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The map label for this gene is lpxK

Identifier: 182680916

GI number: 182680916

Start: 452444

End: 453463

Strand: Direct

Name: lpxK

Synonym: XfasM23_0354

Alternate gene names: 182680916

Gene position: 452444-453463 (Clockwise)

Preceding gene: 182680915

Following gene: 182680922

Centisome position: 17.84

GC content: 54.31

Gene sequence:

>1020_bases
ATGAGTAGTGGACGTGGTTCTAGGATTCCTGAGTATTGGTATGGGCAGGTTCCGGTGCCGCCATTCATGCGGTTCATGGA
GGTCATTTATGCTGGTGCAGTCAGTTTGCGTCGTTTGGCCTATCGCCGCGGCTGGCGGCGTCGCTATGGAGTGGCTGTAC
CCGTCGTGGTGATCGGTAACTTGGTTGCTGGAGGTACTGGTAAAACGCCGTTAACCATCGAAATAGTTGCACGCCTGCGT
GAAGCAGGGTGGACCCCGGGCATCGCCAGCCGTGGTTATGGTCGCCGTGATCCTAAGACTCCCCGCTGGATTCAACCAGA
TACGCCAATTGAATTGGCTGGCGATGAACCAGCAATGATCGCTTGGAAGACCGGCATGCGTGTGCGTGTGGATGTTGATA
GGAGTGCGGCAGCGCGTGCTTTGGTTGCGGAAGGCTGTGACATCGTGGTTTGTGACGATGGGTTGCAGCATTATCGGTTG
ATGCGTGATATCGAGATTGAAGTCATCGACGGTCAGCGTCGTTACGGCAATGGGCATCTGTTGCCCGCTGGTCCGCTGCG
TGAGCCGATGGTGCGTGGTCGCCTTTGCGATTTTCGTGTGCTCAATGCAGGTCAGTATAGTGATCGACCAACGTCTGGGT
TTGGTCCCAGTGACTGGCAGATGCGTTTACACATTGATCACGCGCAGTCGTTACAAGGTTCCCGACGGCGGTCGTTGGAT
GCTTTTTCTGGACAACGTGTGCATGCCGTTGCTGGTATCGCACATCCGGAACGTTTTTTTTCGATGCTGCGTCAGCGTGG
TATTGGCGTGGTGCCGCATGCATTTCCGGATCATCACTTTTATCGGGCAGAGGATTTTACCTTTGGTAGTCGACTTCCTG
TGTTGATGACCGAGAAGGATGCGGTCAAATGCCGTGCATTTGCTGACGATTGGTTTTTCAGCGTGCCGTTGCGAGTTGAA
TTGCCGACGGTGTTCTGGACTGCACTGTTTGATCGCCTAGAACGGCTTGTTTCGTGTTGA

Upstream 100 bases:

>100_bases
ACCAGGGGCGCATCATTGAGTCTGGTACCCATGTCGATCTGTTGGCACGTGATGGGTTGTACGCTTATTTGTACAGCATG
CAATTTCGCGAACGTCCAAC

Downstream 100 bases:

>100_bases
TTATCTCTAATGTAAATTTATCTTAAAAATATATTTTATATTAATTTAAACTCCATAATGAGTAAAATTACTAATTGTTA
TTTTCAGGGGATTTTTGATG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSSGRGSRIPEYWYGQVPVPPFMRFMEVIYAGAVSLRRLAYRRGWRRRYGVAVPVVVIGNLVAGGTGKTPLTIEIVARLR
EAGWTPGIASRGYGRRDPKTPRWIQPDTPIELAGDEPAMIAWKTGMRVRVDVDRSAAARALVAEGCDIVVCDDGLQHYRL
MRDIEIEVIDGQRRYGNGHLLPAGPLREPMVRGRLCDFRVLNAGQYSDRPTSGFGPSDWQMRLHIDHAQSLQGSRRRSLD
AFSGQRVHAVAGIAHPERFFSMLRQRGIGVVPHAFPDHHFYRAEDFTFGSRLPVLMTEKDAVKCRAFADDWFFSVPLRVE
LPTVFWTALFDRLERLVSC

