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The map label for this gene is uvrD [H]

Identifier: 17546954

GI number: 17546954

Start: 2424741

End: 2427230

Strand: Reverse

Name: uvrD [H]

Synonym: RSc2235

Alternate gene names: 17546954

Gene position: 2427230-2424741 (Counterclockwise)

Preceding gene: 17546957

Following gene: 17546949

Centisome position: 65.31

GC content: 67.03

Gene sequence:

>2490_bases
ATGACGGGCGAAAGCCTGGAATTATACGGCCTGTCGGTGGCCGGCATGGGCGAAGCGGGCGAGGCGGCCGGTATAATTTC
CGGATTCCGCAAAGGCTCTCCCCGCATGTCCGAACTGCTCGCTCACCTGAACCCCGAACAACGCGCCGCCGTCACGCTTC
CCGACGAGTCGGCGCTGATCCTGGCCGGGGCGGGCAGCGGCAAGACGCGCGTGCTGACCACCCGCATCGCCTGGCTGATC
CAGAGCGCCCGGGTGTCGCCGTCGGGTGTGCTGGCCGTCACCTTTACCAACAAGGCGGCCAAGGAGATGACCGCCCGGCT
GTCCGCCATGCTGCCGATCAACACGCGCGGCATGTGGATCGGCACCTTCCACGGCCTGTGCAACCGGCTGCTGCGCGCGC
ACTACCGCGACGCCGGGCTGCCGCAGACCTTCCAGATCCTCGATACGCAAGACCAGCTCTCGGCCGTCAAGCGCCTGCTC
AAGTCGCTGAACATCGACGACGAGAAGTTTCCGCCGAAGAACGTCCAGTACTTCATCAATGGCGCCAAGGAACAGGGCCT
GCGCGCAGGCGACCTGGAGATCGCCAATGAGTTCGACCGCCGCATGGCCGACCTGTACGCCGCCTACGATGCGCAGTGCC
AGCGCGAAGGCGTGGTCGATTTTTCAGAGCTGCTGCTGCGCTGCTATGAGCTGCTGCGTTACAACGATGCGATCCGCGCG
CACTACCAGCGGCGCTTCAAGCACATCCTGGTCGACGAGTTCCAGGACACCAACCGCCTGCAATACGCCTGGCTGAAGAT
CCTGGCCGGCCTGGGCGAGGCGGGCGTCACGCCCAACGCCATCTTTGCCGTGGGCGACGACGACCAGAGCATCTACGCCT
TCCGCGGCGCCAACGTCGGCAACATGGTGGACTTCGAGCGCGAATTCCGTGTCGCGCACCGCATCAAGCTGGAGCAGAAC
TACCGTTCGCACGGCAACATCCTGGACACGGCCAACCACCTGATCGCCCACAACACCCGCCGCCTGGGCAAGAACCTGCG
CACCGACGCCGGCCACGGCGAGCCGGTGCGCGTCTACCCGTCCGCCACCGACGGGCAGGAGGCCGGCTGGATCGTCGAAG
AAATCCGCGAGCGCATCGCCAGCGGCACGGCGCGTTCCGAGATCGCCATCCTGTATCGCAGCAACGCGCAGTCGCGGGTG
ATCGAGCATGCGTTGTTCTCGGTGGGTATTCCCTACAAGGTGTATGGCGGGCTGCGCTTCTTCGAGCGCGCCGAAATCAA
GCACGCGCTGGCCTACCTGCAGCTGCTGGAGAACCCTGACAACGATGCCGCCTTCGGCCGCGTGGTCAACTTCCCGGCGC
GCGGCGTCGGGGCGCGGTCGCTGGAGCAGCTGCAGGATGCGGCCAAGCTGTATGGCGTGTCGCTGGCGGCGTCGGTGCCG
TACCTGACTGGCGCGGCGGGGACGAAGCTGGCGGCGTTCGTGCGGCTGATCGAGCAGATGCGCGCCGACACGCGCCAGAT
GACGCTGCCCGAGATCGTCCAGCACGTGATCCACGCCAGCGGCCTCATCACGCATTACCAGGGCGAGAAGGAAGGTCTCG
ACCGCATCGAGAACCTGCAGGAACTGGTGACCGCCGCCCAGGCCTTCGTGGCCGAGGAGGGCTACGGCGTCGATGCCATC
GCCACCGCGCTGCCGATGCGCCACGACGCGATGCTGCGCATCGAGGGCGGCGAGACGGACAGCGATGCCGTCACCGAGCT
GGTCGCCGATGAAACGCCGACGGAGATGACCCCGCTGGTCGCCTTCCTGACGCATGCCTCGCTGGAGGCCGGCGACAACC
AGGCCCAGGCCGGCCAGGACGCGGTGCAACTGATGACCGTGCACGCCGCCAAGGGGTTGGAGTTCCACGTTGTCTTCATT
ACCGGCCTGGAGGAGGGCCTGTTCCCGCACGAGAACAGCCTGCTGGACACCGACGGCCTGGAAGAAGAGCGTCGCCTGAT
GTACGTAGCCATCACCCGGGCGCGCGAGCGCCTGTACCTGTCGTTTGCACAGAGCCGCGTGCTGCACGGGCAGATCCGCT
ACCACATTCGCTCGCGCTTCTTCGACGAGCTGCCGGAAGCCACGCTGAAGTGGCTGACGCCGCAGCATACCGGCTACAGC
CCCACGCGTCGCGCGCAGGGCGGGCAGGGCATGCAGGGCGATAGCGCCTGGGGCCGCGAGTGGTTCAAGCGCCCCGAGCG
CGGCGACAACGAGGCCTACACCGGCCGCCCGACCGGCGGCATGGACACCGGCAACACCTACGCCGACACCAAGCGCGCGG
CCGGAACGGGTTTCCGCGTCGGCCAGTCGGTGTTCCACAACAAGTTCGGGGAAGGCGTCATCACGACGCTGGAAGGCGAG
GGCGCCGATGCGCGCGCCCACATCAAGTTCAGCCGCCACGGCGTGAAGGTGCTGGCGCTGGGCATCGCCAAGCTGGACCC
GATCAACTGA

Upstream 100 bases:

>100_bases
CACTTCTGCTCGATGGCGGCGGGTTCGAAACTCTTGGCAAGGGACTGGTTCGGATCGGTCATGCTGGGAAGGGGCACAAG
AAGACGTTTGGCCCGGGAAA

Downstream 100 bases:

>100_bases
CCTGACCGGGCCCGTGTCCTGCGGGCCGGACGCTCAGGCCGCCGTGTCGGTGGTCTGGCCGGCGGCCTGCGTCACGTTGA
AGCAGCCCCGATAGGTGGCG

Product: DNA helicase II protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 829; Mature: 828

Protein sequence:

>829_residues
MTGESLELYGLSVAGMGEAGEAAGIISGFRKGSPRMSELLAHLNPEQRAAVTLPDESALILAGAGSGKTRVLTTRIAWLI
QSARVSPSGVLAVTFTNKAAKEMTARLSAMLPINTRGMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLL
KSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEFDRRMADLYAAYDAQCQREGVVDFSELLLRCYELLRYNDAIRA
HYQRRFKHILVDEFQDTNRLQYAWLKILAGLGEAGVTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVAHRIKLEQN
YRSHGNILDTANHLIAHNTRRLGKNLRTDAGHGEPVRVYPSATDGQEAGWIVEEIRERIASGTARSEIAILYRSNAQSRV
IEHALFSVGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARGVGARSLEQLQDAAKLYGVSLAASVP
YLTGAAGTKLAAFVRLIEQMRADTRQMTLPEIVQHVIHASGLITHYQGEKEGLDRIENLQELVTAAQAFVAEEGYGVDAI
ATALPMRHDAMLRIEGGETDSDAVTELVADETPTEMTPLVAFLTHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFHVVFI
TGLEEGLFPHENSLLDTDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIRSRFFDELPEATLKWLTPQHTGYS
PTRRAQGGQGMQGDSAWGREWFKRPERGDNEAYTGRPTGGMDTGNTYADTKRAAGTGFRVGQSVFHNKFGEGVITTLEGE
GADARAHIKFSRHGVKVLALGIAKLDPIN

Sequences:

>Translated_829_residues
MTGESLELYGLSVAGMGEAGEAAGIISGFRKGSPRMSELLAHLNPEQRAAVTLPDESALILAGAGSGKTRVLTTRIAWLI
QSARVSPSGVLAVTFTNKAAKEMTARLSAMLPINTRGMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLL
KSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEFDRRMADLYAAYDAQCQREGVVDFSELLLRCYELLRYNDAIRA
HYQRRFKHILVDEFQDTNRLQYAWLKILAGLGEAGVTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVAHRIKLEQN
YRSHGNILDTANHLIAHNTRRLGKNLRTDAGHGEPVRVYPSATDGQEAGWIVEEIRERIASGTARSEIAILYRSNAQSRV
IEHALFSVGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARGVGARSLEQLQDAAKLYGVSLAASVP
YLTGAAGTKLAAFVRLIEQMRADTRQMTLPEIVQHVIHASGLITHYQGEKEGLDRIENLQELVTAAQAFVAEEGYGVDAI
ATALPMRHDAMLRIEGGETDSDAVTELVADETPTEMTPLVAFLTHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFHVVFI
TGLEEGLFPHENSLLDTDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIRSRFFDELPEATLKWLTPQHTGYS
PTRRAQGGQGMQGDSAWGREWFKRPERGDNEAYTGRPTGGMDTGNTYADTKRAAGTGFRVGQSVFHNKFGEGVITTLEGE
GADARAHIKFSRHGVKVLALGIAKLDPIN
>Mature_828_residues
TGESLELYGLSVAGMGEAGEAAGIISGFRKGSPRMSELLAHLNPEQRAAVTLPDESALILAGAGSGKTRVLTTRIAWLIQ
SARVSPSGVLAVTFTNKAAKEMTARLSAMLPINTRGMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLK
SLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEFDRRMADLYAAYDAQCQREGVVDFSELLLRCYELLRYNDAIRAH
YQRRFKHILVDEFQDTNRLQYAWLKILAGLGEAGVTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVAHRIKLEQNY
RSHGNILDTANHLIAHNTRRLGKNLRTDAGHGEPVRVYPSATDGQEAGWIVEEIRERIASGTARSEIAILYRSNAQSRVI
EHALFSVGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARGVGARSLEQLQDAAKLYGVSLAASVPY
LTGAAGTKLAAFVRLIEQMRADTRQMTLPEIVQHVIHASGLITHYQGEKEGLDRIENLQELVTAAQAFVAEEGYGVDAIA
TALPMRHDAMLRIEGGETDSDAVTELVADETPTEMTPLVAFLTHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFHVVFIT
GLEEGLFPHENSLLDTDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIRSRFFDELPEATLKWLTPQHTGYSP
TRRAQGGQGMQGDSAWGREWFKRPERGDNEAYTGRPTGGMDTGNTYADTKRAAGTGFRVGQSVFHNKFGEGVITTLEGEG
ADARAHIKFSRHGVKVLALGIAKLDPIN

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=803, Percent_Identity=43.5865504358655, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI48994965, Length=703, Percent_Identity=36.5576102418208, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1787196, Length=344, Percent_Identity=30.2325581395349, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322369, Length=754, Percent_Identity=28.2493368700265, Blast_Score=213, Evalue=9e-56,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 91589; Mature: 91458

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGESLELYGLSVAGMGEAGEAAGIISGFRKGSPRMSELLAHLNPEQRAAVTLPDESALI
CCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCEEE
LAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTFTNKAAKEMTARLSAMLPINTRGMWI
EEECCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
GTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLKSLNIDDEKFPPKNVQYFIN
EHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
GAKEQGLRAGDLEIANEFDRRMADLYAAYDAQCQREGVVDFSELLLRCYELLRYNDAIRA
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
HYQRRFKHILVDEFQDTNRLQYAWLKILAGLGEAGVTPNAIFAVGDDDQSIYAFRGANVG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCC
NMVDFEREFRVAHRIKLEQNYRSHGNILDTANHLIAHNTRRLGKNLRTDAGHGEPVRVYP
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SATDGQEAGWIVEEIRERIASGTARSEIAILYRSNAQSRVIEHALFSVGIPYKVYGGLRF
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHCCHHH
FERAEIKHALAYLQLLENPDNDAAFGRVVNFPARGVGARSLEQLQDAAKLYGVSLAASVP
HHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
YLTGAAGTKLAAFVRLIEQMRADTRQMTLPEIVQHVIHASGLITHYQGEKEGLDRIENLQ
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
ELVTAAQAFVAEEGYGVDAIATALPMRHDAMLRIEGGETDSDAVTELVADETPTEMTPLV
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHH
AFLTHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFHVVFITGLEEGLFPHENSLLDTDGL
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCC
EEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIRSRFFDELPEATLKWLTPQHTGYS
CHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTRRAQGGQGMQGDSAWGREWFKRPERGDNEAYTGRPTGGMDTGNTYADTKRAAGTGFRV
CCHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHH
GQSVFHNKFGEGVITTLEGEGADARAHIKFSRHGVKVLALGIAKLDPIN
HHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEHHHCCCCC
>Mature Secondary Structure 
TGESLELYGLSVAGMGEAGEAAGIISGFRKGSPRMSELLAHLNPEQRAAVTLPDESALI
CCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCEEE
LAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTFTNKAAKEMTARLSAMLPINTRGMWI
EEECCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
GTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLKSLNIDDEKFPPKNVQYFIN
EHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
GAKEQGLRAGDLEIANEFDRRMADLYAAYDAQCQREGVVDFSELLLRCYELLRYNDAIRA
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
HYQRRFKHILVDEFQDTNRLQYAWLKILAGLGEAGVTPNAIFAVGDDDQSIYAFRGANVG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCC
NMVDFEREFRVAHRIKLEQNYRSHGNILDTANHLIAHNTRRLGKNLRTDAGHGEPVRVYP
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SATDGQEAGWIVEEIRERIASGTARSEIAILYRSNAQSRVIEHALFSVGIPYKVYGGLRF
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHCCHHH
FERAEIKHALAYLQLLENPDNDAAFGRVVNFPARGVGARSLEQLQDAAKLYGVSLAASVP
HHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
YLTGAAGTKLAAFVRLIEQMRADTRQMTLPEIVQHVIHASGLITHYQGEKEGLDRIENLQ
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
ELVTAAQAFVAEEGYGVDAIATALPMRHDAMLRIEGGETDSDAVTELVADETPTEMTPLV
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHH
AFLTHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFHVVFITGLEEGLFPHENSLLDTDGL
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCC
EEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIRSRFFDELPEATLKWLTPQHTGYS
CHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTRRAQGGQGMQGDSAWGREWFKRPERGDNEAYTGRPTGGMDTGNTYADTKRAAGTGFRV
CCHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHH
GQSVFHNKFGEGVITTLEGEGADARAHIKFSRHGVKVLALGIAKLDPIN
HHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]