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The map label for this gene is fabD [H]

Identifier: 17545770

GI number: 17545770

Start: 1104742

End: 1105671

Strand: Direct

Name: fabD [H]

Synonym: RSc1051

Alternate gene names: 17545770

Gene position: 1104742-1105671 (Clockwise)

Preceding gene: 17545769

Following gene: 17545771

Centisome position: 29.73

GC content: 67.31

Gene sequence:

>930_bases
ATGACATTCGCTTTCGTTTTTCCCGGCCAGGGTTCGCAATCGGTCGGCATGCTCAATGCGTTTGCCGATCATCCTGTCGT
CGCCGCCACGCTGGCGGAGGCCTCCGATGCACTGGGCCAGGATATCGGCAAGCTGATCGCTGAAGGCCCGGCCGATGAGC
TGAACCTGACCACCAATACGCAGCCGGTCATGCTGACCGCCGCCGTGGCGGTGTACCGCGCCTGGCAGGCTGCCGGCGGT
CCGACGCCGGCCGTGGTGGCCGGTCACAGCCTGGGCGAGTATTCTGCACTGGTCGCCGCCGGAGCGATCGCGTTCAAGGA
TGCCGTGCCGCTGGTGCGTTTCCGCGCCAAGGCGATGCAGGAGGCCGTGCCGGTCGGCGAGGGCGGCATGGCCGCGATTC
TCGGCCTGTCGGATGACGACGTGCGTGCCGCCTGTGCCGAGGCATCGAGCGCCGGCGTGGTGGAGGCCGTCAATTTCAAT
GCGCCGGCTCAGGTGGTGATCGCGGGGGCCAAGGCTGCGGTCGAGAAGGCTTGTGAGATCGCCAAGGCTAAGGGCGCCAA
GCGCGCGCTGCCGCTGCCCGTGTCCGCGCCGTTCCACTCCTCGCTGCTGAAGCCGGCGTCGGACCGTCTGCGGGAATACC
TGTCCGGCGTGGCGGTCGGCGCGCCGGCCATCCCGGTCATCAACAACGTCGATGTGGCGTTGGTGAGCGATCCCGCCGCC
ATCAAGGATGCGCTGGTACGCCAGGCCGCTTCCCCGGTGCGCTGGGTCGAGACCGTGCAGAAGATGAAGGCCGACGGCAT
CGCCCGCGTGGTCGAATGCGGGCCGGGCAAGGTGCTCGCAGGTCTCACCAAGCGCATCGACGGCGACATTGTCGGCGATG
CGATCTTCGATCCGGCTTCGCTGGAAGCCGTGCTGGTTCAACTCAAATAA

Upstream 100 bases:

>100_bases
GCCACCATGTGCTGCTCGAGGGCGTGGGCGGCGGCTTCACCTGGGGTGCCGCGTTGCTGCGCTTCTGACCGAATTTCGAG
AAAAGACAACCAAACGCGCC

Downstream 100 bases:

>100_bases
CGGAATCCGCATGACCCAAGCATTGAACAACCAGGTCGCTCTCGTCACCGGCGCATCGCGCGGCATCGGCCGGGCGATCG
CCCTGGAGCTGGCGCGCCAG

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTFAFVFPGQGSQSVGMLNAFADHPVVAATLAEASDALGQDIGKLIAEGPADELNLTTNTQPVMLTAAVAVYRAWQAAGG
PTPAVVAGHSLGEYSALVAAGAIAFKDAVPLVRFRAKAMQEAVPVGEGGMAAILGLSDDDVRAACAEASSAGVVEAVNFN
APAQVVIAGAKAAVEKACEIAKAKGAKRALPLPVSAPFHSSLLKPASDRLREYLSGVAVGAPAIPVINNVDVALVSDPAA
IKDALVRQAASPVRWVETVQKMKADGIARVVECGPGKVLAGLTKRIDGDIVGDAIFDPASLEAVLVQLK

Sequences:

>Translated_309_residues
MTFAFVFPGQGSQSVGMLNAFADHPVVAATLAEASDALGQDIGKLIAEGPADELNLTTNTQPVMLTAAVAVYRAWQAAGG
PTPAVVAGHSLGEYSALVAAGAIAFKDAVPLVRFRAKAMQEAVPVGEGGMAAILGLSDDDVRAACAEASSAGVVEAVNFN
APAQVVIAGAKAAVEKACEIAKAKGAKRALPLPVSAPFHSSLLKPASDRLREYLSGVAVGAPAIPVINNVDVALVSDPAA
IKDALVRQAASPVRWVETVQKMKADGIARVVECGPGKVLAGLTKRIDGDIVGDAIFDPASLEAVLVQLK
>Mature_308_residues
TFAFVFPGQGSQSVGMLNAFADHPVVAATLAEASDALGQDIGKLIAEGPADELNLTTNTQPVMLTAAVAVYRAWQAAGGP
TPAVVAGHSLGEYSALVAAGAIAFKDAVPLVRFRAKAMQEAVPVGEGGMAAILGLSDDDVRAACAEASSAGVVEAVNFNA
PAQVVIAGAKAAVEKACEIAKAKGAKRALPLPVSAPFHSSLLKPASDRLREYLSGVAVGAPAIPVINNVDVALVSDPAAI
KDALVRQAASPVRWVETVQKMKADGIARVVECGPGKVLAGLTKRIDGDIVGDAIFDPASLEAVLVQLK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=301, Percent_Identity=33.5548172757475, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1787334, Length=304, Percent_Identity=57.2368421052632, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=30.0341296928328, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=234, Percent_Identity=29.9145299145299, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=292, Percent_Identity=27.0547945205479, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665753, Length=301, Percent_Identity=33.5548172757475, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 31374; Mature: 31243

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00889 CNMP_BINDING_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFAFVFPGQGSQSVGMLNAFADHPVVAATLAEASDALGQDIGKLIAEGPADELNLTTNT
CEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
QPVMLTAAVAVYRAWQAAGGPTPAVVAGHSLGEYSALVAAGAIAFKDAVPLVRFRAKAMQ
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVPVGEGGMAAILGLSDDDVRAACAEASSAGVVEAVNFNAPAQVVIAGAKAAVEKACEI
HHCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHH
AKAKGAKRALPLPVSAPFHSSLLKPASDRLREYLSGVAVGAPAIPVINNVDVALVSDPAA
HHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEECCCCEEEECCCHH
IKDALVRQAASPVRWVETVQKMKADGIARVVECGPGKVLAGLTKRIDGDIVGDAIFDPAS
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCCC
LEAVLVQLK
CEEEEEEEC
>Mature Secondary Structure 
TFAFVFPGQGSQSVGMLNAFADHPVVAATLAEASDALGQDIGKLIAEGPADELNLTTNT
EEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
QPVMLTAAVAVYRAWQAAGGPTPAVVAGHSLGEYSALVAAGAIAFKDAVPLVRFRAKAMQ
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVPVGEGGMAAILGLSDDDVRAACAEASSAGVVEAVNFNAPAQVVIAGAKAAVEKACEI
HHCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHH
AKAKGAKRALPLPVSAPFHSSLLKPASDRLREYLSGVAVGAPAIPVINNVDVALVSDPAA
HHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEECCCCEEEECCCHH
IKDALVRQAASPVRWVETVQKMKADGIARVVECGPGKVLAGLTKRIDGDIVGDAIFDPAS
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCCC
LEAVLVQLK
CEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]