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The map label for this gene is hscB

Identifier: 17545742

GI number: 17545742

Start: 1075278

End: 1075808

Strand: Direct

Name: hscB

Synonym: RSc1023

Alternate gene names: 17545742

Gene position: 1075278-1075808 (Clockwise)

Preceding gene: 17545741

Following gene: 17545743

Centisome position: 28.93

GC content: 68.36

Gene sequence:

>531_bases
ATGAATTCCGCGAGCGATACGCACTTTTCCCTGTTCGGCCTGCCCGAGCATTTCGAGGTCGACGACGGCGCGCTGAACGC
CGCGTACCGCACCGTGCAATCGCGGGCGCACCCGGACCGCCATGCGCATGCCAGCGATGCCGAACGCCGCGTCGCCATGC
AATGGGCCACGCGCGCCAACGAGGCCTACCAGACCCTGCGCGATCCGCTCAAGCGGGCGACCTATCTGCTGCACCTGCGC
GGCGTCGACGTGCAGGCCGAGAACAACACGGCCATGCCGCCGGCCTTCCTGATGCAGCAGCTGGAATGGCGCGAGTCGCT
GGCCGATGCCAAGGCCGCCGGCGACCTGGACGCGCTGGACGACCTGCTGGCCATGCTGCGCGGGGAAAAGCGCGCCCGCT
ATCAGACGCTGGCAGGGCTGCTGAATGGCGGCGGCCACGACGCGGCAGCGGCCGATGCCGTGCGCCAGCTCATGTTCATC
GAAAAAATCGAGCGGGATACCGCCGAGGCGATCGACCGGCTGGACGACTAG

Upstream 100 bases:

>100_bases
AGGTGGTGGAGTGCCTGAAGTGCGACCGGGGCGAACCGGTCGAGTGACCGGGCAAGACGGGTCGGTAAGCAGCAAGGCGG
CGCGGCCGCTTTTTTTATTC

Downstream 100 bases:

>100_bases
ACCCCCTGCAGTTGCGGCAGCCGACCGCGCAGGCCATGACACAATGTCGGGTTTGCCAAGGCCGGCCGCCTCATCCGCGC
AATCGAGACTCGACATGGCT

Product: co-chaperone HscB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRANEAYQTLRDPLKRATYLLHLR
GVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALDDLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFI
EKIERDTAEAIDRLDD

Sequences:

>Translated_176_residues
MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRANEAYQTLRDPLKRATYLLHLR
GVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALDDLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFI
EKIERDTAEAIDRLDD
>Mature_176_residues
MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRANEAYQTLRDPLKRATYLLHLR
GVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALDDLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFI
EKIERDTAEAIDRLDD

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=116, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788876, Length=165, Percent_Identity=40, Blast_Score=116, Evalue=9e-28,
Organism=Drosophila melanogaster, GI161084223, Length=113, Percent_Identity=30.9734513274336, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_RALSO (Q8Y0M0)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519144.1
- ProteinModelPortal:   Q8Y0M0
- SMR:   Q8Y0M0
- GeneID:   1219832
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1023
- NMPDR:   fig|267608.1.peg.1023
- HOGENOM:   HBG751004
- OMA:   AQRVAMQ
- ProtClustDB:   PRK03578
- BioCyc:   RSOL267608:RSC1023-MONOMER
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 19584; Mature: 19584

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRAN
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAYQTLRDPLKRATYLLHLRGVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALD
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
DLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFIEKIERDTAEAIDRLDD
HHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSASDTHFSLFGLPEHFEVDDGALNAAYRTVQSRAHPDRHAHASDAERRVAMQWATRAN
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAYQTLRDPLKRATYLLHLRGVDVQAENNTAMPPAFLMQQLEWRESLADAKAAGDLDALD
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
DLLAMLRGEKRARYQTLAGLLNGGGHDAAAADAVRQLMFIEKIERDTAEAIDRLDD
HHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852