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The map label for this gene is parC [H]

Identifier: 182681182

GI number: 182681182

Start: 736941

End: 739190

Strand: Reverse

Name: parC [H]

Synonym: XfasM23_0624

Alternate gene names: 182681182

Gene position: 739190-736941 (Counterclockwise)

Preceding gene: 182681184

Following gene: 182681180

Centisome position: 29.15

GC content: 54.18

Gene sequence:

>2250_bases
ATGACCGATCTGACTCGTCCCTTCTTCCATGGCTTCGAACAGATGCCACTGCGCGAATACGCCGAACGTGCCTATCTTGA
TTATTCGATGTATGTCGTACTTGATCGCGCACTCCCCTTTATCGGAGACGGTCTCAAGCCGGTACAGCGGCGCATCATCT
ACGCCATGCACGAATTGCGGCTCAATCCAAAGGCAAAACCCAAGAAGTCTGTACGTGCGGTTGGCGACGTGATCGGTAAG
TACCACCCACACGGCGACTTGGCCTGTTACGAAGCACTCGTACTGATGGCACAACCGTTCTCATACCGTTACCCGCTGAT
CGAAGGGCAAGGCAACTTTGGCTCTTCCGACGACCCAAAATCATTCGCAGCGATGCGCTACACCGAGTCCAAACTCACCC
CCATCTCTGAGATCCTACTCAGTGAACTAAGCGAAGGTACAGTGAATTGGATCACCAACTTCGACGGTACCTTGGAAGAA
CCTGCATGGCTGCCGAGCCGCCTCCCACACCTTTTACTTAACGGCACCACTGGCATCGCGGTCGGCATGGCAACCGACGT
ACCACCGCACAATCTCAACGAAATCGCCAGTGCGCTGATTCACCTGCTTGACAACCCAAACGCCACTATTGCCGCGCTGT
GCCAATACATTCGCGGCCCTGACTACCCAACGGCTGCCGAGATCATCACACCACCCAATGACCTGCAAAATCTCTACGAG
ACAGGCAATGGCAGCGTGCGTACCCGTGCCACCTACCATAAAGAAGACGGCAACGTAGTGATCACCTCGTTACCTTACCA
AGTGTCACCGTCCAAAGTAATCGAACAGATCGCCCAGCAAATTCGTTCCAAAAAGCTACCCTGGTTGGACGGCGAAGGGG
TACGCGATGAATCTGACCACAAAAATCCAGTGCGTATCGTGCTGTTCCCACGTTCCCAACGGATTGATGTAGAACAACTC
ATGGGCCACCTATTCGCAACCACCGATCTAGAAAAAAGCCATCGGGTGAACCTCAACGTGATCGGCCTTGACGGCCGCCC
GCAAGTCAAACCTCTGAAACAACTGCTCAGCGAATGGCTCAGTTTCCGCAGCGACACTGTCACCCGCCGTCTCAAGTATC
GACTACAAAAAGTTGAGAGTCGCCTACACCTGCTGGAAGGCTTACTGATCGCCTTTCTCAACCTTGACAAGGTGATCCAC
ATCATTCGCAACGAGGACGAACCCAAGCCAGTCCTGATCGCACGCTTTGGTCTGTCAGATGCGCAAACAGAATACATCCT
CGACACCAAGCTACGCCAACTCGCGCGCCTTGAAGAAATGGCGATTCGCAGTGAACAAGACGCACTGACTAAAGAACGTG
ACGAGATCAATGTCATCCTGGATAGCGACGTCCAACTTAAAAAACTAATCAAGGACGAATTATTGGCAGATGCCAAGACG
TTCGGCGATGCGCGCCGTGCGCCGCTTGTCGCACGCCAAGCGGCACAGGCCATTGATGAAAGCGAACTGGTCGCTAGCGA
ACCGATGACCGTGGTGCTCTCGGAGAAAGGCTGGATTCGAGCGGCCAAAGGCCACGACGTCGATCCAAGCGGGATGTTCT
ACCGTGAAGGTGATCGCCTTTTGGCAGCCGTGCGCACCCGCAGCACCCATCAAGTCTCCTTCCTCGACTCCGAAGGACGT
GCCTATTCAACACTGGTGCATACCCTACCCTCGGCACGCGGCAACGGTGAACCACTGACGGGACGCTTTTCGCCCGCCCC
TGGTGCTTCATTCCAAGCGATGGCTAGTGCCGACAACGACAAATTATTCGTGTTGGCCTCCTCTCACGGCTACGGTTTCA
TCACCCGGTTCGAAAATCTCACCGGACGAAACAAAGCCGGCAAAGCCATGATTCATCTCACACCTGGCGCCCAGGTCATG
GGACTAGCTCCGCTGACCAACGTGCAACATGACCGCATTGTCGCGGTGACCAGCGCCGGCAACCTGCTAGCCATCGCAGC
AAGCGAACTCCCTGAACTAGATAAAGGCAAGGGCAACAAACTGATTGATATTCCAAAAACAAAACTGGCCACTGAACGCC
TAGTCGCTGTCATCGCAGTCGCTTCGAGTCACACCCTACTGCTCTATAGCGGCGAACGCACAATGCGCCTTTCATTTAAA
GATTTGGAGGCTTACCTTGATACACGCGGTAGCCGCGGCCAACTACTGCCAAGAGGTTGGCATAAAATCGACACACTCGA
TATCCAGTAA

