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The map label for this gene is ilvD

Identifier: 182680637

GI number: 182680637

Start: 94459

End: 96291

Strand: Reverse

Name: ilvD

Synonym: XfasM23_0066

Alternate gene names: 182680637

Gene position: 96291-94459 (Counterclockwise)

Preceding gene: 182680641

Following gene: 182680634

Centisome position: 3.8

GC content: 54.5

Gene sequence:

>1833_bases
ATGCCTGAGTACCGATCCAAAACTTCCACCTACGGCCGCAATATGGCTGGTGCGCGTGCGTTATGGCGCGCTACCGGCAT
GAAGGATGACGACTTCCAGAAGCCGATCATCGCGATTGCTAATTCTTTCACTCAATTCGTCCCAGGGCACGTTCATCTAA
AGGATCTTGGCCAGCTAGTCGCACGTGAAATTGAGCGTCTCGGTGGTGTAGCCAAAGAATTCAACACGATTGCGGTAGAT
GACGGTATCGCGATGGGGCACGACGGAATGCTGTATTCGCTACCTAGTCGTGAAATCATCGCCGACTCCGTCGAATACAT
GGCAAACGCGCATTGTGCTGATGCGCTGGTATGCATCTCCAACTGCGACAAAATCACTCCTGGCATGCTGATGGCATCGC
TCCGCCTGAACATCCCAACGGTGTTCGTCTCAGGTGGGCCGATGGAAGCCGGAAAAACGACACTGGCTGATCACAAACTC
GACCTAGTTGACGCAATGGTGCTGGCTGCCGACCCTCACGCGAGTGACGAGGAAGTTGCTACCGTGGAACGCAGTGCCTG
CCCCACTTGCGGTTCATGTTCGGGCATGTTTACTGCCAACTCGATGAACTGTCTCACCGAAGCACTCGGTTTATCCTTGC
CAGGTAACGGGACTGTCGTTGCGACGCATTCTGACCGTAAACAACTGTTTTTGAACGCAGGACGCACTGTCATTGAGTTA
TGTCACCGCTGGTATGGGGCTGAAGATGCCACCGCATTACCTCGAGGCATTGCTACATTTGCTGCGTTCGAAAACGCGAT
AACCCTAGATATCGCGATGGGCGGCTCGACTAATACGATTTTGCACCTACTTGCAGCCGCACAGGAGGCGGAAGTGTCTT
TTACGATGCAAGACATTGATCGCTTGTCACGGAATGTGCCGCAATTATGCAAAGTTGCTCCCAACACGCAGAAATACCAT
ATTGAGGATGTGCACCGCGCTGGAGGCATCTTCGGGATTCTAGCTGAATTGGCACGGGGAAACTTGTTACATACTGACGT
CGCAACCGTACATAGCAAAACCCTGGGTGAGGCCATCGCCACATGGGACATTATCGGGACGCAGGATGAAGCGGTCCATA
CGTTTTATAAAGCAGGTTCAGCAGGCATCCCAACCCAGGTGGCCTTCAGTCAAAGTACGCGTTGGCCGTCACTCGATACT
GATCGTACCGAAGGCTGCATCCGTGACATGGAGCATGCGTTCTCGAAGGAAGGAGGCTTGGCAGTGCTCTATGGCAACAT
TGCCCAGGATGGCTGCGTCGTAAAGACCGCCGGTGTAGACGCATCAATCCATGTGTTCGAAGGTTCGGCCCTGGTGTACG
AAAGCCAGGAGGCAGCGGTCAAAGGAATCCTTAGCGACGAGGTACAACCAGGCATGATCGTCGTGATTCGCTACGAAGGC
CCCAAGGGCGGCCCTGGCATGCAGGAGATGCTGTATCCAACGTCGTATTTGAAGTCCAAAGGTCTCGGGAAGCAATGTGC
TCTATTCACCGATGGCCGGTTTTCTGGCGGGACCTCAGGTTTATCAATTGGCCACGCTTCACCCGAAGCCGCAGCAGGTG
GTGCTATTGGCCTCATCCGGGATGGCGACCGTATCCGCATCGACATTCCACAGCGCGCGATCAATGTGCTCATCAGCGAA
GAGGAGTTGGCTTCACGGCGCCTCGAACAACATGCCATCGGCTGGAAGCCGGCCCAGTCACGGACGCGTAAGGTCAGCAG
TGCTCTGAAGGCGTATGCATTACTTGCAACCAGCGCCGACAAGGGGGCCGTACGCAACAAAACGCTACTTTGA

