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The map label for this gene is uvrB

Identifier: 182682349

GI number: 182682349

Start: 2036418

End: 2038427

Strand: Reverse

Name: uvrB

Synonym: XfasM23_1833

Alternate gene names: 182682349

Gene position: 2038427-2036418 (Counterclockwise)

Preceding gene: 182682351

Following gene: 182682345

Centisome position: 80.39

GC content: 49.85

Gene sequence:

>2010_bases
ATGACAGGTTTGTTTCAGCTTGTTTCTTCATACTCTCCTTCTGGGGATCAGCCTGCGGCTGTACAGAAGCTAGTCACTAA
TTTCCATGCTGGCATTGCTAAGCAGGTGTTGCTTGGCGTTACTGGTTCTGGGAAGACTTACACCATCGCTAATGTGGTTG
AGCAGATTCAGAAGCCAACTCTGGTGATGGCGCCAAACAAGACGTTGGCAGCACAGCTTTACGGGGAATTCAAGGCGTTC
TTCCCGCACAATGCGGTGGAATATTTTGTCAGCTACTATGACTACTATCAGCCTGAGGCGTATGTTCCAGCCTCGGACAC
GTTCATTGAAAAGGACAGTTCTATCAATGAATACATTGAACAGATGCGTTTGGCTGCAACGAAGGCTTTGCTGTCACGTT
CTGATGTGTTGGTGGTGGCGACCGTGTCGGCGATTTATGGTTTGGGTGCGCCTGAGGATTATCTTTCGTTACGTTTGATT
TTGTCGCTGGGTGAGCATATTGAGCAGCGGCAATTGATCAGGCATCTCACTGAGTTGCAGTACACTCGTAACGAGTTGGA
TTTGGTGCGTGGTAGTTTCCGTGTACGTGGTGAGGTTGTTGATGTATTCCCGGCTGAGTCAGAGATGGAGGCGCTGCGCA
TTGAGTTGTTTGATGGTGAGATAGAAAGTTTGAGCTTGTTCGATCCGCTTACCGGTCAGACGGTACGTAAGTTGCAACGT
TTTAGTGTTTACCCTAAAACCCACTATGCAACTACGCGTGAACGTACGCTCAGTGCCGTTGATACGATCAAGGATGAGCT
GAAAGAGTATCTAGAACTTCTGTATGGGCGGAATAAGTTGGTTGAGGCGCAACGTTTAGCTCAGCGTACTCAGTTCGACT
TAGAGATGATGGCCGAGGTTGGTTATTGCAATGGTATTGAAAATTACTCTCGTCACTTAACTGGTAAGGCTCCGGGGGAA
CCTCCACCGACGTTGTTCGATTATCTTCCTCCGGATGCGCTACTGGTCATTGATGAGTCGCATGTGACAATTCCGCAGAT
CGGTGCGATGTTCAAGGGGGACCGTTCCCGTAAAGAAACGCTGGTGGAATTTGGTTTCCGTTTACCATCGGCGTTAGACA
ATCGACCGCTTCGCTTTGAGGAATGGGAAGTGCGTTCGCCGCGTAGCATTTACGTCTCGGCGACTCCAGGATCATATGAG
TTCCGCGAGTCCGCGGGTGAAGTCATAGAGTTGCTGGTGCGTCCGACCGGCTTGATTGATCCTGAGATAGAAATCCGTCC
GGTTGCGACGCAGGTGGATGATCTGATTTCCCAGATCAATGCGTGTATCAAGTTAGGTGATCGGGTTTTGGTCACCACGT
TAACTAAGCGTATGGCTGAGAACCTCACTGAATATTTGAGCGAGCAGGGTATCCGGATACGTTATTTGCATTCGGAAATC
GATACGGTAGAACGTGTGGAGATCATCCGTGATTTGCGTCTTGGTAAATTCGATGTGCTGGTTGGTATCAACCTTCTACG
TGAGGGATTGGATATGCCGGAGGTGTCGTTGGTGGCCATTCTTGACGCTGATAAAGAGGGGTTTTTGCGTTCGACCAGTT
CACTGATTCAGACGATTGGTCGTGCCGCACGCAGTGTGCGCGGTAGGGCAATCTTGTATGCCGATAAAGTGACTCGTTCA
ATGCGCGCTGCAATTGATGAAACCGAGCGACGTCGACAAAAGCAGAAGGAATACAATGCTGAGAACGGTATTGTTCCGAA
ATCCGTTGTACGGCCCATTAGCGACATTTTGGAGGGTGCGCGAGATGGTGTCGAGGTGAAGAGCAAGGGGAAGGGGCGCA
GAGTTGATGAGGTTCCCGCTGACTATGGTGCGCTTAATCAAGCTGAGATTGCCGCACAGATGAAAGTGCTGGAGCAAAAG
ATGTACCAGCATGCGCGTGATTTGGAGTTTGAGGATGCGGCGCGTATTCGCGATCAAATTCAGCGGCTTAGGGAGGCTGG
TCTGGGTTAA

Upstream 100 bases:

>100_bases
GCGAATTAGGTTAATGCCGCTATTTTGTGTAGGGATTTCACCTGATTTCATATCAGTCATTTAATTATAAACTGGCGCAC
CGCTTTGGAATCACTGTGTT

Downstream 100 bases:

>100_bases
ATTGAACTCCCGAATATTGTCCTCTATAAGGCAGCGTGTTGTGACTCAGTGCGGTACTGGGCTACAATCCGGCGCGCAGA
CGTCTGTTTCTGCGTTGTAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 669; Mature: 668

Protein sequence:

>669_residues
MTGLFQLVSSYSPSGDQPAAVQKLVTNFHAGIAKQVLLGVTGSGKTYTIANVVEQIQKPTLVMAPNKTLAAQLYGEFKAF
FPHNAVEYFVSYYDYYQPEAYVPASDTFIEKDSSINEYIEQMRLAATKALLSRSDVLVVATVSAIYGLGAPEDYLSLRLI
LSLGEHIEQRQLIRHLTELQYTRNELDLVRGSFRVRGEVVDVFPAESEMEALRIELFDGEIESLSLFDPLTGQTVRKLQR
FSVYPKTHYATTRERTLSAVDTIKDELKEYLELLYGRNKLVEAQRLAQRTQFDLEMMAEVGYCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMFKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEVRSPRSIYVSATPGSYE
FRESAGEVIELLVRPTGLIDPEIEIRPVATQVDDLISQINACIKLGDRVLVTTLTKRMAENLTEYLSEQGIRIRYLHSEI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTSSLIQTIGRAARSVRGRAILYADKVTRS
MRAAIDETERRRQKQKEYNAENGIVPKSVVRPISDILEGARDGVEVKSKGKGRRVDEVPADYGALNQAEIAAQMKVLEQK
MYQHARDLEFEDAARIRDQIQRLREAGLG

Sequences:

>Translated_669_residues
MTGLFQLVSSYSPSGDQPAAVQKLVTNFHAGIAKQVLLGVTGSGKTYTIANVVEQIQKPTLVMAPNKTLAAQLYGEFKAF
FPHNAVEYFVSYYDYYQPEAYVPASDTFIEKDSSINEYIEQMRLAATKALLSRSDVLVVATVSAIYGLGAPEDYLSLRLI
LSLGEHIEQRQLIRHLTELQYTRNELDLVRGSFRVRGEVVDVFPAESEMEALRIELFDGEIESLSLFDPLTGQTVRKLQR
FSVYPKTHYATTRERTLSAVDTIKDELKEYLELLYGRNKLVEAQRLAQRTQFDLEMMAEVGYCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMFKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEVRSPRSIYVSATPGSYE
FRESAGEVIELLVRPTGLIDPEIEIRPVATQVDDLISQINACIKLGDRVLVTTLTKRMAENLTEYLSEQGIRIRYLHSEI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTSSLIQTIGRAARSVRGRAILYADKVTRS
MRAAIDETERRRQKQKEYNAENGIVPKSVVRPISDILEGARDGVEVKSKGKGRRVDEVPADYGALNQAEIAAQMKVLEQK
MYQHARDLEFEDAARIRDQIQRLREAGLG
>Mature_668_residues
TGLFQLVSSYSPSGDQPAAVQKLVTNFHAGIAKQVLLGVTGSGKTYTIANVVEQIQKPTLVMAPNKTLAAQLYGEFKAFF
PHNAVEYFVSYYDYYQPEAYVPASDTFIEKDSSINEYIEQMRLAATKALLSRSDVLVVATVSAIYGLGAPEDYLSLRLIL
SLGEHIEQRQLIRHLTELQYTRNELDLVRGSFRVRGEVVDVFPAESEMEALRIELFDGEIESLSLFDPLTGQTVRKLQRF
SVYPKTHYATTRERTLSAVDTIKDELKEYLELLYGRNKLVEAQRLAQRTQFDLEMMAEVGYCNGIENYSRHLTGKAPGEP
PPTLFDYLPPDALLVIDESHVTIPQIGAMFKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEVRSPRSIYVSATPGSYEF
RESAGEVIELLVRPTGLIDPEIEIRPVATQVDDLISQINACIKLGDRVLVTTLTKRMAENLTEYLSEQGIRIRYLHSEID
TVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTSSLIQTIGRAARSVRGRAILYADKVTRSM
RAAIDETERRRQKQKEYNAENGIVPKSVVRPISDILEGARDGVEVKSKGKGRRVDEVPADYGALNQAEIAAQMKVLEQKM
YQHARDLEFEDAARIRDQIQRLREAGLG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=66.5667166416792, Blast_Score=899, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=22.3300970873786, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_XYLF2 (B2I8F9)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830509.1
- ProteinModelPortal:   B2I8F9
- GeneID:   6202596
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1833
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75439; Mature: 75308

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLFQLVSSYSPSGDQPAAVQKLVTNFHAGIAKQVLLGVTGSGKTYTIANVVEQIQKPT
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKAFFPHNAVEYFVSYYDYYQPEAYVPASDTFIEKDSSINEYIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHH
QMRLAATKALLSRSDVLVVATVSAIYGLGAPEDYLSLRLILSLGEHIEQRQLIRHLTELQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNELDLVRGSFRVRGEVVDVFPAESEMEALRIELFDGEIESLSLFDPLTGQTVRKLQR
HHHHHHHHHHCCCEECCEEEEECCCCHHHHHHEEEEECCCCCCEECCCCCCHHHHHHHHH
FSVYPKTHYATTRERTLSAVDTIKDELKEYLELLYGRNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GYCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMFKGDRSRKET
HHCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEVRSPRSIYVSATPGSYEFRESAGEVIELLVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PEIEIRPVATQVDDLISQINACIKLGDRVLVTTLTKRMAENLTEYLSEQGIRIRYLHSEI
CCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTSSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARSVRGRAILYADKVTRSMRAAIDETERRRQKQKEYNAENGIVPKSVVRPISDILEGA
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RDGVEVKSKGKGRRVDEVPADYGALNQAEIAAQMKVLEQKMYQHARDLEFEDAARIRDQI
CCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QRLREAGLG
HHHHHCCCC
>Mature Secondary Structure 
TGLFQLVSSYSPSGDQPAAVQKLVTNFHAGIAKQVLLGVTGSGKTYTIANVVEQIQKPT
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKAFFPHNAVEYFVSYYDYYQPEAYVPASDTFIEKDSSINEYIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHH
QMRLAATKALLSRSDVLVVATVSAIYGLGAPEDYLSLRLILSLGEHIEQRQLIRHLTELQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNELDLVRGSFRVRGEVVDVFPAESEMEALRIELFDGEIESLSLFDPLTGQTVRKLQR
HHHHHHHHHHCCCEECCEEEEECCCCHHHHHHEEEEECCCCCCEECCCCCCHHHHHHHHH
FSVYPKTHYATTRERTLSAVDTIKDELKEYLELLYGRNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GYCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMFKGDRSRKET
HHCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEVRSPRSIYVSATPGSYEFRESAGEVIELLVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PEIEIRPVATQVDDLISQINACIKLGDRVLVTTLTKRMAENLTEYLSEQGIRIRYLHSEI
CCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTSSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARSVRGRAILYADKVTRSMRAAIDETERRRQKQKEYNAENGIVPKSVVRPISDILEGA
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RDGVEVKSKGKGRRVDEVPADYGALNQAEIAAQMKVLEQKMYQHARDLEFEDAARIRDQI
CCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QRLREAGLG
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA