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The map label for this gene is ycgO [H]

Identifier: 17545182

GI number: 17545182

Start: 494347

End: 495786

Strand: Direct

Name: ycgO [H]

Synonym: RSc0463

Alternate gene names: 17545182

Gene position: 494347-495786 (Clockwise)

Preceding gene: 17545181

Following gene: 17545183

Centisome position: 13.3

GC content: 65.49

Gene sequence:

>1440_bases
ATGCTGATCTGGTTCGTCATTGTTTATTGGGTGATTTCGGTCGGTATCGGCCTGTGGGCGGCGCTGCGCGTGCGCAATAC
GGCCGACTTCGCGGTGGCCGGCCGCGGCCTGCCGTTCTACGTTGTCACCGCCACGGTGTTCGCGACGTGGTTCGGTTCCG
AGACGGTGCTCGGTATTCCGGCGGTGTTCCTCAAGGAGGGCCTGCACGGCGTGGTGGCCGATCCGTTCGGGTCGTCGCTG
TGCCTGATCCTGGTGGGCCTGTTCTTCGCCCGGCCGCTGTACCGGATGAACCTGCTGACCATCGGCGACTTCTACCGCAA
CCGCTTCGGCCGCGTGGCCGAGGTGCTGACCACCCTGTGCATCGTCGTGTCCTATCTGGGCTGGGTGGCGGCGCAGATCA
AGGCGCTGGGCCTGGTGTTCTATACCGTTTCGGACGGCGGGCTGTCGCAGCAGACCGGCATGATGATCGGCGCGGCCAGC
GTGCTGGTCTACACGCTGTTCGGCGGCATGTGGTCGGTGGCGGTGACGGACTTCATCCAGATGATCATCATCGTGATCGG
CATGATGTACATCGGCTGGGAGGTCTCGGGCCAGGCCGGCGGCGTGGCCACGGTGGTGGCGCATGCATCGGCGGCGGGCA
AGTTCTCGTTCTGGCCGGCGTTCAACCCGATCGAGGTGATCGGCTTCGTGACGGCCTGGATCACCATGATGCTCGGCTCG
ATTCCGCAGCAGGACGTGTTCCAGCGCGTGACGTCGTCGCGCACCGAGCGCATCGCCGGCACGGCCTCGGTGCTGGGCGG
CGTGCTGTATTTCCTGTTCGCCTTCATCCCGATGTTCCTGGCGTATTCGGCTACGCTGATCGACCCGCAGATGGTCGCCA
GGTACATCAACACCGATTCGCAGCTGATCCTGCCCAAGCTGGTGCTCGAGCACGCGCCGCTGGTCGCGCAGGTGATGTTC
TTCGGCGCGCTGCTGTCGGCCATCAAGAGCTGCGCGAGCGCGACGCTGCTGGCGCCGTCGGTCACCTTTGCCGAAAACGT
GCTGCGCCCGATGCTGCCGCGCATGGACGACAAGCGCTTCCTGCGCGTGATGCAGGCGGTGGTGCTGGTCTTCACGGCGC
TGGTGACGCTGTTTGCGCTCAACTCGCATCTGTCGATCTTTCACATGGTGGAGAATGCCTACAAGGTGACGCTGGTCGCC
GCCTTCGTGCCGCTGGCGTTCGGCCTGTTCTGGAAGCGCGCCACGCGCCAGGGCGGCCTGCTGGCCATCGCCCTCGGGCT
GACCGTGTGGATCTGGTGCGAGGTGTTCCTCTCTGATGCGATGTTCCCGCCACAATTGGTCGGCCTGCTGGCCAGCCTGG
GGGCGATGGTGGTCGGCTCGCTGGGTCCGCAATGGATCCGCGATCGCGTTCCGGCCAGCCAGCCCGTCACACAGGCCTGA

Upstream 100 bases:

>100_bases
CCGCAGGGGTGTCCCATCGCTATAATCCCGCCATTTCGCCCGGCGCCGGCGTGGCCGCCAACGGGATTTCCAGGGTCTGT
TCTTCCGTGAATCGAGTGCC

Downstream 100 bases:

>100_bases
CGCGCGGCGTTCCCGCGGGCAGGGCGGGCCACATTGTGGCGCGCTGCATCGGATGCCGCGAATCCGCCGTCGGGGATTTT
GCGGAAAGGGTTTATAATTC

Product: sodium/solute symporter transmembrane protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MLIWFVIVYWVISVGIGLWAALRVRNTADFAVAGRGLPFYVVTATVFATWFGSETVLGIPAVFLKEGLHGVVADPFGSSL
CLILVGLFFARPLYRMNLLTIGDFYRNRFGRVAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGGLSQQTGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMMYIGWEVSGQAGGVATVVAHASAAGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFLFAFIPMFLAYSATLIDPQMVARYINTDSQLILPKLVLEHAPLVAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPMLPRMDDKRFLRVMQAVVLVFTALVTLFALNSHLSIFHMVENAYKVTLVA
AFVPLAFGLFWKRATRQGGLLAIALGLTVWIWCEVFLSDAMFPPQLVGLLASLGAMVVGSLGPQWIRDRVPASQPVTQA

Sequences:

>Translated_479_residues
MLIWFVIVYWVISVGIGLWAALRVRNTADFAVAGRGLPFYVVTATVFATWFGSETVLGIPAVFLKEGLHGVVADPFGSSL
CLILVGLFFARPLYRMNLLTIGDFYRNRFGRVAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGGLSQQTGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMMYIGWEVSGQAGGVATVVAHASAAGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFLFAFIPMFLAYSATLIDPQMVARYINTDSQLILPKLVLEHAPLVAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPMLPRMDDKRFLRVMQAVVLVFTALVTLFALNSHLSIFHMVENAYKVTLVA
AFVPLAFGLFWKRATRQGGLLAIALGLTVWIWCEVFLSDAMFPPQLVGLLASLGAMVVGSLGPQWIRDRVPASQPVTQA
>Mature_479_residues
MLIWFVIVYWVISVGIGLWAALRVRNTADFAVAGRGLPFYVVTATVFATWFGSETVLGIPAVFLKEGLHGVVADPFGSSL
CLILVGLFFARPLYRMNLLTIGDFYRNRFGRVAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGGLSQQTGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMMYIGWEVSGQAGGVATVVAHASAAGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFLFAFIPMFLAYSATLIDPQMVARYINTDSQLILPKLVLEHAPLVAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPMLPRMDDKRFLRVMQAVVLVFTALVTLFALNSHLSIFHMVENAYKVTLVA
AFVPLAFGLFWKRATRQGGLLAIALGLTVWIWCEVFLSDAMFPPQLVGLLASLGAMVVGSLGPQWIRDRVPASQPVTQA

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=403, Percent_Identity=29.0322580645161, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4507035, Length=400, Percent_Identity=27, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI14140236, Length=487, Percent_Identity=23.8193018480493, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI109659836, Length=475, Percent_Identity=22.9473684210526, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4507033, Length=413, Percent_Identity=23.2445520581114, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI157671931, Length=399, Percent_Identity=22.8070175438596, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=433, Percent_Identity=24.4803695150115, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787251, Length=446, Percent_Identity=24.4394618834081, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539284, Length=454, Percent_Identity=25.3303964757709, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24648033, Length=388, Percent_Identity=26.0309278350515, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356865, Length=388, Percent_Identity=26.0309278350515, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52092; Mature: 52092

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIWFVIVYWVISVGIGLWAALRVRNTADFAVAGRGLPFYVVTATVFATWFGSETVLGIP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCHHHHHHHHHHHHCCCCCHHHHH
AVFLKEGLHGVVADPFGSSLCLILVGLFFARPLYRMNLLTIGDFYRNRFGRVAEVLTTLC
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVSYLGWVAAQIKALGLVFYTVSDGGLSQQTGMMIGAASVLVYTLFGGMWSVAVTDFIQ
HHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIIIVIGMMYIGWEVSGQAGGVATVVAHASAAGKFSFWPAFNPIEVIGFVTAWITMMLGS
HHHHHHHHHHHCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFLFAFIPMFLAYSATLIDPQMVARYINTDS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QLILPKLVLEHAPLVAQVMFFGALLSAIKSCASATLLAPSVTFAENVLRPMLPRMDDKRF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
LRVMQAVVLVFTALVTLFALNSHLSIFHMVENAYKVTLVAAFVPLAFGLFWKRATRQGGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LAIALGLTVWIWCEVFLSDAMFPPQLVGLLASLGAMVVGSLGPQWIRDRVPASQPVTQA
EHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLIWFVIVYWVISVGIGLWAALRVRNTADFAVAGRGLPFYVVTATVFATWFGSETVLGIP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCHHHHHHHHHHHHCCCCCHHHHH
AVFLKEGLHGVVADPFGSSLCLILVGLFFARPLYRMNLLTIGDFYRNRFGRVAEVLTTLC
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVSYLGWVAAQIKALGLVFYTVSDGGLSQQTGMMIGAASVLVYTLFGGMWSVAVTDFIQ
HHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIIIVIGMMYIGWEVSGQAGGVATVVAHASAAGKFSFWPAFNPIEVIGFVTAWITMMLGS
HHHHHHHHHHHCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFLFAFIPMFLAYSATLIDPQMVARYINTDS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QLILPKLVLEHAPLVAQVMFFGALLSAIKSCASATLLAPSVTFAENVLRPMLPRMDDKRF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
LRVMQAVVLVFTALVTLFALNSHLSIFHMVENAYKVTLVAAFVPLAFGLFWKRATRQGGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LAIALGLTVWIWCEVFLSDAMFPPQLVGLLASLGAMVVGSLGPQWIRDRVPASQPVTQA
EHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]