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The map label for this gene is phoP [H]

Identifier: 17228581

GI number: 17228581

Start: 1271561

End: 1272697

Strand: Direct

Name: phoP [H]

Synonym: alr1086

Alternate gene names: 17228581

Gene position: 1271561-1272697 (Clockwise)

Preceding gene: 17228580

Following gene: 17228588

Centisome position: 19.83

GC content: 39.58

Gene sequence:

>1137_bases
ATGTTTCAAATTTTGATAATTGATGATGATCTATCAATTCAAATATTATTAAAAAGAATTTTACAAAAACAGGGTTATCA
AATAGTTACTGCGAGTAATGGTGAAGAAGGAATTACTCAAGCATTAACTAGTCGCCCAGCGCTAATTATTTGTGATTGGA
TTATGCCTGGCTTAAATGGTCTGGAGGTTTGCCATCGCATCAAGACAGATCCGAATCTATCCACTACATTTTTTATCTTG
CTCACCTCTTTGGATTCTGTGGCCGATCGCGTTAAAGGTTTAGATGCAGGTGCTGATGATTTTATCACCAAGCCGATTGA
GCAAAATGAGATGCAAGCAAGGGTTAGAGCCGGATTGCGACTGCATCAATTAAGTCGAGATTTGCGGACTCAAAAGCTGC
TATTAGAAGAAGAATTGGCAGAGGCCGCCGAATATGTGCGATCGCTTCTACCAGAACCCTTAGATGAACCCATCAGTATC
AATTCTCGATTCATCCCCTCTCGGCAACTCGGTGGTGATTGTTTTGACTATTACTGGCTGGATGACGATTGCTTGGCACT
ATATCTACTAGATACAGCCGGACACGGATTAAAAGCTGCTCTCCCCTCAATTTCTGTTCTCAATTTACTGCGTTCCCGCG
CCCTGAAAAATCTCAATTATTATCAACCCAGTGATGTATTGAAAAGTCTGAATGAAACCTTCCAGATGAATTATCAAAAT
GATAAATACTTCACTATCTGGTATGGTGTTTATCACCGCATCAAACGACAACTAATTTATGCTAGCGCTGGTCATCCACC
TGCAATTTTGATATCTGGAACATCCCCAGGTAGTACGGAAGTGCAAATTTTAAGAACCCCAGGAATGCCAGTTGGTATGT
TTCCAGAAGCACAATATGTTGATGCGTATTGCGATGTCGAAAAATTGAGCAGTTTGTATATCTTCAGTGATGGCGCTTAC
GAAATTACTAAATCAGATGGCAAACTTTGGAGTTTAGATGCTTTCATTCAGATACTCGCTAGCGTACATCATAATGAAGA
TTATCAACTTGATCAGGTCTTAAATTGCCTTACCGCCTTGAACTCCAAAGATATATTTGAAGATGATTTATCAATCCTAC
TAGTTAAGTTTGACTAA

Upstream 100 bases:

>100_bases
GTTAAATCCTCTTTCGCCACCGTGAAAAGAGGAGCAGGGGGAGTAAAGAAGAATAACTAATGACTAATGACCAATAACCA
ATGACCAATGACTATTGACT

Downstream 100 bases:

>100_bases
CTATTCGCTAGTATAATTTGATTAAATTCATCTTGATTATTAAATATTTCAAATACCTTATCCATACCAGTTAATTCAAA
TAATATTCTCACCTGTTCAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MFQILIIDDDLSIQILLKRILQKQGYQIVTASNGEEGITQALTSRPALIICDWIMPGLNGLEVCHRIKTDPNLSTTFFIL
LTSLDSVADRVKGLDAGADDFITKPIEQNEMQARVRAGLRLHQLSRDLRTQKLLLEEELAEAAEYVRSLLPEPLDEPISI
NSRFIPSRQLGGDCFDYYWLDDDCLALYLLDTAGHGLKAALPSISVLNLLRSRALKNLNYYQPSDVLKSLNETFQMNYQN
DKYFTIWYGVYHRIKRQLIYASAGHPPAILISGTSPGSTEVQILRTPGMPVGMFPEAQYVDAYCDVEKLSSLYIFSDGAY
EITKSDGKLWSLDAFIQILASVHHNEDYQLDQVLNCLTALNSKDIFEDDLSILLVKFD

Sequences:

>Translated_378_residues
MFQILIIDDDLSIQILLKRILQKQGYQIVTASNGEEGITQALTSRPALIICDWIMPGLNGLEVCHRIKTDPNLSTTFFIL
LTSLDSVADRVKGLDAGADDFITKPIEQNEMQARVRAGLRLHQLSRDLRTQKLLLEEELAEAAEYVRSLLPEPLDEPISI
NSRFIPSRQLGGDCFDYYWLDDDCLALYLLDTAGHGLKAALPSISVLNLLRSRALKNLNYYQPSDVLKSLNETFQMNYQN
DKYFTIWYGVYHRIKRQLIYASAGHPPAILISGTSPGSTEVQILRTPGMPVGMFPEAQYVDAYCDVEKLSSLYIFSDGAY
EITKSDGKLWSLDAFIQILASVHHNEDYQLDQVLNCLTALNSKDIFEDDLSILLVKFD
>Mature_378_residues
MFQILIIDDDLSIQILLKRILQKQGYQIVTASNGEEGITQALTSRPALIICDWIMPGLNGLEVCHRIKTDPNLSTTFFIL
LTSLDSVADRVKGLDAGADDFITKPIEQNEMQARVRAGLRLHQLSRDLRTQKLLLEEELAEAAEYVRSLLPEPLDEPISI
NSRFIPSRQLGGDCFDYYWLDDDCLALYLLDTAGHGLKAALPSISVLNLLRSRALKNLNYYQPSDVLKSLNETFQMNYQN
DKYFTIWYGVYHRIKRQLIYASAGHPPAILISGTSPGSTEVQILRTPGMPVGMFPEAQYVDAYCDVEKLSSLYIFSDGAY
EITKSDGKLWSLDAFIQILASVHHNEDYQLDQVLNCLTALNSKDIFEDDLSILLVKFD

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=37.1900826446281, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082012, Length=122, Percent_Identity=40.9836065573771, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=33.0508474576271, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787487, Length=328, Percent_Identity=29.2682926829268, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786911, Length=122, Percent_Identity=33.6065573770492, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790863, Length=115, Percent_Identity=36.5217391304348, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367329, Length=120, Percent_Identity=36.6666666666667, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788394, Length=129, Percent_Identity=32.5581395348837, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789402, Length=156, Percent_Identity=31.4102564102564, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=125, Percent_Identity=33.6, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=31.3559322033898, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 42650; Mature: 42650

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQILIIDDDLSIQILLKRILQKQGYQIVTASNGEEGITQALTSRPALIICDWIMPGLNG
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEECHHCCCCH
LEVCHRIKTDPNLSTTFFILLTSLDSVADRVKGLDAGADDFITKPIEQNEMQARVRAGLR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHH
LHQLSRDLRTQKLLLEEELAEAAEYVRSLLPEPLDEPISINSRFIPSRQLGGDCFDYYWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEEE
DDDCLALYLLDTAGHGLKAALPSISVLNLLRSRALKNLNYYQPSDVLKSLNETFQMNYQN
CCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCC
DKYFTIWYGVYHRIKRQLIYASAGHPPAILISGTSPGSTEVQILRTPGMPVGMFPEAQYV
CCEEEEHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHH
DAYCDVEKLSSLYIFSDGAYEITKSDGKLWSLDAFIQILASVHHNEDYQLDQVLNCLTAL
HHHCCHHHCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NSKDIFEDDLSILLVKFD
CCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MFQILIIDDDLSIQILLKRILQKQGYQIVTASNGEEGITQALTSRPALIICDWIMPGLNG
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEECHHCCCCH
LEVCHRIKTDPNLSTTFFILLTSLDSVADRVKGLDAGADDFITKPIEQNEMQARVRAGLR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHH
LHQLSRDLRTQKLLLEEELAEAAEYVRSLLPEPLDEPISINSRFIPSRQLGGDCFDYYWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEEE
DDDCLALYLLDTAGHGLKAALPSISVLNLLRSRALKNLNYYQPSDVLKSLNETFQMNYQN
CCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCC
DKYFTIWYGVYHRIKRQLIYASAGHPPAILISGTSPGSTEVQILRTPGMPVGMFPEAQYV
CCEEEEHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHH
DAYCDVEKLSSLYIFSDGAYEITKSDGKLWSLDAFIQILASVHHNEDYQLDQVLNCLTAL
HHHCCHHHCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NSKDIFEDDLSILLVKFD
CCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]