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The map label for this gene is tcrA [H]

Identifier: 182682538

GI number: 182682538

Start: 2267175

End: 2267852

Strand: Direct

Name: tcrA [H]

Synonym: XfasM23_2026

Alternate gene names: 182682538

Gene position: 2267175-2267852 (Clockwise)

Preceding gene: 182682537

Following gene: 182682539

Centisome position: 89.41

GC content: 53.69

Gene sequence:

>678_bases
GTGCGCATTTTGGTCATCGAAGACAACAGCGATATCGCCGCCAATCTGGGCGATTACCTTGAAGAACGCGGCCACGCCGT
GGATTTTGCCGCCGATGGCGTGACTGGATTGCATTTGGCCGTAGTCCACGAATTCGACGCCATCGTACTCGACCTTAATC
TGCCTGGCATGGATGGCATTGAAGTCTGCCGCAAGTTGCGCAACGAAGCACGCAAACAAACCCCTGTGCTGATGTTGACC
GCACGTGACTCGCTGGATAACAAACTGACGGGCTTCGACTCGGGTGCTGACGACTACTTGATTAAACCATTCGCTTTGCA
GGAAGTTGAAGTTCGTTTAAACGCACTATCGCGCCGTGGCAAAGGCCTGCAAACCCGAGTATTGGAAACAGGTGATCTCG
AATATAACCTGGACACACTGGAAGTACGCCGCCGCGGCAAACTGCTACAACTCAATCCAACCGGATTGAAGATACTGCAA
GCACTGATGGAAGCCACGCCAGCCGTAGTGACCCGCCAAGATCTAGAAACTCGTGTGTGGGGAGAGGAGCTACCGGATTC
GGATTCGCTGCGTGTGCATATCCACGGATTACGCGCCGTCGTTGATAAGCCTTTCGACGTACCATTGATACAGACTCGTC
ATGGGATCGGATACCGCATCGCCACACCCGATGCATGA

Upstream 100 bases:

>100_bases
GTGGTTACATCCACTTTGCTTCCCAAGCAAGAGGGAAACCATACTCCAACAATCAGGGTCCAGCGGTACCCTCCTCCCCC
TCCGAACAATTGAGGCTCAA

Downstream 100 bases:

>100_bases
AACCGAGGCACAGTCATGTTCGAAAGGGCGACACGCGCGCTACCGGCGCCGGTTAAGAAGCCGAATCATTTTATCCTTCT
TATTTCTTGGCTTTGCACTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRILVIEDNSDIAANLGDYLEERGHAVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGIEVCRKLRNEARKQTPVLMLT
ARDSLDNKLTGFDSGADDYLIKPFALQEVEVRLNALSRRGKGLQTRVLETGDLEYNLDTLEVRRRGKLLQLNPTGLKILQ
ALMEATPAVVTRQDLETRVWGEELPDSDSLRVHIHGLRAVVDKPFDVPLIQTRHGIGYRIATPDA

Sequences:

>Translated_225_residues
MRILVIEDNSDIAANLGDYLEERGHAVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGIEVCRKLRNEARKQTPVLMLT
ARDSLDNKLTGFDSGADDYLIKPFALQEVEVRLNALSRRGKGLQTRVLETGDLEYNLDTLEVRRRGKLLQLNPTGLKILQ
ALMEATPAVVTRQDLETRVWGEELPDSDSLRVHIHGLRAVVDKPFDVPLIQTRHGIGYRIATPDA
>Mature_225_residues
MRILVIEDNSDIAANLGDYLEERGHAVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGIEVCRKLRNEARKQTPVLMLT
ARDSLDNKLTGFDSGADDYLIKPFALQEVEVRLNALSRRGKGLQTRVLETGDLEYNLDTLEVRRRGKLLQLNPTGLKILQ
ALMEATPAVVTRQDLETRVWGEELPDSDSLRVHIHGLRAVVDKPFDVPLIQTRHGIGYRIATPDA

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=37.8995433789954, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.920704845815, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=38.5650224215247, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=35.5855855855856, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=31.5068493150685, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=32.5892857142857, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=32.1888412017167, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.25, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=33.1838565022422, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=32.8828828828829, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=29.1304347826087, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=32.4675324675325, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788550, Length=159, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=118, Percent_Identity=33.0508474576271, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25023; Mature: 25023

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVIEDNSDIAANLGDYLEERGHAVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGI
CEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEEEECCCCCCHH
EVCRKLRNEARKQTPVLMLTARDSLDNKLTGFDSGADDYLIKPFALQEVEVRLNALSRRG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
KGLQTRVLETGDLEYNLDTLEVRRRGKLLQLNPTGLKILQALMEATPAVVTRQDLETRVW
CCCEEEEEECCCCEECCHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHC
GEELPDSDSLRVHIHGLRAVVDKPFDVPLIQTRHGIGYRIATPDA
CCCCCCCCCEEEEEEEEHHHHCCCCCCCEEEECCCCCEEEECCCC
>Mature Secondary Structure
MRILVIEDNSDIAANLGDYLEERGHAVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGI
CEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEEEECCCCCCHH
EVCRKLRNEARKQTPVLMLTARDSLDNKLTGFDSGADDYLIKPFALQEVEVRLNALSRRG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
KGLQTRVLETGDLEYNLDTLEVRRRGKLLQLNPTGLKILQALMEATPAVVTRQDLETRVW
CCCEEEEEECCCCEECCHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEEEHHHHHHHHC
GEELPDSDSLRVHIHGLRAVVDKPFDVPLIQTRHGIGYRIATPDA
CCCCCCCCCEEEEEEEEHHHHCCCCCCCEEEECCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]