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The map label for this gene is pyrC [H]

Identifier: 17545206

GI number: 17545206

Start: 524086

End: 525120

Strand: Direct

Name: pyrC [H]

Synonym: RSc0487

Alternate gene names: 17545206

Gene position: 524086-525120 (Clockwise)

Preceding gene: 17545205

Following gene: 17545207

Centisome position: 14.1

GC content: 69.08

Gene sequence:

>1035_bases
ATGATCGATACCCTGACCATCGTCCGCCCTGATGACTGGCACCTGCACCTGCGCGATGGCGACGCGCTCGCCGACGTGGT
GGGCGACACCGCGCGCCAGTTCGGCCGGGCGATCATCATGCCCAACCTCAAGCCGCCGGTGACGACCACCGCGCAGGCTC
GCGCCTACCGCGAGCGCATCCTCGCCGCGCTGCCGGCGGGCACGCGCTTCGAGCCGCTGATGACGCTGTACCTGACCGAC
AACACCACGCCCGAGGAAGTCCGCGCCGCCCGTGCCAGCGGCTTCGTGCATGGCGTCAAGCTCTACCCGGCCGGTGCCAC
CACCAACAGCGATGCCGGCGTGACCGACCTGCGCCGCTGCGCCAAGACGCTCGAAGCGATGCAGGACGTCGGCATGCCCC
TGCTGGTGCACGGCGAAGTGACCGACCCCACGGTCGACATCTTCGATCGCGAAGCCGTCTTCATCGACACCGTGATGCAG
CCGCTGCGCCGCGATTTTCCGGCGCTCAAGGTCGTGTTCGAGCACATCACCACCAAGCACGCCGCCGAATACGTGCGCGA
CGCGCAGGGGCCGGTCGGCGCGACCATCACGGCACACCACCTGCTGTACAACCGCAACGCGCTGTTCGTTGGCGGCATTC
GTCCGCACTACTACTGCCTGCCGGTGCTCAAGCGCGAAACGCACCGCCTGGCGCTGGTGGCGGCGGCCACCTCGGGCCAT
CCGCGCTTCTTCCTCGGCACCGACAGCGCACCGCATGCCAAGGGCCTGAAGGAGCACGCCTGCGGCTGCGCCGGCTGCTA
TACCGCGCTGCACGCGATGGAGCTGTACGCCGAAGCCTTTGAAGACGCCAACGCGCTCGACAAGCTCGAAGGCTTCGCCA
GCCTGCACGGCCCGGACTTCTACGGCCTGCCGCGCAACGCCGGCACGCTCACGCTCACGCGCTCGCAGTGGCAGCTGCCC
GCCGAGGTGCCCTTCGGCGAGCAGATGCTGGTGCCGCTGCGCGGCGGCGAGATGCTGCGCTGGAAGACGGTCTGA

Upstream 100 bases:

>100_bases
CCTGATCGTCACCGGCCCGACGCGCACCAATGTCAACGACTACCGCGTCATCCTGATTCTCTGAATTTCATTTCTTTCTG
TCTTTTTCTCTTCACGCATC

Downstream 100 bases:

>100_bases
GTGTGCGCTCGGCGGGTTTGACCGGGATCGACTGGGCGCACCCGGCGTTCGCGCCGCTGGCGGCCATCGGCGCACCGGTC
GCCCGGGCGGTCGGCCAAGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTRFEPLMTLYLTD
NTTPEEVRAARASGFVHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQDVGMPLLVHGEVTDPTVDIFDREAVFIDTVMQ
PLRRDFPALKVVFEHITTKHAAEYVRDAQGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
PRFFLGTDSAPHAKGLKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLP
AEVPFGEQMLVPLRGGEMLRWKTV

Sequences:

>Translated_344_residues
MIDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTRFEPLMTLYLTD
NTTPEEVRAARASGFVHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQDVGMPLLVHGEVTDPTVDIFDREAVFIDTVMQ
PLRRDFPALKVVFEHITTKHAAEYVRDAQGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
PRFFLGTDSAPHAKGLKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLP
AEVPFGEQMLVPLRGGEMLRWKTV
>Mature_344_residues
MIDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTRFEPLMTLYLTD
NTTPEEVRAARASGFVHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQDVGMPLLVHGEVTDPTVDIFDREAVFIDTVMQ
PLRRDFPALKVVFEHITTKHAAEYVRDAQGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
PRFFLGTDSAPHAKGLKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLP
AEVPFGEQMLVPLRGGEMLRWKTV

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=338, Percent_Identity=56.2130177514793, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6323452, Length=355, Percent_Identity=35.2112676056338, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37817; Mature: 37817

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERI
CCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHH
LAALPAGTRFEPLMTLYLTDNTTPEEVRAARASGFVHGVKLYPAGATTNSDAGVTDLRRC
HHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AKTLEAMQDVGMPLLVHGEVTDPTVDIFDREAVFIDTVMQPLRRDFPALKVVFEHITTKH
HHHHHHHHHCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAEYVRDAQGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEEEHHHHCCCCEEEEEEEECCCC
PRFFLGTDSAPHAKGLKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDF
CEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YGLPRNAGTLTLTRSQWQLPAEVPFGEQMLVPLRGGEMLRWKTV
CCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECC
>Mature Secondary Structure
MIDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERI
CCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHH
LAALPAGTRFEPLMTLYLTDNTTPEEVRAARASGFVHGVKLYPAGATTNSDAGVTDLRRC
HHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AKTLEAMQDVGMPLLVHGEVTDPTVDIFDREAVFIDTVMQPLRRDFPALKVVFEHITTKH
HHHHHHHHHCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAEYVRDAQGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEEEHHHHCCCCEEEEEEEECCCC
PRFFLGTDSAPHAKGLKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDF
CEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YGLPRNAGTLTLTRSQWQLPAEVPFGEQMLVPLRGGEMLRWKTV
CCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA