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The map label for this gene is degP [H]

Identifier: 17545777

GI number: 17545777

Start: 1111370

End: 1112887

Strand: Direct

Name: degP [H]

Synonym: RSc1058

Alternate gene names: 17545777

Gene position: 1111370-1112887 (Clockwise)

Preceding gene: 17545776

Following gene: 17545778

Centisome position: 29.9

GC content: 66.93

Gene sequence:

>1518_bases
ATGCGTACCGCTCGAACCGTTTACGCCTTGCGTCTGCTTTGCGTTGCCGCCGTCTTCGCTGCCGGTGGCGCGCTGATGCC
GGCTTACGCGCAGAACGCCACCGGTAGCGTGGCGACGGGCACCTATGGCCTGCCTGACTTTGCCGATCTGGTCGAAAAGG
TCAGCCCGGCGGTGGTCAATATCCGCACCACCGAGAAGGTGCGGATGCAGAACAACCCGAGCGATGACGACATGGCCGAG
TTTTTCCGCCGCTTCTTCGGCGTACCGATGCCGGGTACGCCGGGGCAGGGGCAGGGCCAGAAGCGCCGCAACGCCCCGCC
GCAGGCCGAGGAGGAGCAGAGTCGCGGCGTCGGCTCCGGCTTCATCATGTCGGGCGACGGCTATGTGCTGACCAACGCTC
ACGTGGTCGAAGGCGCGGAGACGATCTACGTGACGCTGACCGACAAGCGTGAATTCAAGGCCAAGCTGATCGGCTCCGAC
AAGCGCACCGATGTGGCGCTGGTCAAGGTGGAGGCCACCGGCCTGCCGAGCCTGAAGCTGGGCGATTCGGACAAGGTGCG
TGTGGGCGAGTGGGTGCTGGCGATTGGTTCGCCGTTCGGGCTGGACAACACCGTCACCGCGGGCATCGTGTCGGCCAAGG
GGCGTGACACCGGCGATTATCTGCCGTTCATCCAGTCCGACGTGGCCGTGAATCCCGGCAACTCGGGCGGCCCGCTGATC
AACCTGCGTGGCGAGGTGATCGGCATCAACAACCAGATCTTCAGCCAGAGCGGCGGCTACATGGGCATCTCGTTCGCGAT
TCCGATCGATGAAGCGATGCGCGTGGCCGAGCAGCTCAAGACGCAAGGCCGGGTGACGCGCGGCCGCATCGGTGTGGCGA
TCGACAATGTGCCGAAGGACGCAGCGGAGTCGCTGGGCCTAGGCCGTGCGCGTGGCGCCTATGTGGGCAATGTCGAGTCG
GGTGGCCCCGCCGACAAGGCAGGCATCGAGGCCGGCGACATCGTCCTGAAATTCAATGGGCGCGACGTCGAGAAGGCCGG
TGACCTGCAGCGTCAGGTCGGCGAGAGCAAGCCTGGTACGCGCGCCACCGTGCAGGTGTGGCGCAAGGGCGCGACGCGTG
ATCTGACGGTGACGGTGGCCGAACTGCAGCCCGATACCAAGGTGGCGCAGCGGGGCAAAGGTGGCCAATCCGACAATGGC
CAGCCGGGCGCCGGCAAGCAGAATGCGCTTGGGCTGGTGGTGGCCGATCTGTCGGAAGGCGCGCAGCGAGAGTTCAAGAC
GAAGGCAGGCGTCGAGGTGCAGGTGGCGGATGGTCCCGCCGCGCGCGCCGGCATCCGCCCGGGAGACGTGATCCTGCGCG
TGGGCGACACCGATGTCACCAGCGCCAAGCAATTCAACGACGTGGTCGGCCGGCTGGACAAGAGTCGCATGGTGGCGGTG
TTCGTCCGCCGTGGCGATGCCACGCAGGTCGTGACGATGCGACCGAGCACGGCGCGGGCCGGCGGCGGCCAGCCGTGA

Upstream 100 bases:

>100_bases
TAATTCCTCTCTCTGGACTGAAGCGGTGTCGCCGCGGCGCCATTGATGCCGTGCCGATCGCGCTCAGTCCACATTGATCT
CACTGTTTCGGGGAGCTTGC

Downstream 100 bases:

>100_bases
TTCAGCTGACGCTCTACGGACGCGCTTACTGTCATCTGTGCGACGACATGAAGGTCGCGCTGGAACCGTTCCGGCGCGAC
TTTCCTTTTGTGTTGCACGA

Product: periplasmic protease signal peptide protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MRTARTVYALRLLCVAAVFAAGGALMPAYAQNATGSVATGTYGLPDFADLVEKVSPAVVNIRTTEKVRMQNNPSDDDMAE
FFRRFFGVPMPGTPGQGQGQKRRNAPPQAEEEQSRGVGSGFIMSGDGYVLTNAHVVEGAETIYVTLTDKREFKAKLIGSD
KRTDVALVKVEATGLPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLI
NLRGEVIGINNQIFSQSGGYMGISFAIPIDEAMRVAEQLKTQGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVES
GGPADKAGIEAGDIVLKFNGRDVEKAGDLQRQVGESKPGTRATVQVWRKGATRDLTVTVAELQPDTKVAQRGKGGQSDNG
QPGAGKQNALGLVVADLSEGAQREFKTKAGVEVQVADGPAARAGIRPGDVILRVGDTDVTSAKQFNDVVGRLDKSRMVAV
FVRRGDATQVVTMRPSTARAGGGQP

Sequences:

>Translated_505_residues
MRTARTVYALRLLCVAAVFAAGGALMPAYAQNATGSVATGTYGLPDFADLVEKVSPAVVNIRTTEKVRMQNNPSDDDMAE
FFRRFFGVPMPGTPGQGQGQKRRNAPPQAEEEQSRGVGSGFIMSGDGYVLTNAHVVEGAETIYVTLTDKREFKAKLIGSD
KRTDVALVKVEATGLPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLI
NLRGEVIGINNQIFSQSGGYMGISFAIPIDEAMRVAEQLKTQGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVES
GGPADKAGIEAGDIVLKFNGRDVEKAGDLQRQVGESKPGTRATVQVWRKGATRDLTVTVAELQPDTKVAQRGKGGQSDNG
QPGAGKQNALGLVVADLSEGAQREFKTKAGVEVQVADGPAARAGIRPGDVILRVGDTDVTSAKQFNDVVGRLDKSRMVAV
FVRRGDATQVVTMRPSTARAGGGQP
>Mature_505_residues
MRTARTVYALRLLCVAAVFAAGGALMPAYAQNATGSVATGTYGLPDFADLVEKVSPAVVNIRTTEKVRMQNNPSDDDMAE
FFRRFFGVPMPGTPGQGQGQKRRNAPPQAEEEQSRGVGSGFIMSGDGYVLTNAHVVEGAETIYVTLTDKREFKAKLIGSD
KRTDVALVKVEATGLPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLI
NLRGEVIGINNQIFSQSGGYMGISFAIPIDEAMRVAEQLKTQGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVES
GGPADKAGIEAGDIVLKFNGRDVEKAGDLQRQVGESKPGTRATVQVWRKGATRDLTVTVAELQPDTKVAQRGKGGQSDNG
QPGAGKQNALGLVVADLSEGAQREFKTKAGVEVQVADGPAARAGIRPGDVILRVGDTDVTSAKQFNDVVGRLDKSRMVAV
FVRRGDATQVVTMRPSTARAGGGQP

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=359, Percent_Identity=33.7047353760446, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI22129776, Length=343, Percent_Identity=35.5685131195335, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.2, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=36.4285714285714, Blast_Score=138, Evalue=9e-33,
Organism=Escherichia coli, GI1786356, Length=482, Percent_Identity=35.2697095435685, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1789629, Length=457, Percent_Identity=35.8862144420131, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=38.9285714285714, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24646839, Length=256, Percent_Identity=35.15625, Blast_Score=148, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53009; Mature: 53009

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTARTVYALRLLCVAAVFAAGGALMPAYAQNATGSVATGTYGLPDFADLVEKVSPAVVN
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEECCCCCCCHHHHHHHHCCCEEEE
IRTTEKVRMQNNPSDDDMAEFFRRFFGVPMPGTPGQGQGQKRRNAPPQAEEEQSRGVGSG
EECCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCC
FIMSGDGYVLTNAHVVEGAETIYVTLTDKREFKAKLIGSDKRTDVALVKVEATGLPSLKL
EEECCCCEEEECCEEECCCCEEEEEEECCCCCHHHCCCCCCCCCEEEEEEEECCCCCEEE
GDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLI
CCCCCEEECEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEECCCEEECCCCCCCCEE
NLRGEVIGINNQIFSQSGGYMGISFAIPIDEAMRVAEQLKTQGRVTRGRIGVAIDNVPKD
EECCCEEECCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECEEEEEECCCCHH
AAESLGLGRARGAYVGNVESGGPADKAGIEAGDIVLKFNGRDVEKAGDLQRQVGESKPGT
HHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
RATVQVWRKGATRDLTVTVAELQPDTKVAQRGKGGQSDNGQPGAGKQNALGLVVADLSEG
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
AQREFKTKAGVEVQVADGPAARAGIRPGDVILRVGDTDVTSAKQFNDVVGRLDKSRMVAV
HHHHHHHHCCCEEEECCCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
FVRRGDATQVVTMRPSTARAGGGQP
EEECCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRTARTVYALRLLCVAAVFAAGGALMPAYAQNATGSVATGTYGLPDFADLVEKVSPAVVN
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEECCCCCCCHHHHHHHHCCCEEEE
IRTTEKVRMQNNPSDDDMAEFFRRFFGVPMPGTPGQGQGQKRRNAPPQAEEEQSRGVGSG
EECCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCC
FIMSGDGYVLTNAHVVEGAETIYVTLTDKREFKAKLIGSDKRTDVALVKVEATGLPSLKL
EEECCCCEEEECCEEECCCCEEEEEEECCCCCHHHCCCCCCCCCEEEEEEEECCCCCEEE
GDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLI
CCCCCEEECEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEECCCEEECCCCCCCCEE
NLRGEVIGINNQIFSQSGGYMGISFAIPIDEAMRVAEQLKTQGRVTRGRIGVAIDNVPKD
EECCCEEECCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECEEEEEECCCCHH
AAESLGLGRARGAYVGNVESGGPADKAGIEAGDIVLKFNGRDVEKAGDLQRQVGESKPGT
HHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
RATVQVWRKGATRDLTVTVAELQPDTKVAQRGKGGQSDNGQPGAGKQNALGLVVADLSEG
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
AQREFKTKAGVEVQVADGPAARAGIRPGDVILRVGDTDVTSAKQFNDVVGRLDKSRMVAV
HHHHHHHHCCCEEEECCCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEE
FVRRGDATQVVTMRPSTARAGGGQP
EEECCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]