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The map label for this gene is iscS [H]

Identifier: 17229997

GI number: 17229997

Start: 3005901

End: 3007067

Strand: Direct

Name: iscS [H]

Synonym: alr2505

Alternate gene names: 17229997

Gene position: 3005901-3007067 (Clockwise)

Preceding gene: 17229996

Following gene: 17230002

Centisome position: 46.87

GC content: 44.99

Gene sequence:

>1167_bases
ATGTCTAATCGTCCTATATATCTTGACTGCCACGCTACCACACCTCTAGATGAACAAGTATTAGCAGTAATGCTTCCCTA
CTTTACAGAAAAATTTGGCAACCCGGCTAGTATCGGTCATATTTACGGTTGGGAAGCAGAAGCGGCTGTGAAACAAGCAC
GGGAAATTTTAGCAGCAGAAATTAACGCTAGTCCAGAAGAAATTATCTTTACTAGTGGGGCTACAGAAGCGAATAATTTA
GCAATTAAAGGTGTAGCTGAGGCTTATTTTCAAAAAGGTCAGCATATTATCACTGTTGCAACGGAACATCATGCTGTAAT
TGACCCTTGTGAATATTTAAAAACACTTGGTTTTGAGATAACTATTTTGTCAGTCCAAGCAGATGGATTAATTGATTTAG
CCCAATTAGAAAAAGCTTTGCGTCCTGAGACAATTTTAGTATCGGTGATGGCGGCTAATAACGAAATTGGTGTGTTGCAA
CCTTTGGCAGAAATTGGGGAGATGTGCCGCACTCACAATATAATTTTTCACACAGATGCAGCCCAAGCTATTGGCAAAAT
TCCTCTGGATGTGCAAGCGATGAACATCGATTTGATGTCTCTGACAGCCCACAAAGTTTACGGGCCTAAGGGTATTGGTG
CATTATACGTCCGCAGGCGCAATCCCAGAGTCCAACTCGCACCCCAGCAGCATGGCGGCGGACATGAACGGGGGATGCGT
TCTGGGACGTTGTACACACCGCAAATTGTCGGTTTTGCCAAAGCTGTAGAAATCGCCCTCGCAGAACAGACAACAGAAAA
TCAACGCCTCACTCAGTTAAGGGATAGATTGTGGTCACAACTTGCACAACTGGAAGGAATACACCTCAACGGACATCCCA
CCCAGAGACTAGCCGGAAACTTGAATATCAGCATTGAAGGTGTTGACGGCGCTGCACTCCAGTTGGGTTTACAGCCTGTT
GTGGCTGTGTCTTCCGGTTCCGCTTGTTCCTCCACCAAAACTGCGCCCTCCCACGTCCTCACAGCCTTAGGAAGCCCAGA
AAAGCTAGCCTATGCTTCAATTCGCTTTGGTATTGGACGCTTTAATACAGCAGAAGAAATTGATATAGTAGCGAAACACG
CGATCGCTACTATTCAAAGTTTACGCAAACAAGCAACTTTGGTATAG

Upstream 100 bases:

>100_bases
AAGACCAGCAATTCTAGAGAATGCTTTTAAAACGAAAAAATGAACTATATGAAGTCCTGGCAATATTAAAAAAATTAAGT
CAAATATTAAGTTAATACCT

Downstream 100 bases:

>100_bases
ACAACAATTTATTCCCAACCGTCAACCGTCAATTAATAAGGGTCTGAATCGAACCTCCCCCGTTTCACACTCCTGAAGTA
ATAACCCCTGGCTGGTGGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSNRPIYLDCHATTPLDEQVLAVMLPYFTEKFGNPASIGHIYGWEAEAAVKQAREILAAEINASPEEIIFTSGATEANNL
AIKGVAEAYFQKGQHIITVATEHHAVIDPCEYLKTLGFEITILSVQADGLIDLAQLEKALRPETILVSVMAANNEIGVLQ
PLAEIGEMCRTHNIIFHTDAAQAIGKIPLDVQAMNIDLMSLTAHKVYGPKGIGALYVRRRNPRVQLAPQQHGGGHERGMR
SGTLYTPQIVGFAKAVEIALAEQTTENQRLTQLRDRLWSQLAQLEGIHLNGHPTQRLAGNLNISIEGVDGAALQLGLQPV
VAVSSGSACSSTKTAPSHVLTALGSPEKLAYASIRFGIGRFNTAEEIDIVAKHAIATIQSLRKQATLV

Sequences:

>Translated_388_residues
MSNRPIYLDCHATTPLDEQVLAVMLPYFTEKFGNPASIGHIYGWEAEAAVKQAREILAAEINASPEEIIFTSGATEANNL
AIKGVAEAYFQKGQHIITVATEHHAVIDPCEYLKTLGFEITILSVQADGLIDLAQLEKALRPETILVSVMAANNEIGVLQ
PLAEIGEMCRTHNIIFHTDAAQAIGKIPLDVQAMNIDLMSLTAHKVYGPKGIGALYVRRRNPRVQLAPQQHGGGHERGMR
SGTLYTPQIVGFAKAVEIALAEQTTENQRLTQLRDRLWSQLAQLEGIHLNGHPTQRLAGNLNISIEGVDGAALQLGLQPV
VAVSSGSACSSTKTAPSHVLTALGSPEKLAYASIRFGIGRFNTAEEIDIVAKHAIATIQSLRKQATLV
>Mature_387_residues
SNRPIYLDCHATTPLDEQVLAVMLPYFTEKFGNPASIGHIYGWEAEAAVKQAREILAAEINASPEEIIFTSGATEANNLA
IKGVAEAYFQKGQHIITVATEHHAVIDPCEYLKTLGFEITILSVQADGLIDLAQLEKALRPETILVSVMAANNEIGVLQP
LAEIGEMCRTHNIIFHTDAAQAIGKIPLDVQAMNIDLMSLTAHKVYGPKGIGALYVRRRNPRVQLAPQQHGGGHERGMRS
GTLYTPQIVGFAKAVEIALAEQTTENQRLTQLRDRLWSQLAQLEGIHLNGHPTQRLAGNLNISIEGVDGAALQLGLQPVV
AVSSGSACSSTKTAPSHVLTALGSPEKLAYASIRFGIGRFNTAEEIDIVAKHAIATIQSLRKQATLV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=385, Percent_Identity=52.7272727272727, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI156713448, Length=419, Percent_Identity=35.5608591885441, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=53.2467532467532, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1787970, Length=230, Percent_Identity=31.304347826087, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789175, Length=213, Percent_Identity=29.1079812206573, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=388, Percent_Identity=50.5154639175258, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17533177, Length=330, Percent_Identity=32.7272727272727, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=52.6041666666667, Blast_Score=405, Evalue=1e-114,
Organism=Drosophila melanogaster, GI20129463, Length=385, Percent_Identity=54.025974025974, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41864; Mature: 41732

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRPIYLDCHATTPLDEQVLAVMLPYFTEKFGNPASIGHIYGWEAEAAVKQAREILAAE
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHH
INASPEEIIFTSGATEANNLAIKGVAEAYFQKGQHIITVATEHHAVIDPCEYLKTLGFEI
CCCCCCCEEEECCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCEE
TILSVQADGLIDLAQLEKALRPETILVSVMAANNEIGVLQPLAEIGEMCRTHNIIFHTDA
EEEEEECCCCEEHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECH
AQAIGKIPLDVQAMNIDLMSLTAHKVYGPKGIGALYVRRRNPRVQLAPQQHGGGHERGMR
HHHHCCCCCEEEEEEEEEEEEEHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCHHCCCC
SGTLYTPQIVGFAKAVEIALAEQTTENQRLTQLRDRLWSQLAQLEGIHLNGHPTQRLAGN
CCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHCCC
LNISIEGVDGAALQLGLQPVVAVSSGSACSSTKTAPSHVLTALGSPEKLAYASIRFGIGR
EEEEEECCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCHHEEEEEEECCCC
FNTAEEIDIVAKHAIATIQSLRKQATLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNRPIYLDCHATTPLDEQVLAVMLPYFTEKFGNPASIGHIYGWEAEAAVKQAREILAAE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHH
INASPEEIIFTSGATEANNLAIKGVAEAYFQKGQHIITVATEHHAVIDPCEYLKTLGFEI
CCCCCCCEEEECCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCEE
TILSVQADGLIDLAQLEKALRPETILVSVMAANNEIGVLQPLAEIGEMCRTHNIIFHTDA
EEEEEECCCCEEHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECH
AQAIGKIPLDVQAMNIDLMSLTAHKVYGPKGIGALYVRRRNPRVQLAPQQHGGGHERGMR
HHHHCCCCCEEEEEEEEEEEEEHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCHHCCCC
SGTLYTPQIVGFAKAVEIALAEQTTENQRLTQLRDRLWSQLAQLEGIHLNGHPTQRLAGN
CCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHCCC
LNISIEGVDGAALQLGLQPVVAVSSGSACSSTKTAPSHVLTALGSPEKLAYASIRFGIGR
EEEEEECCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCHHEEEEEEECCCC
FNTAEEIDIVAKHAIATIQSLRKQATLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA