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The map label for this gene is ndh [H]

Identifier: 17546948

GI number: 17546948

Start: 2417026

End: 2418351

Strand: Reverse

Name: ndh [H]

Synonym: RSc2229

Alternate gene names: 17546948

Gene position: 2418351-2417026 (Counterclockwise)

Preceding gene: 17546949

Following gene: 17546947

Centisome position: 65.07

GC content: 69.38

Gene sequence:

>1326_bases
ATGGCAGGGCAGGTGGACGGCGCGGGTGGTCCGCGCATCGTGGTGGTCGGCGGTGGCGCCGGCGGGCTGGAACTGGCAAC
GCGCCTGGGCGACAAGCTCGGCAAGCGCCGCGCCGCGCGGGTCGTCCTGGTCGATCGCAACCCGACACATATCTGGAAGC
CGCTGCTGCACGAAGTGGCCGCCGGCAGCATGGACCCGAACACCCACCAGCTCGAATACGCCGCCCAGGCGCGCTGGCAC
GGCTTCGAGTTCCAGCAGGGCGAGCTGAAGGGCCTGGACCGCGCCGCCAAGACCATCACCGTGTCCGGCTGCGTCGACGC
CGACGGCACCGAGGTGCTGCCCGAGCGCGCCATCGCCTATGACATGCTGGTGCTCGCCATCGGCAGCGTGACGCATTTCT
TCGGCGTGCCGGGCACGGCCGAGCATGCGATTGCGCTGGATGCCGCGTCGCAGGCCGAGCGCTTCCGCCGCAAGCTGATT
TCGGCGTGCATGCGCGCGCAGAACGGCGTGGGCGATGCGCGCGCGCAGGTGGACATCGCCATCGTCGGCGCGGGCGCGAC
CGGCGTGGAACTGTCGGCGGAACTGCGCAACACCGCCCACGTGCTGGCGGCCTACGGCCTGCACAAGCTGGACCCGCTCC
GCGATATCCGCATCCACCTGATCGAAGGGAGCCCGCGCATCCTGGCCGCCCTGTCCGAACGTGTCTCCACCGAGACCACC
AAGCTGCTGCAGAAGCTGAACGTGGAGGTGATCACCGGCGAGCGCGTCAACCAGGTCACCGACAGCGCGGTCAAGACGGC
CAGCGGCAAGTCGATCCCGGCCGATCTGACGGTGTGGGCGGCGGGCATCCGCGCGCCGGCGATCCTGGGCGAGCTGGGGC
TGCCGGTGAACAAGCTGGGGCAGGTGGTCGTCTCGCGCACGCTGCAGGCCGAAGGCGATGACGCCATCTATGCCTTCGGC
GATTGCGCCAGCTGCCCGTGGCCCGAGGCATCGGCCAGCGTGCCGCCGCGCGCCCAGGCCGCCCACCAGCAGGCGACCTA
TCTGTATAAAGCCCTGTGCCGCCGGCTGGAAGGCAAGCCGGTGGAGCCGTTCGGCTTCAAGGATCTGGGCTCGCTGGTGT
CGCTCGGCCACTTCAGCGCGGTCGGCAGCCTGATGGGCGGCCTGATCGGCGGCACCATGTTCATCGAAGGGATGATGGCG
CGGCTGATGTACACGTCGCTGTACCGCATGCACGTGATGGCGCTGCACGGCTTCGTGCGCATGGCGCTGGATACCGTCAC
GCACTGGCTGCGCAGCAAGACCAATCCGCGGGTCAAGCTACACTAG

Upstream 100 bases:

>100_bases
CCGCTTCCGCGGCCCGTATCGCGAGCGGGCGGGGTTGCAGCGGATGTTGCGTTGCAGCAAACTGCAACCGGAAGATCACA
AGACTCACAGGAGTAGCAGC

Downstream 100 bases:

>100_bases
CCGCTTCGTTGACCGTCGCCTGCGGGCGCTTTGGGAGAATGCGATGCATGAGCTCGATGCGGAAGTGGAAAGCCTGGTGC
CCGGCCGCAGCTTCGACCGC

Product: NADH dehydrogenase, membrane flavoprotein FAD NAD ubiquinone electron transport oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAGQVDGAGGPRIVVVGGGAGGLELATRLGDKLGKRRAARVVLVDRNPTHIWKPLLHEVAAGSMDPNTHQLEYAAQARWH
GFEFQQGELKGLDRAAKTITVSGCVDADGTEVLPERAIAYDMLVLAIGSVTHFFGVPGTAEHAIALDAASQAERFRRKLI
SACMRAQNGVGDARAQVDIAIVGAGATGVELSAELRNTAHVLAAYGLHKLDPLRDIRIHLIEGSPRILAALSERVSTETT
KLLQKLNVEVITGERVNQVTDSAVKTASGKSIPADLTVWAAGIRAPAILGELGLPVNKLGQVVVSRTLQAEGDDAIYAFG
DCASCPWPEASASVPPRAQAAHQQATYLYKALCRRLEGKPVEPFGFKDLGSLVSLGHFSAVGSLMGGLIGGTMFIEGMMA
RLMYTSLYRMHVMALHGFVRMALDTVTHWLRSKTNPRVKLH

Sequences:

>Translated_441_residues
MAGQVDGAGGPRIVVVGGGAGGLELATRLGDKLGKRRAARVVLVDRNPTHIWKPLLHEVAAGSMDPNTHQLEYAAQARWH
GFEFQQGELKGLDRAAKTITVSGCVDADGTEVLPERAIAYDMLVLAIGSVTHFFGVPGTAEHAIALDAASQAERFRRKLI
SACMRAQNGVGDARAQVDIAIVGAGATGVELSAELRNTAHVLAAYGLHKLDPLRDIRIHLIEGSPRILAALSERVSTETT
KLLQKLNVEVITGERVNQVTDSAVKTASGKSIPADLTVWAAGIRAPAILGELGLPVNKLGQVVVSRTLQAEGDDAIYAFG
DCASCPWPEASASVPPRAQAAHQQATYLYKALCRRLEGKPVEPFGFKDLGSLVSLGHFSAVGSLMGGLIGGTMFIEGMMA
RLMYTSLYRMHVMALHGFVRMALDTVTHWLRSKTNPRVKLH
>Mature_440_residues
AGQVDGAGGPRIVVVGGGAGGLELATRLGDKLGKRRAARVVLVDRNPTHIWKPLLHEVAAGSMDPNTHQLEYAAQARWHG
FEFQQGELKGLDRAAKTITVSGCVDADGTEVLPERAIAYDMLVLAIGSVTHFFGVPGTAEHAIALDAASQAERFRRKLIS
ACMRAQNGVGDARAQVDIAIVGAGATGVELSAELRNTAHVLAAYGLHKLDPLRDIRIHLIEGSPRILAALSERVSTETTK
LLQKLNVEVITGERVNQVTDSAVKTASGKSIPADLTVWAAGIRAPAILGELGLPVNKLGQVVVSRTLQAEGDDAIYAFGD
CASCPWPEASASVPPRAQAAHQQATYLYKALCRRLEGKPVEPFGFKDLGSLVSLGHFSAVGSLMGGLIGGTMFIEGMMAR
LMYTSLYRMHVMALHGFVRMALDTVTHWLRSKTNPRVKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=431, Percent_Identity=49.4199535962877, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6323515, Length=474, Percent_Identity=23.2067510548523, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320118, Length=461, Percent_Identity=23.4273318872017, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323794, Length=464, Percent_Identity=24.1379310344828, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47049; Mature: 46918

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQVDGAGGPRIVVVGGGAGGLELATRLGDKLGKRRAARVVLVDRNPTHIWKPLLHEVA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHH
AGSMDPNTHQLEYAAQARWHGFEFQQGELKGLDRAAKTITVSGCVDADGTEVLPERAIAY
CCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHH
DMLVLAIGSVTHFFGVPGTAEHAIALDAASQAERFRRKLISACMRAQNGVGDARAQVDIA
HHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
IVGAGATGVELSAELRNTAHVLAAYGLHKLDPLRDIRIHLIEGSPRILAALSERVSTETT
EEECCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KLLQKLNVEVITGERVNQVTDSAVKTASGKSIPADLTVWAAGIRAPAILGELGLPVNKLG
HHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHCCCCHHHHH
QVVVSRTLQAEGDDAIYAFGDCASCPWPEASASVPPRAQAAHQQATYLYKALCRRLEGKP
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
VEPFGFKDLGSLVSLGHFSAVGSLMGGLIGGTMFIEGMMARLMYTSLYRMHVMALHGFVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALDTVTHWLRSKTNPRVKLH
HHHHHHHHHHHCCCCCCEEEC
>Mature Secondary Structure 
AGQVDGAGGPRIVVVGGGAGGLELATRLGDKLGKRRAARVVLVDRNPTHIWKPLLHEVA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHH
AGSMDPNTHQLEYAAQARWHGFEFQQGELKGLDRAAKTITVSGCVDADGTEVLPERAIAY
CCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHH
DMLVLAIGSVTHFFGVPGTAEHAIALDAASQAERFRRKLISACMRAQNGVGDARAQVDIA
HHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
IVGAGATGVELSAELRNTAHVLAAYGLHKLDPLRDIRIHLIEGSPRILAALSERVSTETT
EEECCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KLLQKLNVEVITGERVNQVTDSAVKTASGKSIPADLTVWAAGIRAPAILGELGLPVNKLG
HHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHCCCCHHHHH
QVVVSRTLQAEGDDAIYAFGDCASCPWPEASASVPPRAQAAHQQATYLYKALCRRLEGKP
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
VEPFGFKDLGSLVSLGHFSAVGSLMGGLIGGTMFIEGMMARLMYTSLYRMHVMALHGFVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALDTVTHWLRSKTNPRVKLH
HHHHHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]