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The map label for this gene is lpxC

Identifier: 182682475

GI number: 182682475

Start: 2201650

End: 2202591

Strand: Reverse

Name: lpxC

Synonym: XfasM23_1962

Alternate gene names: 182682475

Gene position: 2202591-2201650 (Counterclockwise)

Preceding gene: 182682476

Following gene: 182682473

Centisome position: 86.86

GC content: 49.89

Gene sequence:

>942_bases
ATGCTTCATTTTTTCAGACTTCCTCCTATGAGCCAGCAACGTACCCTTAACAACACGATTCGCGCGACTGGCGTTGGTCT
GCACAGCGGCAATAAGATCCATATTACCCTCCGTCCTGCTCCGGTCAACCACGGTATCGTGTTCCGGCGCGTGGACCTGG
ATCCTGTGGTTGAAATCCCTGCTAGTGGGGATTTGGTGACCGAGGTGATCTTATGCACTGGTTTGACGCGCAATGGGGCT
AAAGTACAGACGGTCGAACATTTGATGTCAGCCTTTGCTGGGCTTGGTATCGACAACGCTATTGTGGATCTGTCGTCGGC
TGAGTTACCGATTATGGATGGGTCTTCTGCGCCGTTTGTATTCCTGTTGCAGTCGGCGGGTATCTTAGAGCAGAACGCTG
CTAAGCGTTTCATCCGTATTAAGCGTTCTGTGGAGGTGCGCCAAGGGGATAAGGTGGCCAAGTTTAGCCCTTACGATGGT
TATAAATTGGGTTTTACCATTGAGTTCGATCATCCAATGATCCCGCATAAACAGTCGTATTATGAGATGGAGTTTTCTAC
TGCGGCTTATATCAAGGAAATTTCTCTGGCGCGTACTTTTGGTTTTATGCATGACTTGGAAGATATGCGTGAGCGTAACC
TTGGACTTGGCGGTTCAATGGACAATGCGATCTTGCTGGACGACTTCCGTGTGCTCAATGAGGATGGCTTGCGCTATGGC
AACGAGTTCGTGCGTCACAAAATACTTGATGCAATCGGTGATCTTTACTTAATTGGTGGCCCGATTTTGGGGGCTTATGA
GGCATTTAAGTCTGGTCATGCGCTGAACAATAAGCTGGTTCGTGCTGTACTTGCCGATGAGACTTCTTGGGAGTGGATCA
GCTTCCCTAGTCCAGCCGCTGAGCAGCCGCCTGTCGTCTACACGCATCCCGCTTGCATTTGA

Upstream 100 bases:

>100_bases
GGCTGCCGGGGGTGCCTATTGTTATTTCTATGTGCTTGTACTGCTAATATGAGGGCATTCATCATATTGCTACTAAATAC
GGTGGCGCTAATTTCTTGCC

Downstream 100 bases:

>100_bases
ATCATTCTCAGAAAACTTGACTATATGATTATTAATCAATGATTTCTTAATCTGCAAATAACGAATCAAGAGCCGATACC
AGTTACTATGCGCCAGGTCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MLHFFRLPPMSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGA
KVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDG
YKLGFTIEFDHPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYG
NEFVRHKILDAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI

Sequences:

>Translated_313_residues
MLHFFRLPPMSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGA
KVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDG
YKLGFTIEFDHPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYG
NEFVRHKILDAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI
>Mature_313_residues
MLHFFRLPPMSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGA
KVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDG
YKLGFTIEFDHPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYG
NEFVRHKILDAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=53.7704918032787, Blast_Score=354, Evalue=5e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34710; Mature: 34710

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHFFRLPPMSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIP
CCEEEECCCCCHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECC
ASGDLVTEVILCTGLTRNGAKVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFV
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCEEECCCCCCEE
FLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEFDHPMIPHKQSY
EEEECCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCE
YEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYG
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHH
NEFVRHKILDAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAA
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCC
EQPPVVYTHPACI
CCCCEEEECCCCC
>Mature Secondary Structure
MLHFFRLPPMSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIP
CCEEEECCCCCHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECC
ASGDLVTEVILCTGLTRNGAKVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFV
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCEEECCCCCCEE
FLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEFDHPMIPHKQSY
EEEECCCCHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCE
YEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYG
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHH
NEFVRHKILDAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAA
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCC
EQPPVVYTHPACI
CCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]