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The map label for this gene is uvrB

Identifier: 17545730

GI number: 17545730

Start: 1061898

End: 1063988

Strand: Direct

Name: uvrB

Synonym: RSc1011

Alternate gene names: 17545730

Gene position: 1061898-1063988 (Clockwise)

Preceding gene: 17545726

Following gene: 17545731

Centisome position: 28.57

GC content: 65.61

Gene sequence:

>2091_bases
ATGACCGACCTCAGCCAAGTCCCCAGCCCGTACGACGAGTCGAAGTTCGTCACATTCGACGGCTCGCCGTTCCAGCTGTA
TCAGCCGTATCCGCCCGCCGGCGACCAGCCCGAGGCGATCCGCCAACTGGTCGAGGGTATCGGTGACGGCCTGTCGTACC
AGACGCTGCTGGGCGTGACGGGCTCGGGCAAGACCTACACGATGGCCAACGTGATCGCACAGGCGGGGCGGCCCGCGATC
GTGTTCGCGCCCAACAAGACGTTGGCGGCGCAACTGTATTCGGAGTTCCGCGAGTTCTTCCCGCGCAATGCGGTCGAGTA
CTTCGTCTCGTACTACGACTACTACCAGCCGGAAGCGTACGTGCCGCAGCGCGACCTGTTCATCGAGAAAGATTCGTCGG
TCAACGAGCATATCGAGCAGATGCGGCTGTCGGCCACCAAGAGCCTGCTGGAGCGCCGCGACGTGGTGATCGTGGCCACC
GTGTCGGCCATCTACGGCATCGGCAACCCGACCGAATACCACCAGATGATCCTGACGCTGCGCACTGGCGACAAGATCAG
CCAGCGCGACGTGATCGCGCGCCTGATCGCCATGCAGTACACGCGCAACGAGACGGACTTCCAGCGCGGCACCTTCCGCG
TGCGCGGCGACACCGTCGACATCTTTCCCGCCGAGCACGCCGAGATGGCGGTGCGGCTGGAGCTGTTCGACGACGAGGTC
GATTCGCTGCAGCTGTTCGATCCGCTCACCGGGCGCGTGCGGCAGAAGATCCTGCGCTTCACGGTGTACCCGTCGAGCCA
CTACGTGACGCCGCGCGAGACCGTGCTGCGCGCCATCGGGACCATCAAGGCCGAGCTGCGCGAGCGGCTGGATTTCTTCT
ACCAGGAGAACAAGCTGGTCGAGGCGCAGCGCCTGGAGCAGCGCACGCGCTTCGACCTGGAGATGCTGCAGGAGCTGGGC
TTCTGCAAGGGCATCGAGAACTATTCGCGGCACCTGTCCGGCGCCCAGCCGGGCGAGCCGCCTCCGACCCTGGTCGACTA
CCTGCCGTCCGACGCGCTGATGTTCCTGGACGAGTCGCACGTGCTGATCGGCCAGCTCAACGGCATGTACAACGGCGACC
GCGCGCGCAAGGAGACGCTGTCCGCGTATGGCTTCCGCCTGCCGTCCGCGCTGGACAACCGGCCGCTGAAGTTTGCCGAG
TTCGAGGGCAAGATGCGGCAGGTGGTTTTCGTGTCCGCCACGCCGGCCGATTACGAGAAGCAGCGCGCCGGCGACGAGGT
GGTCGAGCAGGTGGTGCGGCCCACGGGCCTGGTCGATCCGATCATCCACGTGCGGCCGGCCACCACGCAGGTGGACGACC
TGCTGTCGGAGATCCACGAGCGCGTCAAGGCCGGCGAGCGCGTGCTGGTCACCACGCTCACCAAGCGCATGGCCGAGCAG
CTGACCGAGTTCCTGTCGGAAAACGGCGTCAAGGTCCGCTACCTGCACTCGGACATCGACACCGTCGAGCGCGTGGAGAT
CATCCGCGACCTGCGGCTGGGCACCTTCGACGTGCTGGTCGGCATCAACCTGCTGCGCGAGGGGCTGGACATTCCCGAGG
TGTCGCTGGTGGCCATCCTCGACGCCGACAAGGAAGGCTTCCTGCGCGCCGAGCGCTCGCTGATCCAGACCATCGGCCGC
GCCGCGCGCAACGTCAACGGCACCGCCATCCTCTATGGGGATCGCATCACCGAGTCGATGAAGAAGGCCATTGGCGAGAC
CGAGCGGCGACGCGCCAAGCAGATCGCCCACAACGAGGCCCATGGCATCACGCCGCGCGGCGTGGTCAAGCGCATCAAGG
ACATCATTGACGGCGTGTACAACGTCGACGATGCGCGCGCGGAGCTGAAGGCCGCGCAGGATGCCGCCAAGTACGAAGAC
ATGAGCGAGAAGCAGGTCGGCAAGGAAATCAAGCGTCTCGAAAAGCAGATGCTCGACCACGCCAAGAACCTGGAATTCGA
GAAGGCGGCCGCGGTGCGCGACCAGTTGGCCAAGCTCAAGTCGCAGGTCTTCGGGGCCAGCGGCGAAGACCATATCGTGC
CGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCTACACTACACGATCGGTTGCAATCGCCGCCGCCGTCCCCATGTGTCAGGGGCGTGCGAGTCACTTCAACGACTGTCC
GCGCCCACCCCCAAGCCGCC

Downstream 100 bases:

>100_bases
GCCGGCCATCCCGTTCTGCGGTGCCGCCCGCCCTTGCCCCGGCAGGGGTGGGTGCCGCCGCAGCCCACATCCATCGATGT
CCCTGGCGCCGCGTCTTGCG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTDLSQVPSPYDESKFVTFDGSPFQLYQPYPPAGDQPEAIRQLVEGIGDGLSYQTLLGVTGSGKTYTMANVIAQAGRPAI
VFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLLERRDVVIVAT
VSAIYGIGNPTEYHQMILTLRTGDKISQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
DSLQLFDPLTGRVRQKILRFTVYPSSHYVTPRETVLRAIGTIKAELRERLDFFYQENKLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHLSGAQPGEPPPTLVDYLPSDALMFLDESHVLIGQLNGMYNGDRARKETLSAYGFRLPSALDNRPLKFAE
FEGKMRQVVFVSATPADYEKQRAGDEVVEQVVRPTGLVDPIIHVRPATTQVDDLLSEIHERVKAGERVLVTTLTKRMAEQ
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGTAILYGDRITESMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQDAAKYED
MSEKQVGKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQVFGASGEDHIVPAA

Sequences:

>Translated_696_residues
MTDLSQVPSPYDESKFVTFDGSPFQLYQPYPPAGDQPEAIRQLVEGIGDGLSYQTLLGVTGSGKTYTMANVIAQAGRPAI
VFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLLERRDVVIVAT
VSAIYGIGNPTEYHQMILTLRTGDKISQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
DSLQLFDPLTGRVRQKILRFTVYPSSHYVTPRETVLRAIGTIKAELRERLDFFYQENKLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHLSGAQPGEPPPTLVDYLPSDALMFLDESHVLIGQLNGMYNGDRARKETLSAYGFRLPSALDNRPLKFAE
FEGKMRQVVFVSATPADYEKQRAGDEVVEQVVRPTGLVDPIIHVRPATTQVDDLLSEIHERVKAGERVLVTTLTKRMAEQ
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGTAILYGDRITESMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQDAAKYED
MSEKQVGKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQVFGASGEDHIVPAA
>Mature_695_residues
TDLSQVPSPYDESKFVTFDGSPFQLYQPYPPAGDQPEAIRQLVEGIGDGLSYQTLLGVTGSGKTYTMANVIAQAGRPAIV
FAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSVNEHIEQMRLSATKSLLERRDVVIVATV
SAIYGIGNPTEYHQMILTLRTGDKISQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEVD
SLQLFDPLTGRVRQKILRFTVYPSSHYVTPRETVLRAIGTIKAELRERLDFFYQENKLVEAQRLEQRTRFDLEMLQELGF
CKGIENYSRHLSGAQPGEPPPTLVDYLPSDALMFLDESHVLIGQLNGMYNGDRARKETLSAYGFRLPSALDNRPLKFAEF
EGKMRQVVFVSATPADYEKQRAGDEVVEQVVRPTGLVDPIIHVRPATTQVDDLLSEIHERVKAGERVLVTTLTKRMAEQL
TEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRA
ARNVNGTAILYGDRITESMKKAIGETERRRAKQIAHNEAHGITPRGVVKRIKDIIDGVYNVDDARAELKAAQDAAKYEDM
SEKQVGKEIKRLEKQMLDHAKNLEFEKAAAVRDQLAKLKSQVFGASGEDHIVPAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=66.7660208643815, Blast_Score=890, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=22.9773462783171, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_RALSO (Q8Y0N2)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519132.1
- ProteinModelPortal:   Q8Y0N2
- GeneID:   1219820
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1011
- NMPDR:   fig|267608.1.peg.1011
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   RSOL267608:RSC1011-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 78664; Mature: 78533

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLSQVPSPYDESKFVTFDGSPFQLYQPYPPAGDQPEAIRQLVEGIGDGLSYQTLLGVT
CCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHEEEC
GSGKTYTMANVIAQAGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAY
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
VPQRDLFIEKDSSVNEHIEQMRLSATKSLLERRDVVIVATVSAIYGIGNPTEYHQMILTL
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHEEEEE
RTGDKISQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCCC
DSLQLFDPLTGRVRQKILRFTVYPSSHYVTPRETVLRAIGTIKAELRERLDFFYQENKLV
CHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGAQPGEPPPTLVDYLPSDALMFLDESH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEECCCC
VLIGQLNGMYNGDRARKETLSAYGFRLPSALDNRPLKFAEFEGKMRQVVFVSATPADYEK
EEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHCCCEEEEEEEECCCCCHHH
QRAGDEVVEQVVRPTGLVDPIIHVRPATTQVDDLLSEIHERVKAGERVLVTTLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHH
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGTAILYGDRITESMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHCCC
HGITPRGVVKRIKDIIDGVYNVDDARAELKAAQDAAKYEDMSEKQVGKEIKRLEKQMLDH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAAVRDQLAKLKSQVFGASGEDHIVPAA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLSQVPSPYDESKFVTFDGSPFQLYQPYPPAGDQPEAIRQLVEGIGDGLSYQTLLGVT
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHEEEC
GSGKTYTMANVIAQAGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAY
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
VPQRDLFIEKDSSVNEHIEQMRLSATKSLLERRDVVIVATVSAIYGIGNPTEYHQMILTL
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHEEEEE
RTGDKISQRDVIARLIAMQYTRNETDFQRGTFRVRGDTVDIFPAEHAEMAVRLELFDDEV
ECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCCC
DSLQLFDPLTGRVRQKILRFTVYPSSHYVTPRETVLRAIGTIKAELRERLDFFYQENKLV
CHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGAQPGEPPPTLVDYLPSDALMFLDESH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEECCCC
VLIGQLNGMYNGDRARKETLSAYGFRLPSALDNRPLKFAEFEGKMRQVVFVSATPADYEK
EEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHCCCEEEEEEEECCCCCHHH
QRAGDEVVEQVVRPTGLVDPIIHVRPATTQVDDLLSEIHERVKAGERVLVTTLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHH
LTEFLSENGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGTAILYGDRITESMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHCCC
HGITPRGVVKRIKDIIDGVYNVDDARAELKAAQDAAKYEDMSEKQVGKEIKRLEKQMLDH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAAVRDQLAKLKSQVFGASGEDHIVPAA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852