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The map label for this gene is tpx

Identifier: 17547509

GI number: 17547509

Start: 3001027

End: 3001527

Strand: Direct

Name: tpx

Synonym: RSc2790

Alternate gene names: 17547509

Gene position: 3001027-3001527 (Clockwise)

Preceding gene: 17547508

Following gene: 17547510

Centisome position: 80.75

GC content: 65.87

Gene sequence:

>501_bases
ATGGCAAACGTGACCCTTGGCGGCAATCCGATCGAAGTTGGCGGCGCCCTGCCGTCCGTTGGCGCGAAGGCCCCGGCGTT
CACCCTGGTCGGCAAGGACCTGAAGGATGTGTCGCTGGCCGACTTTGCCGGCAAGCGCAAGGTGCTGAACATCGTGCCGA
GCCTGGACACGCCGGTGTGCGCCACCTCCACGCGCAAGTTCAACGAAGCCGTCTCCAAGCTGGAGAACACCGTGGTGTTC
TCCATCTCCGCCGACCTGCCGTTCGCGGCCGGCCGCTTCTGCACGACCGAGGGCCTGGACAACGTGGTGCCGCTGTCGAC
CTTCCGTGATGCCGGCTTCAAGCAGGCCTACGGCGTCGACATCAAGACCGGTCCGCTGGCCGGCCTGACCGCGCGCGCGG
TGGTGGTGCTCGATGCCAACGACAACGTGCTGCACGCCCAGCTCGTGCCTGAAATCAAGGAAGAGCCGAACTACGACGCT
GCCCTGGCGGCGCTGAAGTAA

Upstream 100 bases:

>100_bases
TCGGGTACGATTCCAGTCCCAGCGCCCGACGGCCAACTACCGGGTCCTGATTTTCTACCCCTGATTCCCTGTTGAACTGT
ATAGAAGGAGCAAGCACACC

Downstream 100 bases:

>100_bases
GCTTCGTCGAAGCGGTCCTTTCCGTATCCCGTTCATCACACGGCCGTCCAGTGGACGGCCGCATTCTTATCTGGAGCCCT
TCTCCCATGGCCAGCGTGAT

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MANVTLGGNPIEVGGALPSVGAKAPAFTLVGKDLKDVSLADFAGKRKVLNIVPSLDTPVCATSTRKFNEAVSKLENTVVF
SISADLPFAAGRFCTTEGLDNVVPLSTFRDAGFKQAYGVDIKTGPLAGLTARAVVVLDANDNVLHAQLVPEIKEEPNYDA
ALAALK

Sequences:

>Translated_166_residues
MANVTLGGNPIEVGGALPSVGAKAPAFTLVGKDLKDVSLADFAGKRKVLNIVPSLDTPVCATSTRKFNEAVSKLENTVVF
SISADLPFAAGRFCTTEGLDNVVPLSTFRDAGFKQAYGVDIKTGPLAGLTARAVVVLDANDNVLHAQLVPEIKEEPNYDA
ALAALK
>Mature_165_residues
ANVTLGGNPIEVGGALPSVGAKAPAFTLVGKDLKDVSLADFAGKRKVLNIVPSLDTPVCATSTRKFNEAVSKLENTVVFS
ISADLPFAAGRFCTTEGLDNVVPLSTFRDAGFKQAYGVDIKTGPLAGLTARAVVVLDANDNVLHAQLVPEIKEEPNYDAA
LAALK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=163, Percent_Identity=63.8036809815951, Blast_Score=213, Evalue=4e-57,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_RALSO (Q8XVP0)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520911.1
- ProteinModelPortal:   Q8XVP0
- SMR:   Q8XVP0
- GeneID:   1221637
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2790
- NMPDR:   fig|267608.1.peg.2790
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- ProtClustDB:   PRK00522
- BioCyc:   RSOL267608:RSC2790-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17283; Mature: 17152

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVTLGGNPIEVGGALPSVGAKAPAFTLVGKDLKDVSLADFAGKRKVLNIVPSLDTPVC
CCEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCC
ATSTRKFNEAVSKLENTVVFSISADLPFAAGRFCTTEGLDNVVPLSTFRDAGFKQAYGVD
CCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCEECCCCCCCCCCCHHHCCCCCCEECCCC
IKTGPLAGLTARAVVVLDANDNVLHAQLVPEIKEEPNYDAALAALK
CCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCCCCCCEEEECC
>Mature Secondary Structure 
ANVTLGGNPIEVGGALPSVGAKAPAFTLVGKDLKDVSLADFAGKRKVLNIVPSLDTPVC
CEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCC
ATSTRKFNEAVSKLENTVVFSISADLPFAAGRFCTTEGLDNVVPLSTFRDAGFKQAYGVD
CCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCEECCCCCCCCCCCHHHCCCCCCEECCCC
IKTGPLAGLTARAVVVLDANDNVLHAQLVPEIKEEPNYDAALAALK
CCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852