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The map label for this gene is holA

Identifier: 182681846

GI number: 182681846

Start: 1444640

End: 1445671

Strand: Direct

Name: holA

Synonym: XfasM23_1311

Alternate gene names: 182681846

Gene position: 1444640-1445671 (Clockwise)

Preceding gene: 182681845

Following gene: 182681847

Centisome position: 56.97

GC content: 54.65

Gene sequence:

>1032_bases
ATGGAACTTCGCCCAGAGCAACTCGCCAACCTGCCTGCCAATCAACCCTTAGAGCCTGCCTACCTCATCGCCGGCCCCGA
AACCCTACGCTTAGTAGAAGCTGCCGATGCGATACGTACGCGTGCTCGTGCCGACGGCATCACCGAACGCGAAATATTCG
ACGTCGAAAGCCGTGACTTCGACTGGCAACAACTTGCCTCCAGCTTCAACGCCCCCAGCCTCTTCAGCTCACGTCGCTTA
ATCGAAATACGCCTCCCGGGAGGTAAACCTGGTAAAGAAGGCAGTGAAGTCATCACAAGGTTCTGCGCCACCCCCTCATC
AGATGTTATCTTGCTGATCACATGCAACGAATGGAGCAAAGCACACCATGGCAAGTGGACCGATGCCATCGCTCGCATCG
GTAAAATCGCAATCGCCTGGAGCATCAAGCCTCACGAACTACCCGACTGGATTACACGGCGCCTACATAGCAAAGGCTTA
CGTGCCAACACGGATGTAATACACCGATTAAGCACACGCCTAGAAGGCAACCTACTGGCCGCCGCCCAAGAAATTGACAA
ATTGGCGTTATTGAATCAAGGCCCTCTCCTCGACCTGGAGACCATGGAATCATTCGTTGCCGACACAGCGCGTTACGACG
TATTCCGACTTACCGAAGCGATGCTCTCCGGCCAACCCACCGCAACGATACGCATGCTCGGCAAACTGCGGGCCGAAGGT
GAAGCAGTGGCAGCACTGCTGCCCATTCTGATCAAAGAACTCATCCGTACCACGACCCTGTCATGGGTCAAACATGACAA
CGGCAATCTAGCTGCCGAAATGAAAGCCCAGGGAATCTGGGAAACACGTCAAGCACCCTTCAAGCGCGCATTACAACGTC
ATACCTCACCGTACAAATGGGAACACTTCGTTGCCGAAGTCGGGCGCATAGACCGCATCACCAAAGGACGCAACGACGGC
AATGCCTGGCTGTCACTCGAACGTCTCATGGTGGCAGTAGCAGAAGCAGATGCAACACGTCTGCTAGCATAA

Upstream 100 bases:

>100_bases
CGTATCGATAGCGTCATCCGTTCACGTCTTGAAAAGAGAGAACTATTAGAACAAGCAAAACCACCCTCACCTGCAACCTC
CGGCGCCTGATCAAGGCATC

Downstream 100 bases:

>100_bases
CGCCCCCTTCCTGGACACCGAGCGATGCTATGCCCAGCCTGCACGTATTTTATGGCGGCACCTTTGATCCTGTGCATGTC
GGCCACTTAGCCATCGCACG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MELRPEQLANLPANQPLEPAYLIAGPETLRLVEAADAIRTRARADGITEREIFDVESRDFDWQQLASSFNAPSLFSSRRL
IEIRLPGGKPGKEGSEVITRFCATPSSDVILLITCNEWSKAHHGKWTDAIARIGKIAIAWSIKPHELPDWITRRLHSKGL
RANTDVIHRLSTRLEGNLLAAAQEIDKLALLNQGPLLDLETMESFVADTARYDVFRLTEAMLSGQPTATIRMLGKLRAEG
EAVAALLPILIKELIRTTTLSWVKHDNGNLAAEMKAQGIWETRQAPFKRALQRHTSPYKWEHFVAEVGRIDRITKGRNDG
NAWLSLERLMVAVAEADATRLLA

Sequences:

>Translated_343_residues
MELRPEQLANLPANQPLEPAYLIAGPETLRLVEAADAIRTRARADGITEREIFDVESRDFDWQQLASSFNAPSLFSSRRL
IEIRLPGGKPGKEGSEVITRFCATPSSDVILLITCNEWSKAHHGKWTDAIARIGKIAIAWSIKPHELPDWITRRLHSKGL
RANTDVIHRLSTRLEGNLLAAAQEIDKLALLNQGPLLDLETMESFVADTARYDVFRLTEAMLSGQPTATIRMLGKLRAEG
EAVAALLPILIKELIRTTTLSWVKHDNGNLAAEMKAQGIWETRQAPFKRALQRHTSPYKWEHFVAEVGRIDRITKGRNDG
NAWLSLERLMVAVAEADATRLLA
>Mature_343_residues
MELRPEQLANLPANQPLEPAYLIAGPETLRLVEAADAIRTRARADGITEREIFDVESRDFDWQQLASSFNAPSLFSSRRL
IEIRLPGGKPGKEGSEVITRFCATPSSDVILLITCNEWSKAHHGKWTDAIARIGKIAIAWSIKPHELPDWITRRLHSKGL
RANTDVIHRLSTRLEGNLLAAAQEIDKLALLNQGPLLDLETMESFVADTARYDVFRLTEAMLSGQPTATIRMLGKLRAEG
EAVAALLPILIKELIRTTTLSWVKHDNGNLAAEMKAQGIWETRQAPFKRALQRHTSPYKWEHFVAEVGRIDRITKGRNDG
NAWLSLERLMVAVAEADATRLLA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=331, Percent_Identity=29.9093655589124, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38358; Mature: 38358

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRPEQLANLPANQPLEPAYLIAGPETLRLVEAADAIRTRARADGITEREIFDVESRDF
CCCCHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
DWQQLASSFNAPSLFSSRRLIEIRLPGGKPGKEGSEVITRFCATPSSDVILLITCNEWSK
CHHHHHHCCCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
AHHGKWTDAIARIGKIAIAWSIKPHELPDWITRRLHSKGLRANTDVIHRLSTRLEGNLLA
CCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
AAQEIDKLALLNQGPLLDLETMESFVADTARYDVFRLTEAMLSGQPTATIRMLGKLRAEG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EAVAALLPILIKELIRTTTLSWVKHDNGNLAAEMKAQGIWETRQAPFKRALQRHTSPYKW
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCCHH
EHFVAEVGRIDRITKGRNDGNAWLSLERLMVAVAEADATRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELRPEQLANLPANQPLEPAYLIAGPETLRLVEAADAIRTRARADGITEREIFDVESRDF
CCCCHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
DWQQLASSFNAPSLFSSRRLIEIRLPGGKPGKEGSEVITRFCATPSSDVILLITCNEWSK
CHHHHHHCCCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
AHHGKWTDAIARIGKIAIAWSIKPHELPDWITRRLHSKGLRANTDVIHRLSTRLEGNLLA
CCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
AAQEIDKLALLNQGPLLDLETMESFVADTARYDVFRLTEAMLSGQPTATIRMLGKLRAEG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EAVAALLPILIKELIRTTTLSWVKHDNGNLAAEMKAQGIWETRQAPFKRALQRHTSPYKW
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCCHH
EHFVAEVGRIDRITKGRNDGNAWLSLERLMVAVAEADATRLLA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]