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The map label for this gene is etfA [H]

Identifier: 17545643

GI number: 17545643

Start: 975294

End: 976229

Strand: Direct

Name: etfA [H]

Synonym: RSc0924

Alternate gene names: 17545643

Gene position: 975294-976229 (Clockwise)

Preceding gene: 17545642

Following gene: 17545644

Centisome position: 26.24

GC content: 70.09

Gene sequence:

>936_bases
ATGACCGCACTCGTTATTGCTGAACACGACAACCAATCCATCAAGGCCGCGACGCTGAACACCGTGACCGCCGCGCTGCA
ATGCGGCGGCGAGGTCCACGTGCTGGTGGCCGGCGCGGGCTGCGCCGCCGCCGCGCAGGCCGCCGCGCAGATCGCCGGCG
TGGCCAAGGTGCTGGTGGCCGACGCGCCCCAGTTCGCCGACGGCCTGGCCGAGAACGTCGCCGAGCAGGCGCTGGCCGTC
GCCGGCCGCTACAGCCACATCCTGGCGCCCGCCACCGCCTACGGCAAGAACATCCTGCCGCGCGTGGCCGCCAAGCTGGA
CGTGGCGCAACTGTCCGACATCACCAAGATCGACAGCCCCGATACCTTCGAGCGCCCGATCTACGCCGGCAACGCGATCG
CCATGGTGCAGTCGGCCGACCAGGTGAAGGTGATCACCGTGCGCGGCACGGCATTCGACGCGGCCGCCGCCACGGGCGGC
TCGGCAGCGACCGAGGCCCTGACGCCGGTGGCCGATGCCGGCATCTCGCAGTTCGTCTCGCGCGAGGTGACCAAGAGCGA
CCGTCCGGAGCTGACCGCCGCCAAGATCATCGTATCGGGTGGCCGGGGCGTGGGCTCGGGCGAGAACTACACCAAGGTGC
TGACGCCGCTGGCCGACAAGCTGGGTGCCGCGCTGGGCGCTTCGCGCGCGGCGGTGGACGCCGGCTTCGTGCCGAACGAC
TACCAGGTCGGCCAGACCGGCAAGATCGTCGCGCCGCAGCTGTACATCGCCGTCGGCATCTCGGGGGCGATCCAGCACCT
GGCCGGCATGAAGGATTCCAAGGTGATCGTGGCGATCAACAAGGATCCTGAGGCGCCGATCTTCCAGGTGGCCGACTACG
GCCTGGTGGGCGACCTGAACACCCTGGTGCCAGAGCTGGTGGCCGCGCTGGGCTGA

Upstream 100 bases:

>100_bases
GGCGACGCTGGTGGCCAAGCTCAAGACGGAAGCCAAGGTGCTGTGAGGCGGCCAGCCGCATTCCGCACGTCTTTCAAGCA
CACCGAACAGGCAGATCAAG

Downstream 100 bases:

>100_bases
TCGCCGGGCGCGGCGCGACAGCGCCACCATGCCATGCCGCCGAAGCCGTTTCCGACCCGTTTGGAAACGGCTTTTTCATA
GAGGGATTGGAGAGAGACAT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTALVIAEHDNQSIKAATLNTVTAALQCGGEVHVLVAGAGCAAAAQAAAQIAGVAKVLVADAPQFADGLAENVAEQALAV
AGRYSHILAPATAYGKNILPRVAAKLDVAQLSDITKIDSPDTFERPIYAGNAIAMVQSADQVKVITVRGTAFDAAAATGG
SAATEALTPVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVGDLNTLVPELVAALG

Sequences:

>Translated_311_residues
MTALVIAEHDNQSIKAATLNTVTAALQCGGEVHVLVAGAGCAAAAQAAAQIAGVAKVLVADAPQFADGLAENVAEQALAV
AGRYSHILAPATAYGKNILPRVAAKLDVAQLSDITKIDSPDTFERPIYAGNAIAMVQSADQVKVITVRGTAFDAAAATGG
SAATEALTPVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVGDLNTLVPELVAALG
>Mature_310_residues
TALVIAEHDNQSIKAATLNTVTAALQCGGEVHVLVAGAGCAAAAQAAAQIAGVAKVLVADAPQFADGLAENVAEQALAVA
GRYSHILAPATAYGKNILPRVAAKLDVAQLSDITKIDSPDTFERPIYAGNAIAMVQSADQVKVITVRGTAFDAAAATGGS
AATEALTPVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPNDY
QVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVGDLNTLVPELVAALG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=62.7009646302251, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI189181759, Length=270, Percent_Identity=63.7037037037037, Blast_Score=331, Evalue=5e-91,
Organism=Escherichia coli, GI1786226, Length=232, Percent_Identity=36.2068965517241, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787990, Length=255, Percent_Identity=33.7254901960784, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082157, Length=243, Percent_Identity=33.7448559670782, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506929, Length=313, Percent_Identity=56.2300319488818, Blast_Score=332, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6325261, Length=275, Percent_Identity=46.9090909090909, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17136898, Length=313, Percent_Identity=61.9808306709265, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652801, Length=313, Percent_Identity=61.9808306709265, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31361; Mature: 31230

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALVIAEHDNQSIKAATLNTVTAALQCGGEVHVLVAGAGCAAAAQAAAQIAGVAKVLVA
CEEEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
DAPQFADGLAENVAEQALAVAGRYSHILAPATAYGKNILPRVAAKLDVAQLSDITKIDSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTFERPIYAGNAIAMVQSADQVKVITVRGTAFDAAAATGGSAATEALTPVADAGISQFVS
CCCCCCEECCCEEEEEECCCCEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
REVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
HHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVGDLN
CEECCCCCEECCEEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHH
TLVPELVAALG
HHHHHHHHHCC
>Mature Secondary Structure 
TALVIAEHDNQSIKAATLNTVTAALQCGGEVHVLVAGAGCAAAAQAAAQIAGVAKVLVA
EEEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
DAPQFADGLAENVAEQALAVAGRYSHILAPATAYGKNILPRVAAKLDVAQLSDITKIDSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTFERPIYAGNAIAMVQSADQVKVITVRGTAFDAAAATGGSAATEALTPVADAGISQFVS
CCCCCCEECCCEEEEEECCCCEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
REVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
HHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVGDLN
CEECCCCCEECCEEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHH
TLVPELVAALG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]