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The map label for this gene is pcm

Identifier: 182682433

GI number: 182682433

Start: 2138199

End: 2138876

Strand: Direct

Name: pcm

Synonym: XfasM23_1919

Alternate gene names: 182682433

Gene position: 2138199-2138876 (Clockwise)

Preceding gene: 182682432

Following gene: 182682434

Centisome position: 84.32

GC content: 55.16

Gene sequence:

>678_bases
ATGACTGCACCTCCATCCCTGCAAGCGAAAGCCGTAGGGATCGGCATGACGTCGCAACGCGTCCGAGACCGCCTGGTCGA
ACGACTACGCGAATGCGGCATCCAAGACGAACGGGTACTCAGCACCATTCGCATCGTGCCACGCCATTTATTCATTGATG
AAGCCTTGGCACTGCGCGCTTACGAAGACACCGCATTGCCCATCGGCCATGGACAGACCATCTCGCAACCCTGGGTCGTC
GCACGGATGACCGAAGCTGTCATGCAGGTTGTCCCCAAAAAAATACTCGAGATCGGTACAGGTTCCGGCTACCAGAGCGC
CATTCTGGCCTCACTAGGATTGGAGGTGTACACCATTGAGCGTATCGGCAAACTACTGCGTCAAGCACGTAAGCGTTTCC
GCCAGCTTGGCATAAAAATACGCAGCAAACACGATGACGGGAGCACCGGCTGGACAGAACATGCACCTTACAACGCCATC
TTGGTCACAGCAGCAGCCCCGACACTGATCGACACTCTCATCGAACAACTTGCAATAGGCGGACGCCTGGTGGCTCCTGT
CGGCACCGCTTCAGAGCAAGCCCTAGTGCAGCTCACACGAACAATCGACGGTAGCATCACACACGAGATTTTAGAACCAG
TCACATTTGTATCCCTGCTACCAGGGATGTTGGATTAA

Upstream 100 bases:

>100_bases
TCTCCATTACCCCGATTCACGTCGATCTGACCCGTTACCAAGCCCTGGAAAATGTCACCCGATGGACGGACAGACTCACC
GCACACATGGACTGGCCCAC

Downstream 100 bases:

>100_bases
ATCCACCTTAAGGACGCCATTGATGAAAATATTCGGTCCTTTGTACAACCGCGCAATCACCTGGTCACGTCATCGTTATG
CCCCCGCACTCCTCACAGGA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTAPPSLQAKAVGIGMTSQRVRDRLVERLRECGIQDERVLSTIRIVPRHLFIDEALALRAYEDTALPIGHGQTISQPWVV
ARMTEAVMQVVPKKILEIGTGSGYQSAILASLGLEVYTIERIGKLLRQARKRFRQLGIKIRSKHDDGSTGWTEHAPYNAI
LVTAAAPTLIDTLIEQLAIGGRLVAPVGTASEQALVQLTRTIDGSITHEILEPVTFVSLLPGMLD

Sequences:

>Translated_225_residues
MTAPPSLQAKAVGIGMTSQRVRDRLVERLRECGIQDERVLSTIRIVPRHLFIDEALALRAYEDTALPIGHGQTISQPWVV
ARMTEAVMQVVPKKILEIGTGSGYQSAILASLGLEVYTIERIGKLLRQARKRFRQLGIKIRSKHDDGSTGWTEHAPYNAI
LVTAAAPTLIDTLIEQLAIGGRLVAPVGTASEQALVQLTRTIDGSITHEILEPVTFVSLLPGMLD
>Mature_224_residues
TAPPSLQAKAVGIGMTSQRVRDRLVERLRECGIQDERVLSTIRIVPRHLFIDEALALRAYEDTALPIGHGQTISQPWVVA
RMTEAVMQVVPKKILEIGTGSGYQSAILASLGLEVYTIERIGKLLRQARKRFRQLGIKIRSKHDDGSTGWTEHAPYNAIL
VTAAAPTLIDTLIEQLAIGGRLVAPVGTASEQALVQLTRTIDGSITHEILEPVTFVSLLPGMLD

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=209, Percent_Identity=33.0143540669856, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789100, Length=211, Percent_Identity=47.39336492891, Blast_Score=174, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71983477, Length=217, Percent_Identity=30.8755760368664, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193207222, Length=215, Percent_Identity=29.7674418604651, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17981723, Length=179, Percent_Identity=35.195530726257, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_XYLF2 (B2I8X8)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830593.1
- ProteinModelPortal:   B2I8X8
- GeneID:   6203239
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1919
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- ProtClustDB:   CLSK446106
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 24590; Mature: 24459

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 75-75

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPPSLQAKAVGIGMTSQRVRDRLVERLRECGIQDERVLSTIRIVPRHLFIDEALALRA
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YEDTALPIGHGQTISQPWVVARMTEAVMQVVPKKILEIGTGSGYQSAILASLGLEVYTIE
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEHH
RIGKLLRQARKRFRQLGIKIRSKHDDGSTGWTEHAPYNAILVTAAAPTLIDTLIEQLAIG
HHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHC
GRLVAPVGTASEQALVQLTRTIDGSITHEILEPVTFVSLLPGMLD
CEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAPPSLQAKAVGIGMTSQRVRDRLVERLRECGIQDERVLSTIRIVPRHLFIDEALALRA
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YEDTALPIGHGQTISQPWVVARMTEAVMQVVPKKILEIGTGSGYQSAILASLGLEVYTIE
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEHH
RIGKLLRQARKRFRQLGIKIRSKHDDGSTGWTEHAPYNAILVTAAAPTLIDTLIEQLAIG
HHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHC
GRLVAPVGTASEQALVQLTRTIDGSITHEILEPVTFVSLLPGMLD
CEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA