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The map label for this gene is purK [H]

Identifier: 17228484

GI number: 17228484

Start: 1155388

End: 1155915

Strand: Direct

Name: purK [H]

Synonym: alr0989

Alternate gene names: 17228484

Gene position: 1155388-1155915 (Clockwise)

Preceding gene: 17228482

Following gene: 17228485

Centisome position: 18.01

GC content: 45.27

Gene sequence:

>528_bases
ATGGCTCCCTTGGTTGGCATTATTATGGGCAGCGATTCAGATTTGCCCACAATGAAAGAGGCGATCGCTATTTGTGAGGA
ATTTGGTGTAGAAAATGAAGTGGCGATCGTTTCAGCCCATCGCACCCCAGAACGGATGGTGGAATATGCCCAAACAGCCC
ATCATCGGGGTATTAAGGTGATTATTGCTGGTGCTGGTGGTGCCGCCCATCTTCCCGGCATGGTAGCATCTTTAACTCCT
CTACCAGTGATTGGTGTGCCAGTCGCTACACGAAACTTACAAGGTGTGGATTCTTTATATTCAATTGTACAAATGCCTGG
GGGTATTCCTGTGGCTACGGTGGCGATCGGTAACGCCAAAAATGCTGGACTATTAGCTGTGCAAATCCTCGCTACTCAAC
AGCCAGAATTATTAACTAAAGTCCAAGCATACCGTCAAAACCTATCTGAATCAGTAATAACAAAGCAAGCAAAGTTAGAA
CAACTAGGTTACAAGCAGTATTTGGAACAGGAAATATCTGGAAAATAG

Upstream 100 bases:

>100_bases
TATCCCCTCATTCGTTGAATAGTAACTCTATGTGAGATGATAATTGCACCTACACCTTTATATGTGGGTAAAAATTTTGA
ATTTTGAATTTTGAATTATT

Downstream 100 bases:

>100_bases
ACAATGGGAACTGATGGGACAAAGGGGACTGGGGACAAGGAGAAACAAAGCTTTTGCCTTTGCGCGCTTCTTCATCCACG
GGAGGTGTAGCCATAATTAT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MAPLVGIIMGSDSDLPTMKEAIAICEEFGVENEVAIVSAHRTPERMVEYAQTAHHRGIKVIIAGAGGAAHLPGMVASLTP
LPVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAKNAGLLAVQILATQQPELLTKVQAYRQNLSESVITKQAKLE
QLGYKQYLEQEISGK

Sequences:

>Translated_175_residues
MAPLVGIIMGSDSDLPTMKEAIAICEEFGVENEVAIVSAHRTPERMVEYAQTAHHRGIKVIIAGAGGAAHLPGMVASLTP
LPVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAKNAGLLAVQILATQQPELLTKVQAYRQNLSESVITKQAKLE
QLGYKQYLEQEISGK
>Mature_174_residues
APLVGIIMGSDSDLPTMKEAIAICEEFGVENEVAIVSAHRTPERMVEYAQTAHHRGIKVIIAGAGGAAHLPGMVASLTPL
PVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAKNAGLLAVQILATQQPELLTKVQAYRQNLSESVITKQAKLEQ
LGYKQYLEQEISGK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=151, Percent_Identity=52.9801324503311, Blast_Score=130, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=169, Percent_Identity=62.7218934911243, Blast_Score=208, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18493; Mature: 18362

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLVGIIMGSDSDLPTMKEAIAICEEFGVENEVAIVSAHRTPERMVEYAQTAHHRGIKV
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEE
IIAGAGGAAHLPGMVASLTPLPVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAK
EEECCCCCHHCCCHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVQILATQQPELLTKVQAYRQNLSESVITKQAKLEQLGYKQYLEQEISGK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
APLVGIIMGSDSDLPTMKEAIAICEEFGVENEVAIVSAHRTPERMVEYAQTAHHRGIKV
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEE
IIAGAGGAAHLPGMVASLTPLPVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAK
EEECCCCCHHCCCHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVQILATQQPELLTKVQAYRQNLSESVITKQAKLEQLGYKQYLEQEISGK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]