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The map label for this gene is yiaY [H]

Identifier: 182677174

GI number: 182677174

Start: 206349

End: 207512

Strand: Direct

Name: yiaY [H]

Synonym: Bind_0174

Alternate gene names: 182677174

Gene position: 206349-207512 (Clockwise)

Preceding gene: 182677172

Following gene: 182677175

Centisome position: 4.95

GC content: 61.43

Gene sequence:

>1164_bases
ATGACGAGTACGATCGCATTGCCGCGCCTGTTGCGGATTGGCGCTGGCGCCTCGCGTGAATTGGCGTCGGTGCTGCAAAG
TTTGGGGCTCAGCCGCCCTTTCATCGTCACCGACGCTTATTTGCAGGAAAGCGGCCGGGCCGATGGTCTGGTGCAGGGGC
TCGAGGCTTCTGGTCTTACGGCGGCGGTATTTTCGCATACGGTGCCGGACCCGACTGTCAGATCCGTCGATGCCGCGCTC
GAGGCTTTTCGGCAGGGCGATCATGATTGTATCATTGGTTTTGGTGGGGGCAGTCCGATCGATACGGCCAAGGCCGTGGC
TGTGCTCGCCGTGCATGGCGGCCCGATGAGCCAATATAAGGCGCCGCATGCGCAGGATCTGCCGGGCGTGCCGATCATCG
CCATTCCCACCACGGCCGGCACTGGTTCGGAGGTGACGCGTTTCACCATTATTACGGACGAGAGCAATGACGAGAAAATG
CTCTGCGCCGGCCTTGCCTATCTGCCCGTTGCGGCCCTCGTCGATTACGAATTGACACTGACGAAACCCAAGCGTCTGAC
CGCCGATACCGGTATCGACGCCTTGACCCATGCGATCGAGGCCTATGTCTCGAAAAAGGCCAATCCTTTCTCGAGCACTT
TTGCTTTGGCGGCGATGCGGGCGATTGCGCCCAATCTACGCCGGGTCTTTGCCAATCCCGATGATCGCCCCGCGCGCGAG
GCGATGATGTTGGGCGCGACGCAGGCCGGTATCGCCTTCTCGAACAGTTCGGTTGCGCTTGTCCATGGCATGAGCCGGCC
GATCGGCGCGCATTTTCATGTGCCGCATGGTCTCTCGAACGCCATGCTTCTGCCCGCGATTACCGCCTTTTCTGCGCCGG
TGGCATTGCCGCTCTATGCTGATTGCGCGAGGGCCATGGGCGTGGCGCGCGAGGAGGAGGGCGATCAGGCCTCCGTTGCC
CGGCTTATCGATGAATTGCGCCAACTCAATGCCGATCTCCAAGTGCCGGGACCGCGCGCATACGGCATTGAGGAGACACG
CTGGAACAGCTTGCTGCCCTTGATGGCGGAGCAGGCTTTAGCCTCGGGCTCGCCCGGCAATAATCCGATTGTTCCGACAT
CCGACCAGATTCAAACCCTTTACCGCCAGGCCTGGGCGGCTTGA

Upstream 100 bases:

>100_bases
GTTTCTCTCAAGATCATCACTCTTCAATCGCTGGCGCTGCGTCCGAGGCTTTGGGTGCCGGCGATTGCGGAGAAAAACAG
CCCAAGCCCTGGGAGGAAAA

Downstream 100 bases:

>100_bases
ACAGGAGTTGACCAATGACCCTTCCCGTGACCCCCGCACAGACGACGATCGAGCCTATCCCGCATGTCATCAACGGCCAA
TTGACAGAGGGGCAATCCGG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTSTIALPRLLRIGAGASRELASVLQSLGLSRPFIVTDAYLQESGRADGLVQGLEASGLTAAVFSHTVPDPTVRSVDAAL
EAFRQGDHDCIIGFGGGSPIDTAKAVAVLAVHGGPMSQYKAPHAQDLPGVPIIAIPTTAGTGSEVTRFTIITDESNDEKM
LCAGLAYLPVAALVDYELTLTKPKRLTADTGIDALTHAIEAYVSKKANPFSSTFALAAMRAIAPNLRRVFANPDDRPARE
AMMLGATQAGIAFSNSSVALVHGMSRPIGAHFHVPHGLSNAMLLPAITAFSAPVALPLYADCARAMGVAREEEGDQASVA
RLIDELRQLNADLQVPGPRAYGIEETRWNSLLPLMAEQALASGSPGNNPIVPTSDQIQTLYRQAWAA

Sequences:

>Translated_387_residues
MTSTIALPRLLRIGAGASRELASVLQSLGLSRPFIVTDAYLQESGRADGLVQGLEASGLTAAVFSHTVPDPTVRSVDAAL
EAFRQGDHDCIIGFGGGSPIDTAKAVAVLAVHGGPMSQYKAPHAQDLPGVPIIAIPTTAGTGSEVTRFTIITDESNDEKM
LCAGLAYLPVAALVDYELTLTKPKRLTADTGIDALTHAIEAYVSKKANPFSSTFALAAMRAIAPNLRRVFANPDDRPARE
AMMLGATQAGIAFSNSSVALVHGMSRPIGAHFHVPHGLSNAMLLPAITAFSAPVALPLYADCARAMGVAREEEGDQASVA
RLIDELRQLNADLQVPGPRAYGIEETRWNSLLPLMAEQALASGSPGNNPIVPTSDQIQTLYRQAWAA
>Mature_386_residues
TSTIALPRLLRIGAGASRELASVLQSLGLSRPFIVTDAYLQESGRADGLVQGLEASGLTAAVFSHTVPDPTVRSVDAALE
AFRQGDHDCIIGFGGGSPIDTAKAVAVLAVHGGPMSQYKAPHAQDLPGVPIIAIPTTAGTGSEVTRFTIITDESNDEKML
CAGLAYLPVAALVDYELTLTKPKRLTADTGIDALTHAIEAYVSKKANPFSSTFALAAMRAIAPNLRRVFANPDDRPAREA
MMLGATQAGIAFSNSSVALVHGMSRPIGAHFHVPHGLSNAMLLPAITAFSAPVALPLYADCARAMGVAREEEGDQASVAR
LIDELRQLNADLQVPGPRAYGIEETRWNSLLPLMAEQALASGSPGNNPIVPTSDQIQTLYRQAWAA

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=363, Percent_Identity=31.404958677686, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI48994951, Length=384, Percent_Identity=37.5, Blast_Score=250, Evalue=9e-68,
Organism=Escherichia coli, GI1789163, Length=388, Percent_Identity=34.7938144329897, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082107, Length=324, Percent_Identity=36.4197530864198, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1787493, Length=380, Percent_Identity=34.4736842105263, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789386, Length=347, Percent_Identity=21.3256484149856, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537053, Length=420, Percent_Identity=28.5714285714286, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=31.6753926701571, Blast_Score=202, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24657991, Length=357, Percent_Identity=29.1316526610644, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40665; Mature: 40534

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTIALPRLLRIGAGASRELASVLQSLGLSRPFIVTDAYLQESGRADGLVQGLEASGLT
CCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCHHHHHHCCCCCC
AAVFSHTVPDPTVRSVDAALEAFRQGDHDCIIGFGGGSPIDTAKAVAVLAVHGGPMSQYK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHEEEEEEECCCCHHHCC
APHAQDLPGVPIIAIPTTAGTGSEVTRFTIITDESNDEKMLCAGLAYLPVAALVDYELTL
CCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEE
TKPKRLTADTGIDALTHAIEAYVSKKANPFSSTFALAAMRAIAPNLRRVFANPDDRPARE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AMMLGATQAGIAFSNSSVALVHGMSRPIGAHFHVPHGLSNAMLLPAITAFSAPVALPLYA
HHHHCCHHHCEEECCCCEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCHHHH
DCARAMGVAREEEGDQASVARLIDELRQLNADLQVPGPRAYGIEETRWNSLLPLMAEQAL
HHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ASGSPGNNPIVPTSDQIQTLYRQAWAA
HCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSTIALPRLLRIGAGASRELASVLQSLGLSRPFIVTDAYLQESGRADGLVQGLEASGLT
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCHHHHHHCCCCCC
AAVFSHTVPDPTVRSVDAALEAFRQGDHDCIIGFGGGSPIDTAKAVAVLAVHGGPMSQYK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHEEEEEEECCCCHHHCC
APHAQDLPGVPIIAIPTTAGTGSEVTRFTIITDESNDEKMLCAGLAYLPVAALVDYELTL
CCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEE
TKPKRLTADTGIDALTHAIEAYVSKKANPFSSTFALAAMRAIAPNLRRVFANPDDRPARE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AMMLGATQAGIAFSNSSVALVHGMSRPIGAHFHVPHGLSNAMLLPAITAFSAPVALPLYA
HHHHCCHHHCEEECCCCEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCHHHH
DCARAMGVAREEEGDQASVARLIDELRQLNADLQVPGPRAYGIEETRWNSLLPLMAEQAL
HHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ASGSPGNNPIVPTSDQIQTLYRQAWAA
HCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]