Click here to switch to the map view.

The map label for this gene is silR [H]

Identifier: 17228726

GI number: 17228726

Start: 1457572

End: 1458735

Strand: Direct

Name: silR [H]

Synonym: alr1231

Alternate gene names: 17228726

Gene position: 1457572-1458735 (Clockwise)

Preceding gene: 17228725

Following gene: 17228727

Centisome position: 22.73

GC content: 35.82

Gene sequence:

>1164_bases
ATGAATAAAATTCTGGTTATTGAAGATGATATCCATGTACGCCAAAATATCTTAGATTTGTTAGAAGGTGAGGGATTTAA
TATACTTGAAGCGCACAATGGACTCCTTGGTGTGCAATTAGCTCAAGAAGAAATTCCTGACTTAATTATTTGCGATGTCA
TGATGCCAGAACTAGATGGATATGAAGTCTTAAAGGCATTACGCCAATGCCCAGAAACGGCAATAATTCCTTTAATTTTT
CTAACTGCTAAGTCTGATAAGAATGACTTCCGTCAAGGTATGGAGATGGGAGCAGATGACTATATCATCAAACCTTTCAC
AAGAGCAGAGCTATTAGCAGCTATTGCCTGTCGATTAGAGAAACATATCACAATTAAACAAGAGAATCAAAGAAAACTAG
ATAATCTACGCAACAGTATTGCTTTATCTTTGCCTCACGAAATGCGAACACCTTTAAATGGGATATTAGGCTTTTCTCAA
ATTCTGATGGAAGAGAGTGATAGTCTTGATTCGCAAGCGATTCAGGAGATGGCAGAATCCATCTATTTATCTGGTGAACG
TCTATTTGGCTTGATTCAAAACTTTTTAATGTACGCAGAATTAGAAGTTATGGGAACTGACCCACAGCAAATTAAATTGC
TGCAAAGTCAAACTACCATATTTCCTAACCCAACACTAATAGAACTTATTACTGAAAAAGCTAAAAAAGCAGCCAGAAAA
GCCGATTTAAGCTTAGAATTACATCCCTGTAGTGTAAGAATTTCTACAACCAAGATAGCTAAAATTATAGAAGAATTATT
AGATAATGCTTTCAAATTTTCCTCTCCAGGCAGCCTAGTTAAAATCAAAAACCAGGTTATTAACAATTGCTTAATCTTAT
CATTTATTGATCATGGACGAGGAATTACAGCAGCACAAATTGCTGAATTAGGAGCGTATCAGCAATTTGAACGTAAACTT
TATGAGCAACAAGGTTCTGGATTAGGTTTAACTATTGCTAAACGCATAGCTGAACTACATGGCGGCAAATTAAAAATTCA
CAGCAAGCCACAAGAAAAAACAATTGTGCAAGTAGTACTACCATGTAGCCAGCGACAAGAAGACTATTGTGACAGTACTT
ACTATCAAAAATCGTCAACTATAGGAATCCGAATGGATTATTGA

Upstream 100 bases:

>100_bases
TATAGTGATAGTTGCTTTTTGGTAATTTTTTTATAAACAAAGATCAGTAATCATCCATACAATCTTATGCAATTATTAAA
AACTTATTTTGTTGACCAAT

Downstream 100 bases:

>100_bases
AAAAATTTAACGCGAGGACTGTTGAGAGTTGATAGTCAACAGTCCTGATTAGTAGTTATGCAACTTAGACGCGCATTAGC
TTATCTGTAGTGGCGTGGCA

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNKILVIEDDIHVRQNILDLLEGEGFNILEAHNGLLGVQLAQEEIPDLIICDVMMPELDGYEVLKALRQCPETAIIPLIF
LTAKSDKNDFRQGMEMGADDYIIKPFTRAELLAAIACRLEKHITIKQENQRKLDNLRNSIALSLPHEMRTPLNGILGFSQ
ILMEESDSLDSQAIQEMAESIYLSGERLFGLIQNFLMYAELEVMGTDPQQIKLLQSQTTIFPNPTLIELITEKAKKAARK
ADLSLELHPCSVRISTTKIAKIIEELLDNAFKFSSPGSLVKIKNQVINNCLILSFIDHGRGITAAQIAELGAYQQFERKL
YEQQGSGLGLTIAKRIAELHGGKLKIHSKPQEKTIVQVVLPCSQRQEDYCDSTYYQKSSTIGIRMDY

Sequences:

>Translated_387_residues
MNKILVIEDDIHVRQNILDLLEGEGFNILEAHNGLLGVQLAQEEIPDLIICDVMMPELDGYEVLKALRQCPETAIIPLIF
LTAKSDKNDFRQGMEMGADDYIIKPFTRAELLAAIACRLEKHITIKQENQRKLDNLRNSIALSLPHEMRTPLNGILGFSQ
ILMEESDSLDSQAIQEMAESIYLSGERLFGLIQNFLMYAELEVMGTDPQQIKLLQSQTTIFPNPTLIELITEKAKKAARK
ADLSLELHPCSVRISTTKIAKIIEELLDNAFKFSSPGSLVKIKNQVINNCLILSFIDHGRGITAAQIAELGAYQQFERKL
YEQQGSGLGLTIAKRIAELHGGKLKIHSKPQEKTIVQVVLPCSQRQEDYCDSTYYQKSSTIGIRMDY
>Mature_387_residues
MNKILVIEDDIHVRQNILDLLEGEGFNILEAHNGLLGVQLAQEEIPDLIICDVMMPELDGYEVLKALRQCPETAIIPLIF
LTAKSDKNDFRQGMEMGADDYIIKPFTRAELLAAIACRLEKHITIKQENQRKLDNLRNSIALSLPHEMRTPLNGILGFSQ
ILMEESDSLDSQAIQEMAESIYLSGERLFGLIQNFLMYAELEVMGTDPQQIKLLQSQTTIFPNPTLIELITEKAKKAARK
ADLSLELHPCSVRISTTKIAKIIEELLDNAFKFSSPGSLVKIKNQVINNCLILSFIDHGRGITAAQIAELGAYQQFERKL
YEQQGSGLGLTIAKRIAELHGGKLKIHSKPQEKTIVQVVLPCSQRQEDYCDSTYYQKSSTIGIRMDY

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=28.6324786324786, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=38.3333333333333, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87082012, Length=120, Percent_Identity=37.5, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI2367329, Length=130, Percent_Identity=44.6153846153846, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786911, Length=122, Percent_Identity=36.8852459016393, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786784, Length=134, Percent_Identity=35.0746268656716, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=32.2033898305085, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=36.6666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790863, Length=108, Percent_Identity=37.037037037037, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=35.9223300970874, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788394, Length=119, Percent_Identity=31.0924369747899, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=33.6363636363636, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=26.0504201680672, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790299, Length=128, Percent_Identity=30.46875, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=26.457399103139, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786600, Length=323, Percent_Identity=22.2910216718266, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787229, Length=134, Percent_Identity=28.3582089552239, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789402, Length=152, Percent_Identity=28.9473684210526, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786912, Length=259, Percent_Identity=24.7104247104247, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 43530; Mature: 43530

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILVIEDDIHVRQNILDLLEGEGFNILEAHNGLLGVQLAQEEIPDLIICDVMMPELDG
CCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEHHHHCCCEEEEHHHCCCCCC
YEVLKALRQCPETAIIPLIFLTAKSDKNDFRQGMEMGADDYIIKPFTRAELLAAIACRLE
HHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHH
KHITIKQENQRKLDNLRNSIALSLPHEMRTPLNGILGFSQILMEESDSLDSQAIQEMAES
HCEEECCHHHHHHHHHHHHEEEECCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IYLSGERLFGLIQNFLMYAELEVMGTDPQQIKLLQSQTTIFPNPTLIELITEKAKKAARK
HHCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHH
ADLSLELHPCSVRISTTKIAKIIEELLDNAFKFSSPGSLVKIKNQVINNCLILSFIDHGR
CCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHEEEEHHCCC
GITAAQIAELGAYQQFERKLYEQQGSGLGLTIAKRIAELHGGKLKIHSKPQEKTIVQVVL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCHHEEEEEEE
PCSQRQEDYCDSTYYQKSSTIGIRMDY
CCCCCCHHHHCCHHCCCCCEEEEEECC
>Mature Secondary Structure
MNKILVIEDDIHVRQNILDLLEGEGFNILEAHNGLLGVQLAQEEIPDLIICDVMMPELDG
CCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEHHHHCCCEEEEHHHCCCCCC
YEVLKALRQCPETAIIPLIFLTAKSDKNDFRQGMEMGADDYIIKPFTRAELLAAIACRLE
HHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHH
KHITIKQENQRKLDNLRNSIALSLPHEMRTPLNGILGFSQILMEESDSLDSQAIQEMAES
HCEEECCHHHHHHHHHHHHEEEECCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IYLSGERLFGLIQNFLMYAELEVMGTDPQQIKLLQSQTTIFPNPTLIELITEKAKKAARK
HHCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHH
ADLSLELHPCSVRISTTKIAKIIEELLDNAFKFSSPGSLVKIKNQVINNCLILSFIDHGR
CCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHEEEEHHCCC
GITAAQIAELGAYQQFERKLYEQQGSGLGLTIAKRIAELHGGKLKIHSKPQEKTIVQVVL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCHHEEEEEEE
PCSQRQEDYCDSTYYQKSSTIGIRMDY
CCCCCCHHHHCCHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]