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The map label for this gene is barA [H]

Identifier: 17228803

GI number: 17228803

Start: 1549876

End: 1551633

Strand: Direct

Name: barA [H]

Synonym: alr1308

Alternate gene names: 17228803

Gene position: 1549876-1551633 (Clockwise)

Preceding gene: 17228802

Following gene: 17228804

Centisome position: 24.16

GC content: 42.72

Gene sequence:

>1758_bases
ATGACTATTACTGCCAATTCCCAATTACCAAATAGATTTCCTCAAAATCTAGAATCGATGAACCACAAGGCTGATGGCTT
ATTAGCAAACCTCGGTGCTGAGTTGGTATATGTGCAGGATGGGGTGGGGCGTTACCTGTCCTTTTATTGGCAGAAAAGTG
AACTTTTGGGTTTCAACCCAGAGCAAATAGTATGCGATGGTAATGGACAGGAAATTTTTGTCCCACTGGACAAGGTTTCT
TACATGAAAAGACTGCACTGTATCATGGCTAACTTAGCTCCAGAAAAGTTCCCTTGCTGGTTTAGCTGTCATCAAAATCT
ATTTGAGTTGGAACTGGCTATCACGCCGATTATTCCACCTTTGGGAACTGGTGCCACTACGGTCTTGGTCATGGGAAGGT
TATTACAAGTTAAAGTAAATAACCAAGAGGTAAATGTAGCAATTACTACCCCTACACAAACAGACTTAGCTTCGCGATCG
CAGCAACACCAAAGATTGGTAAATAAAATTACCAGAAATATTCGCCGGACACTAGATTTAGACCTTATTTGGCAACAAAC
AGTTGACAGTCTAGGTAAAGCACTCAGACTAGAGCGCTGTATTATTTGTCCTTACCAGCCCTCTAGCTCCAAAGTGCGAG
TAATTGCCGAATATCATCAACCAGACCGTCCTTCCATGCTGGGTTTAGAAATAGATGTAACTTCTGAACCAGCTTTTGCT
CAGGCGTTGACAACCTTGGAACCAATCATTATGGAAGTTCCGGGTTATGAACTTTGCCCACAACAGAAAATTCTAGTAGT
AGCCACTTGTTACCAAGACCAAGCTAATGGCTTAATTGCGATCAATTTACGGCACGAATGTTATCCCCTAACTAATGCCG
AACTAGAACTAGCTAAAGAAGTAGCAGATCAGTTGGGAACAGCGATCGCTCATGCTACCTTATATAAAGAATTAGAAGCA
GCACGACAAAAAGCTGAAGAAGCTTCCCGCCTCAAGAGTGAGTTTCTCGCTAATGTCTCTCACGAAATCCGCACCCCCTT
GAATGGGATGATTGGTTTCCTCAAGCTGATTTTAGAAGGTATGGCAGACGATGTCGAAGAAAAAAATCAGTTTTTATCCG
AAGCCCATCAATTATCTTTACATCTACTCAACATTATTAACGACATCTTAGATATAGCTAAAATCGAAGCTGGCAAAATG
GAGTTAGTGTGCGCTCCCATCAAGCTGGAAGAACTATTCTCTGATGTAGATAACTTCATGCGCCCACAAGCAGAGGTCAA
AAACCTCAGTTTCCGAATGCAATTGCCACCAACCTCGGATGAAATCGTTGTGCAAGGCAATTACCAACGGCTTTTACAAG
TCATGTTAAATATAGTCGGCAATGCCATTAAATTTACTCATGAAGGTGGTATCACTGTTACTGCCGACGTTGTCCTGAAA
AAAGGGAAACTCCAAGAACAGAACTTCCCCGGTATGGTGAGAGTGAGAATAGCCGATACAGGTATTGGTGTTTCCTTAGA
CCAGCAAGACAAATTATTTCAATTATTCTCTCAAGTAGATGGTTCCCGCACCCGTCAATACGGTGGCACAGGTTTGGGAT
TGGCAATATCCCAAAAACTTGTAGAGACGATGGGTGGGGAAGTGCATTTTTACAGTCTTGGTGAGGGACTTGGTTCTACA
GTCACATTCACCGTACCTCTATACCAGCAGCCAGTCATGCTTTCTTCTAACGACACTGACGCTGAGTGTATCGGTTAA

