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The map label for this gene is pepA [H]

Identifier: 182680786

GI number: 182680786

Start: 289619

End: 290986

Strand: Reverse

Name: pepA [H]

Synonym: XfasM23_0215

Alternate gene names: 182680786

Gene position: 290986-289619 (Counterclockwise)

Preceding gene: 182680787

Following gene: 182680783

Centisome position: 11.48

GC content: 59.43

Gene sequence:

>1368_bases
ATGCCCATCCCCTTCGGTTTCACTGTTGCTACCACCAATACCCTGCCATTGCATGTACTCGATCGCGCACACTTCGCCAA
CTGGTTGACCGCACAATCACCGGCGATTCAATCATGGGTACAGGCACAGGGCTTTGCCGCTGCCGCAGGGAGTGTACTGC
TACTACCGGGCGAACACGGCCTCAGTGGAGCAGTGCTGGGCACGGGTGACTACGCTGATCCCTACGCCTATGCACACGGC
CCATTTGCACTCCCAGCCGGCACCCACTGGCAACCTACCGGAACATGGGACCCCATCAAGCAAGCCACCCTGACACTGGG
TTGGGGCCTGGGTAGCTATCGCTTCACGCGCTACCGTCTCCCAGACCGCGCACCGGCGGAATTGGCCGTTACACCAACAC
CAGAAACTCTGGCACTGATTCAGGCGTGCCTACGCGTACGCGACTGGGTCAACACACCAACCCAGGACATGGGTCCGGAA
GAACTCCAAACCATTACCCGCGACTTGGCCCAGAGACACGGCGGTACATTCGAAAGCATCATCGGGGAAGCACTATTGAC
GCAAAACTTTCCCACCATCCACGCCGTCGGCCGCGCCTCCCACCGTGCGCCACGTCTTTTACAACTCAACTGGGGTCAAC
ACACCCATCCTCACTTAGTCCTGATCGGCAAGGCAGTGTGCTTTGACACTGGCGGCCTAGATCTGAAACCTGCCGACGGC
ATGCGCCACATGAAAAAAGACATGGGTGGTGCCGCACACGCTCTAGCGCTGGCCGGACTGGTGATGGAGCAACAACTACC
AGTGCGACTGACCGTGCTGATACCAGCGGTAGAAAATGCAATTGGACCTGACGCCTTTCGCCCCGGAGAAGTGATTGTGA
CTCGGGCAGGAGTGAGCGTTGAAATTGACAACACCGACGCCGAGGGCCGCCTCATCTTGTGCGATACGCTGGCATACGCC
AACGAACTGAAGCCGCACACGATCCTGGATTTCGCAACCTTGACCGGCGCAGCGCGGATCGCTCTAGGACCGGACCTGCC
AGCACTTTTCAGTAACAACGAGGTGTTGGCCCAGGCCTGGCTGGATGCTGGTAAGCAGACCCGCGACCCAGTGTGGCGCA
TGCCACTGTGGCGCCCATATTTGCACTACCTCAACAGCCATGTTGCCGACCTGGCCAACGCCGGTTCACGCATGGCTGGC
GCAGTAACCGCCGCACTGTACTTGGAACGATTCGTCGCTCAAGACCTGCCTTGGGCGCACCTTGATGTTTACGCATGGAA
CGACCTCAATCGCCCCGGGCGCCCAGCAGGTGGCGAGGCACTGGGACTACGCTCGGCTTGGGCGATGCTGAAAGAACGCT
ACAGATAA

Upstream 100 bases:

>100_bases
TCCCTTCGGACGCTTACAAATATTTCCCCCTGAACAGGGTAGTACAGCGCACAACGCCCCCATCGCCACATCTGACTACA
GCCACCAAGACACTTAGTTT

Downstream 100 bases:

>100_bases
GCAACCAAAGGACCCAGCCAGACAGCACCGAACGATGCTAGCCATCGTTCGTTCATCAAAATACGACTGCAACCCGCCAC
CGCCCATAACACACTGGCAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPIPFGFTVATTNTLPLHVLDRAHFANWLTAQSPAIQSWVQAQGFAAAAGSVLLLPGEHGLSGAVLGTGDYADPYAYAHG
PFALPAGTHWQPTGTWDPIKQATLTLGWGLGSYRFTRYRLPDRAPAELAVTPTPETLALIQACLRVRDWVNTPTQDMGPE
ELQTITRDLAQRHGGTFESIIGEALLTQNFPTIHAVGRASHRAPRLLQLNWGQHTHPHLVLIGKAVCFDTGGLDLKPADG
MRHMKKDMGGAAHALALAGLVMEQQLPVRLTVLIPAVENAIGPDAFRPGEVIVTRAGVSVEIDNTDAEGRLILCDTLAYA
NELKPHTILDFATLTGAARIALGPDLPALFSNNEVLAQAWLDAGKQTRDPVWRMPLWRPYLHYLNSHVADLANAGSRMAG
AVTAALYLERFVAQDLPWAHLDVYAWNDLNRPGRPAGGEALGLRSAWAMLKERYR

Sequences:

>Translated_455_residues
MPIPFGFTVATTNTLPLHVLDRAHFANWLTAQSPAIQSWVQAQGFAAAAGSVLLLPGEHGLSGAVLGTGDYADPYAYAHG
PFALPAGTHWQPTGTWDPIKQATLTLGWGLGSYRFTRYRLPDRAPAELAVTPTPETLALIQACLRVRDWVNTPTQDMGPE
ELQTITRDLAQRHGGTFESIIGEALLTQNFPTIHAVGRASHRAPRLLQLNWGQHTHPHLVLIGKAVCFDTGGLDLKPADG
MRHMKKDMGGAAHALALAGLVMEQQLPVRLTVLIPAVENAIGPDAFRPGEVIVTRAGVSVEIDNTDAEGRLILCDTLAYA
NELKPHTILDFATLTGAARIALGPDLPALFSNNEVLAQAWLDAGKQTRDPVWRMPLWRPYLHYLNSHVADLANAGSRMAG
AVTAALYLERFVAQDLPWAHLDVYAWNDLNRPGRPAGGEALGLRSAWAMLKERYR
>Mature_454_residues
PIPFGFTVATTNTLPLHVLDRAHFANWLTAQSPAIQSWVQAQGFAAAAGSVLLLPGEHGLSGAVLGTGDYADPYAYAHGP
FALPAGTHWQPTGTWDPIKQATLTLGWGLGSYRFTRYRLPDRAPAELAVTPTPETLALIQACLRVRDWVNTPTQDMGPEE
LQTITRDLAQRHGGTFESIIGEALLTQNFPTIHAVGRASHRAPRLLQLNWGQHTHPHLVLIGKAVCFDTGGLDLKPADGM
RHMKKDMGGAAHALALAGLVMEQQLPVRLTVLIPAVENAIGPDAFRPGEVIVTRAGVSVEIDNTDAEGRLILCDTLAYAN
ELKPHTILDFATLTGAARIALGPDLPALFSNNEVLAQAWLDAGKQTRDPVWRMPLWRPYLHYLNSHVADLANAGSRMAGA
VTAALYLERFVAQDLPWAHLDVYAWNDLNRPGRPAGGEALGLRSAWAMLKERYR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=284, Percent_Identity=35.9154929577465, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI47155554, Length=289, Percent_Identity=34.9480968858132, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1790710, Length=298, Percent_Identity=38.255033557047, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI87082123, Length=290, Percent_Identity=40.3448275862069, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=319, Percent_Identity=35.423197492163, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=191, Percent_Identity=32.9842931937173, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357381, Length=297, Percent_Identity=34.6801346801347, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379063, Length=297, Percent_Identity=34.6801346801347, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI221379062, Length=297, Percent_Identity=34.6801346801347, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24661038, Length=240, Percent_Identity=36.6666666666667, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21355725, Length=240, Percent_Identity=35.4166666666667, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24662227, Length=292, Percent_Identity=29.1095890410959, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=292, Percent_Identity=28.7671232876712, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355645, Length=292, Percent_Identity=28.0821917808219, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662223, Length=292, Percent_Identity=28.0821917808219, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19922386, Length=294, Percent_Identity=28.2312925170068, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077148, Length=281, Percent_Identity=27.7580071174377, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130057, Length=281, Percent_Identity=27.7580071174377, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129963, Length=290, Percent_Identity=27.2413793103448, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646701, Length=224, Percent_Identity=33.0357142857143, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=224, Percent_Identity=33.0357142857143, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=224, Percent_Identity=33.0357142857143, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49427; Mature: 49296

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPFGFTVATTNTLPLHVLDRAHFANWLTAQSPAIQSWVQAQGFAAAAGSVLLLPGEHG
CCCCCCEEEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCC
LSGAVLGTGDYADPYAYAHGPFALPAGTHWQPTGTWDPIKQATLTLGWGLGSYRFTRYRL
CCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHCEEEEECCCCCCEEEEEEC
PDRAPAELAVTPTPETLALIQACLRVRDWVNTPTQDMGPEELQTITRDLAQRHGGTFESI
CCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
IGEALLTQNFPTIHAVGRASHRAPRLLQLNWGQHTHPHLVLIGKAVCFDTGGLDLKPADG
HHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCHH
MRHMKKDMGGAAHALALAGLVMEQQLPVRLTVLIPAVENAIGPDAFRPGEVIVTRAGVSV
HHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCCCCEEEEECCEEE
EIDNTDAEGRLILCDTLAYANELKPHTILDFATLTGAARIALGPDLPALFSNNEVLAQAW
EECCCCCCCEEEEEECHHHHHCCCCCCEEHHHHHCCCEEEEECCCCCHHHCCCHHHHHHH
LDAGKQTRDPVWRMPLWRPYLHYLNSHVADLANAGSRMAGAVTAALYLERFVAQDLPWAH
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEE
LDVYAWNDLNRPGRPAGGEALGLRSAWAMLKERYR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PIPFGFTVATTNTLPLHVLDRAHFANWLTAQSPAIQSWVQAQGFAAAAGSVLLLPGEHG
CCCCCEEEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCC
LSGAVLGTGDYADPYAYAHGPFALPAGTHWQPTGTWDPIKQATLTLGWGLGSYRFTRYRL
CCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHCEEEEECCCCCCEEEEEEC
PDRAPAELAVTPTPETLALIQACLRVRDWVNTPTQDMGPEELQTITRDLAQRHGGTFESI
CCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
IGEALLTQNFPTIHAVGRASHRAPRLLQLNWGQHTHPHLVLIGKAVCFDTGGLDLKPADG
HHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCHH
MRHMKKDMGGAAHALALAGLVMEQQLPVRLTVLIPAVENAIGPDAFRPGEVIVTRAGVSV
HHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCCCCCCCCCCEEEEECCEEE
EIDNTDAEGRLILCDTLAYANELKPHTILDFATLTGAARIALGPDLPALFSNNEVLAQAW
EECCCCCCCEEEEEECHHHHHCCCCCCEEHHHHHCCCEEEEECCCCCHHHCCCHHHHHHH
LDAGKQTRDPVWRMPLWRPYLHYLNSHVADLANAGSRMAGAVTAALYLERFVAQDLPWAH
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEE
LDVYAWNDLNRPGRPAGGEALGLRSAWAMLKERYR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA