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The map label for this gene is coxA [H]

Identifier: 17228446

GI number: 17228446

Start: 1105412

End: 1107139

Strand: Direct

Name: coxA [H]

Synonym: alr0951

Alternate gene names: 17228446

Gene position: 1105412-1107139 (Clockwise)

Preceding gene: 17228445

Following gene: 17228447

Centisome position: 17.23

GC content: 47.16

Gene sequence:

>1728_bases
ATGACACAAGCTCAGTTGCAAGAAACTGCCAATATCCCGGCGCTGATTGAAGAACCAGGGGAAAGACATTGGCGAGATTA
CTTCAGTTTTAATACCGACCATAAGGTGATTGGTCTGCAATACTTAGTCACTTCCTTCATTTTTTACTGCATTGGCGGCG
TGATGGCTGACTTGGTGCGGACAGAACTACGCACCCCTGAAGTAGATTTTGTCAGTCCAGAAGTCTACAACAGTCTATTT
ACACTGCACGCCACAATCATGATTTTCTTGTGGATTGTGCCGGCAGGTGCAGGATTTGCTAACTATCTGATTCCCCTGAT
GATTGGGGCCAGAGATATGGCGTTCCCCAGATTGAATGCTGTGGCTTTTTGGATGATTCCCCCGGCTGGATTGTTGCTCA
TTGCCAGTTTGGTCGTGGGTGATGCACCTGATGCCGGTTGGACTTCCTACCCTCCCTTGAGCTTAGTAACAGGACAAGTA
GGAGAAGGTATTTGGATTATCAGTGTCCTGCTGTTGGGTACGTCTTCGATTTTGGGGGCGATTAATTTCCTCGTCACCCT
TCTGAAGATGCGTATCCCTAGTATGGGCTTCCATCAAATGCCTTTGTTCTGTTGGGCAATGTTTGCCACTTCAGCATTAG
TTTTACTGTCAACGCCGGTGTTAGCAGCCGGGTTGATTCTGCTGGCTTTTGACCTCATCGCCGGTACCACATTTTTTAAC
CCTACAGGTGGTGGTGATCCGGTGGTATACCAGCATATGTTCTGGTTTTACTCCCACCCGGCGGTATACATCATGATTTT
GCCCTTCTTTGGGGCAATTTCTGAGATTATCCCCGTACATTCGCGTAAACCAATTTTCGGTTATAAAGCGATCGCCTATT
CATCCTTAGCCATCAGTTTTTTAGGGCTAATTGTCTGGGCGCACCATATGTTTACCAGTGGTATTCCCGGTTGGTTACGG
ATGTTCTTCATGATCACCACCATGATCATTGCCGTACCTACAGGGATCAAAATTTTCAGCTGGTTGGCTACGATGTGGGG
CGGCAAAATCCAGTTCAATAGTGCCATGTTGTTTGCCGCCGGCTTTGTCGGAACCTTCGTAATTGGTGGTATTAGTGGTG
TCATGTTGGCAGCAGTGCCTTTTGATATTCACGTCCACGATACTTATTTTGTGGTGGCTCACCTCCACTACGTTTTGTTT
GGTGGTAGTGTGCTGGGCATTTTCGCCGCCATTTATCATTGGTTCCCGAAAATGACGGGACGAATGATCAACGAATTTTG
GGGTAAGGTTCACTTTGCCTTAACTATTGTCGGTTTAAATATGACCTTCTTACCCATGCACAAGCTGGGTTTGATGGGAA
TGAACCGCCGGATTGCACAATATGACCCCAAATTCACCTTATTAAACGAAATCTGCACTTACGGTTCTTACATCCTCGCA
GTTTCCACCTTCCCCTTCATCTTTAATGCGATTTGGAGTTGGTTATACGGCGAGAAAGCTGGTAACAATCCCTGGCGCGC
TCTCACCTTAGAGTGGATGACAACATCTCCACCAGCCATTGAGAATTTTGACAAACTCCCAGTCCTAGCTACAGGGCCTT
ATGACTACGGTTTGGAAAAGGCTAACGAAGGTGTACCTTTATCCGACCCCAACCCAGTCTTATCGGCTGGCCCCAACTCA
GTTCTCAGGGCTGAACCTGATGAGCCATATCCAACAATTGAGTCGTAG

Upstream 100 bases:

>100_bases
ACAAACGACTATTGACTACTAGTCCATACTCCAAAGCTATAGCTCATGAACATTGACTATTGACCATTGACTATTGACCA
TTGACTATTGACTCTTAACC

Downstream 100 bases:

>100_bases
AGGATAGGGGTGTAAGGGTGTAAGGGTGTAAGGGTGTAGGGGTTGATGAAACTATAGTTGAGTTATTCGTTTTACATTGC
TTCTACTCCCCAATCCCCAT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTQAQLQETANIPALIEEPGERHWRDYFSFNTDHKVIGLQYLVTSFIFYCIGGVMADLVRTELRTPEVDFVSPEVYNSLF
TLHATIMIFLWIVPAGAGFANYLIPLMIGARDMAFPRLNAVAFWMIPPAGLLLIASLVVGDAPDAGWTSYPPLSLVTGQV
GEGIWIISVLLLGTSSILGAINFLVTLLKMRIPSMGFHQMPLFCWAMFATSALVLLSTPVLAAGLILLAFDLIAGTTFFN
PTGGGDPVVYQHMFWFYSHPAVYIMILPFFGAISEIIPVHSRKPIFGYKAIAYSSLAISFLGLIVWAHHMFTSGIPGWLR
MFFMITTMIIAVPTGIKIFSWLATMWGGKIQFNSAMLFAAGFVGTFVIGGISGVMLAAVPFDIHVHDTYFVVAHLHYVLF
GGSVLGIFAAIYHWFPKMTGRMINEFWGKVHFALTIVGLNMTFLPMHKLGLMGMNRRIAQYDPKFTLLNEICTYGSYILA
VSTFPFIFNAIWSWLYGEKAGNNPWRALTLEWMTTSPPAIENFDKLPVLATGPYDYGLEKANEGVPLSDPNPVLSAGPNS
VLRAEPDEPYPTIES

Sequences:

>Translated_575_residues
MTQAQLQETANIPALIEEPGERHWRDYFSFNTDHKVIGLQYLVTSFIFYCIGGVMADLVRTELRTPEVDFVSPEVYNSLF
TLHATIMIFLWIVPAGAGFANYLIPLMIGARDMAFPRLNAVAFWMIPPAGLLLIASLVVGDAPDAGWTSYPPLSLVTGQV
GEGIWIISVLLLGTSSILGAINFLVTLLKMRIPSMGFHQMPLFCWAMFATSALVLLSTPVLAAGLILLAFDLIAGTTFFN
PTGGGDPVVYQHMFWFYSHPAVYIMILPFFGAISEIIPVHSRKPIFGYKAIAYSSLAISFLGLIVWAHHMFTSGIPGWLR
MFFMITTMIIAVPTGIKIFSWLATMWGGKIQFNSAMLFAAGFVGTFVIGGISGVMLAAVPFDIHVHDTYFVVAHLHYVLF
GGSVLGIFAAIYHWFPKMTGRMINEFWGKVHFALTIVGLNMTFLPMHKLGLMGMNRRIAQYDPKFTLLNEICTYGSYILA
VSTFPFIFNAIWSWLYGEKAGNNPWRALTLEWMTTSPPAIENFDKLPVLATGPYDYGLEKANEGVPLSDPNPVLSAGPNS
VLRAEPDEPYPTIES
>Mature_574_residues
TQAQLQETANIPALIEEPGERHWRDYFSFNTDHKVIGLQYLVTSFIFYCIGGVMADLVRTELRTPEVDFVSPEVYNSLFT
LHATIMIFLWIVPAGAGFANYLIPLMIGARDMAFPRLNAVAFWMIPPAGLLLIASLVVGDAPDAGWTSYPPLSLVTGQVG
EGIWIISVLLLGTSSILGAINFLVTLLKMRIPSMGFHQMPLFCWAMFATSALVLLSTPVLAAGLILLAFDLIAGTTFFNP
TGGGDPVVYQHMFWFYSHPAVYIMILPFFGAISEIIPVHSRKPIFGYKAIAYSSLAISFLGLIVWAHHMFTSGIPGWLRM
FFMITTMIIAVPTGIKIFSWLATMWGGKIQFNSAMLFAAGFVGTFVIGGISGVMLAAVPFDIHVHDTYFVVAHLHYVLFG
GSVLGIFAAIYHWFPKMTGRMINEFWGKVHFALTIVGLNMTFLPMHKLGLMGMNRRIAQYDPKFTLLNEICTYGSYILAV
STFPFIFNAIWSWLYGEKAGNNPWRALTLEWMTTSPPAIENFDKLPVLATGPYDYGLEKANEGVPLSDPNPVLSAGPNSV
LRAEPDEPYPTIES

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=44.4444444444444, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI1786634, Length=546, Percent_Identity=38.8278388278388, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6226519, Length=523, Percent_Identity=41.1089866156788, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=44.6540880503145, Blast_Score=266, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=39.1129032258064, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 63641; Mature: 63509

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAQLQETANIPALIEEPGERHWRDYFSFNTDHKVIGLQYLVTSFIFYCIGGVMADLVR
CCHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TELRTPEVDFVSPEVYNSLFTLHATIMIFLWIVPAGAGFANYLIPLMIGARDMAFPRLNA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCE
VAFWMIPPAGLLLIASLVVGDAPDAGWTSYPPLSLVTGQVGEGIWIISVLLLGTSSILGA
EEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
INFLVTLLKMRIPSMGFHQMPLFCWAMFATSALVLLSTPVLAAGLILLAFDLIAGTTFFN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEC
PTGGGDPVVYQHMFWFYSHPAVYIMILPFFGAISEIIPVHSRKPIFGYKAIAYSSLAISF
CCCCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LGLIVWAHHMFTSGIPGWLRMFFMITTMIIAVPTGIKIFSWLATMWGGKIQFNSAMLFAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCHHHHHH
GFVGTFVIGGISGVMLAAVPFDIHVHDTYFVVAHLHYVLFGGSVLGIFAAIYHWFPKMTG
HHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RMINEFWGKVHFALTIVGLNMTFLPMHKLGLMGMNRRIAQYDPKFTLLNEICTYGSYILA
HHHHHHHHHHEEEEEEEECCEEEHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCHHHH
VSTFPFIFNAIWSWLYGEKAGNNPWRALTLEWMTTSPPAIENFDKLPVLATGPYDYGLEK
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCHHH
ANEGVPLSDPNPVLSAGPNSVLRAEPDEPYPTIES
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
TQAQLQETANIPALIEEPGERHWRDYFSFNTDHKVIGLQYLVTSFIFYCIGGVMADLVR
CHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TELRTPEVDFVSPEVYNSLFTLHATIMIFLWIVPAGAGFANYLIPLMIGARDMAFPRLNA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCE
VAFWMIPPAGLLLIASLVVGDAPDAGWTSYPPLSLVTGQVGEGIWIISVLLLGTSSILGA
EEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
INFLVTLLKMRIPSMGFHQMPLFCWAMFATSALVLLSTPVLAAGLILLAFDLIAGTTFFN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEC
PTGGGDPVVYQHMFWFYSHPAVYIMILPFFGAISEIIPVHSRKPIFGYKAIAYSSLAISF
CCCCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LGLIVWAHHMFTSGIPGWLRMFFMITTMIIAVPTGIKIFSWLATMWGGKIQFNSAMLFAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCHHHHHH
GFVGTFVIGGISGVMLAAVPFDIHVHDTYFVVAHLHYVLFGGSVLGIFAAIYHWFPKMTG
HHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RMINEFWGKVHFALTIVGLNMTFLPMHKLGLMGMNRRIAQYDPKFTLLNEICTYGSYILA
HHHHHHHHHHEEEEEEEECCEEEHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCHHHH
VSTFPFIFNAIWSWLYGEKAGNNPWRALTLEWMTTSPPAIENFDKLPVLATGPYDYGLEK
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCHHH
ANEGVPLSDPNPVLSAGPNSVLRAEPDEPYPTIES
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]