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The map label for this gene is thiL [H]

Identifier: 17547487

GI number: 17547487

Start: 2980257

End: 2981255

Strand: Direct

Name: thiL [H]

Synonym: RSc2768

Alternate gene names: 17547487

Gene position: 2980257-2981255 (Clockwise)

Preceding gene: 17547483

Following gene: 17547488

Centisome position: 80.19

GC content: 73.87

Gene sequence:

>999_bases
GTGCTGAAGCCCCCTGTCCCTGCCGATTCCGCTGAACACCTGTCCGAATTCGGGCTGATCCGCCGGTATTTCACCCGACC
GGCGCGGCACGCCACGCTCGGCGTCGGCGACGATTGCGCGCTGCTCGGCCCGCGCCCCGGTCACGAACTGGCGATCTCCA
CCGACATGCTGGTCGCCGGTCGCCACTTCTTTGCCGATGCCGAGCCGCGCGCGCTCGGCCACAAGGCGCTGGCGGTCAAC
CTGTCGGACCTGGCCGCGATGGGCGCCGAGCCGCGCGCCTTTACGCTGGCCATGGCGCTGCCGGCGGCCGATCCGGCCTG
GCTGGGCCCGTTCGCCGACGGCCTGCTGGCGCTGGCCGACGCCTTTCACTGCGAACTGATCGGCGGCGACACCACGCGCG
GGCCGCTGACGCTCAGCCTGACGGTCTTCGGCGACGTTCCGGCCGACCTCGCGCTGCGCCGCGATGCTGCCCGCCCGGAC
GACGACCTGTGGGTCTCCGGCACCGTGGGCGATGCACGCCTGGCACTGGGCGCGCTGCGCGGCGAATGGCCGCTCGCGCC
CGAGGCGCTGGCCCGGGTGCAGCCGCGCATGGATGCGCCCACGCCCCGCGTGGCGCTGGGCCTGGCGCTGCGCGGCATTG
CCCGGGCGGCGCTGGACGTGTCCGACGGGCTGCTGGGCGACCTGGGCCACATCCTGGCCCAATCGCAGGTCGGGGCGACC
GTCGAGGTGGATCGCGTGCCGCGCTCCGCCACGCTGGCCGAGGAGCCGCCCGCGCGCCAGCTGCAGTGCATGCTGGCCGG
CGGCGACGACTATGAACTCTGCTTCACGGCCCCCGCCGGCCTGCGCGAGGCCGTGCTGGCGGCGGGGCAGCACGCCGGCG
TCCCGGTCACCCGCATCGGACGCATCGACACCGAGCCCGGCCTGCGGCTGATCGACGCGCACGGCAAGCCGGTCGCGTTC
AGCCAGGCCGGATTCGACCATTTCTCTTCCACATCATGA

Upstream 100 bases:

>100_bases
CGGGATTTTGGGTGGGGGTGTTGTGCGCATTCGCTACAATATTCCACCCGTCCTGACACGGCACCCCCGGGCTTGCCCCA
TTCCTGCCTCCGTCAAAGCC

Downstream 100 bases:

>100_bases
TGTCTTCCGCCCCCTTCCCGCCCTCCACCCCGCCCAGCCAGCCCGAGACCGTGGTTCTCGAGGCCGGCCAGACCGCGCAG
GTGCGCCGCCCGACGGCACG

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAGRHFFADAEPRALGHKALAVN
LSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALADAFHCELIGGDTTRGPLTLSLTVFGDVPADLALRRDAARPD
DDLWVSGTVGDARLALGALRGEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLGDLGHILAQSQVGAT
VEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIGRIDTEPGLRLIDAHGKPVAF
SQAGFDHFSSTS

Sequences:

>Translated_332_residues
MLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAGRHFFADAEPRALGHKALAVN
LSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALADAFHCELIGGDTTRGPLTLSLTVFGDVPADLALRRDAARPD
DDLWVSGTVGDARLALGALRGEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLGDLGHILAQSQVGAT
VEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIGRIDTEPGLRLIDAHGKPVAF
SQAGFDHFSSTS
>Mature_332_residues
MLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAGRHFFADAEPRALGHKALAVN
LSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALADAFHCELIGGDTTRGPLTLSLTVFGDVPADLALRRDAARPD
DDLWVSGTVGDARLALGALRGEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLGDLGHILAQSQVGAT
VEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIGRIDTEPGLRLIDAHGKPVAF
SQAGFDHFSSTS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=321, Percent_Identity=47.0404984423676, Blast_Score=251, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34744; Mature: 34744

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAG
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCEEEEECCEEEEC
RHFFADAEPRALGHKALAVNLSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALAD
HHHCCCCCCHHCCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
AFHCELIGGDTTRGPLTLSLTVFGDVPADLALRRDAARPDDDLWVSGTVGDARLALGALR
HHEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHC
GEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLGDLGHILAQSQVGAT
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCE
VEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIG
EEECCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEC
RIDTEPGLRLIDAHGKPVAFSQAGFDHFSSTS
CCCCCCCCEEEECCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLKPPVPADSAEHLSEFGLIRRYFTRPARHATLGVGDDCALLGPRPGHELAISTDMLVAG
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCEEEEECCEEEEC
RHFFADAEPRALGHKALAVNLSDLAAMGAEPRAFTLAMALPAADPAWLGPFADGLLALAD
HHHCCCCCCHHCCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHH
AFHCELIGGDTTRGPLTLSLTVFGDVPADLALRRDAARPDDDLWVSGTVGDARLALGALR
HHEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHC
GEWPLAPEALARVQPRMDAPTPRVALGLALRGIARAALDVSDGLLGDLGHILAQSQVGAT
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCE
VEVDRVPRSATLAEEPPARQLQCMLAGGDDYELCFTAPAGLREAVLAAGQHAGVPVTRIG
EEECCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEC
RIDTEPGLRLIDAHGKPVAFSQAGFDHFSSTS
CCCCCCCCEEEECCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]