGTTGGATTTTCCACCAGGGGCTGTGCGCTTGAA
GTTTGATGGTGGTCATGGTGGTCAGAATGGGTTGCGTGATATTACCAAGTTGCTTGGTCACGGACGTTTTCATCGTCTGC
GTGTAGGTATTGGTCATCCTGGCCATAAAGACCGTGTGGTGAGTTGGGTGCTAGGTTGTCCAACGTGCGATGAAAATATT
GCTATTGATGCTGCTTTGGAACGAGCCAGTGTAGTGTTGCCTTTAGCGGTTGCTGGTGACTTTGATGGGGCGATGAAAAA
GCTACATACGGTAGTGTGA

Upstream 100 bases:

>100_bases
TGAGGATGACGCTCCTGCAGAAGAAGGGGAGGGTGACTCCAAGTAATGTGCTGCATTCCTTGCATCCTAAATGGCGGGGT
AATTCAGTAACAATGTTCAT

Downstream 100 bases:

>100_bases
TGGGAAATCTATATGGGTATTAAATGCGGTATCGTTGGGTTGCCTAATGTTGGTAAGTCGACTTTGTTCAATGCGTTGAC
TAAAGCTGGTATCGCTGCCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MLGLRLIVGLGNPGSEYIKTRHNAGFRFVDGLVQREGQCWALESKLFAYVARVFIAGQWVWLLRPVTFMNLSGKSICAGL
NFWKIKPEQMLVAHDELDFPPGAVRLKFDGGHGGQNGLRDITKLLGHGRFHRLRVGIGHPGHKDRVVSWVLGCPTCDENI
AIDAALERASVVLPLAVAGDFDGAMKKLHTVV

Sequences:

>Translated_192_residues
MLGLRLIVGLGNPGSEYIKTRHNAGFRFVDGLVQREGQCWALESKLFAYVARVFIAGQWVWLLRPVTFMNLSGKSICAGL
NFWKIKPEQMLVAHDELDFPPGAVRLKFDGGHGGQNGLRDITKLLGHGRFHRLRVGIGHPGHKDRVVSWVLGCPTCDENI
AIDAALERASVVLPLAVAGDFDGAMKKLHTVV
>Mature_192_residues
MLGLRLIVGLGNPGSEYIKTRHNAGFRFVDGLVQREGQCWALESKLFAYVARVFIAGQWVWLLRPVTFMNLSGKSICAGL
NFWKIKPEQMLVAHDELDFPPGAVRLKFDGGHGGQNGLRDITKLLGHGRFHRLRVGIGHPGHKDRVVSWVLGCPTCDENI
AIDAALERASVVLPLAVAGDFDGAMKKLHTVV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=167, Percent_Identity=34.7305389221557, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1787455, Length=189, Percent_Identity=49.7354497354497, Blast_Score=168, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321983, Length=167, Percent_Identity=33.5329341317365, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_XYLF2 (B2IA78)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830788.1
- ProteinModelPortal:   B2IA78
- SMR:   B2IA78
- GeneID:   6202513
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2116
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21120; Mature: 21120

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLRLIVGLGNPGSEYIKTRHNAGFRFVDGLVQREGQCWALESKLFAYVARVFIAGQWV
CCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHH
WLLRPVTFMNLSGKSICAGLNFWKIKPEQMLVAHDELDFPPGAVRLKFDGGHGGQNGLRD
HHHCCEEEEECCCCCEEECCCEEEECHHHEEEECCCCCCCCCEEEEEEECCCCCCHHHHH
ITKLLGHGRFHRLRVGIGHPGHKDRVVSWVLGCPTCDENIAIDAALERASVVLPLAVAGD
HHHHHCCCCEEEEEEECCCCCCHHHHEEHEECCCCCCCCEEEHHHHCCCEEEEEEEEECC
FDGAMKKLHTVV
CHHHHHHHHHCC
>Mature Secondary Structure
MLGLRLIVGLGNPGSEYIKTRHNAGFRFVDGLVQREGQCWALESKLFAYVARVFIAGQWV
CCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHH
WLLRPVTFMNLSGKSICAGLNFWKIKPEQMLVAHDELDFPPGAVRLKFDGGHGGQNGLRD
HHHCCEEEEECCCCCEEECCCEEEECHHHEEEECCCCCCCCCEEEEEEECCCCCCHHHHH
ITKLLGHGRFHRLRVGIGHPGHKDRVVSWVLGCPTCDENIAIDAALERASVVLPLAVAGD
HHHHHCCCCEEEEEEECCCCCCHHHHEEHEECCCCCCCCEEEHHHHCCCEEEEEEEEECC
FDGAMKKLHTVV
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA