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The map label for this gene is livH [H]

Identifier: 17230028

GI number: 17230028

Start: 3041755

End: 3042705

Strand: Direct

Name: livH [H]

Synonym: alr2536

Alternate gene names: 17230028

Gene position: 3041755-3042705 (Clockwise)

Preceding gene: 17230027

Following gene: 17230029

Centisome position: 47.43

GC content: 39.64

Gene sequence:

>951_bases
ATGGATATTAGTGTATTTTTACAACAATTATTGAATGGGTTATCTATTGGCAGCGTTTATGCAATCTTTGCCTTAGGTTA
TACATTGGTTTATTCCATTTTGGGAATTATTAATTTAGCACATGGGGCAATTTTTACTCTGGGAGCATATTTTACTTATG
CTCTTATGGGTGGAACCTTTGGGTTTAATGGTTTGCTGGCTAACGCTACTTTGCCGATACAATTACCATTTGCTATGGCA
TTGATTATGGGTAGTAGTTTAGCTGGTTTAGTGGGAGTAGCAATGGAAAGAATTGCTTTTCAACCTTTACGAAAAAAAGG
ATCTGACACCTTACTAACTGTGGTTTCTAGCTTAGGGGTAGCAGTGGTAATTGTGAACCTAATTCAATATTTAGTAGGTG
CAGAAAGTTATACATTTCCAGCAAATACTTTTGGGAATTTACCCCCAGCGTTTAACTTTGGAACTTTGGAAAAACCGATT
CCTATTCGTAGCGTACAGGTGGTAATTTTTACTGTATCTGTTGTGATTGTGGCTATTCTTACTTACTTTATTAATCGTAC
TAAATACGGTAAAGCAATTCAGGCGATCGCCGAAGATGCCACTACTGCTAGTTTATTAGGTATCAATAGCGATCGCTTTA
TTGTCTTAACTTTTTTTATCAGCAGTTTTCTCGCTGGCTTGGCGGGTACATTAGTCGCTTCTAGTGTAAGCATTGCAGGC
CCTTATTTTGGGATTGGCTTTGGGTTGCGGGGTTTAGCGGTGATTGTTTTGGGTGGCTTAGGTAGCATTCCTGGCGCAGT
GCTGGGAGGTTTACTGATTGGTGTGGTTGAGGCGCTGGTTCCCTCTGATTACTCTGGTTATAAAGACGCTGTAGCTTTCG
GCATTTTGTTTATCATGCTATTAGTTAGACCCCAAGGATTATTAGGTCGTCGGTTTATTCAGAAAGTCTGA

Upstream 100 bases:

>100_bases
AAGTTTACATTTTTGAAATAGGAAATTTAGGGTGGATAGTGGGAGGGTGAAGAAAACTATTGACTAATGACAACTGACAA
CTGACAACTGACTAAATTAA

Downstream 100 bases:

>100_bases
GGTACAAAGCCATGACAGCAATCGCAAGACAAAAATTAACCTTTGATCAGTTTCTCGATAAATGTCCAGAGGAGGGTTTT
TATGAACTTGTAAATGGAGA

Product: permease protein of branched-chain amino acid ABC transporter

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MDISVFLQQLLNGLSIGSVYAIFALGYTLVYSILGIINLAHGAIFTLGAYFTYALMGGTFGFNGLLANATLPIQLPFAMA
LIMGSSLAGLVGVAMERIAFQPLRKKGSDTLLTVVSSLGVAVVIVNLIQYLVGAESYTFPANTFGNLPPAFNFGTLEKPI
PIRSVQVVIFTVSVVIVAILTYFINRTKYGKAIQAIAEDATTASLLGINSDRFIVLTFFISSFLAGLAGTLVASSVSIAG
PYFGIGFGLRGLAVIVLGGLGSIPGAVLGGLLIGVVEALVPSDYSGYKDAVAFGILFIMLLVRPQGLLGRRFIQKV

Sequences:

>Translated_316_residues
MDISVFLQQLLNGLSIGSVYAIFALGYTLVYSILGIINLAHGAIFTLGAYFTYALMGGTFGFNGLLANATLPIQLPFAMA
LIMGSSLAGLVGVAMERIAFQPLRKKGSDTLLTVVSSLGVAVVIVNLIQYLVGAESYTFPANTFGNLPPAFNFGTLEKPI
PIRSVQVVIFTVSVVIVAILTYFINRTKYGKAIQAIAEDATTASLLGINSDRFIVLTFFISSFLAGLAGTLVASSVSIAG
PYFGIGFGLRGLAVIVLGGLGSIPGAVLGGLLIGVVEALVPSDYSGYKDAVAFGILFIMLLVRPQGLLGRRFIQKV
>Mature_316_residues
MDISVFLQQLLNGLSIGSVYAIFALGYTLVYSILGIINLAHGAIFTLGAYFTYALMGGTFGFNGLLANATLPIQLPFAMA
LIMGSSLAGLVGVAMERIAFQPLRKKGSDTLLTVVSSLGVAVVIVNLIQYLVGAESYTFPANTFGNLPPAFNFGTLEKPI
PIRSVQVVIFTVSVVIVAILTYFINRTKYGKAIQAIAEDATTASLLGINSDRFIVLTFFISSFLAGLAGTLVASSVSIAG
PYFGIGFGLRGLAVIVLGGLGSIPGAVLGGLLIGVVEALVPSDYSGYKDAVAFGILFIMLLVRPQGLLGRRFIQKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=314, Percent_Identity=36.9426751592357, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789865, Length=124, Percent_Identity=34.6774193548387, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 33135; Mature: 33135

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00053 RIBOSOMAL_S8 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISVFLQQLLNGLSIGSVYAIFALGYTLVYSILGIINLAHGAIFTLGAYFTYALMGGTF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GFNGLLANATLPIQLPFAMALIMGSSLAGLVGVAMERIAFQPLRKKGSDTLLTVVSSLGV
CCCCEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVVIVNLIQYLVGAESYTFPANTFGNLPPAFNFGTLEKPIPIRSVQVVIFTVSVVIVAIL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TYFINRTKYGKAIQAIAEDATTASLLGINSDRFIVLTFFISSFLAGLAGTLVASSVSIAG
HHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PYFGIGFGLRGLAVIVLGGLGSIPGAVLGGLLIGVVEALVPSDYSGYKDAVAFGILFIML
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LVRPQGLLGRRFIQKV
HHCCCCHHHHHHHHCC
>Mature Secondary Structure
MDISVFLQQLLNGLSIGSVYAIFALGYTLVYSILGIINLAHGAIFTLGAYFTYALMGGTF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GFNGLLANATLPIQLPFAMALIMGSSLAGLVGVAMERIAFQPLRKKGSDTLLTVVSSLGV
CCCCEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVVIVNLIQYLVGAESYTFPANTFGNLPPAFNFGTLEKPIPIRSVQVVIFTVSVVIVAIL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TYFINRTKYGKAIQAIAEDATTASLLGINSDRFIVLTFFISSFLAGLAGTLVASSVSIAG
HHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PYFGIGFGLRGLAVIVLGGLGSIPGAVLGGLLIGVVEALVPSDYSGYKDAVAFGILFIML
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LVRPQGLLGRRFIQKV
HHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]