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The map label for this gene is hemE

Identifier: 182681167

GI number: 182681167

Start: 720944

End: 722008

Strand: Reverse

Name: hemE

Synonym: XfasM23_0609

Alternate gene names: 182681167

Gene position: 722008-720944 (Counterclockwise)

Preceding gene: 182681168

Following gene: 182681166

Centisome position: 28.47

GC content: 58.5

Gene sequence:

>1065_bases
ATGCTCAAAAACGATCGCCTACTGCGTGCCCTACGACGCGACACCGTGGACCGTACCCCAATCTGGCTGATGCGCCAGGC
CGGACGCTATCTGCCGGAATACCGTGCTGCCCGGCAACACGCCGGCAGCTTCCTCAAAATGGCAAAAACTCCTGAACTGG
CCTGTGAAATCACCCTGCAACCACTGCGCCGCTTCCCACTAGACGCGGCGATTCTGTTCTCTGACATCCTCATGATCCCC
GACGCGATGGGCCTAGAACTGCACTTCATTGAAGGTGAAGGGCCACGCTTGGGCAAACCAATCCGCGACGCCGCAGCCAT
CACACAACTCGCCGTGCCGGATATGGAAACCGAACTACGCTACGTCATGGACGCCGTGCGACTGATCCGTAAAGAACTGG
ACAACAGCGTCCCGCTCATTGGTTTCTCCGGAAGCCCATGGACACTGGCCTGCTACATGATCGAAGGAGGAAGCAGCAAA
GAATACGCACGCATTAAGGCCATGGCATTCAACGCACCGGACGTACTACATCAACTGCTAAACACCGTCACCGACGCAGT
GATCAGCTACTTGGCAGCGCAGCGCGCCGCTGGCGCACAAGCACTACAGGTCTTCGATACTTGGGGAGGTATCCTGTCGC
CCACGATGTACCGAACATTCTCGCTGCCCTACTTAACGCGGATTGCACGCGAACTAGAACGCGGCACCGGTACCGAACAT
ACCCCCCTGGTGTTGTTCGGCAAAGGCAACGGACCTTACATCGCAGAACTCGCCATGAGCGGTACCGAAGCCGTCGGCGT
GGACTGGACCATCGAATTAGAAGACGCCGCACGCCGCAGCAACGGCCAAGTGGCATTACAAGGCAACCTCGACCCAGCCA
CACTGTACGGAACCCCAAACAACATCGCACGTGAAGTACAACGCACCCTGGACAGCTACGCAGCCGGTAACGGTGGCTCA
CGCGAGGGACATGTCTTCAACCTTGGCCACGGCATGACCCCTGGCATGAACCCGGATCACGTCAGCGCACTTGTCGAAGC
CGTGCAGCGCTTGAGCCGTCGTTGA

Upstream 100 bases:

>100_bases
ATAGCACGCGTTTGACAAGACGCAACAACAGACAAAGCTCACATCAAACACCGCAGTCATACTCACCCATCATTCCTAAC
GCATCACACTGAGAGTCCCT

Downstream 100 bases:

>100_bases
CTGGAGTGATCTCAGTTCATTGCATCGTGTCTAACAAACGTGAAACGCTGTCAGCCCAGATGCTATTCACCTGCCCCCCG
CTGTGAGCGCATCAAGACAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLKNDRLLRALRRDTVDRTPIWLMRQAGRYLPEYRAARQHAGSFLKMAKTPELACEITLQPLRRFPLDAAILFSDILMIP
DAMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDMETELRYVMDAVRLIRKELDNSVPLIGFSGSPWTLACYMIEGGSSK
EYARIKAMAFNAPDVLHQLLNTVTDAVISYLAAQRAAGAQALQVFDTWGGILSPTMYRTFSLPYLTRIARELERGTGTEH
TPLVLFGKGNGPYIAELAMSGTEAVGVDWTIELEDAARRSNGQVALQGNLDPATLYGTPNNIAREVQRTLDSYAAGNGGS
REGHVFNLGHGMTPGMNPDHVSALVEAVQRLSRR

Sequences:

>Translated_354_residues
MLKNDRLLRALRRDTVDRTPIWLMRQAGRYLPEYRAARQHAGSFLKMAKTPELACEITLQPLRRFPLDAAILFSDILMIP
DAMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDMETELRYVMDAVRLIRKELDNSVPLIGFSGSPWTLACYMIEGGSSK
EYARIKAMAFNAPDVLHQLLNTVTDAVISYLAAQRAAGAQALQVFDTWGGILSPTMYRTFSLPYLTRIARELERGTGTEH
TPLVLFGKGNGPYIAELAMSGTEAVGVDWTIELEDAARRSNGQVALQGNLDPATLYGTPNNIAREVQRTLDSYAAGNGGS
REGHVFNLGHGMTPGMNPDHVSALVEAVQRLSRR
>Mature_354_residues
MLKNDRLLRALRRDTVDRTPIWLMRQAGRYLPEYRAARQHAGSFLKMAKTPELACEITLQPLRRFPLDAAILFSDILMIP
DAMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDMETELRYVMDAVRLIRKELDNSVPLIGFSGSPWTLACYMIEGGSSK
EYARIKAMAFNAPDVLHQLLNTVTDAVISYLAAQRAAGAQALQVFDTWGGILSPTMYRTFSLPYLTRIARELERGTGTEH
TPLVLFGKGNGPYIAELAMSGTEAVGVDWTIELEDAARRSNGQVALQGNLDPATLYGTPNNIAREVQRTLDSYAAGNGGS
REGHVFNLGHGMTPGMNPDHVSALVEAVQRLSRR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=356, Percent_Identity=45.2247191011236, Blast_Score=318, Evalue=3e-87,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=54.957507082153, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320252, Length=361, Percent_Identity=39.612188365651, Blast_Score=286, Evalue=4e-78,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=43.9093484419263, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=43.9093484419263, Blast_Score=284, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_XYLF2 (B2I9F9)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829327.1
- ProteinModelPortal:   B2I9F9
- SMR:   B2I9F9
- GeneID:   6202965
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0609
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38991; Mature: 38991

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 152-152 BINDING 207-207 BINDING 330-330

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDRLLRALRRDTVDRTPIWLMRQAGRYLPEYRAARQHAGSFLKMAKTPELACEITLQ
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
PLRRFPLDAAILFSDILMIPDAMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDMETELR
HHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
YVMDAVRLIRKELDNSVPLIGFSGSPWTLACYMIEGGSSKEYARIKAMAFNAPDVLHQLL
HHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
NTVTDAVISYLAAQRAAGAQALQVFDTWGGILSPTMYRTFSLPYLTRIARELERGTGTEH
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGPYIAELAMSGTEAVGVDWTIELEDAARRSNGQVALQGNLDPATLYGTPN
CCEEEEECCCCCEEEEEECCCCCEECCEEEEEEHHHHCCCCCCEEEECCCCCEEEECCCH
NIAREVQRTLDSYAAGNGGSREGHVFNLGHGMTPGMNPDHVSALVEAVQRLSRR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNDRLLRALRRDTVDRTPIWLMRQAGRYLPEYRAARQHAGSFLKMAKTPELACEITLQ
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
PLRRFPLDAAILFSDILMIPDAMGLELHFIEGEGPRLGKPIRDAAAITQLAVPDMETELR
HHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
YVMDAVRLIRKELDNSVPLIGFSGSPWTLACYMIEGGSSKEYARIKAMAFNAPDVLHQLL
HHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
NTVTDAVISYLAAQRAAGAQALQVFDTWGGILSPTMYRTFSLPYLTRIARELERGTGTEH
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHCCHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGPYIAELAMSGTEAVGVDWTIELEDAARRSNGQVALQGNLDPATLYGTPN
CCEEEEECCCCCEEEEEECCCCCEECCEEEEEEHHHHCCCCCCEEEECCCCCEEEECCCH
NIAREVQRTLDSYAAGNGGSREGHVFNLGHGMTPGMNPDHVSALVEAVQRLSRR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA