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The map label for this gene is lon [H]

Identifier: 17546432

GI number: 17546432

Start: 1830509

End: 1832929

Strand: Direct

Name: lon [H]

Synonym: RSc1713

Alternate gene names: 17546432

Gene position: 1830509-1832929 (Clockwise)

Preceding gene: 17546431

Following gene: 17546433

Centisome position: 49.25

GC content: 63.32

Gene sequence:

>2421_bases
ATGTCCGGAACCCAACTCCTACCCGCTGAGCAGATTCGCCTGCCGCTGTTGCCGCTGCGCGACGTGGTGGTGTTCCCGCA
CATGGTGATTCCGCTGTTCGTGGGGCGCCCCAAATCCATCAAGGCTCTGGAAGCCGCGATGGAAGCGGGCAAGAGCATCA
TGCTGGTTGCCCAGAAGACGGCCGCCAAGGATGAGCCGACCGACAAGGATCTCTACGAGGTCGGTTGTATCGCCAACATC
CTGCAGATGCTGAAACTGCCGGACGGCACCGTGAAGGTGCTGGTCGAAGGCACGCAGCGTGCCAACATCCTGTCCGTGAC
CGACGACGAGTCGCACTTCCATTGCGAAGCGATGCCCATCGGCCCGGAGCCGACCGAGTCGGCCGAGACCGAGGCGCTGC
GTCGCGCCATCGTGTCGCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATTCCGCCGGAGATCCTGACCTCGCTGTCG
GGCATCGACGAGCCGGGTCGTCTGGCCGACACCATCGCCGCGCATCTGCCGATCAAGCTTGAGCAGAAGCAGAAGATCCT
CGAGATGTTCAATGTGACCGAACGTCTGGAGAGCCTGCTGTCGCAACTGGAAGGCGAGATCGACATCCTGCAGGTGGAAA
AGCGCATCCGCGGCCGCGTCAAGCGCCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCCATC
CAGAAGGAACTGGGCGAAGGCGAAGAGGGCGCTGATCTCGAGGAGCTGGACAAGAAGATCAAGGCCGCGCGCATGCCCAA
GGAGGCCAAGAAGAAGGCCGACTCGGAATTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCCGAGGCAACGGTCGTGC
GCAACTATATCGACACGCTTGTCGGTCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGTCGAACGCCGAGCAG
GTGCTGGATCAAGATCACTATGGTCTGGAGAAGGTCAAGGAGCGCATCCTTGAATATCTCGCAGTGCAGCAGCGCGTCGA
CAAGCTGAAGGCGCCGATCCTGTGCCTCGTGGGGCCGCCGGGTGTCGGCAAGACCTCGCTCGGGCAGTCGGTGGCGCGTG
CGACGAACCGCAAGTTCGTGCGCATGGCGCTGGGCGGCGTGCGTGACGAGGCTGAAATCCGCGGTCACCGCCGGACCTAC
ATCGGGTCGATGCCGGGCAAGATTCTGCAGAGCCTGACCAAGGTCGGCGTGCGTAACCCGCTGTTCCTGCTCGACGAGAT
CGACAAGATGGGTGCGGATTTCCGCGGCGATCCGTCGTCGGCGCTGCTCGAAGTGCTGGACCCGGAGCAGAACCACACGT
TCCAGGACCACTACATCGAGGTGGACTTCGACCTGTCGGACGTGATGTTCGTGGCAACGTCGAACTCGCTGAACATCCCG
GCGCCGCTGCTCGACCGGATGGAAGTGATCCGGCTGTCGGGCTACACCGAGGACGAAAAGGTCAACATCGCCCAGCGCTA
CCTGCTGCCCAAGCAGACCAAGAACAACGGTCTGAAGGGTGGCGAGATCGAGGTGGCGGAAGGCGCGCTGCGCGACATCA
TCCGCTACTACACCCGTGAAGCCGGCGTGCGGTCGCTGGAGCGCGAGGTCTCGAAGATCTGCCGCAAGGTGGTCAAGCAA
CTGCTGCTGAAGAAGGAAGCCGGCGCGTCGGTGAAGGTCGATTCGGACAACCTGGACAAGTTCCTGGGCGTGCGTCGCTT
CGACTTCGGTTTGGCCGGCAAGGAAGACCAGGTGGGCCAGGTGACCGGCCTCGCCTGGACGGAAGTGGGCGGCGACCTGC
TGACCATCGAAGCCGCGCTCATGCCGGGCAAGGGCAACATCACCCGTACGGGTTCGCTGGGCGACGTGATGAAGGAGTCG
GTCGAGGCGGCGCGCTCGGTGGTGCGTTCGCGATCGGCTCGCCTGGGCATCAAGGATGAGATGTTCGAGAAGCGCGACAT
CCACATCCACGTGCCCGAAGGCGCGACGCCCAAGGATGGCCCGTCCGCGGGGATTGCCATGACGACCGCGCTGGTGTCGG
TGCTGACCGGCATCCCGGTGCGTGCCGATGTGGCCATGACCGGCGAGATCACGCTGCGCGGCGAGGTGCTGCCGATCGGC
GGCCTGAAGGAGAAGCTGCTAGCCGCGCACCGTGGCGGCATCAAGCTGGTGCTGATTCCGGAAGAGAACGTCAAGGATCT
GGCGGACATTCCGGACAACGTGAAGAACAGCATCGAGATCATGCCGGTCCGCTGGATCGACAAGGTGTTGGAGCTCGCGT
TGGTGCGCAAGCCCGAGCCGCTGCCGGAAGAGGAGCCGAAGCCGGCGCCGGAAGCCGGCAAGACCGAAGGCGGCGACGCG
CACGAGATGGTGCACCACTGA