Upstream 100 bases:

>100_bases
TTGGCTTCCTGGGCCACATACGGATAATCGATACTTGAATCTGAATGAGTGACGCATCAGTACAGCCCGATTCCTTGAAT
AGAGAACACACTTCCACACA

Downstream 100 bases:

>100_bases
CCAACATGGCGGAAGATACACAGCCACACAAAAATGGAACCCTGTAGATGAGGCTAAACTACCCCGTAAAACACCATTGC
CAGCTGGTTTGATAGTAAGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MTDLTRPFFHGFEQMPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMHELRLNPKAKPKKSVRAVGDVIGK
YHPHGDLACYEALVLMAQPFSYRYPLIEGQGNFGSSDDPKSFAAMRYTESKLTPISEILLSELSEGTVNWITNFDGTLEE
PAWLPSRLPHLLLNGTTGIAVGMATDVPPHNLNEIASALIHLLDNPNATIAALCQYIRGPDYPTAAEIITPPNDLQNLYE
TGNGSVRTRATYHKEDGNVVITSLPYQVSPSKVIEQIAQQIRSKKLPWLDGEGVRDESDHKNPVRIVLFPRSQRIDVEQL
MGHLFATTDLEKSHRVNLNVIGLDGRPQVKPLKQLLSEWLSFRSDTVTRRLKYRLQKVESRLHLLEGLLIAFLNLDKVIH
IIRNEDEPKPVLIARFGLSDAQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKT
FGDARRAPLVARQAAQAIDESELVASEPMTVVLSEKGWIRAAKGHDVDPSGMFYREGDRLLAAVRTRSTHQVSFLDSEGR
AYSTLVHTLPSARGNGEPLTGRFSPAPGASFQAMASADNDKLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVM
GLAPLTNVQHDRIVAVTSAGNLLAIAASELPELDKGKGNKLIDIPKTKLATERLVAVIAVASSHTLLLYSGERTMRLSFK
DLEAYLDTRGSRGQLLPRGWHKIDTLDIQ

Sequences:

>Translated_749_residues
MTDLTRPFFHGFEQMPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMHELRLNPKAKPKKSVRAVGDVIGK
YHPHGDLACYEALVLMAQPFSYRYPLIEGQGNFGSSDDPKSFAAMRYTESKLTPISEILLSELSEGTVNWITNFDGTLEE
PAWLPSRLPHLLLNGTTGIAVGMATDVPPHNLNEIASALIHLLDNPNATIAALCQYIRGPDYPTAAEIITPPNDLQNLYE
TGNGSVRTRATYHKEDGNVVITSLPYQVSPSKVIEQIAQQIRSKKLPWLDGEGVRDESDHKNPVRIVLFPRSQRIDVEQL
MGHLFATTDLEKSHRVNLNVIGLDGRPQVKPLKQLLSEWLSFRSDTVTRRLKYRLQKVESRLHLLEGLLIAFLNLDKVIH
IIRNEDEPKPVLIARFGLSDAQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKT
FGDARRAPLVARQAAQAIDESELVASEPMTVVLSEKGWIRAAKGHDVDPSGMFYREGDRLLAAVRTRSTHQVSFLDSEGR
AYSTLVHTLPSARGNGEPLTGRFSPAPGASFQAMASADNDKLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVM
GLAPLTNVQHDRIVAVTSAGNLLAIAASELPELDKGKGNKLIDIPKTKLATERLVAVIAVASSHTLLLYSGERTMRLSFK
DLEAYLDTRGSRGQLLPRGWHKIDTLDIQ
>Mature_748_residues
TDLTRPFFHGFEQMPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMHELRLNPKAKPKKSVRAVGDVIGKY
HPHGDLACYEALVLMAQPFSYRYPLIEGQGNFGSSDDPKSFAAMRYTESKLTPISEILLSELSEGTVNWITNFDGTLEEP
AWLPSRLPHLLLNGTTGIAVGMATDVPPHNLNEIASALIHLLDNPNATIAALCQYIRGPDYPTAAEIITPPNDLQNLYET
GNGSVRTRATYHKEDGNVVITSLPYQVSPSKVIEQIAQQIRSKKLPWLDGEGVRDESDHKNPVRIVLFPRSQRIDVEQLM
GHLFATTDLEKSHRVNLNVIGLDGRPQVKPLKQLLSEWLSFRSDTVTRRLKYRLQKVESRLHLLEGLLIAFLNLDKVIHI
IRNEDEPKPVLIARFGLSDAQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKTF
GDARRAPLVARQAAQAIDESELVASEPMTVVLSEKGWIRAAKGHDVDPSGMFYREGDRLLAAVRTRSTHQVSFLDSEGRA
YSTLVHTLPSARGNGEPLTGRFSPAPGASFQAMASADNDKLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVMG
LAPLTNVQHDRIVAVTSAGNLLAIAASELPELDKGKGNKLIDIPKTKLATERLVAVIAVASSHTLLLYSGERTMRLSFKD
LEAYLDTRGSRGQLLPRGWHKIDTLDIQ

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=26.5895953757225, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI19913408, Length=232, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789396, Length=738, Percent_Identity=57.7235772357724, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=707, Percent_Identity=34.9363507779349, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=387, Percent_Identity=23.5142118863049, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=274, Percent_Identity=26.6423357664234, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=402, Percent_Identity=21.8905472636816, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=196, Percent_Identity=26.0204081632653, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83399; Mature: 83267

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTRPFFHGFEQMPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMHELR
CCCCCCHHHCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNPKAKPKKSVRAVGDVIGKYHPHGDLACYEALVLMAQPFSYRYPLIEGQGNFGSSDDPK
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCC
SFAAMRYTESKLTPISEILLSELSEGTVNWITNFDGTLEEPAWLPSRLPHLLLNGTTGIA
HHHHHEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEECCCCCEE
VGMATDVPPHNLNEIASALIHLLDNPNATIAALCQYIRGPDYPTAAEIITPPNDLQNLYE
EEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHH
TGNGSVRTRATYHKEDGNVVITSLPYQVSPSKVIEQIAQQIRSKKLPWLDGEGVRDESDH
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KNPVRIVLFPRSQRIDVEQLMGHLFATTDLEKSHRVNLNVIGLDGRPQVKPLKQLLSEWL
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
SFRSDTVTRRLKYRLQKVESRLHLLEGLLIAFLNLDKVIHIIRNEDEPKPVLIARFGLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
AQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKT
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
FGDARRAPLVARQAAQAIDESELVASEPMTVVLSEKGWIRAAKGHDVDPSGMFYREGDRL
HCCHHCCHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCCEEECCCCE
LAAVRTRSTHQVSFLDSEGRAYSTLVHTLPSARGNGEPLTGRFSPAPGASFQAMASADND
EEHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCC
KLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVMGLAPLTNVQHDRIVAVTSAG
EEEEEECCCCCEEEEEHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEEECCC
NLLAIAASELPELDKGKGNKLIDIPKTKLATERLVAVIAVASSHTLLLYSGERTMRLSFK
CEEEEECHHCCCCCCCCCCEEEECCCHHHHHHHHHHHEEEECCCEEEEEECCCEEEEEHH
DLEAYLDTRGSRGQLLPRGWHKIDTLDIQ
HHHHHHHCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
TDLTRPFFHGFEQMPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMHELR
CCCCCHHHCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LNPKAKPKKSVRAVGDVIGKYHPHGDLACYEALVLMAQPFSYRYPLIEGQGNFGSSDDPK
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCC
SFAAMRYTESKLTPISEILLSELSEGTVNWITNFDGTLEEPAWLPSRLPHLLLNGTTGIA
HHHHHEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEECCCCCEE
VGMATDVPPHNLNEIASALIHLLDNPNATIAALCQYIRGPDYPTAAEIITPPNDLQNLYE
EEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHH
TGNGSVRTRATYHKEDGNVVITSLPYQVSPSKVIEQIAQQIRSKKLPWLDGEGVRDESDH
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KNPVRIVLFPRSQRIDVEQLMGHLFATTDLEKSHRVNLNVIGLDGRPQVKPLKQLLSEWL
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHH
SFRSDTVTRRLKYRLQKVESRLHLLEGLLIAFLNLDKVIHIIRNEDEPKPVLIARFGLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
AQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKT
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
FGDARRAPLVARQAAQAIDESELVASEPMTVVLSEKGWIRAAKGHDVDPSGMFYREGDRL
HCCHHCCHHHHHHHHHHCCHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCCEEECCCCE
LAAVRTRSTHQVSFLDSEGRAYSTLVHTLPSARGNGEPLTGRFSPAPGASFQAMASADND
EEHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCC
KLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVMGLAPLTNVQHDRIVAVTSAG
EEEEEECCCCCEEEEEHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEEECCC
NLLAIAASELPELDKGKGNKLIDIPKTKLATERLVAVIAVASSHTLLLYSGERTMRLSFK
CEEEEECHHCCCCCCCCCCEEEECCCHHHHHHHHHHHEEEECCCEEEEEECCCEEEEEHH
DLEAYLDTRGSRGQLLPRGWHKIDTLDIQ
HHHHHHHCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]