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The map label for this gene is dnaA

Identifier: 182680573

GI number: 182680573

Start: 25

End: 1356

Strand: Direct

Name: dnaA

Synonym: XfasM23_0001

Alternate gene names: 182680573

Gene position: 25-1356 (Clockwise)

Preceding gene: NA

Following gene: 182680574

Centisome position: 0.0

GC content: 41.22

Gene sequence:

>1332_bases
ATGACAACATTGATGGAATCTTGGTCCCGTTGCCTGGAACGTCTTGAAACTGAATTTCCACCAGAAGATGTTCATACTTG
GTTGAGACCTTTACAAGCTGACCAACGCGGTGACAGTGTCATCCTTTACGCACCCAATACCTTTATCATTGAACTAGTAG
AAGAGCGATACTTAGGGCGTCTTCGAGAATTGTTATCCTATTTTTCAGGAATACGTGAAGTAGTCCTTGCAATTGGCTCA
CGACCTAAAACAACAGAACTAACCGTACCAGTAGATACTACAGGACGTTTGTCTCAAACAGTCCCATTTAACGGAAATCT
GGACACACACTATAACTTTGATAATTTTGTTGAGGGACGAAGCAATCAACTCGCTCGTGCTGCAGCTTGGCAAGCCGCAC
AGAAACCGGGAGACCGTACTCACAACCCTCTATTACTCTATGGTGGGACTGGTTTGGGTAAAACCCATTTAATGTTTGCT
GCAGGTAACGTAATGCGGCAAGTAAACCCAACTTATAAAGTCATGTATCTTCGTTCGGAACAATTTTTCAGCGCCATGAT
AAGAGCGTTACAAGACAAAAGTATGGACCAGTTTAAGCGTCAGTTCCATCAAATTGACGCGCTATTGATTGATGACATTC
AATTTTTTGCTGGAAAAGATCGTACTCAAGAAGAATTCTTTCATACTTTTAATGCTTTATTCGACGGGAAACAGCAAATT
ATTTTAACATGTGATCGTTATCCTAGAGAAGTTAATGGTCTAGAACCACGATTAAAATCTCGTTTAGCTTGGGGACTTTC
CGTAGCGATCGATCCTCCTGACTTTGAAACCAGAGCTGCGATTGTATTGGCTAAAGCACGTGAACGTGGCGCTACGATTC
CAGATGAGGTTGCATTCTTAATTGCAAAAAAAATGCACAGTAATGTCCGTGACTTAGAGGGTGCACTAAATACCTTAGTA
GCACGTGCAAACTTTACTGGGAGAGCTGTAACTATTGAATTCTCACAAGAGACCTTAAGAGATTTATTGCGTGCACAGCA
ACAAACAATTGGCATCCCTAATATCCAAAAGATTGTAGCTGATTATTATGGTTTACAAATCAAAGATTTGCTTTCAAAAC
GCCGTACTCGTTCATTAGCACGACCAAGACAATTGGCAATGGCATTAGCTAAAGAGCTGACTGAGCATAGCTTGCCTGAA
ATTGGAGACGCTTTTGCAGGCCGAGATCATACAACAGTGTTGCATGCTTGCCGTCAAATCAAGTTATTGATGGAAACTGA
AACCAAATTGCGAGAAGACTGGGATAAACTAATGCGAAAATTTAGTGAATAA

Upstream 100 bases:

>100_bases
AAATCCGCTCCCAATGATAGTCTGATAGTCAATTTCATGATCCCTTGAGCTGCTTTCGCATCATCTTCATCTTTTCTCAA
AGTGAAACAGCCCATTACTG

Downstream 100 bases:

>100_bases
ATCCCCCCATTATATGACTACTCATTTTCTATAGAAATGTAGAAATAAATTAGTTCTTTCCAAGAAAGTGTAAAAAACTT
GTGGATAAAATGCGATTTGG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTTLMESWSRCLERLETEFPPEDVHTWLRPLQADQRGDSVILYAPNTFIIELVEERYLGRLRELLSYFSGIREVVLAIGS
RPKTTELTVPVDTTGRLSQTVPFNGNLDTHYNFDNFVEGRSNQLARAAAWQAAQKPGDRTHNPLLLYGGTGLGKTHLMFA
AGNVMRQVNPTYKVMYLRSEQFFSAMIRALQDKSMDQFKRQFHQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGKQQI
ILTCDRYPREVNGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGATIPDEVAFLIAKKMHSNVRDLEGALNTLV
ARANFTGRAVTIEFSQETLRDLLRAQQQTIGIPNIQKIVADYYGLQIKDLLSKRRTRSLARPRQLAMALAKELTEHSLPE
IGDAFAGRDHTTVLHACRQIKLLMETETKLREDWDKLMRKFSE

Sequences:

>Translated_443_residues
MTTLMESWSRCLERLETEFPPEDVHTWLRPLQADQRGDSVILYAPNTFIIELVEERYLGRLRELLSYFSGIREVVLAIGS
RPKTTELTVPVDTTGRLSQTVPFNGNLDTHYNFDNFVEGRSNQLARAAAWQAAQKPGDRTHNPLLLYGGTGLGKTHLMFA
AGNVMRQVNPTYKVMYLRSEQFFSAMIRALQDKSMDQFKRQFHQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGKQQI
ILTCDRYPREVNGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGATIPDEVAFLIAKKMHSNVRDLEGALNTLV
ARANFTGRAVTIEFSQETLRDLLRAQQQTIGIPNIQKIVADYYGLQIKDLLSKRRTRSLARPRQLAMALAKELTEHSLPE
IGDAFAGRDHTTVLHACRQIKLLMETETKLREDWDKLMRKFSE
>Mature_442_residues
TTLMESWSRCLERLETEFPPEDVHTWLRPLQADQRGDSVILYAPNTFIIELVEERYLGRLRELLSYFSGIREVVLAIGSR
PKTTELTVPVDTTGRLSQTVPFNGNLDTHYNFDNFVEGRSNQLARAAAWQAAQKPGDRTHNPLLLYGGTGLGKTHLMFAA
GNVMRQVNPTYKVMYLRSEQFFSAMIRALQDKSMDQFKRQFHQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGKQQII
LTCDRYPREVNGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGATIPDEVAFLIAKKMHSNVRDLEGALNTLVA
RANFTGRAVTIEFSQETLRDLLRAQQQTIGIPNIQKIVADYYGLQIKDLLSKRRTRSLARPRQLAMALAKELTEHSLPEI
GDAFAGRDHTTVLHACRQIKLLMETETKLREDWDKLMRKFSE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=462, Percent_Identity=53.2467532467532, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI226510964, Length=197, Percent_Identity=27.4111675126904, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 50675; Mature: 50544

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLMESWSRCLERLETEFPPEDVHTWLRPLQADQRGDSVILYAPNTFIIELVEERYLGR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LRELLSYFSGIREVVLAIGSRPKTTELTVPVDTTGRLSQTVPFNGNLDTHYNFDNFVEGR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
SNQLARAAAWQAAQKPGDRTHNPLLLYGGTGLGKTHLMFAAGNVMRQVNPTYKVMYLRSE
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHH
QFFSAMIRALQDKSMDQFKRQFHQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGKQQI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEE
ILTCDRYPREVNGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGATIPDEVAFL
EEEECCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHEEHHHHCCCCCHHHHHHH
IAKKMHSNVRDLEGALNTLVARANFTGRAVTIEFSQETLRDLLRAQQQTIGIPNIQKIVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHH
DYYGLQIKDLLSKRRTRSLARPRQLAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQI
HHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
KLLMETETKLREDWDKLMRKFSE
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTLMESWSRCLERLETEFPPEDVHTWLRPLQADQRGDSVILYAPNTFIIELVEERYLGR
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LRELLSYFSGIREVVLAIGSRPKTTELTVPVDTTGRLSQTVPFNGNLDTHYNFDNFVEGR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
SNQLARAAAWQAAQKPGDRTHNPLLLYGGTGLGKTHLMFAAGNVMRQVNPTYKVMYLRSE
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHH
QFFSAMIRALQDKSMDQFKRQFHQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGKQQI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEE
ILTCDRYPREVNGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGATIPDEVAFL
EEEECCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHEEHHHHCCCCCHHHHHHH
IAKKMHSNVRDLEGALNTLVARANFTGRAVTIEFSQETLRDLLRAQQQTIGIPNIQKIVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHH
DYYGLQIKDLLSKRRTRSLARPRQLAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQI
HHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
KLLMETETKLREDWDKLMRKFSE
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]