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The map label for this gene is iscS [H]

Identifier: 182677099

GI number: 182677099

Start: 109805

End: 110986

Strand: Direct

Name: iscS [H]

Synonym: Bind_0097

Alternate gene names: 182677099

Gene position: 109805-110986 (Clockwise)

Preceding gene: 182677096

Following gene: 182677100

Centisome position: 2.63

GC content: 61.68

Gene sequence:

>1182_bases
TTGACGGCGCGGCGAGTCTATCTCGACCATAATGCGACGACGCCTTTGCGGCCGGCGGCGCGCGCCGCCATGATCGCGGC
CATGGATCTATGCGGAAATGCCTCCTCGATCCATGCCGAAGGCCGCGCTGCGCGCGCTCTAATCGAGGGTGCGCGCGAGG
CAATGGCGCGTTTCGTCAAGACTTTGCCGCGCCGGGTGATCTTTACCTCCGGCGCCACCGAGGCGCTCAACGCTATTCTG
ACACCACGTCTCGAACGGTCAAACCGGCCCACGGCACCGTTTGATGTTCTTTTAGTCAATGCCGGCGAACATGCGAGCGT
GCTTTTTGGGCATCGCTTTTCTGCCGACGCGGTCGAAACGATTGGCATGACGCCGGACGGGCGGCTTGATCTCGACGCGC
TCGCCAAGGTCCTTGAGCGCTATGCGGGGCGGCGCATCATGCTGGCCCTGCAAGCAGCCAATAATGAGACCGGTGTCGTG
CAGCCGGTTCTGCAGGCGGAAGCCCTGCTGCGCGCGGCTTCGTCTGATACGTTTTTCGTCTGCGATGCCGTGCAAGCCGC
TGGCAAGATCGCATGTGATTTCGACGCCTTGCCTGCCGATGCGCTGATTTTTTCGGCACATAAATTCGGTGGCCCGGCTG
GGATCGGGGCTCTTTGCCTGCGCGAGGATGTGCTGCTCGGGGAGCCTTTGTTGCGCGGCGGCGGTCAGGAATTTCGCCAG
CGCGCCGGGACGCAGGCTGTGATCTCCATTGCTGGTCTTGCTGGCGCCCTTGTGGACATGCGCGAGACTTTTGTGCAGGA
CAGTGTCCGGCTTGCGCAGCTGCGGGATCAGCTCGAGAGCTTTCTTCGCACTCTCGCGCCGGCTGCCGTCCTTTTTGGAA
CCGAGGTGGAGCGTCTGCCCAACACGCTCTGTTTCGCCGTTCCGGGGATGGAGGCACAGGTCTTGCTTATGTTTTTGGAT
GTAGAGGGAGTGGCGGTTTCGTCCGGCGCGGCCTGTTCCTCCGGCAAGGTCAAGGCATCGCATGTGCTAGAGGCAATGCG
GGTCGATCCGTCCCTGGCTGGTGCGGCAATCAGGCTCAGTCTGGGGTGGACCAGTCATCTTGAAGAATGTGCCTTGTTCA
TGCAGGCCTTTGAAAAGGCTTTCCGCACGATCAAGGCGAGGCAGGTCAAATCTGCCGCGTAG

Upstream 100 bases:

>100_bases
CCACTTGTCCTCATTGAACCGCGATGAGTCGCGGTTAAATGAGGGTGGATACTAGGGCTCCGGTCGAATTCATGGACGGA
ACGCGGAGAAGGTTATCAGT

Downstream 100 bases:

>100_bases
ACGATCGGGCAATGTCCGGTCACCACTCGGGTTGATCGGGTTCAGGCCCGATCGAAGGGTCTGAACCAGCGGTCCTTGAA
ACCGCGAAGGTGAGGAGAAG

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTARRVYLDHNATTPLRPAARAAMIAAMDLCGNASSIHAEGRAARALIEGAREAMARFVKTLPRRVIFTSGATEALNAIL
TPRLERSNRPTAPFDVLLVNAGEHASVLFGHRFSADAVETIGMTPDGRLDLDALAKVLERYAGRRIMLALQAANNETGVV
QPVLQAEALLRAASSDTFFVCDAVQAAGKIACDFDALPADALIFSAHKFGGPAGIGALCLREDVLLGEPLLRGGGQEFRQ
RAGTQAVISIAGLAGALVDMRETFVQDSVRLAQLRDQLESFLRTLAPAAVLFGTEVERLPNTLCFAVPGMEAQVLLMFLD
VEGVAVSSGAACSSGKVKASHVLEAMRVDPSLAGAAIRLSLGWTSHLEECALFMQAFEKAFRTIKARQVKSAA

Sequences:

>Translated_393_residues
MTARRVYLDHNATTPLRPAARAAMIAAMDLCGNASSIHAEGRAARALIEGAREAMARFVKTLPRRVIFTSGATEALNAIL
TPRLERSNRPTAPFDVLLVNAGEHASVLFGHRFSADAVETIGMTPDGRLDLDALAKVLERYAGRRIMLALQAANNETGVV
QPVLQAEALLRAASSDTFFVCDAVQAAGKIACDFDALPADALIFSAHKFGGPAGIGALCLREDVLLGEPLLRGGGQEFRQ
RAGTQAVISIAGLAGALVDMRETFVQDSVRLAQLRDQLESFLRTLAPAAVLFGTEVERLPNTLCFAVPGMEAQVLLMFLD
VEGVAVSSGAACSSGKVKASHVLEAMRVDPSLAGAAIRLSLGWTSHLEECALFMQAFEKAFRTIKARQVKSAA
>Mature_392_residues
TARRVYLDHNATTPLRPAARAAMIAAMDLCGNASSIHAEGRAARALIEGAREAMARFVKTLPRRVIFTSGATEALNAILT
PRLERSNRPTAPFDVLLVNAGEHASVLFGHRFSADAVETIGMTPDGRLDLDALAKVLERYAGRRIMLALQAANNETGVVQ
PVLQAEALLRAASSDTFFVCDAVQAAGKIACDFDALPADALIFSAHKFGGPAGIGALCLREDVLLGEPLLRGGGQEFRQR
AGTQAVISIAGLAGALVDMRETFVQDSVRLAQLRDQLESFLRTLAPAAVLFGTEVERLPNTLCFAVPGMEAQVLLMFLDV
EGVAVSSGAACSSGKVKASHVLEAMRVDPSLAGAAIRLSLGWTSHLEECALFMQAFEKAFRTIKARQVKSAA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=391, Percent_Identity=32.4808184143223, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=31.3253012048193, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=31.4285714285714, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1787970, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789175, Length=367, Percent_Identity=26.4305177111717, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=370, Percent_Identity=31.0810810810811, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17533177, Length=309, Percent_Identity=28.1553398058252, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319831, Length=381, Percent_Identity=33.8582677165354, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI20129463, Length=375, Percent_Identity=32.5333333333333, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41767; Mature: 41636

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARRVYLDHNATTPLRPAARAAMIAAMDLCGNASSIHAEGRAARALIEGAREAMARFVK
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TLPRRVIFTSGATEALNAILTPRLERSNRPTAPFDVLLVNAGEHASVLFGHRFSADAVET
HCCHHEEEECCHHHHHHHHHCCCHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHH
IGMTPDGRLDLDALAKVLERYAGRRIMLALQAANNETGVVQPVLQAEALLRAASSDTFFV
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEE
CDAVQAAGKIACDFDALPADALIFSAHKFGGPAGIGALCLREDVLLGEPLLRGGGQEFRQ
EEHHHHCCCEEECCCCCCCHHHHEEHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHH
RAGTQAVISIAGLAGALVDMRETFVQDSVRLAQLRDQLESFLRTLAPAAVLFGTEVERLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
NTLCFAVPGMEAQVLLMFLDVEGVAVSSGAACSSGKVKASHVLEAMRVDPSLAGAAIRLS
CCEEEECCCCCCEEEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEE
LGWTSHLEECALFMQAFEKAFRTIKARQVKSAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TARRVYLDHNATTPLRPAARAAMIAAMDLCGNASSIHAEGRAARALIEGAREAMARFVK
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TLPRRVIFTSGATEALNAILTPRLERSNRPTAPFDVLLVNAGEHASVLFGHRFSADAVET
HCCHHEEEECCHHHHHHHHHCCCHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHH
IGMTPDGRLDLDALAKVLERYAGRRIMLALQAANNETGVVQPVLQAEALLRAASSDTFFV
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEE
CDAVQAAGKIACDFDALPADALIFSAHKFGGPAGIGALCLREDVLLGEPLLRGGGQEFRQ
EEHHHHCCCEEECCCCCCCHHHHEEHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHH
RAGTQAVISIAGLAGALVDMRETFVQDSVRLAQLRDQLESFLRTLAPAAVLFGTEVERLP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
NTLCFAVPGMEAQVLLMFLDVEGVAVSSGAACSSGKVKASHVLEAMRVDPSLAGAAIRLS
CCEEEECCCCCCEEEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEE
LGWTSHLEECALFMQAFEKAFRTIKARQVKSAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA