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The map label for this gene is argD

Identifier: 17228575

GI number: 17228575

Start: 1263865

End: 1265148

Strand: Direct

Name: argD

Synonym: alr1080

Alternate gene names: 17228575

Gene position: 1263865-1265148 (Clockwise)

Preceding gene: 17228573

Following gene: 17228576

Centisome position: 19.71

GC content: 47.74

Gene sequence:

>1284_bases
GTGAGCCTACAAACTCTCATTGAGCAAGCCACGAACCCCCCAGAGTCAGGTTCTGCTGCATCTAGCCCCTTTAGTACAGA
TAGCTTTGACGCATCTGTTATGTCCACATACGGACGCTTTCCCCTCGCTTTAGAACGGGGTGCAGGTTGCCGAGTATGGG
ATACCCAGGGCAAAGAATACCTAGACTTTGTGGCGGGGATTGCCACTTGTACACTGGGACACGCCCACCCAGCTATGGTA
GAAGCGGTGACACGCCAAATCCAAAAGCTGCACCATGTATCTAATTTGTACTACATTCCCGAACAAGGTGAATTAGCCCA
ATGGATTATTCAACACTCCTGCGCTGATCGGGTATTTTTCTGTAATTCTGGCGCTGAAGCCAACGAAGCCGCTATTAAAC
TGGCTCGTAAATATGCCCATACAGTTTTAGACATAGAAAAGCCTATTATTCTCACCGCCAATGCCAGTTTCCACGGACGG
ACATTGGCAACTATTACCGCTACTGGGCAAGCAAAGTATCAAAAATATTTTGACCCCCTAGTACCCGGATTTCACTATGT
AAATTACAACGATATCAGTGCGGTAGAAGCAGCTATTAGCGAGTTAGACGAGGGAGATTACCGAGTAGCGGCAATTCTCA
TCGAACCATTACAAGGGGAAGGCGGTGTTCGTCCTGGTGATGTGGAATACTTCCAAAAGCTGCGGCAAATTTGTGATGAC
ACCGGCATTTTGTTGATGTTCGATGAAGTGCAGGTCGGGATGGGACGCAGTGGTAAATTGTGGGGTTATGAATACCTGGG
TGTAGAACCAGACATTTTCACCAGCGCCAAAGGTTTGGGTGGTGGTATCCCCATTGGGGCGATGATGAGTAAGAAATTCT
GCGATGTCTTCCAACCAGGAGAACACGCCAGCACCTTTGGTGGTAATCCCTTTGCTTGTGGTGTAGCGTTGGCTGTGTGT
CAGACCTTGGAAAGGGAGAATATTTTGCAGAATGTGCAAGATAGAGGGGAACAGTTAAGGAGTGGCTTAAGAGCGATCGC
TGCTAAATATCCCCATCATCTAACTGAAGTTCGCGGCTGGGGTTTAATTAACGGTCTGGAATTAGCCGCAGATATTCCAT
TAACTGCTGCTGATGTCGTCAAGGCTGCTATCAACGAGGGCTTATTGTTAGTACCAGCCGGGCCAAAGGTCGTCCGCTTT
GTACCACCATTAATTGTCACAGAGGCAGAAATCAACACCGCCTTAAAATTACTGGAAAAAGCATTAGCAACTGTGACAGC
GTAA

Upstream 100 bases:

>100_bases
AAGAGAAAGTAAGAAACACAATAAATAAAAATTTATTTTTAAGAAACTCTAGGAAACTAGTAAGTAAGTATACAATCAAA
AATCCGCAGGAGGAGCGTTA

Downstream 100 bases:

>100_bases
ATCATAGACTGCTGGCAAAAATAGCGAAAATAATCACCGCCGATACACACCAATGAACGCTGATAAATGTCTGTGTTCAT
CTACTGAAATCGGCGGCTTA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSLQTLIEQATNPPESGSAASSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEYLDFVAGIATCTLGHAHPAMV
EAVTRQIQKLHHVSNLYYIPEQGELAQWIIQHSCADRVFFCNSGAEANEAAIKLARKYAHTVLDIEKPIILTANASFHGR
TLATITATGQAKYQKYFDPLVPGFHYVNYNDISAVEAAISELDEGDYRVAAILIEPLQGEGGVRPGDVEYFQKLRQICDD
TGILLMFDEVQVGMGRSGKLWGYEYLGVEPDIFTSAKGLGGGIPIGAMMSKKFCDVFQPGEHASTFGGNPFACGVALAVC
QTLERENILQNVQDRGEQLRSGLRAIAAKYPHHLTEVRGWGLINGLELAADIPLTAADVVKAAINEGLLLVPAGPKVVRF
VPPLIVTEAEINTALKLLEKALATVTA

Sequences:

>Translated_427_residues
MSLQTLIEQATNPPESGSAASSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEYLDFVAGIATCTLGHAHPAMV
EAVTRQIQKLHHVSNLYYIPEQGELAQWIIQHSCADRVFFCNSGAEANEAAIKLARKYAHTVLDIEKPIILTANASFHGR
TLATITATGQAKYQKYFDPLVPGFHYVNYNDISAVEAAISELDEGDYRVAAILIEPLQGEGGVRPGDVEYFQKLRQICDD
TGILLMFDEVQVGMGRSGKLWGYEYLGVEPDIFTSAKGLGGGIPIGAMMSKKFCDVFQPGEHASTFGGNPFACGVALAVC
QTLERENILQNVQDRGEQLRSGLRAIAAKYPHHLTEVRGWGLINGLELAADIPLTAADVVKAAINEGLLLVPAGPKVVRF
VPPLIVTEAEINTALKLLEKALATVTA
>Mature_426_residues
SLQTLIEQATNPPESGSAASSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEYLDFVAGIATCTLGHAHPAMVE
AVTRQIQKLHHVSNLYYIPEQGELAQWIIQHSCADRVFFCNSGAEANEAAIKLARKYAHTVLDIEKPIILTANASFHGRT
LATITATGQAKYQKYFDPLVPGFHYVNYNDISAVEAAISELDEGDYRVAAILIEPLQGEGGVRPGDVEYFQKLRQICDDT
GILLMFDEVQVGMGRSGKLWGYEYLGVEPDIFTSAKGLGGGIPIGAMMSKKFCDVFQPGEHASTFGGNPFACGVALAVCQ
TLERENILQNVQDRGEQLRSGLRAIAAKYPHHLTEVRGWGLINGLELAADIPLTAADVVKAAINEGLLLVPAGPKVVRFV
PPLIVTEAEINTALKLLEKALATVTA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=433, Percent_Identity=34.1801385681293, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=36.3344051446945, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=25.7918552036199, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=28.169014084507, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=28.3544303797468, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=28.2660332541568, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=27.4004683840749, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI188536080, Length=430, Percent_Identity=24.6511627906977, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI38679950, Length=430, Percent_Identity=24.6511627906977, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI38679946, Length=430, Percent_Identity=24.6511627906977, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=42.7860696517413, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=40.8521303258145, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=35.9605911330049, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=35.5263157894737, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=33.6708860759494, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786991, Length=402, Percent_Identity=27.6119402985075, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786349, Length=322, Percent_Identity=28.8819875776398, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=395, Percent_Identity=35.1898734177215, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=31.6397228637413, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=34.4947735191638, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=27.6255707762557, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=450, Percent_Identity=27.1111111111111, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71981843, Length=159, Percent_Identity=35.8490566037736, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=409, Percent_Identity=41.5647921760391, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323470, Length=402, Percent_Identity=33.5820895522388, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321456, Length=417, Percent_Identity=26.6187050359712, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=33.6683417085427, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=29.9065420560748, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574759, Length=428, Percent_Identity=29.9065420560748, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356575, Length=425, Percent_Identity=27.5294117647059, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281366494, Length=434, Percent_Identity=26.4976958525346, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24667139, Length=434, Percent_Identity=26.4976958525346, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24667143, Length=434, Percent_Identity=26.4976958525346, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_NOSS1 (P54752)

Other databases:

- EMBL:   X78854
- EMBL:   BA000019
- PIR:   AE1941
- RefSeq:   NP_485123.1
- ProteinModelPortal:   P54752
- SMR:   P54752
- STRING:   P54752
- GeneID:   1104674
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr1080
- NMPDR:   fig|103690.1.peg.1390
- eggNOG:   COG4992
- HOGENOM:   HBG725944
- OMA:   NATFADR
- PhylomeDB:   P54752
- ProtClustDB:   PRK02627
- BioCyc:   NSP103690:ALR1080-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 46140; Mature: 46009

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 157-157 BINDING 160-160 BINDING 304-304 BINDING 305-305

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQTLIEQATNPPESGSAASSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEY
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEEECCCCHHH
LDFVAGIATCTLGHAHPAMVEAVTRQIQKLHHVSNLYYIPEQGELAQWIIQHSCADRVFF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCEEE
CNSGAEANEAAIKLARKYAHTVLDIEKPIILTANASFHGRTLATITATGQAKYQKYFDPL
ECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHH
VPGFHYVNYNDISAVEAAISELDEGDYRVAAILIEPLQGEGGVRPGDVEYFQKLRQICDD
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCC
TGILLMFDEVQVGMGRSGKLWGYEYLGVEPDIFTSAKGLGGGIPIGAMMSKKFCDVFQPG
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EHASTFGGNPFACGVALAVCQTLERENILQNVQDRGEQLRSGLRAIAAKYPHHLTEVRGW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
GLINGLELAADIPLTAADVVKAAINEGLLLVPAGPKVVRFVPPLIVTEAEINTALKLLEK
CCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCEEEHHHHHHHHHHHHH
ALATVTA
HHHHHCC
>Mature Secondary Structure 
SLQTLIEQATNPPESGSAASSPFSTDSFDASVMSTYGRFPLALERGAGCRVWDTQGKEY
CHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEEECCCCHHH
LDFVAGIATCTLGHAHPAMVEAVTRQIQKLHHVSNLYYIPEQGELAQWIIQHSCADRVFF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCEEE
CNSGAEANEAAIKLARKYAHTVLDIEKPIILTANASFHGRTLATITATGQAKYQKYFDPL
ECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHH
VPGFHYVNYNDISAVEAAISELDEGDYRVAAILIEPLQGEGGVRPGDVEYFQKLRQICDD
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCC
TGILLMFDEVQVGMGRSGKLWGYEYLGVEPDIFTSAKGLGGGIPIGAMMSKKFCDVFQPG
CCEEEEEECCCCCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EHASTFGGNPFACGVALAVCQTLERENILQNVQDRGEQLRSGLRAIAAKYPHHLTEVRGW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
GLINGLELAADIPLTAADVVKAAINEGLLLVPAGPKVVRFVPPLIVTEAEINTALKLLEK
CCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCEEEHHHHHHHHHHHHH
ALATVTA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929012; 11759840