Upstream 100 bases:

>100_bases
TTGCTTCGGGAAACCGGGCCGGCACGCGACTTGCGGCGGCGGTCTTGTAAAACTGTCGCGGCACCCAATTTAGCCCTTAC
ATGACTTTCTGGGGAAAATA

Downstream 100 bases:

>100_bases
TGAGGTGATGCGCTTTCCGGGCTAGCCCGAGGAGGGCCCGACTTGTTCGGGCCCTTTTCTTTGGGCGCGCGCAATCCATG
TGCCCGCCGCCGGCTGCGGC

Product: ATP-dependent protease LA protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANILSVTDDESHFHCEAMPIGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKKIKAARMPKEAKKKADSEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQ
VLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
APLLDRMEVIRLSGYTEDEKVNIAQRYLLPKQTKNNGLKGGEIEVAEGALRDIIRYYTREAGVRSLEREVSKICRKVVKQ
LLLKKEAGASVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKES
VEAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
GLKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNSIEIMPVRWIDKVLELALVRKPEPLPEEEPKPAPEAGKTEGGDA
HEMVHH

Sequences:

>Translated_806_residues
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANI
LQMLKLPDGTVKVLVEGTQRANILSVTDDESHFHCEAMPIGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELDKKIKAARMPKEAKKKADSEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQ
VLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
APLLDRMEVIRLSGYTEDEKVNIAQRYLLPKQTKNNGLKGGEIEVAEGALRDIIRYYTREAGVRSLEREVSKICRKVVKQ
LLLKKEAGASVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKES
VEAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
GLKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNSIEIMPVRWIDKVLELALVRKPEPLPEEEPKPAPEAGKTEGGDA
HEMVHH
>Mature_805_residues
SGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKTAAKDEPTDKDLYEVGCIANIL
QMLKLPDGTVKVLVEGTQRANILSVTDDESHFHCEAMPIGPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEPGRLADTIAAHLPIKLEQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKKIKAARMPKEAKKKADSEFKKLKLMSPMSAEATVVRNYIDTLVGLPWRKKSKVNNDLSNAEQV
LDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIPA
PLLDRMEVIRLSGYTEDEKVNIAQRYLLPKQTKNNGLKGGEIEVAEGALRDIIRYYTREAGVRSLEREVSKICRKVVKQL
LLKKEAGASVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQVTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESV
EAARSVVRSRSARLGIKDEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNSIEIMPVRWIDKVLELALVRKPEPLPEEEPKPAPEAGKTEGGDAH
EMVHH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=828, Percent_Identity=38.5265700483092, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=664, Percent_Identity=41.2650602409639, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=70.5577172503243, Blast_Score=1095, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=693, Percent_Identity=40.5483405483405, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=40.1851851851852, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=709, Percent_Identity=40.7616361071932, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221513036, Length=631, Percent_Identity=44.2155309033281, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=631, Percent_Identity=44.2155309033281, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89175; Mature: 89044

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKT
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHH
AAKDEPTDKDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANILSVTDDESHFHCEAMPI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCEEEEEECC
GPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEPGRLADTIAAHLPIKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
EQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKKIKAARMPKEAKKKADSEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGLPWRKKSKVNNDLSNAEQVLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
APLLDRMEVIRLSGYTEDEKVNIAQRYLLPKQTKNNGLKGGEIEVAEGALRDIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKQLLLKKEAGASVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHCCCCCCCCCCCCC
VTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESVEAARSVVRSRSARLGIKDE
EECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
HHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECC
GLKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNSIEIMPVRWIDKVLELALVRKPEP
CHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHCCCEEEEEHHHHHHHHHHHHHCCCCC
LPEEEPKPAPEAGKTEGGDAHEMVHH
CCCCCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SGTQLLPAEQIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEAGKSIMLVAQKT
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHH
AAKDEPTDKDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANILSVTDDESHFHCEAMPI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCEEEEEECC
GPEPTESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEPGRLADTIAAHLPIKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
EQKQKILEMFNVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELDKKIKAARMPKEAKKKADSEFKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VGLPWRKKSKVNNDLSNAEQVLDQDHYGLEKVKERILEYLAVQQRVDKLKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC
APLLDRMEVIRLSGYTEDEKVNIAQRYLLPKQTKNNGLKGGEIEVAEGALRDIIRYYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKQLLLKKEAGASVKVDSDNLDKFLGVRRFDFGLAGKEDQVGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHCCCCCCCCCCCCC
VTGLAWTEVGGDLLTIEAALMPGKGNITRTGSLGDVMKESVEAARSVVRSRSARLGIKDE
EECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIG
HHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECC
GLKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNSIEIMPVRWIDKVLELALVRKPEP
CHHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHCCCEEEEEHHHHHHHHHHHHHCCCCC
LPEEEPKPAPEAGKTEGGDAHEMVHH
CCCCCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]