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The map label for this gene is cusR [H]

Identifier: 182681977

GI number: 182681977

Start: 1603300

End: 1604013

Strand: Reverse

Name: cusR [H]

Synonym: XfasM23_1452

Alternate gene names: 182681977

Gene position: 1604013-1603300 (Counterclockwise)

Preceding gene: 182681978

Following gene: 182681976

Centisome position: 63.26

GC content: 52.94

Gene sequence:

>714_bases
ATGCGTCAGACCAAGGAAACCTCAGGGCTTGTCCTGATAGTGGAAGATAACCGCAACATCTCAGAGATGATCGGCGAATA
CTTGGAAGGCCGTGGCTTTGAGGTGGATTACGCAGTCGATGGGTTGGATGGCTATCGTTTGGCCGTTGAGAACAGCTATG
ACGTGGTGGTACTCGATTTGATGTTGCCACGCCTGGATGGCATAGAGGTTTGTCGCCAGCTACGTAAGGACGCACGTAAA
TCGACACCTGTGCTGATGTTGACAGCGCGTGACACACTGGACGACAAGCTCACCGGATTGGGATTCGGTGCTGATGATTA
TCTGACGAAGCCATTTGCAATTCAGGAGTTAGAAGCTCGCTTGCGTGCTCTCATCCGTCGGGAGCGTCGCCAAGTTGGTG
CGGAAGTGTTGAAGCTTGCTGATCTTGTCCTGGATCCGGTGAGCCTGCGTGCTACCCGTGCCGGTACTGAGCTGCAACTT
TCCCCGATTGGGCTACGTCTTCTGACGATCTTGATGCGGGAGTCACCACGTGTCGTCAGTCGCCAGGAGATTGAACGCGA
AATCTGGGGAAACTGTTTGCCGGATTCGGATACATTGCGCAGCCATCTATATAACCTGCGTAAGGTGGTTGATAAGCCAT
TTGGCCGACCGCTGTTACACACGGTACAGAGCGCAGGCTACCGGATGGTTGATATCGAACAATCAATGGATTGA

Upstream 100 bases:

>100_bases
AAACGCTCACTGAATGTCCTCAATAAATGGCAGGATCTTCACGCTGCTTCTACACGGTCATCCAGCACGATTTCACAAAC
CTGAAGAATTGGGAGCTGTC

Downstream 100 bases:

>100_bases
TAGTTAATCGTCATATGAAACTCTCTAATCAGGTGCTGTATTGGTGCCAAAAGAAATTAAGTATCCCTACTAGACGTTGG
CGATGCTTGCGCTGAATAGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MRQTKETSGLVLIVEDNRNISEMIGEYLEGRGFEVDYAVDGLDGYRLAVENSYDVVVLDLMLPRLDGIEVCRQLRKDARK
STPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGAEVLKLADLVLDPVSLRATRAGTELQL
SPIGLRLLTILMRESPRVVSRQEIEREIWGNCLPDSDTLRSHLYNLRKVVDKPFGRPLLHTVQSAGYRMVDIEQSMD

Sequences:

>Translated_237_residues
MRQTKETSGLVLIVEDNRNISEMIGEYLEGRGFEVDYAVDGLDGYRLAVENSYDVVVLDLMLPRLDGIEVCRQLRKDARK
STPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGAEVLKLADLVLDPVSLRATRAGTELQL
SPIGLRLLTILMRESPRVVSRQEIEREIWGNCLPDSDTLRSHLYNLRKVVDKPFGRPLLHTVQSAGYRMVDIEQSMD
>Mature_237_residues
MRQTKETSGLVLIVEDNRNISEMIGEYLEGRGFEVDYAVDGLDGYRLAVENSYDVVVLDLMLPRLDGIEVCRQLRKDARK
STPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGAEVLKLADLVLDPVSLRATRAGTELQL
SPIGLRLLTILMRESPRVVSRQEIEREIWGNCLPDSDTLRSHLYNLRKVVDKPFGRPLLHTVQSAGYRMVDIEQSMD

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=39.0909090909091, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=36.4444444444444, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.3665158371041, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=35.7466063348416, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=36.322869955157, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=38.6266094420601, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.9912663755458, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=30.8695652173913, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1790860, Length=199, Percent_Identity=34.6733668341709, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=39.8305084745763, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.4372294372294, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=26.3392857142857, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=30.5084745762712, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26912; Mature: 26912

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKETSGLVLIVEDNRNISEMIGEYLEGRGFEVDYAVDGLDGYRLAVENSYDVVVLDL
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEHHH
MLPRLDGIEVCRQLRKDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEAR
HHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCHHHCCCCHHHHHHHHH
LRALIRRERRQVGAEVLKLADLVLDPVSLRATRAGTELQLSPIGLRLLTILMRESPRVVS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHH
RQEIEREIWGNCLPDSDTLRSHLYNLRKVVDKPFGRPLLHTVQSAGYRMVDIEQSMD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MRQTKETSGLVLIVEDNRNISEMIGEYLEGRGFEVDYAVDGLDGYRLAVENSYDVVVLDL
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEHHH
MLPRLDGIEVCRQLRKDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEAR
HHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCHHHCCCCHHHHHHHHH
LRALIRRERRQVGAEVLKLADLVLDPVSLRATRAGTELQLSPIGLRLLTILMRESPRVVS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHH
RQEIEREIWGNCLPDSDTLRSHLYNLRKVVDKPFGRPLLHTVQSAGYRMVDIEQSMD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]