Upstream 100 bases:

>100_bases
ACTCAGTATGTAAAATTGGTCAAATTTTACGCCAAGCTTTGCCCAGCCTTAGTAAGACTGTTTTGAGTTGCCATTAGTCC
ATCCAACTCGATTCAACGTA

Downstream 100 bases:

>100_bases
ATTTAGGACTTATGCAGCCAGTTTGTCTGTTGAGACTAGGGTAAGGGTATAGGGGTGTAAGGGTGTGAGGGTGTGAGGGT
TTTAAACATTTACACTCCCT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTITANSQLPNRFPQNLESMNHKADGLLANLGAELVYVQDGVGRYLSFYWQKSELLGFNPEQIVCDGNGQEIFVPLDKVS
YMKRLHCIMANLAPEKFPCWFSCHQNLFELELAITPIIPPLGTGATTVLVMGRLLQVKVNNQEVNVAITTPTQTDLASRS
QQHQRLVNKITRNIRRTLDLDLIWQQTVDSLGKALRLERCIICPYQPSSSKVRVIAEYHQPDRPSMLGLEIDVTSEPAFA
QALTTLEPIIMEVPGYELCPQQKILVVATCYQDQANGLIAINLRHECYPLTNAELELAKEVADQLGTAIAHATLYKELEA
ARQKAEEASRLKSEFLANVSHEIRTPLNGMIGFLKLILEGMADDVEEKNQFLSEAHQLSLHLLNIINDILDIAKIEAGKM
ELVCAPIKLEELFSDVDNFMRPQAEVKNLSFRMQLPPTSDEIVVQGNYQRLLQVMLNIVGNAIKFTHEGGITVTADVVLK
KGKLQEQNFPGMVRVRIADTGIGVSLDQQDKLFQLFSQVDGSRTRQYGGTGLGLAISQKLVETMGGEVHFYSLGEGLGST
VTFTVPLYQQPVMLSSNDTDAECIG

Sequences:

>Translated_585_residues
MTITANSQLPNRFPQNLESMNHKADGLLANLGAELVYVQDGVGRYLSFYWQKSELLGFNPEQIVCDGNGQEIFVPLDKVS
YMKRLHCIMANLAPEKFPCWFSCHQNLFELELAITPIIPPLGTGATTVLVMGRLLQVKVNNQEVNVAITTPTQTDLASRS
QQHQRLVNKITRNIRRTLDLDLIWQQTVDSLGKALRLERCIICPYQPSSSKVRVIAEYHQPDRPSMLGLEIDVTSEPAFA
QALTTLEPIIMEVPGYELCPQQKILVVATCYQDQANGLIAINLRHECYPLTNAELELAKEVADQLGTAIAHATLYKELEA
ARQKAEEASRLKSEFLANVSHEIRTPLNGMIGFLKLILEGMADDVEEKNQFLSEAHQLSLHLLNIINDILDIAKIEAGKM
ELVCAPIKLEELFSDVDNFMRPQAEVKNLSFRMQLPPTSDEIVVQGNYQRLLQVMLNIVGNAIKFTHEGGITVTADVVLK
KGKLQEQNFPGMVRVRIADTGIGVSLDQQDKLFQLFSQVDGSRTRQYGGTGLGLAISQKLVETMGGEVHFYSLGEGLGST
VTFTVPLYQQPVMLSSNDTDAECIG
>Mature_584_residues
TITANSQLPNRFPQNLESMNHKADGLLANLGAELVYVQDGVGRYLSFYWQKSELLGFNPEQIVCDGNGQEIFVPLDKVSY
MKRLHCIMANLAPEKFPCWFSCHQNLFELELAITPIIPPLGTGATTVLVMGRLLQVKVNNQEVNVAITTPTQTDLASRSQ
QHQRLVNKITRNIRRTLDLDLIWQQTVDSLGKALRLERCIICPYQPSSSKVRVIAEYHQPDRPSMLGLEIDVTSEPAFAQ
ALTTLEPIIMEVPGYELCPQQKILVVATCYQDQANGLIAINLRHECYPLTNAELELAKEVADQLGTAIAHATLYKELEAA
RQKAEEASRLKSEFLANVSHEIRTPLNGMIGFLKLILEGMADDVEEKNQFLSEAHQLSLHLLNIINDILDIAKIEAGKME
LVCAPIKLEELFSDVDNFMRPQAEVKNLSFRMQLPPTSDEIVVQGNYQRLLQVMLNIVGNAIKFTHEGGITVTADVVLKK
GKLQEQNFPGMVRVRIADTGIGVSLDQQDKLFQLFSQVDGSRTRQYGGTGLGLAISQKLVETMGGEVHFYSLGEGLGSTV
TFTVPLYQQPVMLSSNDTDAECIG

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=41.9607843137255, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=35.1239669421488, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=33.984375, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=34.3511450381679, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081816, Length=257, Percent_Identity=35.408560311284, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=30.4526748971193, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786600, Length=275, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786912, Length=270, Percent_Identity=27.4074074074074, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=296, Percent_Identity=24.6621621621622, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=24.1803278688525, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=25.5060728744939, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65050; Mature: 64919

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITANSQLPNRFPQNLESMNHKADGLLANLGAELVYVQDGVGRYLSFYWQKSELLGFNP
CEEECCCCCCCCCHHHHHHHCCHHCCHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCC
EQIVCDGNGQEIFVPLDKVSYMKRLHCIMANLAPEKFPCWFSCHQNLFELELAITPIIPP
CEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCC
LGTGATTVLVMGRLLQVKVNNQEVNVAITTPTQTDLASRSQQHQRLVNKITRNIRRTLDL
CCCCHHHHHHHHCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIWQQTVDSLGKALRLERCIICPYQPSSSKVRVIAEYHQPDRPSMLGLEIDVTSEPAFA
HHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHH
QALTTLEPIIMEVPGYELCPQQKILVVATCYQDQANGLIAINLRHECYPLTNAELELAKE
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCEECCCCCHHHHHHH
VADQLGTAIAHATLYKELEAARQKAEEASRLKSEFLANVSHEIRTPLNGMIGFLKLILEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MADDVEEKNQFLSEAHQLSLHLLNIINDILDIAKIEAGKMELVCAPIKLEELFSDVDNFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
RPQAEVKNLSFRMQLPPTSDEIVVQGNYQRLLQVMLNIVGNAIKFTHEGGITVTADVVLK
CCHHHHCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEE
KGKLQEQNFPGMVRVRIADTGIGVSLDQQDKLFQLFSQVDGSRTRQYGGTGLGLAISQKL
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHH
VETMGGEVHFYSLGEGLGSTVTFTVPLYQQPVMLSSNDTDAECIG
HHHHCCCEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TITANSQLPNRFPQNLESMNHKADGLLANLGAELVYVQDGVGRYLSFYWQKSELLGFNP
EEECCCCCCCCCHHHHHHHCCHHCCHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCC
EQIVCDGNGQEIFVPLDKVSYMKRLHCIMANLAPEKFPCWFSCHQNLFELELAITPIIPP
CEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCC
LGTGATTVLVMGRLLQVKVNNQEVNVAITTPTQTDLASRSQQHQRLVNKITRNIRRTLDL
CCCCHHHHHHHHCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIWQQTVDSLGKALRLERCIICPYQPSSSKVRVIAEYHQPDRPSMLGLEIDVTSEPAFA
HHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHH
QALTTLEPIIMEVPGYELCPQQKILVVATCYQDQANGLIAINLRHECYPLTNAELELAKE
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCEECCCCCHHHHHHH
VADQLGTAIAHATLYKELEAARQKAEEASRLKSEFLANVSHEIRTPLNGMIGFLKLILEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MADDVEEKNQFLSEAHQLSLHLLNIINDILDIAKIEAGKMELVCAPIKLEELFSDVDNFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHH
RPQAEVKNLSFRMQLPPTSDEIVVQGNYQRLLQVMLNIVGNAIKFTHEGGITVTADVVLK
CCHHHHCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEE
KGKLQEQNFPGMVRVRIADTGIGVSLDQQDKLFQLFSQVDGSRTRQYGGTGLGLAISQKL
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHH
VETMGGEVHFYSLGEGLGSTVTFTVPLYQQPVMLSSNDTDAECIG
HHHHCCCEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]