Upstream 100 bases:

>100_bases
ACGTAAGGAGGCATTTTTATCGCAAAGTGATCTTTCAATAGGCATCGCTTGTTGCTGTAGAGATGCTCTGACTGCTACTC
GCTATCACCTTCGCACCACC

Downstream 100 bases:

>100_bases
ATATCATCGCAATCAGGTGCCCGGATGTGAGTCAAACGCAGGAAGTGAGATATAGAGAACTGAACGGGAAACAACAGATA
CTGGCCGAAAAAATTCCACA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MPEYRSKTSTYGRNMAGARALWRATGMKDDDFQKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERLGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKTTLADHKL
DLVDAMVLAADPHASDEEVATVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHSDRKQLFLNAGRTVIEL
CHRWYGAEDATALPRGIATFAAFENAITLDIAMGGSTNTILHLLAAAQEAEVSFTMQDIDRLSRNVPQLCKVAPNTQKYH
IEDVHRAGGIFGILAELARGNLLHTDVATVHSKTLGEAIATWDIIGTQDEAVHTFYKAGSAGIPTQVAFSQSTRWPSLDT
DRTEGCIRDMEHAFSKEGGLAVLYGNIAQDGCVVKTAGVDASIHVFEGSALVYESQEAAVKGILSDEVQPGMIVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALFTDGRFSGGTSGLSIGHASPEAAAGGAIGLIRDGDRIRIDIPQRAINVLISE
EELASRRLEQHAIGWKPAQSRTRKVSSALKAYALLATSADKGAVRNKTLL

Sequences:

>Translated_610_residues
MPEYRSKTSTYGRNMAGARALWRATGMKDDDFQKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERLGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKTTLADHKL
DLVDAMVLAADPHASDEEVATVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHSDRKQLFLNAGRTVIEL
CHRWYGAEDATALPRGIATFAAFENAITLDIAMGGSTNTILHLLAAAQEAEVSFTMQDIDRLSRNVPQLCKVAPNTQKYH
IEDVHRAGGIFGILAELARGNLLHTDVATVHSKTLGEAIATWDIIGTQDEAVHTFYKAGSAGIPTQVAFSQSTRWPSLDT
DRTEGCIRDMEHAFSKEGGLAVLYGNIAQDGCVVKTAGVDASIHVFEGSALVYESQEAAVKGILSDEVQPGMIVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALFTDGRFSGGTSGLSIGHASPEAAAGGAIGLIRDGDRIRIDIPQRAINVLISE
EELASRRLEQHAIGWKPAQSRTRKVSSALKAYALLATSADKGAVRNKTLL
>Mature_609_residues
PEYRSKTSTYGRNMAGARALWRATGMKDDDFQKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERLGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKTTLADHKLD
LVDAMVLAADPHASDEEVATVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHSDRKQLFLNAGRTVIELC
HRWYGAEDATALPRGIATFAAFENAITLDIAMGGSTNTILHLLAAAQEAEVSFTMQDIDRLSRNVPQLCKVAPNTQKYHI
EDVHRAGGIFGILAELARGNLLHTDVATVHSKTLGEAIATWDIIGTQDEAVHTFYKAGSAGIPTQVAFSQSTRWPSLDTD
RTEGCIRDMEHAFSKEGGLAVLYGNIAQDGCVVKTAGVDASIHVFEGSALVYESQEAAVKGILSDEVQPGMIVVIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKQCALFTDGRFSGGTSGLSIGHASPEAAAGGAIGLIRDGDRIRIDIPQRAINVLISEE
ELASRRLEQHAIGWKPAQSRTRKVSSALKAYALLATSADKGAVRNKTLL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=72.6829268292683, Blast_Score=920, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=565, Percent_Identity=29.7345132743363, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI2367371, Length=523, Percent_Identity=30.9751434034417, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1786464, Length=577, Percent_Identity=30.6759098786828, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=601, Percent_Identity=37.1048252911814, Blast_Score=354, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_XYLF2 (B2I699)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828797.1
- GeneID:   6202417
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0066
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65063; Mature: 64932

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYRSKTSTYGRNMAGARALWRATGMKDDDFQKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERLGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKTTLADHKLDLVDAMVLAADPHASDEEVA
CCCCCCHHHHHHHHEECCCEEEEECCCCCCCCCCHHHCHHHHHHHHHEECCCCCCCCHHH
TVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHSDRKQLFLNAGRTVIEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCHHHHHH
CHRWYGAEDATALPRGIATFAAFENAITLDIAMGGSTNTILHLLAAAQEAEVSFTMQDID
HHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHEEEEHHHHH
RLSRNVPQLCKVAPNTQKYHIEDVHRAGGIFGILAELARGNLLHTDVATVHSKTLGEAIA
HHHCCHHHHHHCCCCCCEEEHHHHHHHCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHH
TWDIIGTQDEAVHTFYKAGSAGIPTQVAFSQSTRWPSLDTDRTEGCIRDMEHAFSKEGGL
HEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
AVLYGNIAQDGCVVKTAGVDASIHVFEGSALVYESQEAAVKGILSDEVQPGMIVVIRYEG
EEEECCCCCCCEEEEECCCCEEEEEEECCEEEEECHHHHHHHHHHCCCCCCEEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALFTDGRFSGGTSGLSIGHASPEAAAGGAIGLIR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDRIRIDIPQRAINVLISEEELASRRLEQHAIGWKPAQSRTRKVSSALKAYALLATSAD
CCCEEEEECCHHHHHHEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCC
KGAVRNKTLL
CCCCCCCCCC
>Mature Secondary Structure 
PEYRSKTSTYGRNMAGARALWRATGMKDDDFQKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERLGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMANAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKTTLADHKLDLVDAMVLAADPHASDEEVA
CCCCCCHHHHHHHHEECCCEEEEECCCCCCCCCCHHHCHHHHHHHHHEECCCCCCCCHHH
TVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHSDRKQLFLNAGRTVIEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCHHHHHH
CHRWYGAEDATALPRGIATFAAFENAITLDIAMGGSTNTILHLLAAAQEAEVSFTMQDID
HHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHEEEEHHHHH
RLSRNVPQLCKVAPNTQKYHIEDVHRAGGIFGILAELARGNLLHTDVATVHSKTLGEAIA
HHHCCHHHHHHCCCCCCEEEHHHHHHHCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHH
TWDIIGTQDEAVHTFYKAGSAGIPTQVAFSQSTRWPSLDTDRTEGCIRDMEHAFSKEGGL
HEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
AVLYGNIAQDGCVVKTAGVDASIHVFEGSALVYESQEAAVKGILSDEVQPGMIVVIRYEG
EEEECCCCCCCEEEEECCCCEEEEEEECCEEEEECHHHHHHHHHHCCCCCCEEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALFTDGRFSGGTSGLSIGHASPEAAAGGAIGLIR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDRIRIDIPQRAINVLISEEELASRRLEQHAIGWKPAQSRTRKVSSALKAYALLATSAD
CCCEEEEECCHHHHHHEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCC
KGAVRNKTLL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA