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The map label for this gene is lysA [H]

Identifier: 182677052

GI number: 182677052

Start: 50754

End: 52025

Strand: Direct

Name: lysA [H]

Synonym: Bind_0050

Alternate gene names: 182677052

Gene position: 50754-52025 (Clockwise)

Preceding gene: 182677051

Following gene: 182677053

Centisome position: 1.22

GC content: 60.46

Gene sequence:

>1272_bases
ATGCATCATTTCGCACTGCGGAACGGCGTCATGCACGCCGAGGACGTCGATCTCGAACGCCTCGCCGAAACGATTGGCAC
GCCTTTTTATTGCTATTCCACGGCGACGATCACGCGCCATTACGAGGTGTTCAAGGCGGCCTTCGCGGGCCAGGATAGCC
TCGTCTGCTATGCGATGAAGGCCAATTCCAACCAGGCGGTGCTGCAGACCCTGGCCCGTCTGGGGGCCGGCATGGATGTC
GTCTCGGAAGGGGAATTGCGCCGTGCCCGCGCGGCAGGCGTGCCGGCCGATCGCGTCACGTTTTCCGGCGTCGGCAAGAC
GGAGCGGGAGATCGCTCTCGCGCTCGATGAAGGCATTTTCTGCTTCAATGTCGAATCGGAGCCGGAACTTGCGGCCATTT
CGGCGCTTGCCGTCGCAAGAAACAAAACGGCGCATATCGCCTTGCGGGTCAATCCGGATGTCGATGCCAAAACCCATGCG
AAAATAGCGACCGGCAAATCGGAGAATAAATTCGGCATTCCGATTTCGCGGGCGCGCGAAGTCTATCGCATGGCGAAAAA
CCTGCCCGGCATCGCGATCACCGGCGTCGATCTGCATATCGGCTCGCAGATCACCGATCTCACGCCTTTCGATCATGCTT
TTGCGCGGGCGGCCGAATTCGTGGCCCTGTTGCGTGCCGATGGCCATGCCATCGATCATGTCGATCTTGGCGGTGGCCTT
GGCATTCCCTACCATTCAGGTGATGATCCGGAAACCTATCACCCTGATCTCTATGCCGGGATCATCAAAAAGCGGCTTGG
TGGCCTGGGGCTGAAACTCGTCCTGGAGCCCGGCCGGCTCATCGTCGGCAATGCCGGGGTTCTCGTCACCCGTGTCCTTT
ATGTCAAACAGGGCGAGAACAAGACATTCGTCATCGTCGATGCGGCGATGAATGATCTGGTGCGGCCGACGCTTTATGAA
GCGCATCACGAGATCGCACCGTTGCGGCCGCCGCTGCAGGACGCGCCGGGTGTGGTCGCCGATATTGTCGGACCCGTCTG
CGAGACGGGCGATTATCTAGCCCTCGCGCGCCGCATGCCGGAGCCACGCCCGGGCGATTATCTCGCCATTCTTTCCGCCG
GTGCCTATGGTGCGGTGCAGGCTTGTACCTATAATACGCGGCTCCTGGTCCCGGAAGTGCTCGTCAAGGGAGCGGCCTAT
GCGGTTGTGCGGCCGCGCGGAACTTACGAGGAATTGATCGGGCTCGACAAAATTCCGGCGTGGTTGGAGTAA

Upstream 100 bases:

>100_bases
TGGATACGGTTTAAAAAGTGACGTATCGAGAATCCGTGATTCTCGATACGAGGGTCTCTATCCCCTTTGGGGCCCGATGC
GTTAATTCCGGAATTCTAGA

Downstream 100 bases:

>100_bases
ATTCTTCCTTTTCGTCCTTCTTTCGGGGACCGGCATGGCAATAACACAAGCGCCTGGGACAGATCCTCGACCCGCCGAAA
CGGCGGCGGCGACAACCCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MHHFALRNGVMHAEDVDLERLAETIGTPFYCYSTATITRHYEVFKAAFAGQDSLVCYAMKANSNQAVLQTLARLGAGMDV
VSEGELRRARAAGVPADRVTFSGVGKTEREIALALDEGIFCFNVESEPELAAISALAVARNKTAHIALRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYRMAKNLPGIAITGVDLHIGSQITDLTPFDHAFARAAEFVALLRADGHAIDHVDLGGGL
GIPYHSGDDPETYHPDLYAGIIKKRLGGLGLKLVLEPGRLIVGNAGVLVTRVLYVKQGENKTFVIVDAAMNDLVRPTLYE
AHHEIAPLRPPLQDAPGVVADIVGPVCETGDYLALARRMPEPRPGDYLAILSAGAYGAVQACTYNTRLLVPEVLVKGAAY
AVVRPRGTYEELIGLDKIPAWLE

Sequences:

>Translated_423_residues
MHHFALRNGVMHAEDVDLERLAETIGTPFYCYSTATITRHYEVFKAAFAGQDSLVCYAMKANSNQAVLQTLARLGAGMDV
VSEGELRRARAAGVPADRVTFSGVGKTEREIALALDEGIFCFNVESEPELAAISALAVARNKTAHIALRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYRMAKNLPGIAITGVDLHIGSQITDLTPFDHAFARAAEFVALLRADGHAIDHVDLGGGL
GIPYHSGDDPETYHPDLYAGIIKKRLGGLGLKLVLEPGRLIVGNAGVLVTRVLYVKQGENKTFVIVDAAMNDLVRPTLYE
AHHEIAPLRPPLQDAPGVVADIVGPVCETGDYLALARRMPEPRPGDYLAILSAGAYGAVQACTYNTRLLVPEVLVKGAAY
AVVRPRGTYEELIGLDKIPAWLE
>Mature_423_residues
MHHFALRNGVMHAEDVDLERLAETIGTPFYCYSTATITRHYEVFKAAFAGQDSLVCYAMKANSNQAVLQTLARLGAGMDV
VSEGELRRARAAGVPADRVTFSGVGKTEREIALALDEGIFCFNVESEPELAAISALAVARNKTAHIALRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYRMAKNLPGIAITGVDLHIGSQITDLTPFDHAFARAAEFVALLRADGHAIDHVDLGGGL
GIPYHSGDDPETYHPDLYAGIIKKRLGGLGLKLVLEPGRLIVGNAGVLVTRVLYVKQGENKTFVIVDAAMNDLVRPTLYE
AHHEIAPLRPPLQDAPGVVADIVGPVCETGDYLALARRMPEPRPGDYLAILSAGAYGAVQACTYNTRLLVPEVLVKGAAY
AVVRPRGTYEELIGLDKIPAWLE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=351, Percent_Identity=27.0655270655271, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI22538418, Length=339, Percent_Identity=26.2536873156342, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI21361583, Length=339, Percent_Identity=26.2536873156342, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI16506287, Length=343, Percent_Identity=24.4897959183673, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=31.4769975786925, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=347, Percent_Identity=25.9365994236311, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322664, Length=361, Percent_Identity=24.0997229916898, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586472, Length=393, Percent_Identity=23.6641221374046, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586474, Length=342, Percent_Identity=23.6842105263158, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45561; Mature: 45561

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFALRNGVMHAEDVDLERLAETIGTPFYCYSTATITRHYEVFKAAFAGQDSLVCYAMK
CCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEE
ANSNQAVLQTLARLGAGMDVVSEGELRRARAAGVPADRVTFSGVGKTEREIALALDEGIF
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCEEEEEEECCEE
CFNVESEPELAAISALAVARNKTAHIALRVNPDVDAKTHAKIATGKSENKFGIPISRARE
EEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VYRMAKNLPGIAITGVDLHIGSQITDLTPFDHAFARAAEFVALLRADGHAIDHVDLGGGL
HHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYHSGDDPETYHPDLYAGIIKKRLGGLGLKLVLEPGRLIVGNAGVLVTRVLYVKQGEN
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHEEEEEEEEECCC
KTFVIVDAAMNDLVRPTLYEAHHEIAPLRPPLQDAPGVVADIVGPVCETGDYLALARRMP
CEEEEEEHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCC
EPRPGDYLAILSAGAYGAVQACTYNTRLLVPEVLVKGAAYAVVRPRGTYEELIGLDKIPA
CCCCCCEEEEEECCCCCCEEEEECCCEEEHHHHHHCCCEEEEECCCCCHHHHHCCCCCCC
WLE
CCC
>Mature Secondary Structure
MHHFALRNGVMHAEDVDLERLAETIGTPFYCYSTATITRHYEVFKAAFAGQDSLVCYAMK
CCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEE
ANSNQAVLQTLARLGAGMDVVSEGELRRARAAGVPADRVTFSGVGKTEREIALALDEGIF
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCEEEEEEECCEE
CFNVESEPELAAISALAVARNKTAHIALRVNPDVDAKTHAKIATGKSENKFGIPISRARE
EEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VYRMAKNLPGIAITGVDLHIGSQITDLTPFDHAFARAAEFVALLRADGHAIDHVDLGGGL
HHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYHSGDDPETYHPDLYAGIIKKRLGGLGLKLVLEPGRLIVGNAGVLVTRVLYVKQGEN
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHEEEEEEEEECCC
KTFVIVDAAMNDLVRPTLYEAHHEIAPLRPPLQDAPGVVADIVGPVCETGDYLALARRMP
CEEEEEEHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCC
EPRPGDYLAILSAGAYGAVQACTYNTRLLVPEVLVKGAAYAVVRPRGTYEELIGLDKIPA
CCCCCCEEEEEECCCCCCEEEEECCCEEEHHHHHHCCCEEEEECCCCCHHHHHCCCCCCC
WLE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]