Sequences:

>Translated_339_residues
MSSGRGSRIPEYWYGQVPVPPFMRFMEVIYAGAVSLRRLAYRRGWRRRYGVAVPVVVIGNLVAGGTGKTPLTIEIVARLR
EAGWTPGIASRGYGRRDPKTPRWIQPDTPIELAGDEPAMIAWKTGMRVRVDVDRSAAARALVAEGCDIVVCDDGLQHYRL
MRDIEIEVIDGQRRYGNGHLLPAGPLREPMVRGRLCDFRVLNAGQYSDRPTSGFGPSDWQMRLHIDHAQSLQGSRRRSLD
AFSGQRVHAVAGIAHPERFFSMLRQRGIGVVPHAFPDHHFYRAEDFTFGSRLPVLMTEKDAVKCRAFADDWFFSVPLRVE
LPTVFWTALFDRLERLVSC
>Mature_338_residues
SSGRGSRIPEYWYGQVPVPPFMRFMEVIYAGAVSLRRLAYRRGWRRRYGVAVPVVVIGNLVAGGTGKTPLTIEIVARLRE
AGWTPGIASRGYGRRDPKTPRWIQPDTPIELAGDEPAMIAWKTGMRVRVDVDRSAAARALVAEGCDIVVCDDGLQHYRLM
RDIEIEVIDGQRRYGNGHLLPAGPLREPMVRGRLCDFRVLNAGQYSDRPTSGFGPSDWQMRLHIDHAQSLQGSRRRSLDA
FSGQRVHAVAGIAHPERFFSMLRQRGIGVVPHAFPDHHFYRAEDFTFGSRLPVLMTEKDAVKCRAFADDWFFSVPLRVEL
PTVFWTALFDRLERLVSC

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=337, Percent_Identity=38.2789317507418, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_XYLF2 (B2I804)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829076.1
- GeneID:   6202072
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0354
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- ProtClustDB:   PRK00652
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38319; Mature: 38187

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGRGSRIPEYWYGQVPVPPFMRFMEVIYAGAVSLRRLAYRRGWRRRYGVAVPVVVIGN
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
LVAGGTGKTPLTIEIVARLREAGWTPGIASRGYGRRDPKTPRWIQPDTPIELAGDEPAMI
HHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
AWKTGMRVRVDVDRSAAARALVAEGCDIVVCDDGLQHYRLMRDIEIEVIDGQRRYGNGHL
EEECCCEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCEEEEECCCEECCCCCC
LPAGPLREPMVRGRLCDFRVLNAGQYSDRPTSGFGPSDWQMRLHIDHAQSLQGSRRRSLD
CCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCHHHHCCH
AFSGQRVHAVAGIAHPERFFSMLRQRGIGVVPHAFPDHHFYRAEDFTFGSRLPVLMTEKD
HCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCC
AVKCRAFADDWFFSVPLRVELPTVFWTALFDRLERLVSC
CEEEEEECCCCEEECCEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSGRGSRIPEYWYGQVPVPPFMRFMEVIYAGAVSLRRLAYRRGWRRRYGVAVPVVVIGN
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
LVAGGTGKTPLTIEIVARLREAGWTPGIASRGYGRRDPKTPRWIQPDTPIELAGDEPAMI
HHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
AWKTGMRVRVDVDRSAAARALVAEGCDIVVCDDGLQHYRLMRDIEIEVIDGQRRYGNGHL
EEECCCEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCEEEEECCCEECCCCCC
LPAGPLREPMVRGRLCDFRVLNAGQYSDRPTSGFGPSDWQMRLHIDHAQSLQGSRRRSLD
CCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCHHHHCCH
AFSGQRVHAVAGIAHPERFFSMLRQRGIGVVPHAFPDHHFYRAEDFTFGSRLPVLMTEKD
HCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCC
AVKCRAFADDWFFSVPLRVELPTVFWTALFDRLERLVSC
CEEEEEECCCCEEECCEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA