Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 17228537

GI number: 17228537

Start: 1213221

End: 1214507

Strand: Direct

Name: hemA [H]

Synonym: alr1042

Alternate gene names: 17228537

Gene position: 1213221-1214507 (Clockwise)

Preceding gene: 17228536

Following gene: 17228539

Centisome position: 18.92

GC content: 44.29

Gene sequence:

>1287_bases
ATGAATATTGCAGTGGTGGGGTTAAGCCATAAAACAGCCCCAGTTGAAATTCGGGAAAAGCTGAGTATTCCAGAACCACA
GACAGAAAGTGCGATCGCACAACTTACCAGCTATCCTCATATTGATGAAGTCGCCATTCTCAGCACCTGTAACCGTCTAG
AAATTTACATCGTTGCGGGTGAAACAGATCACGGTATTCGAGAAGTAACTCAGTTTCTTTCCGAACACAGTAAATTGCCA
GTGCATTCCCTACGTCAGCACTTATTTGTCTTGCTACATGAGGACGCAGTTATGCACATCATGCGAGTGGCGGCTGGATT
GGATAGCCTCGTACTAGGCGAAGGTCAAATTCTGGCTCAGGTCAAAAATACTCACAAACTGGGGCAGCAATATAACGGTA
TAAAAACAATTTTGAATCGATTATTTAAACAAGCGCTGACAGCAGGTAAGCGAGTCCGCACGGAAACTAGCATTGGTACT
GGTGCAGTTTCCATCAGTTCCGCAGCTGTGGAGTTAGCGCAAATAAAAGCTGAAAATTTAGCAGCTTGCCGAGTCACAAT
TCTCGGTGCTGGTAAGATGTCACGGCTGTTAGTGCAACACCTCGTTTCTAAAGGTGCTACACAAATCAGTATTGTCAATC
GTTCACGAGAACGCGCCCAAGAATTAGCAAAGCAATTTTCAGAACACCCCATTCGTACTCATTTGCTTCCAGAAATGATG
ACAGTCATTGCTGAAAGCCATTTGGTGTTTACAAGTACCTCCGCAACAGAGCCAATACTTGATCGGGCTAAATTAGAAAT
GGTTTTAGCACCAAACCAGCCCCTCATGTTATTTGATATTTCCGTACCACGCAACGTCCATACAGACGTGAATGAACTGG
TCAACGTCCAGGCTTTCAACGTGGATGATTTAAAGGCGGTTGTAGCCCAAAATTACGAAAGCCGCAGGAAGATGGCTCAA
GAGGCAGAACGGCTTTTAGAAGAAGAAATTGAGGCTTTTGATATTTGGTGGCGCAGTTTAGAAACTGTGTCTACAATTAG
CAGTCTGCGGAGTAAAATCGAAACCATCCGCGAACAGGAATTAGAGAAAGCCTTATCAAGATTGGGTTCAGAATTCGGCG
ACAAACATCAAGAGGTGATTGAAGCCTTAACAAGAGGTATTGTTAATAAAATTTTACATGACCCGATGGTGCAATTGCGG
GCGCAGCAAGATGTTGAAGCCAGAAGGCGCTGTATGCAAACCCTGCAAATGTTGTTCAACCTAGATGTGGGTGAGCAGTT
TAGTTAA

Upstream 100 bases:

>100_bases
AGTACCCAATCCCCAGTACCCAATCCCCAATCCCCAACCCCCAATCCCCAATCCCCAACCCCCAATCATTAAATAACCCA
TTACTAATTACCGATAAGAA

Downstream 100 bases:

>100_bases
TTAGGGATTTAGGGGTGTAGGGGTGTAGGGGTTTAGGGGTTTAGGGGTTTAGGGGAAAGAGTAAAACTAAATTTTTCCCT
CACACCCTCACGCCCTCACA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELVNVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS

Sequences:

>Translated_428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELVNVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS
>Mature_428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELVNVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=36.0696517412935, Blast_Score=240, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47910; Mature: 47910

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAG
CCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEC
ETDHGIREVTQFLSEHSKLPVHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
VKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGTGAVSISSAAVELAQIKAENL
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCH
AACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
HEEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELVNVQAFN
HHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCEECC
VDDLKAVVAQNYESRRKMAQEAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLRAQQDVEARRRCMQTLQMLFN
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDVGEQFS
CCCCCCCC
>Mature Secondary Structure
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAG
CCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEC
ETDHGIREVTQFLSEHSKLPVHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
VKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGTGAVSISSAAVELAQIKAENL
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCH
AACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
HEEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELVNVQAFN
HHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCEECC
VDDLKAVVAQNYESRRKMAQEAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLRAQQDVEARRRCMQTLQMLFN
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDVGEQFS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA